## Database ID URL or Descriptions # COFACTOR A8WC96_PIG Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000256|PIRSR PIRSR038051-1}; # GO_component GO:0005634 nucleus; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0034720 histone H3-K4 demethylation; IEA:InterPro. # GOslim_component GO:0005634 nucleus # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0008150 biological_process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.50.50.60 -; 2. # Genevisible A8WC96 SS # InterPro IPR002937 Amino_oxidase # InterPro IPR007526 SWIRM # InterPro IPR009057 Homeodomain-like # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR017366 Hist_Lys-spec_deMease # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03036 Chromosome # Organism A8WC96_PIG Sus scrofa (Pig) # PIRSF PIRSF038051 Histone_Lys-demethylase # PROSITE PS50934 SWIRM # Pfam PF01593 Amino_oxidase # Pfam PF04433 SWIRM # RefSeq NP_001106157 NM_001112687.1 # SUPFAM SSF46689 SSF46689 # SUPFAM SSF51905 SSF51905; 3 # SubName A8WC96_PIG Amine oxidase (Flavin containing) domain 2 isoform a {ECO 0000313|EMBL ABX10190.1} # eggNOG ENOG410XSNC LUCA # eggNOG KOG0029 Eukaryota # eggNOG KOG0685 Eukaryota BLAST swissprot:A8WC96_PIG http://rest.g-language.org/emboss/kblast/swissprot:A8WC96_PIG DOI 10.1007/s12010-012-9966-3 http://dx.doi.org/10.1007/s12010-012-9966-3 EMBL EU219915 http://www.ebi.ac.uk/ena/data/view/EU219915 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0034720 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034720 GOslim_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 100127157 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100127157 HOGENOM HOG000246945 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246945&db=HOGENOM6 HOVERGEN HBG102081 http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG102081&db=HOVERGEN InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR007526 http://www.ebi.ac.uk/interpro/entry/IPR007526 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR017366 http://www.ebi.ac.uk/interpro/entry/IPR017366 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ssc:100127157 http://www.genome.jp/dbget-bin/www_bget?ssc:100127157 KEGG_Orthology KO:K11450 http://www.genome.jp/dbget-bin/www_bget?KO:K11450 PROSITE PS50934 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50934 PSORT swissprot:A8WC96_PIG http://rest.g-language.org/emboss/kpsort/swissprot:A8WC96_PIG PSORT-B swissprot:A8WC96_PIG http://rest.g-language.org/emboss/kpsortb/swissprot:A8WC96_PIG PSORT2 swissprot:A8WC96_PIG http://rest.g-language.org/emboss/kpsort2/swissprot:A8WC96_PIG Pfam PF01593 http://pfam.xfam.org/family/PF01593 Pfam PF04433 http://pfam.xfam.org/family/PF04433 Phobius swissprot:A8WC96_PIG http://rest.g-language.org/emboss/kphobius/swissprot:A8WC96_PIG ProteinModelPortal A8WC96 http://www.proteinmodelportal.org/query/uniprot/A8WC96 PubMed 23229475 http://www.ncbi.nlm.nih.gov/pubmed/23229475 RefSeq NP_001106157 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001106157 STRING 9823.ENSSSCP00000003832 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9823.ENSSSCP00000003832&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniGene Ssc.30810 http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Ssc.30810 UniGene Ssc.7578 http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Ssc.7578 UniProtKB A8WC96_PIG http://www.uniprot.org/uniprot/A8WC96_PIG UniProtKB-AC A8WC96 http://www.uniprot.org/uniprot/A8WC96 charge swissprot:A8WC96_PIG http://rest.g-language.org/emboss/charge/swissprot:A8WC96_PIG eggNOG ENOG410XSNC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSNC eggNOG KOG0029 http://eggnogapi.embl.de/nog_data/html/tree/KOG0029 eggNOG KOG0685 http://eggnogapi.embl.de/nog_data/html/tree/KOG0685 epestfind swissprot:A8WC96_PIG http://rest.g-language.org/emboss/epestfind/swissprot:A8WC96_PIG garnier swissprot:A8WC96_PIG http://rest.g-language.org/emboss/garnier/swissprot:A8WC96_PIG helixturnhelix swissprot:A8WC96_PIG http://rest.g-language.org/emboss/helixturnhelix/swissprot:A8WC96_PIG hmoment swissprot:A8WC96_PIG http://rest.g-language.org/emboss/hmoment/swissprot:A8WC96_PIG iep swissprot:A8WC96_PIG http://rest.g-language.org/emboss/iep/swissprot:A8WC96_PIG inforesidue swissprot:A8WC96_PIG http://rest.g-language.org/emboss/inforesidue/swissprot:A8WC96_PIG octanol swissprot:A8WC96_PIG http://rest.g-language.org/emboss/octanol/swissprot:A8WC96_PIG pepcoil swissprot:A8WC96_PIG http://rest.g-language.org/emboss/pepcoil/swissprot:A8WC96_PIG pepdigest swissprot:A8WC96_PIG http://rest.g-language.org/emboss/pepdigest/swissprot:A8WC96_PIG pepinfo swissprot:A8WC96_PIG http://rest.g-language.org/emboss/pepinfo/swissprot:A8WC96_PIG pepnet swissprot:A8WC96_PIG http://rest.g-language.org/emboss/pepnet/swissprot:A8WC96_PIG pepstats swissprot:A8WC96_PIG http://rest.g-language.org/emboss/pepstats/swissprot:A8WC96_PIG pepwheel swissprot:A8WC96_PIG http://rest.g-language.org/emboss/pepwheel/swissprot:A8WC96_PIG pepwindow swissprot:A8WC96_PIG http://rest.g-language.org/emboss/pepwindow/swissprot:A8WC96_PIG sigcleave swissprot:A8WC96_PIG http://rest.g-language.org/emboss/sigcleave/swissprot:A8WC96_PIG ## Database ID URL or Descriptions # EnsemblPlants EDP07797 EDP07797; CHLREDRAFT_187612 # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.50.50.60 -; 3. # Gramene EDP07797 EDP07797; CHLREDRAFT_187612 # InterPro IPR001613 Flavin_amine_oxidase # InterPro IPR002937 Amino_oxidase # InterPro IPR023753 FAD/NAD-binding_dom # Organism A8HZE6_CHLRE Chlamydomonas reinhardtii (Chlamydomonas smithii) # PRINTS PR00757 AMINEOXDASEF # Pfam PF01593 Amino_oxidase # Proteomes UP000006906 Unassembled WGS sequence # RefSeq XP_001698304 XM_001698252.1 # SUPFAM SSF51905 SSF51905; 2 # SubName A8HZE6_CHLRE Amine oxidoreductase {ECO 0000313|EMBL EDP07797.1} # eggNOG ENOG410XSNC LUCA # eggNOG KOG0029 Eukaryota BLAST swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/kblast/swissprot:A8HZE6_CHLRE DOI 10.1126/science.1143609 http://dx.doi.org/10.1126/science.1143609 EMBL DS496111 http://www.ebi.ac.uk/ena/data/view/DS496111 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 5724032 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5724032 InParanoid A8HZE6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=A8HZE6 InterPro IPR001613 http://www.ebi.ac.uk/interpro/entry/IPR001613 InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Gene cre:CHLREDRAFT_187612 http://www.genome.jp/dbget-bin/www_bget?cre:CHLREDRAFT_187612 PRINTS PR00757 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00757 PSORT swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/kpsort/swissprot:A8HZE6_CHLRE PSORT-B swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/kpsortb/swissprot:A8HZE6_CHLRE PSORT2 swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/kpsort2/swissprot:A8HZE6_CHLRE Pfam PF01593 http://pfam.xfam.org/family/PF01593 Phobius swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/kphobius/swissprot:A8HZE6_CHLRE ProteinModelPortal A8HZE6 http://www.proteinmodelportal.org/query/uniprot/A8HZE6 PubMed 17932292 http://www.ncbi.nlm.nih.gov/pubmed/17932292 RefSeq XP_001698304 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=XP_001698304 STRING 3055.EDP07797 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=3055.EDP07797&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniGene Cre.11304 http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Cre.11304 UniProtKB A8HZE6_CHLRE http://www.uniprot.org/uniprot/A8HZE6_CHLRE UniProtKB-AC A8HZE6 http://www.uniprot.org/uniprot/A8HZE6 charge swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/charge/swissprot:A8HZE6_CHLRE eggNOG ENOG410XSNC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSNC eggNOG KOG0029 http://eggnogapi.embl.de/nog_data/html/tree/KOG0029 epestfind swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/epestfind/swissprot:A8HZE6_CHLRE garnier swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/garnier/swissprot:A8HZE6_CHLRE helixturnhelix swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/helixturnhelix/swissprot:A8HZE6_CHLRE hmoment swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/hmoment/swissprot:A8HZE6_CHLRE iep swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/iep/swissprot:A8HZE6_CHLRE inforesidue swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/inforesidue/swissprot:A8HZE6_CHLRE octanol swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/octanol/swissprot:A8HZE6_CHLRE pepcoil swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/pepcoil/swissprot:A8HZE6_CHLRE pepdigest swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/pepdigest/swissprot:A8HZE6_CHLRE pepinfo swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/pepinfo/swissprot:A8HZE6_CHLRE pepnet swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/pepnet/swissprot:A8HZE6_CHLRE pepstats swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/pepstats/swissprot:A8HZE6_CHLRE pepwheel swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/pepwheel/swissprot:A8HZE6_CHLRE pepwindow swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/pepwindow/swissprot:A8HZE6_CHLRE sigcleave swissprot:A8HZE6_CHLRE http://rest.g-language.org/emboss/sigcleave/swissprot:A8HZE6_CHLRE ## Database ID URL or Descriptions # GO_function GO:0008168 methyltransferase activity; IEA:UniProtKB-KW. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0016491 oxidoreductase activity # InterPro IPR002937 Amino_oxidase # InterPro IPR023753 FAD/NAD-binding_dom # Organism A0A061S6Q5_9CHLO Tetraselmis sp. GSL018 # Pfam PF01593 Amino_oxidase # SUPFAM SSF51905 SSF51905; 2 # SubName A0A061S6Q5_9CHLO Lysine-specific histone demethylase 1 {ECO 0000313|EMBL JAC78560.1} BLAST swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/kblast/swissprot:A0A061S6Q5_9CHLO EMBL GBEZ01006860 http://www.ebi.ac.uk/ena/data/view/GBEZ01006860 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 PSORT swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/kpsort/swissprot:A0A061S6Q5_9CHLO PSORT-B swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/kpsortb/swissprot:A0A061S6Q5_9CHLO PSORT2 swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/kpsort2/swissprot:A0A061S6Q5_9CHLO Pfam PF01593 http://pfam.xfam.org/family/PF01593 Phobius swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/kphobius/swissprot:A0A061S6Q5_9CHLO SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB A0A061S6Q5_9CHLO http://www.uniprot.org/uniprot/A0A061S6Q5_9CHLO UniProtKB-AC A0A061S6Q5 http://www.uniprot.org/uniprot/A0A061S6Q5 charge swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/charge/swissprot:A0A061S6Q5_9CHLO epestfind swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/epestfind/swissprot:A0A061S6Q5_9CHLO garnier swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/garnier/swissprot:A0A061S6Q5_9CHLO helixturnhelix swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/helixturnhelix/swissprot:A0A061S6Q5_9CHLO hmoment swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/hmoment/swissprot:A0A061S6Q5_9CHLO iep swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/iep/swissprot:A0A061S6Q5_9CHLO inforesidue swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/inforesidue/swissprot:A0A061S6Q5_9CHLO octanol swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/octanol/swissprot:A0A061S6Q5_9CHLO pepcoil swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/pepcoil/swissprot:A0A061S6Q5_9CHLO pepdigest swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/pepdigest/swissprot:A0A061S6Q5_9CHLO pepinfo swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/pepinfo/swissprot:A0A061S6Q5_9CHLO pepnet swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/pepnet/swissprot:A0A061S6Q5_9CHLO pepstats swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/pepstats/swissprot:A0A061S6Q5_9CHLO pepwheel swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/pepwheel/swissprot:A0A061S6Q5_9CHLO pepwindow swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/pepwindow/swissprot:A0A061S6Q5_9CHLO sigcleave swissprot:A0A061S6Q5_9CHLO http://rest.g-language.org/emboss/sigcleave/swissprot:A0A061S6Q5_9CHLO ## Database ID URL or Descriptions # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0008168 methyltransferase activity; IEA:UniProtKB-KW. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 1.10.10.10 -; 1. # Gene3D 3.40.50.720 -; 1. # InterPro IPR001613 Flavin_amine_oxidase # InterPro IPR002937 Amino_oxidase # InterPro IPR007526 SWIRM # InterPro IPR009057 Homeodomain-like # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023753 FAD/NAD-binding_dom # Organism A0A061R7P1_9CHLO Tetraselmis sp. GSL018 # PRINTS PR00757 AMINEOXDASEF # PROSITE PS50934 SWIRM # Pfam PF01593 Amino_oxidase # Pfam PF04433 SWIRM # SUPFAM SSF46689 SSF46689 # SUPFAM SSF51905 SSF51905; 2 # SubName A0A061R7P1_9CHLO Lysine-specific histone demethylase 1 {ECO 0000313|EMBL JAC67998.1} BLAST swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/kblast/swissprot:A0A061R7P1_9CHLO EMBL GBEZ01018437 http://www.ebi.ac.uk/ena/data/view/GBEZ01018437 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 InterPro IPR001613 http://www.ebi.ac.uk/interpro/entry/IPR001613 InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR007526 http://www.ebi.ac.uk/interpro/entry/IPR007526 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 PRINTS PR00757 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00757 PROSITE PS50934 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50934 PSORT swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/kpsort/swissprot:A0A061R7P1_9CHLO PSORT-B swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/kpsortb/swissprot:A0A061R7P1_9CHLO PSORT2 swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/kpsort2/swissprot:A0A061R7P1_9CHLO Pfam PF01593 http://pfam.xfam.org/family/PF01593 Pfam PF04433 http://pfam.xfam.org/family/PF04433 Phobius swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/kphobius/swissprot:A0A061R7P1_9CHLO SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB A0A061R7P1_9CHLO http://www.uniprot.org/uniprot/A0A061R7P1_9CHLO UniProtKB-AC A0A061R7P1 http://www.uniprot.org/uniprot/A0A061R7P1 charge swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/charge/swissprot:A0A061R7P1_9CHLO epestfind swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/epestfind/swissprot:A0A061R7P1_9CHLO garnier swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/garnier/swissprot:A0A061R7P1_9CHLO helixturnhelix swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/helixturnhelix/swissprot:A0A061R7P1_9CHLO hmoment swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/hmoment/swissprot:A0A061R7P1_9CHLO iep swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/iep/swissprot:A0A061R7P1_9CHLO inforesidue swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/inforesidue/swissprot:A0A061R7P1_9CHLO octanol swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/octanol/swissprot:A0A061R7P1_9CHLO pepcoil swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/pepcoil/swissprot:A0A061R7P1_9CHLO pepdigest swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/pepdigest/swissprot:A0A061R7P1_9CHLO pepinfo swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/pepinfo/swissprot:A0A061R7P1_9CHLO pepnet swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/pepnet/swissprot:A0A061R7P1_9CHLO pepstats swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/pepstats/swissprot:A0A061R7P1_9CHLO pepwheel swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/pepwheel/swissprot:A0A061R7P1_9CHLO pepwindow swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/pepwindow/swissprot:A0A061R7P1_9CHLO sigcleave swissprot:A0A061R7P1_9CHLO http://rest.g-language.org/emboss/sigcleave/swissprot:A0A061R7P1_9CHLO ## Database ID URL or Descriptions # COFACTOR B3STT9_RAT Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000256|PIRSR PIRSR038051-1}; # GO_component GO:0000790 nuclear chromatin; IDA:RGD. # GO_component GO:0005634 nucleus; IDA:RGD. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0003682 chromatin binding; IDA:RGD. # GO_function GO:0008134 transcription factor binding; IPI:RGD. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0000380 alternative mRNA splicing, via spliceosome; IEP:RGD. # GO_process GO:0010976 positive regulation of neuron projection development; IMP:RGD. # GO_process GO:0014070 response to organic cyclic compound; IEP:RGD. # GO_process GO:0021987 cerebral cortex development; IEP:RGD. # GO_process GO:0034720 histone H3-K4 demethylation; IMP:RGD. # GO_process GO:0035563 positive regulation of chromatin binding; IMP:RGD. # GO_process GO:0042551 neuron maturation; IEP:RGD. # GO_process GO:0045793 positive regulation of cell size; IMP:RGD. # GO_process GO:0045944 positive regulation of transcription from RNA polymerase II promoter; IMP:RGD. # GO_process GO:0046098 guanine metabolic process; IMP:RGD. # GO_process GO:0060992 response to fungicide; IEP:RGD. # GO_process GO:0071320 cellular response to cAMP; IEP:RGD. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005634 nucleus # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008134 transcription factor binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006397 mRNA processing # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0021700 developmental maturation # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0048856 anatomical structure development # Gene3D 1.10.10.10 -; 1. # Gene3D 3.50.50.60 -; 2. # Genevisible B3STT9 RN # InterPro IPR002937 Amino_oxidase # InterPro IPR007526 SWIRM # InterPro IPR009057 Homeodomain-like # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR017366 Hist_Lys-spec_deMease # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03036 Chromosome # Organism B3STT9_RAT Rattus norvegicus (Rat) # PIRSF PIRSF038051 Histone_Lys-demethylase # PROSITE PS50934 SWIRM # Pfam PF01593 Amino_oxidase # Pfam PF04433 SWIRM # RGD 1562975 Kdm1a # RefSeq NP_001123570 NM_001130098.1 # SUPFAM SSF46689 SSF46689 # SUPFAM SSF51905 SSF51905; 3 # SubName B3STT9_RAT Neuroprotective protein 3 {ECO 0000313|EMBL ABX10434.1} # eggNOG ENOG410XSNC LUCA # eggNOG KOG0029 Eukaryota # eggNOG KOG0685 Eukaryota BLAST swissprot:B3STT9_RAT http://rest.g-language.org/emboss/kblast/swissprot:B3STT9_RAT COXPRESdb 500569 http://coxpresdb.jp/data/gene/500569.shtml DOI 10.1371/journal.pone.0015008 http://dx.doi.org/10.1371/journal.pone.0015008 EMBL EF688598 http://www.ebi.ac.uk/ena/data/view/EF688598 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_component GO:0000790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000790 GO_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003682 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003682 GO_function GO:0008134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008134 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0000380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000380 GO_process GO:0010976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010976 GO_process GO:0014070 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014070 GO_process GO:0021987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021987 GO_process GO:0034720 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034720 GO_process GO:0035563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035563 GO_process GO:0042551 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042551 GO_process GO:0045793 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045793 GO_process GO:0045944 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944 GO_process GO:0046098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046098 GO_process GO:0060992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060992 GO_process GO:0071320 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008134 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006397 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0021700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021700 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0048856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 500569 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=500569 HOGENOM HOG000246945 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246945&db=HOGENOM6 HOVERGEN HBG102081 http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG102081&db=HOVERGEN InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR007526 http://www.ebi.ac.uk/interpro/entry/IPR007526 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR017366 http://www.ebi.ac.uk/interpro/entry/IPR017366 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene rno:500569 http://www.genome.jp/dbget-bin/www_bget?rno:500569 KEGG_Orthology KO:K11450 http://www.genome.jp/dbget-bin/www_bget?KO:K11450 PROSITE PS50934 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50934 PSORT swissprot:B3STT9_RAT http://rest.g-language.org/emboss/kpsort/swissprot:B3STT9_RAT PSORT-B swissprot:B3STT9_RAT http://rest.g-language.org/emboss/kpsortb/swissprot:B3STT9_RAT PSORT2 swissprot:B3STT9_RAT http://rest.g-language.org/emboss/kpsort2/swissprot:B3STT9_RAT Pfam PF01593 http://pfam.xfam.org/family/PF01593 Pfam PF04433 http://pfam.xfam.org/family/PF04433 Phobius swissprot:B3STT9_RAT http://rest.g-language.org/emboss/kphobius/swissprot:B3STT9_RAT ProteinModelPortal B3STT9 http://www.proteinmodelportal.org/query/uniprot/B3STT9 PubMed 21124846 http://www.ncbi.nlm.nih.gov/pubmed/21124846 RGD 1562975 http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1562975 RefSeq NP_001123570 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001123570 STRING 10116.ENSRNOP00000052846 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=10116.ENSRNOP00000052846&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniGene Rn.203461 http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Rn.203461 UniProtKB B3STT9_RAT http://www.uniprot.org/uniprot/B3STT9_RAT UniProtKB-AC B3STT9 http://www.uniprot.org/uniprot/B3STT9 charge swissprot:B3STT9_RAT http://rest.g-language.org/emboss/charge/swissprot:B3STT9_RAT eggNOG ENOG410XSNC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSNC eggNOG KOG0029 http://eggnogapi.embl.de/nog_data/html/tree/KOG0029 eggNOG KOG0685 http://eggnogapi.embl.de/nog_data/html/tree/KOG0685 epestfind swissprot:B3STT9_RAT http://rest.g-language.org/emboss/epestfind/swissprot:B3STT9_RAT garnier swissprot:B3STT9_RAT http://rest.g-language.org/emboss/garnier/swissprot:B3STT9_RAT helixturnhelix swissprot:B3STT9_RAT http://rest.g-language.org/emboss/helixturnhelix/swissprot:B3STT9_RAT hmoment swissprot:B3STT9_RAT http://rest.g-language.org/emboss/hmoment/swissprot:B3STT9_RAT iep swissprot:B3STT9_RAT http://rest.g-language.org/emboss/iep/swissprot:B3STT9_RAT inforesidue swissprot:B3STT9_RAT http://rest.g-language.org/emboss/inforesidue/swissprot:B3STT9_RAT octanol swissprot:B3STT9_RAT http://rest.g-language.org/emboss/octanol/swissprot:B3STT9_RAT pepcoil swissprot:B3STT9_RAT http://rest.g-language.org/emboss/pepcoil/swissprot:B3STT9_RAT pepdigest swissprot:B3STT9_RAT http://rest.g-language.org/emboss/pepdigest/swissprot:B3STT9_RAT pepinfo swissprot:B3STT9_RAT http://rest.g-language.org/emboss/pepinfo/swissprot:B3STT9_RAT pepnet swissprot:B3STT9_RAT http://rest.g-language.org/emboss/pepnet/swissprot:B3STT9_RAT pepstats swissprot:B3STT9_RAT http://rest.g-language.org/emboss/pepstats/swissprot:B3STT9_RAT pepwheel swissprot:B3STT9_RAT http://rest.g-language.org/emboss/pepwheel/swissprot:B3STT9_RAT pepwindow swissprot:B3STT9_RAT http://rest.g-language.org/emboss/pepwindow/swissprot:B3STT9_RAT sigcleave swissprot:B3STT9_RAT http://rest.g-language.org/emboss/sigcleave/swissprot:B3STT9_RAT ## Database ID URL or Descriptions # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # InterPro IPR002937 Amino_oxidase # InterPro IPR023753 FAD/NAD-binding_dom # Organism A7YEZ4_MYRTR Myrmecophaga tridactyla (Giant anteater) # Pfam PF01593 Amino_oxidase # SUPFAM SSF51905 SSF51905 # SubName A7YEZ4_MYRTR Amine oxidase flavin-containing domain 2 {ECO 0000313|EMBL ABU96083.1} BLAST swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/kblast/swissprot:A7YEZ4_MYRTR EMBL EF674534 http://www.ebi.ac.uk/ena/data/view/EF674534 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 PSORT swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/kpsort/swissprot:A7YEZ4_MYRTR PSORT-B swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/kpsortb/swissprot:A7YEZ4_MYRTR PSORT2 swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/kpsort2/swissprot:A7YEZ4_MYRTR Pfam PF01593 http://pfam.xfam.org/family/PF01593 Phobius swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/kphobius/swissprot:A7YEZ4_MYRTR SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB A7YEZ4_MYRTR http://www.uniprot.org/uniprot/A7YEZ4_MYRTR UniProtKB-AC A7YEZ4 http://www.uniprot.org/uniprot/A7YEZ4 charge swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/charge/swissprot:A7YEZ4_MYRTR epestfind swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/epestfind/swissprot:A7YEZ4_MYRTR garnier swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/garnier/swissprot:A7YEZ4_MYRTR helixturnhelix swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/helixturnhelix/swissprot:A7YEZ4_MYRTR hmoment swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/hmoment/swissprot:A7YEZ4_MYRTR iep swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/iep/swissprot:A7YEZ4_MYRTR inforesidue swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/inforesidue/swissprot:A7YEZ4_MYRTR octanol swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/octanol/swissprot:A7YEZ4_MYRTR pepcoil swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/pepcoil/swissprot:A7YEZ4_MYRTR pepdigest swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/pepdigest/swissprot:A7YEZ4_MYRTR pepinfo swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/pepinfo/swissprot:A7YEZ4_MYRTR pepnet swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/pepnet/swissprot:A7YEZ4_MYRTR pepstats swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/pepstats/swissprot:A7YEZ4_MYRTR pepwheel swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/pepwheel/swissprot:A7YEZ4_MYRTR pepwindow swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/pepwindow/swissprot:A7YEZ4_MYRTR sigcleave swissprot:A7YEZ4_MYRTR http://rest.g-language.org/emboss/sigcleave/swissprot:A7YEZ4_MYRTR ## Database ID URL or Descriptions # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # InterPro IPR002937 Amino_oxidase # InterPro IPR023753 FAD/NAD-binding_dom # Organism A7YEZ5_ROULA Rousettus lanosus (Long-haired rousette) (Stenonycteris lanosus) # Pfam PF01593 Amino_oxidase # SUPFAM SSF51905 SSF51905 # SubName A7YEZ5_ROULA Amine oxidase flavin-containing domain 2 {ECO 0000313|EMBL ABU96084.1} BLAST swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/kblast/swissprot:A7YEZ5_ROULA EMBL EF674535 http://www.ebi.ac.uk/ena/data/view/EF674535 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 PSORT swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/kpsort/swissprot:A7YEZ5_ROULA PSORT-B swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/kpsortb/swissprot:A7YEZ5_ROULA PSORT2 swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/kpsort2/swissprot:A7YEZ5_ROULA Pfam PF01593 http://pfam.xfam.org/family/PF01593 Phobius swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/kphobius/swissprot:A7YEZ5_ROULA SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB A7YEZ5_ROULA http://www.uniprot.org/uniprot/A7YEZ5_ROULA UniProtKB-AC A7YEZ5 http://www.uniprot.org/uniprot/A7YEZ5 charge swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/charge/swissprot:A7YEZ5_ROULA epestfind swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/epestfind/swissprot:A7YEZ5_ROULA garnier swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/garnier/swissprot:A7YEZ5_ROULA helixturnhelix swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/helixturnhelix/swissprot:A7YEZ5_ROULA hmoment swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/hmoment/swissprot:A7YEZ5_ROULA iep swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/iep/swissprot:A7YEZ5_ROULA inforesidue swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/inforesidue/swissprot:A7YEZ5_ROULA octanol swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/octanol/swissprot:A7YEZ5_ROULA pepcoil swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/pepcoil/swissprot:A7YEZ5_ROULA pepdigest swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/pepdigest/swissprot:A7YEZ5_ROULA pepinfo swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/pepinfo/swissprot:A7YEZ5_ROULA pepnet swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/pepnet/swissprot:A7YEZ5_ROULA pepstats swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/pepstats/swissprot:A7YEZ5_ROULA pepwheel swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/pepwheel/swissprot:A7YEZ5_ROULA pepwindow swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/pepwindow/swissprot:A7YEZ5_ROULA sigcleave swissprot:A7YEZ5_ROULA http://rest.g-language.org/emboss/sigcleave/swissprot:A7YEZ5_ROULA ## Database ID URL or Descriptions # ALTERNATIVE PRODUCTS KDM1A_HUMAN Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60341-1; Sequence=Displayed; Name=2; IsoId=O60341-2; Sequence=VSP_011198, VSP_011199; Note=No experimental confirmation available.; # AltName KDM1A_HUMAN BRAF35-HDAC complex protein BHC110 # AltName KDM1A_HUMAN Flavin-containing amine oxidase domain-containing protein 2 # BIOPHYSICOCHEMICAL PROPERTIES KDM1A_HUMAN Kinetic parameters KM=3.0 uM for H3 monomethyl-K4 {ECO 0000269|PubMed 16223729}; KM=4.2 uM for H3 dimethyl-K4 {ECO 0000269|PubMed 16223729}; KM=3.9 uM for H3 monomethyl-K4-monomethyl-K9 {ECO 0000269|PubMed 16223729}; KM=17.5 uM for monomethyl-K4-acetyl-K9 {ECO 0000269|PubMed 16223729}; # BRENDA 1.14.11.B1 2681 # BRENDA 1.14.11.B2 2681 # BioGrid 116667 310 # CCDS CCDS30627 -. [O60341-1] # CCDS CCDS53278 -. [O60341-2] # COFACTOR KDM1A_HUMAN Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000269|PubMed 15620353, ECO 0000269|PubMed 15811342}; # ChiTaRS KDM1A human # DISEASE KDM1A_HUMAN Cleft palate, psychomotor retardation, and distinctive facial features (CPRF) [MIM 616728] A syndrome characterized by cleft palate, developmental delay, psychomotor retardation, and facial dysmorphic features including a prominent forehead, slightly arched eyebrows, elongated palpebral fissures, a wide nasal bridge, thin lips, and widely spaced teeth. Cleft palate is a congenital fissure of the soft and/or hard palate, due to faulty fusion. {ECO 0000269|PubMed 23020937, ECO 0000269|PubMed 24838796, ECO 0000269|PubMed 26656649}. Note=The disease is caused by mutations affecting the gene represented in this entry. # DOMAIN KDM1A_HUMAN The SWIRM domain may act as an anchor site for a histone tail. {ECO 0000269|PubMed 16531230}. # Ensembl ENST00000356634 ENSP00000349049; ENSG00000004487. [O60341-1] # Ensembl ENST00000400181 ENSP00000383042; ENSG00000004487. [O60341-2] # ExpressionAtlas O60341 baseline and differential # FUNCTION KDM1A_HUMAN Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr- 6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E- cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. {ECO 0000269|PubMed 12032298, ECO 0000269|PubMed 15620353, ECO 0000269|PubMed 16079795, ECO 0000269|PubMed 17805299, ECO 0000269|PubMed 20228790, ECO 0000269|PubMed 20562920}. # GO_component GO:0000784 nuclear chromosome, telomeric region; IDA:BHF-UCL. # GO_component GO:0000790 nuclear chromatin; IDA:BHF-UCL. # GO_component GO:0005634 nucleus; IDA:UniProtKB. # GO_component GO:0005654 nucleoplasm; IDA:HPA. # GO_component GO:0005667 transcription factor complex; ISS:UniProtKB. # GO_component GO:0043234 protein complex; IDA:MGI. # GO_component GO:1990391 DNA repair complex; IDA:MGI. # GO_function GO:0002039 p53 binding; IPI:BHF-UCL. # GO_function GO:0003682 chromatin binding; IDA:UniProtKB. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:Ensembl. # GO_function GO:0004407 histone deacetylase activity; TAS:Reactome. # GO_function GO:0008134 transcription factor binding; IDA:BHF-UCL. # GO_function GO:0016491 oxidoreductase activity; IDA:UniProtKB. # GO_function GO:0019899 enzyme binding; IPI:BHF-UCL. # GO_function GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity; IMP:UniProtKB. # GO_function GO:0032451 demethylase activity; IMP:BHF-UCL. # GO_function GO:0032452 histone demethylase activity; IDA:BHF-UCL. # GO_function GO:0032453 histone demethylase activity (H3-K4 specific); IDA:UniProtKB. # GO_function GO:0032454 histone demethylase activity (H3-K9 specific); IDA:UniProtKB. # GO_function GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific); IDA:UniProtKB. # GO_function GO:0042162 telomeric DNA binding; IMP:BHF-UCL. # GO_function GO:0043426 MRF binding; IDA:BHF-UCL. # GO_function GO:0044212 transcription regulatory region DNA binding; ISS:BHF-UCL. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:UniProtKB. # GO_function GO:0050681 androgen receptor binding; IDA:UniProtKB. # GO_function GO:0061752 telomeric repeat-containing RNA binding; IDA:BHF-UCL. # GO_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL. # GO_process GO:0000380 alternative mRNA splicing, via spliceosome; IEA:Ensembl. # GO_process GO:0001701 in utero embryonic development; IEA:Ensembl. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006357 regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB. # GO_process GO:0006482 protein demethylation; IMP:BHF-UCL. # GO_process GO:0007596 blood coagulation; TAS:Reactome. # GO_process GO:0008283 cell proliferation; IEA:Ensembl. # GO_process GO:0010569 regulation of double-strand break repair via homologous recombination; IMP:MGI. # GO_process GO:0010725 regulation of primitive erythrocyte differentiation; IEA:Ensembl. # GO_process GO:0010976 positive regulation of neuron projection development; IEA:Ensembl. # GO_process GO:0021983 pituitary gland development; IEA:Ensembl. # GO_process GO:0021987 cerebral cortex development; IEA:Ensembl. # GO_process GO:0030851 granulocyte differentiation; IEA:Ensembl. # GO_process GO:0032091 negative regulation of protein binding; IMP:BHF-UCL. # GO_process GO:0033169 histone H3-K9 demethylation; IDA:UniProtKB. # GO_process GO:0033184 positive regulation of histone ubiquitination; IMP:MGI. # GO_process GO:0034644 cellular response to UV; IDA:MGI. # GO_process GO:0034720 histone H3-K4 demethylation; IDA:UniProtKB. # GO_process GO:0035563 positive regulation of chromatin binding; IEA:Ensembl. # GO_process GO:0042551 neuron maturation; IEA:Ensembl. # GO_process GO:0043392 negative regulation of DNA binding; IC:BHF-UCL. # GO_process GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL. # GO_process GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator; IMP:BHF-UCL. # GO_process GO:0045648 positive regulation of erythrocyte differentiation; IEA:Ensembl. # GO_process GO:0045654 positive regulation of megakaryocyte differentiation; IEA:Ensembl. # GO_process GO:0045793 positive regulation of cell size; IEA:Ensembl. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:BHF-UCL. # GO_process GO:0045944 positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL. # GO_process GO:0046098 guanine metabolic process; IEA:Ensembl. # GO_process GO:0046886 positive regulation of hormone biosynthetic process; IEA:Ensembl. # GO_process GO:0050768 negative regulation of neurogenesis; IEA:Ensembl. # GO_process GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL. # GO_process GO:0051572 negative regulation of histone H3-K4 methylation; IEA:Ensembl. # GO_process GO:0051573 negative regulation of histone H3-K9 methylation; IEA:Ensembl. # GO_process GO:0055001 muscle cell development; ISS:BHF-UCL. # GO_process GO:0060992 response to fungicide; IEA:Ensembl. # GO_process GO:0071320 cellular response to cAMP; IEA:Ensembl. # GO_process GO:0071480 cellular response to gamma radiation; IMP:MGI. # GO_process GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IMP:BHF-UCL. # GO_process GO:1903827 regulation of cellular protein localization; IMP:MGI. # GO_process GO:1990138 neuron projection extension; IEA:Ensembl. # GO_process GO:2000179 positive regulation of neural precursor cell proliferation; IEA:Ensembl. # GO_process GO:2000648 positive regulation of stem cell proliferation; IEA:Ensembl. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005634 nucleus # GOslim_component GO:0005654 nucleoplasm # GOslim_component GO:0043234 protein complex # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008134 transcription factor binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0019899 enzyme binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006397 mRNA processing # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0008283 cell proliferation # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0009790 embryo development # GOslim_process GO:0021700 developmental maturation # GOslim_process GO:0030154 cell differentiation # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0040007 growth # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0048856 anatomical structure development # Gene3D 1.10.10.10 -; 1. # Gene3D 3.50.50.60 -; 2. # Genevisible O60341 HS # HGNC HGNC:29079 KDM1A # INTERACTION KDM1A_HUMAN Q99996 AKAP9; NbExp=2; IntAct=EBI-710124, EBI-1048311; Q8IXJ9 ASXL1; NbExp=2; IntAct=EBI-710124, EBI-1646500; P59598 Asxl1 (xeno); NbExp=2; IntAct=EBI-710124, EBI-5743705; Q6P047 C8orf74; NbExp=2; IntAct=EBI-710124, EBI-8466055; A5D8V7 CCDC151; NbExp=2; IntAct=EBI-710124, EBI-8466445; Q9Y3C0 CCDC53; NbExp=4; IntAct=EBI-710124, EBI-712969; Q9BXL8 CDCA4; NbExp=2; IntAct=EBI-710124, EBI-1773949; Q8NHQ1 CEP70; NbExp=2; IntAct=EBI-710124, EBI-739624; Q12873 CHD3; NbExp=4; IntAct=EBI-710124, EBI-523590; Q96EY1 DNAJA3; NbExp=2; IntAct=EBI-710124, EBI-356767; Q8IZU1 FAM9A; NbExp=2; IntAct=EBI-710124, EBI-8468186; Q9BQS8 FYCO1; NbExp=2; IntAct=EBI-710124, EBI-2869338; Q8NEC7 GSTCD; NbExp=2; IntAct=EBI-710124, EBI-8469616; Q9BX10 GTPBP2; NbExp=2; IntAct=EBI-710124, EBI-6115579; Q96CS2 HAUS1; NbExp=2; IntAct=EBI-710124, EBI-2514791; O15379 HDAC3; NbExp=4; IntAct=EBI-710124, EBI-607682; Q9UBX0 HESX1; NbExp=2; IntAct=EBI-710124, EBI-8470369; Q16695 HIST3H3; NbExp=2; IntAct=EBI-710124, EBI-358900; Q16891 IMMT; NbExp=2; IntAct=EBI-710124, EBI-473801; Q8TBB5 KLHDC4; NbExp=2; IntAct=EBI-710124, EBI-8472352; Q96JB6 LOXL4; NbExp=2; IntAct=EBI-710124, EBI-749562; O95983 MBD3; NbExp=4; IntAct=EBI-710124, EBI-1783068; Q13133 NR1H3; NbExp=2; IntAct=EBI-710124, EBI-781356; Q8IZS5 OFCC1; NbExp=2; IntAct=EBI-710124, EBI-8477661; Q8IZL8 PELP1; NbExp=6; IntAct=EBI-710124, EBI-716449; Q5T6S3 PHF19; NbExp=2; IntAct=EBI-710124, EBI-2339674; Q03181 PPARD; NbExp=2; IntAct=EBI-710124, EBI-6426768; P62191 PSMC1; NbExp=2; IntAct=EBI-710124, EBI-357598; Q9NS23 RASSF1; NbExp=2; IntAct=EBI-710124, EBI-367363; P50749 RASSF2; NbExp=2; IntAct=EBI-710124, EBI-960081; Q9UKL0 RCOR1; NbExp=6; IntAct=EBI-710124, EBI-926563; Q8N6K7 SAMD3; NbExp=2; IntAct=EBI-710124, EBI-748741; Q9UGK8 SERGEF; NbExp=2; IntAct=EBI-710124, EBI-465368; Q13435 SF3B2; NbExp=2; IntAct=EBI-710124, EBI-749111; O15198 SMAD9; NbExp=2; IntAct=EBI-710124, EBI-748763; O95863 SNAI1; NbExp=32; IntAct=EBI-710124, EBI-1045459; Q96H20 SNF8; NbExp=2; IntAct=EBI-710124, EBI-747719; Q96BD6 SPSB1; NbExp=2; IntAct=EBI-710124, EBI-2659201; Q8N4C7 STX19; NbExp=2; IntAct=EBI-710124, EBI-8484990; Q9BUZ4 TRAF4; NbExp=3; IntAct=EBI-710124, EBI-3650647; O96006 ZBED1; NbExp=3; IntAct=EBI-710124, EBI-740037; # IntAct O60341 258 # InterPro IPR002937 Amino_oxidase # InterPro IPR007526 SWIRM # InterPro IPR009057 Homeodomain-like # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR017366 Hist_Lys-spec_deMease # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03036 Chromosome # MIM 609132 gene # MIM 616728 phenotype # Organism KDM1A_HUMAN Homo sapiens (Human) # PDB 2COM NMR; -; A=169-279 # PDB 2DW4 X-ray; 2.30 A; A=172-831 # PDB 2EJR X-ray; 2.70 A; A=172-833 # PDB 2H94 X-ray; 2.90 A; A=172-835 # PDB 2HKO X-ray; 2.80 A; A=172-835 # PDB 2IW5 X-ray; 2.57 A; A=171-836 # PDB 2L3D NMR; -; A=174-273 # PDB 2UXN X-ray; 2.72 A; A=171-836 # PDB 2UXX X-ray; 2.74 A; A=171-836 # PDB 2V1D X-ray; 3.10 A; A=123-852 # PDB 2X0L X-ray; 3.00 A; A=123-852 # PDB 2XAF X-ray; 3.25 A; A=1-852 # PDB 2XAG X-ray; 3.10 A; A=1-852 # PDB 2XAH X-ray; 3.10 A; A=1-852 # PDB 2XAJ X-ray; 3.30 A; A=1-852 # PDB 2XAQ X-ray; 3.20 A; A=1-852 # PDB 2XAS X-ray; 3.20 A; A=1-852 # PDB 2Y48 X-ray; 3.00 A; A=123-852 # PDB 2Z3Y X-ray; 2.25 A; A=172-833 # PDB 2Z5U X-ray; 2.25 A; A=172-833 # PDB 3ABT X-ray; 3.20 A; A=172-833 # PDB 3ABU X-ray; 3.10 A; A=172-833 # PDB 3ZMS X-ray; 2.96 A; A=1-852 # PDB 3ZMT X-ray; 3.10 A; A=1-852 # PDB 3ZMU X-ray; 3.20 A; A=1-852 # PDB 3ZMV X-ray; 3.00 A; A=1-852 # PDB 3ZMZ X-ray; 3.00 A; A=1-852 # PDB 3ZN0 X-ray; 2.80 A; A=1-852 # PDB 3ZN1 X-ray; 3.10 A; A=1-852 # PDB 4BAY X-ray; 3.10 A; A=172-852 # PDB 4CZZ X-ray; 3.00 A; A=1-852 # PDB 4KUM X-ray; 3.05 A; A=171-836 # PDB 4UV8 X-ray; 2.80 A; A=1-852 # PDB 4UV9 X-ray; 3.00 A; A=1-852 # PDB 4UVA X-ray; 2.90 A; A=1-852 # PDB 4UVB X-ray; 2.80 A; A=1-852 # PDB 4UVC X-ray; 3.10 A; A=1-852 # PDB 4UXN X-ray; 2.85 A; A=1-852 # PDB 4XBF X-ray; 2.80 A; A=171-836 # PDB 5AFW X-ray; 1.60 A; B=108-119 # PDB 5IT3 X-ray; 1.40 A; A/B=183-267 # PDB 5L3B X-ray; 3.30 A; A=1-852 # PDB 5L3C X-ray; 3.31 A; A=1-852 # PDB 5L3D X-ray; 2.60 A; A=1-852 # PDB 5L3E X-ray; 2.80 A; A=123-852 # PDB 5L3F X-ray; 3.50 A; A=123-852 # PDB 5L3G X-ray; 3.10 A; A=123-852 # PDB 5LBQ X-ray; 3.30 A; A=123-852 # PIRSF PIRSF038051 Histone_Lys-demethylase # PROSITE PS50934 SWIRM # Pfam PF01593 Amino_oxidase # Pfam PF04433 SWIRM # Proteomes UP000005640 Chromosome 1 # Reactome R-HSA-3214815 HDACs deacetylate histones # Reactome R-HSA-3214842 HDMs demethylate histones # Reactome R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 # Reactome R-HSA-983231 Factors involved in megakaryocyte development and platelet production # RecName KDM1A_HUMAN Lysine-specific histone demethylase 1A # RefSeq NP_001009999 NM_001009999.2. [O60341-2] # RefSeq NP_055828 NM_015013.3. [O60341-1] # SEQUENCE CAUTION Sequence=BAA25527.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the flavin monoamine oxidase family. {ECO 0000305}. # SIMILARITY Contains 1 SWIRM domain. {ECO:0000255|PROSITE- ProRule PRU00247}. # SUBCELLULAR LOCATION KDM1A_HUMAN Nucleus {ECO 0000269|PubMed 11102443, ECO 0000269|PubMed 16079795}. # SUBUNIT KDM1A_HUMAN Component of a RCOR/GFI/KDM1A/HDAC complex. Interacts directly with GFI1 and GFI1B. Interacts with INSM1 (By similarity). Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B, KDM1A, RCOR1 and PHF21A. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, RCOR1/CoREST strongly enhances the demethylase activity and protects it from the proteasome while PHF21A/BHC80 inhibits the demethylase activity. Interacts with the androgen receptor (AR). Interacts with ASXL1. Interacts with SNAI1 (via SNAG domain). {ECO 0000250, ECO 0000269|PubMed 11102443, ECO 0000269|PubMed 12032298, ECO 0000269|PubMed 12493763, ECO 0000269|PubMed 16079794, ECO 0000269|PubMed 16079795, ECO 0000269|PubMed 16140033, ECO 0000269|PubMed 16885027, ECO 0000269|PubMed 16956976, ECO 0000269|PubMed 19880879, ECO 0000269|PubMed 20562920}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF51905 SSF51905; 3 # TISSUE SPECIFICITY Ubiquitously expressed. {ECO:0000269|PubMed 16079795}. # UCSC uc001bgi human. [O60341-1] # eggNOG ENOG410XSNC LUCA # eggNOG KOG0029 Eukaryota # eggNOG KOG0685 Eukaryota BLAST swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/kblast/swissprot:KDM1A_HUMAN BioCyc ZFISH:ENSG00000004487-MONOMER http://biocyc.org/getid?id=ZFISH:ENSG00000004487-MONOMER COXPRESdb 23028 http://coxpresdb.jp/data/gene/23028.shtml CleanEx HS_AOF2 http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_AOF2 DIP DIP-34641N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-34641N DOI 10.1002/ajmg.a.36450 http://dx.doi.org/10.1002/ajmg.a.36450 DOI 10.1016/S0140-6736(12)61480-9 http://dx.doi.org/10.1016/S0140-6736(12)61480-9 DOI 10.1016/j.cell.2004.12.012 http://dx.doi.org/10.1016/j.cell.2004.12.012 DOI 10.1016/j.cell.2006.09.026 http://dx.doi.org/10.1016/j.cell.2006.09.026 DOI 10.1016/j.febslet.2005.03.015 http://dx.doi.org/10.1016/j.febslet.2005.03.015 DOI 10.1016/j.jprot.2013.11.014 http://dx.doi.org/10.1016/j.jprot.2013.11.014 DOI 10.1016/j.molcel.2005.08.027 http://dx.doi.org/10.1016/j.molcel.2005.08.027 DOI 10.1016/j.molcel.2006.07.012 http://dx.doi.org/10.1016/j.molcel.2006.07.012 DOI 10.1016/j.molcel.2008.07.007 http://dx.doi.org/10.1016/j.molcel.2008.07.007 DOI 10.1016/j.str.2005.12.004 http://dx.doi.org/10.1016/j.str.2005.12.004 DOI 10.1021/ac9004309 http://dx.doi.org/10.1021/ac9004309 DOI 10.1021/pr0705441 http://dx.doi.org/10.1021/pr0705441 DOI 10.1021/pr300630k http://dx.doi.org/10.1021/pr300630k DOI 10.1038/gim.2015.161 http://dx.doi.org/10.1038/gim.2015.161 DOI 10.1038/nature04020 http://dx.doi.org/10.1038/nature04020 DOI 10.1038/nature04021 http://dx.doi.org/10.1038/nature04021 DOI 10.1038/nature04727 http://dx.doi.org/10.1038/nature04727 DOI 10.1038/nature06092 http://dx.doi.org/10.1038/nature06092 DOI 10.1038/nature08839 http://dx.doi.org/10.1038/nature08839 DOI 10.1038/onc.2010.234 http://dx.doi.org/10.1038/onc.2010.234 DOI 10.1073/pnas.0606381103 http://dx.doi.org/10.1073/pnas.0606381103 DOI 10.1073/pnas.0805139105 http://dx.doi.org/10.1073/pnas.0805139105 DOI 10.1073/pnas.112008599 http://dx.doi.org/10.1073/pnas.112008599 DOI 10.1074/jbc.M007372200 http://dx.doi.org/10.1074/jbc.M007372200 DOI 10.1074/jbc.M109.065862 http://dx.doi.org/10.1074/jbc.M109.065862 DOI 10.1074/jbc.M208992200 http://dx.doi.org/10.1074/jbc.M208992200 DOI 10.1074/jbc.M509549200 http://dx.doi.org/10.1074/jbc.M509549200 DOI 10.1074/mcp.M800588-MCP200 http://dx.doi.org/10.1074/mcp.M800588-MCP200 DOI 10.1093/dnares/5.1.31 http://dx.doi.org/10.1093/dnares/5.1.31 DOI 10.1101/gr.2596504 http://dx.doi.org/10.1101/gr.2596504 DOI 10.1126/scisignal.2000007 http://dx.doi.org/10.1126/scisignal.2000007 DOI 10.1126/scisignal.2000475 http://dx.doi.org/10.1126/scisignal.2000475 DOI 10.1126/scisignal.2001570 http://dx.doi.org/10.1126/scisignal.2001570 DOI 10.1186/1471-2164-8-399 http://dx.doi.org/10.1186/1471-2164-8-399 DOI 10.1186/1752-0509-5-17 http://dx.doi.org/10.1186/1752-0509-5-17 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AB011173 http://www.ebi.ac.uk/ena/data/view/AB011173 EMBL AL031428 http://www.ebi.ac.uk/ena/data/view/AL031428 EMBL AL031428 http://www.ebi.ac.uk/ena/data/view/AL031428 EMBL AL833812 http://www.ebi.ac.uk/ena/data/view/AL833812 EMBL BC016639 http://www.ebi.ac.uk/ena/data/view/BC016639 EMBL BC025362 http://www.ebi.ac.uk/ena/data/view/BC025362 EMBL BC040194 http://www.ebi.ac.uk/ena/data/view/BC040194 EMBL BC048134 http://www.ebi.ac.uk/ena/data/view/BC048134 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- Ensembl ENST00000356634 http://www.ensembl.org/id/ENST00000356634 Ensembl ENST00000400181 http://www.ensembl.org/id/ENST00000400181 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_component GO:0000784 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000784 GO_component GO:0000790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000790 GO_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GO_component GO:0005654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654 GO_component GO:0005667 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005667 GO_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GO_component GO:1990391 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990391 GO_function GO:0002039 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002039 GO_function GO:0003682 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003682 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0004407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004407 GO_function GO:0008134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008134 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GO_function GO:0030374 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030374 GO_function GO:0032451 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032451 GO_function GO:0032452 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032452 GO_function GO:0032453 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032453 GO_function GO:0032454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032454 GO_function GO:0034648 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034648 GO_function GO:0042162 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042162 GO_function GO:0043426 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043426 GO_function GO:0044212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044212 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0050681 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050681 GO_function GO:0061752 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061752 GO_process GO:0000122 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000122 GO_process GO:0000380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000380 GO_process GO:0001701 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001701 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006357 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006357 GO_process GO:0006482 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006482 GO_process GO:0007596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007596 GO_process GO:0008283 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283 GO_process GO:0010569 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010569 GO_process GO:0010725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010725 GO_process GO:0010976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010976 GO_process GO:0021983 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021983 GO_process GO:0021987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021987 GO_process GO:0030851 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030851 GO_process GO:0032091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032091 GO_process GO:0033169 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033169 GO_process GO:0033184 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033184 GO_process GO:0034644 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034644 GO_process GO:0034720 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034720 GO_process GO:0035563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035563 GO_process GO:0042551 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042551 GO_process GO:0043392 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043392 GO_process GO:0043433 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043433 GO_process GO:0043518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043518 GO_process GO:0045648 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045648 GO_process GO:0045654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045654 GO_process GO:0045793 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045793 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045944 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944 GO_process GO:0046098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046098 GO_process GO:0046886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046886 GO_process GO:0050768 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050768 GO_process GO:0051091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051091 GO_process GO:0051572 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051572 GO_process GO:0051573 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051573 GO_process GO:0055001 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055001 GO_process GO:0060992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060992 GO_process GO:0071320 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320 GO_process GO:0071480 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071480 GO_process GO:1902166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902166 GO_process GO:1903827 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903827 GO_process GO:1990138 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990138 GO_process GO:2000179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000179 GO_process GO:2000648 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000648 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GOslim_component GO:0005654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008134 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006397 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0008283 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0009790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009790 GOslim_process GO:0021700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021700 GOslim_process GO:0030154 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0040007 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0048856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneCards KDM1A http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KDM1A GeneID 23028 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23028 GeneTree ENSGT00530000062888 http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062888 HGNC HGNC:29079 http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:29079 HPA CAB005884 http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB005884 HPA HPA053660 http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA053660 InParanoid O60341 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O60341 IntAct O60341 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O60341* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR007526 http://www.ebi.ac.uk/interpro/entry/IPR007526 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR017366 http://www.ebi.ac.uk/interpro/entry/IPR017366 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 Jabion 23028 http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=23028 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene hsa:23028 http://www.genome.jp/dbget-bin/www_bget?hsa:23028 KEGG_Orthology KO:K11450 http://www.genome.jp/dbget-bin/www_bget?KO:K11450 MIM 609132 http://www.ncbi.nlm.nih.gov/omim/609132 MIM 616728 http://www.ncbi.nlm.nih.gov/omim/616728 MINT MINT-1372817 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1372817 OMA PDWKQQA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PDWKQQA OrthoDB EOG091G04NO http://cegg.unige.ch/orthodb/results?searchtext=EOG091G04NO PDB 2COM http://www.ebi.ac.uk/pdbe-srv/view/entry/2COM PDB 2DW4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2DW4 PDB 2EJR http://www.ebi.ac.uk/pdbe-srv/view/entry/2EJR PDB 2H94 http://www.ebi.ac.uk/pdbe-srv/view/entry/2H94 PDB 2HKO http://www.ebi.ac.uk/pdbe-srv/view/entry/2HKO PDB 2IW5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IW5 PDB 2L3D http://www.ebi.ac.uk/pdbe-srv/view/entry/2L3D PDB 2UXN http://www.ebi.ac.uk/pdbe-srv/view/entry/2UXN PDB 2UXX http://www.ebi.ac.uk/pdbe-srv/view/entry/2UXX PDB 2V1D http://www.ebi.ac.uk/pdbe-srv/view/entry/2V1D PDB 2X0L http://www.ebi.ac.uk/pdbe-srv/view/entry/2X0L PDB 2XAF http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAF PDB 2XAG http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAG PDB 2XAH http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAH PDB 2XAJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAJ PDB 2XAQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAQ PDB 2XAS http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAS PDB 2Y48 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y48 PDB 2Z3Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z3Y PDB 2Z5U http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z5U PDB 3ABT http://www.ebi.ac.uk/pdbe-srv/view/entry/3ABT PDB 3ABU http://www.ebi.ac.uk/pdbe-srv/view/entry/3ABU PDB 3ZMS http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZMS PDB 3ZMT http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZMT PDB 3ZMU http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZMU PDB 3ZMV http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZMV PDB 3ZMZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZMZ PDB 3ZN0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZN0 PDB 3ZN1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZN1 PDB 4BAY http://www.ebi.ac.uk/pdbe-srv/view/entry/4BAY PDB 4CZZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4CZZ PDB 4KUM http://www.ebi.ac.uk/pdbe-srv/view/entry/4KUM PDB 4UV8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UV8 PDB 4UV9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UV9 PDB 4UVA http://www.ebi.ac.uk/pdbe-srv/view/entry/4UVA PDB 4UVB http://www.ebi.ac.uk/pdbe-srv/view/entry/4UVB PDB 4UVC http://www.ebi.ac.uk/pdbe-srv/view/entry/4UVC PDB 4UXN http://www.ebi.ac.uk/pdbe-srv/view/entry/4UXN PDB 4XBF http://www.ebi.ac.uk/pdbe-srv/view/entry/4XBF PDB 5AFW http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFW PDB 5IT3 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT3 PDB 5L3B http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3B PDB 5L3C http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3C PDB 5L3D http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3D PDB 5L3E http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3E PDB 5L3F http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3F PDB 5L3G http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3G PDB 5LBQ http://www.ebi.ac.uk/pdbe-srv/view/entry/5LBQ PDBsum 2COM http://www.ebi.ac.uk/pdbsum/2COM PDBsum 2DW4 http://www.ebi.ac.uk/pdbsum/2DW4 PDBsum 2EJR http://www.ebi.ac.uk/pdbsum/2EJR PDBsum 2H94 http://www.ebi.ac.uk/pdbsum/2H94 PDBsum 2HKO http://www.ebi.ac.uk/pdbsum/2HKO PDBsum 2IW5 http://www.ebi.ac.uk/pdbsum/2IW5 PDBsum 2L3D http://www.ebi.ac.uk/pdbsum/2L3D PDBsum 2UXN http://www.ebi.ac.uk/pdbsum/2UXN PDBsum 2UXX http://www.ebi.ac.uk/pdbsum/2UXX PDBsum 2V1D http://www.ebi.ac.uk/pdbsum/2V1D PDBsum 2X0L http://www.ebi.ac.uk/pdbsum/2X0L PDBsum 2XAF http://www.ebi.ac.uk/pdbsum/2XAF PDBsum 2XAG http://www.ebi.ac.uk/pdbsum/2XAG PDBsum 2XAH http://www.ebi.ac.uk/pdbsum/2XAH PDBsum 2XAJ http://www.ebi.ac.uk/pdbsum/2XAJ PDBsum 2XAQ http://www.ebi.ac.uk/pdbsum/2XAQ PDBsum 2XAS http://www.ebi.ac.uk/pdbsum/2XAS PDBsum 2Y48 http://www.ebi.ac.uk/pdbsum/2Y48 PDBsum 2Z3Y http://www.ebi.ac.uk/pdbsum/2Z3Y PDBsum 2Z5U http://www.ebi.ac.uk/pdbsum/2Z5U PDBsum 3ABT http://www.ebi.ac.uk/pdbsum/3ABT PDBsum 3ABU http://www.ebi.ac.uk/pdbsum/3ABU PDBsum 3ZMS http://www.ebi.ac.uk/pdbsum/3ZMS PDBsum 3ZMT http://www.ebi.ac.uk/pdbsum/3ZMT PDBsum 3ZMU http://www.ebi.ac.uk/pdbsum/3ZMU PDBsum 3ZMV http://www.ebi.ac.uk/pdbsum/3ZMV PDBsum 3ZMZ http://www.ebi.ac.uk/pdbsum/3ZMZ PDBsum 3ZN0 http://www.ebi.ac.uk/pdbsum/3ZN0 PDBsum 3ZN1 http://www.ebi.ac.uk/pdbsum/3ZN1 PDBsum 4BAY http://www.ebi.ac.uk/pdbsum/4BAY PDBsum 4CZZ http://www.ebi.ac.uk/pdbsum/4CZZ PDBsum 4KUM http://www.ebi.ac.uk/pdbsum/4KUM PDBsum 4UV8 http://www.ebi.ac.uk/pdbsum/4UV8 PDBsum 4UV9 http://www.ebi.ac.uk/pdbsum/4UV9 PDBsum 4UVA http://www.ebi.ac.uk/pdbsum/4UVA PDBsum 4UVB http://www.ebi.ac.uk/pdbsum/4UVB PDBsum 4UVC http://www.ebi.ac.uk/pdbsum/4UVC PDBsum 4UXN http://www.ebi.ac.uk/pdbsum/4UXN PDBsum 4XBF http://www.ebi.ac.uk/pdbsum/4XBF PDBsum 5AFW http://www.ebi.ac.uk/pdbsum/5AFW PDBsum 5IT3 http://www.ebi.ac.uk/pdbsum/5IT3 PDBsum 5L3B http://www.ebi.ac.uk/pdbsum/5L3B PDBsum 5L3C http://www.ebi.ac.uk/pdbsum/5L3C PDBsum 5L3D http://www.ebi.ac.uk/pdbsum/5L3D PDBsum 5L3E http://www.ebi.ac.uk/pdbsum/5L3E PDBsum 5L3F http://www.ebi.ac.uk/pdbsum/5L3F PDBsum 5L3G http://www.ebi.ac.uk/pdbsum/5L3G PDBsum 5LBQ http://www.ebi.ac.uk/pdbsum/5LBQ PROSITE PS50934 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50934 PSORT swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/kpsort/swissprot:KDM1A_HUMAN PSORT-B swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/kpsortb/swissprot:KDM1A_HUMAN PSORT2 swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/kpsort2/swissprot:KDM1A_HUMAN Pfam PF01593 http://pfam.xfam.org/family/PF01593 Pfam PF04433 http://pfam.xfam.org/family/PF04433 PharmGKB PA165751392 http://www.pharmgkb.org/do/serve?objId=PA165751392&objCls=Gene Phobius swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/kphobius/swissprot:KDM1A_HUMAN PhylomeDB O60341 http://phylomedb.org/?seqid=O60341 ProteinModelPortal O60341 http://www.proteinmodelportal.org/query/uniprot/O60341 PubMed 11102443 http://www.ncbi.nlm.nih.gov/pubmed/11102443 PubMed 12032298 http://www.ncbi.nlm.nih.gov/pubmed/12032298 PubMed 12493763 http://www.ncbi.nlm.nih.gov/pubmed/12493763 PubMed 15489334 http://www.ncbi.nlm.nih.gov/pubmed/15489334 PubMed 15620353 http://www.ncbi.nlm.nih.gov/pubmed/15620353 PubMed 15811342 http://www.ncbi.nlm.nih.gov/pubmed/15811342 PubMed 16079794 http://www.ncbi.nlm.nih.gov/pubmed/16079794 PubMed 16079795 http://www.ncbi.nlm.nih.gov/pubmed/16079795 PubMed 16140033 http://www.ncbi.nlm.nih.gov/pubmed/16140033 PubMed 16223729 http://www.ncbi.nlm.nih.gov/pubmed/16223729 PubMed 16531230 http://www.ncbi.nlm.nih.gov/pubmed/16531230 PubMed 16710414 http://www.ncbi.nlm.nih.gov/pubmed/16710414 PubMed 16885027 http://www.ncbi.nlm.nih.gov/pubmed/16885027 PubMed 16956976 http://www.ncbi.nlm.nih.gov/pubmed/16956976 PubMed 17081983 http://www.ncbi.nlm.nih.gov/pubmed/17081983 PubMed 17805299 http://www.ncbi.nlm.nih.gov/pubmed/17805299 PubMed 17974005 http://www.ncbi.nlm.nih.gov/pubmed/17974005 PubMed 18220336 http://www.ncbi.nlm.nih.gov/pubmed/18220336 PubMed 18669648 http://www.ncbi.nlm.nih.gov/pubmed/18669648 PubMed 18691976 http://www.ncbi.nlm.nih.gov/pubmed/18691976 PubMed 19369195 http://www.ncbi.nlm.nih.gov/pubmed/19369195 PubMed 19413330 http://www.ncbi.nlm.nih.gov/pubmed/19413330 PubMed 19690332 http://www.ncbi.nlm.nih.gov/pubmed/19690332 PubMed 19880879 http://www.ncbi.nlm.nih.gov/pubmed/19880879 PubMed 20068231 http://www.ncbi.nlm.nih.gov/pubmed/20068231 PubMed 20228790 http://www.ncbi.nlm.nih.gov/pubmed/20228790 PubMed 20562920 http://www.ncbi.nlm.nih.gov/pubmed/20562920 PubMed 21269460 http://www.ncbi.nlm.nih.gov/pubmed/21269460 PubMed 21406692 http://www.ncbi.nlm.nih.gov/pubmed/21406692 PubMed 23020937 http://www.ncbi.nlm.nih.gov/pubmed/23020937 PubMed 23186163 http://www.ncbi.nlm.nih.gov/pubmed/23186163 PubMed 24275569 http://www.ncbi.nlm.nih.gov/pubmed/24275569 PubMed 24838796 http://www.ncbi.nlm.nih.gov/pubmed/24838796 PubMed 26656649 http://www.ncbi.nlm.nih.gov/pubmed/26656649 PubMed 9628581 http://www.ncbi.nlm.nih.gov/pubmed/9628581 Reactome R-HSA-3214815 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3214815 Reactome R-HSA-3214842 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3214842 Reactome R-HSA-5625886 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5625886 Reactome R-HSA-983231 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983231 RefSeq NP_001009999 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001009999 RefSeq NP_055828 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_055828 SMR O60341 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O60341 STRING 9606.ENSP00000383042 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000383042&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UCSC uc001bgi http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc001bgi&org=rat UniGene Hs.591518 http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.591518 UniProtKB KDM1A_HUMAN http://www.uniprot.org/uniprot/KDM1A_HUMAN UniProtKB-AC O60341 http://www.uniprot.org/uniprot/O60341 charge swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/charge/swissprot:KDM1A_HUMAN eggNOG ENOG410XSNC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSNC eggNOG KOG0029 http://eggnogapi.embl.de/nog_data/html/tree/KOG0029 eggNOG KOG0685 http://eggnogapi.embl.de/nog_data/html/tree/KOG0685 epestfind swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/epestfind/swissprot:KDM1A_HUMAN garnier swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/garnier/swissprot:KDM1A_HUMAN helixturnhelix swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDM1A_HUMAN hmoment swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/hmoment/swissprot:KDM1A_HUMAN iep swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/iep/swissprot:KDM1A_HUMAN inforesidue swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/inforesidue/swissprot:KDM1A_HUMAN neXtProt NX_O60341 http://www.nextprot.org/db/entry/NX_O60341 octanol swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/octanol/swissprot:KDM1A_HUMAN pepcoil swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/pepcoil/swissprot:KDM1A_HUMAN pepdigest swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/pepdigest/swissprot:KDM1A_HUMAN pepinfo swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/pepinfo/swissprot:KDM1A_HUMAN pepnet swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/pepnet/swissprot:KDM1A_HUMAN pepstats swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/pepstats/swissprot:KDM1A_HUMAN pepwheel swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/pepwheel/swissprot:KDM1A_HUMAN pepwindow swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/pepwindow/swissprot:KDM1A_HUMAN sigcleave swissprot:KDM1A_HUMAN http://rest.g-language.org/emboss/sigcleave/swissprot:KDM1A_HUMAN ## Database ID URL or Descriptions # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # InterPro IPR002937 Amino_oxidase # InterPro IPR023753 FAD/NAD-binding_dom # Organism A7YEZ9_TUPMI Tupaia minor (Pigmy tree shrew) # Pfam PF01593 Amino_oxidase # SUPFAM SSF51905 SSF51905 # SubName A7YEZ9_TUPMI Amine oxidase flavin-containing domain 2 {ECO 0000313|EMBL ABU96086.1} BLAST swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/kblast/swissprot:A7YEZ9_TUPMI EMBL EF674537 http://www.ebi.ac.uk/ena/data/view/EF674537 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 PSORT swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/kpsort/swissprot:A7YEZ9_TUPMI PSORT-B swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/kpsortb/swissprot:A7YEZ9_TUPMI PSORT2 swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/kpsort2/swissprot:A7YEZ9_TUPMI Pfam PF01593 http://pfam.xfam.org/family/PF01593 Phobius swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/kphobius/swissprot:A7YEZ9_TUPMI SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB A7YEZ9_TUPMI http://www.uniprot.org/uniprot/A7YEZ9_TUPMI UniProtKB-AC A7YEZ9 http://www.uniprot.org/uniprot/A7YEZ9 charge swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/charge/swissprot:A7YEZ9_TUPMI epestfind swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/epestfind/swissprot:A7YEZ9_TUPMI garnier swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/garnier/swissprot:A7YEZ9_TUPMI helixturnhelix swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/helixturnhelix/swissprot:A7YEZ9_TUPMI hmoment swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/hmoment/swissprot:A7YEZ9_TUPMI iep swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/iep/swissprot:A7YEZ9_TUPMI inforesidue swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/inforesidue/swissprot:A7YEZ9_TUPMI octanol swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/octanol/swissprot:A7YEZ9_TUPMI pepcoil swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/pepcoil/swissprot:A7YEZ9_TUPMI pepdigest swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/pepdigest/swissprot:A7YEZ9_TUPMI pepinfo swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/pepinfo/swissprot:A7YEZ9_TUPMI pepnet swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/pepnet/swissprot:A7YEZ9_TUPMI pepstats swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/pepstats/swissprot:A7YEZ9_TUPMI pepwheel swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/pepwheel/swissprot:A7YEZ9_TUPMI pepwindow swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/pepwindow/swissprot:A7YEZ9_TUPMI sigcleave swissprot:A7YEZ9_TUPMI http://rest.g-language.org/emboss/sigcleave/swissprot:A7YEZ9_TUPMI ## Database ID URL or Descriptions # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # InterPro IPR002937 Amino_oxidase # InterPro IPR023753 FAD/NAD-binding_dom # Organism A7YEZ2_EUPSX Euphractus sexcinctus (Six-banded armadillo) (Dasypus sexcinctus) # Pfam PF01593 Amino_oxidase # SUPFAM SSF51905 SSF51905 # SubName A7YEZ2_EUPSX Amine oxidase flavin-containing domain 2 {ECO 0000313|EMBL ABU96082.1} BLAST swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/kblast/swissprot:A7YEZ2_EUPSX EMBL EF674533 http://www.ebi.ac.uk/ena/data/view/EF674533 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 PSORT swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/kpsort/swissprot:A7YEZ2_EUPSX PSORT-B swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/kpsortb/swissprot:A7YEZ2_EUPSX PSORT2 swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/kpsort2/swissprot:A7YEZ2_EUPSX Pfam PF01593 http://pfam.xfam.org/family/PF01593 Phobius swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/kphobius/swissprot:A7YEZ2_EUPSX SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB A7YEZ2_EUPSX http://www.uniprot.org/uniprot/A7YEZ2_EUPSX UniProtKB-AC A7YEZ2 http://www.uniprot.org/uniprot/A7YEZ2 charge swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/charge/swissprot:A7YEZ2_EUPSX epestfind swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/epestfind/swissprot:A7YEZ2_EUPSX garnier swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/garnier/swissprot:A7YEZ2_EUPSX helixturnhelix swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/helixturnhelix/swissprot:A7YEZ2_EUPSX hmoment swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/hmoment/swissprot:A7YEZ2_EUPSX iep swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/iep/swissprot:A7YEZ2_EUPSX inforesidue swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/inforesidue/swissprot:A7YEZ2_EUPSX octanol swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/octanol/swissprot:A7YEZ2_EUPSX pepcoil swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/pepcoil/swissprot:A7YEZ2_EUPSX pepdigest swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/pepdigest/swissprot:A7YEZ2_EUPSX pepinfo swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/pepinfo/swissprot:A7YEZ2_EUPSX pepnet swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/pepnet/swissprot:A7YEZ2_EUPSX pepstats swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/pepstats/swissprot:A7YEZ2_EUPSX pepwheel swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/pepwheel/swissprot:A7YEZ2_EUPSX pepwindow swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/pepwindow/swissprot:A7YEZ2_EUPSX sigcleave swissprot:A7YEZ2_EUPSX http://rest.g-language.org/emboss/sigcleave/swissprot:A7YEZ2_EUPSX ## Database ID URL or Descriptions # AltName KDM1A_MOUSE BRAF35-HDAC complex protein BHC110 # AltName KDM1A_MOUSE Flavin-containing amine oxidase domain-containing protein 2 # BioGrid 221360 17 # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Evidence={ECO:0000250}; # ChiTaRS Kdm1a mouse # DEVELOPMENTAL STAGE Zygotic expression first appears at the morula stage. In blastocysts, expressed in the inner cell mass and trophectodermal cells. In postimplantation embryos, expression becomes ubiquitous. {ECO:0000269|PubMed 19098913}. # DOMAIN KDM1A_MOUSE The SWIRM domain may act as an anchor site for a histone tail. {ECO 0000250}. # Ensembl ENSMUST00000116273 ENSMUSP00000111977; ENSMUSG00000036940 # ExpressionAtlas Q6ZQ88 baseline and differential # FUNCTION KDM1A_MOUSE Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr- 6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation (By similarity). Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. {ECO 0000250, ECO 0000269|PubMed 17707228, ECO 0000269|PubMed 19098913}. # GO_component GO:0000784 nuclear chromosome, telomeric region; ISO:MGI. # GO_component GO:0000790 nuclear chromatin; IDA:BHF-UCL. # GO_component GO:0005634 nucleus; ISS:UniProtKB. # GO_component GO:0005654 nucleoplasm; ISO:MGI. # GO_component GO:0005667 transcription factor complex; IDA:MGI. # GO_component GO:0043234 protein complex; ISO:MGI. # GO_component GO:1990391 DNA repair complex; ISO:MGI. # GO_function GO:0001085 RNA polymerase II transcription factor binding; IPI:BHF-UCL. # GO_function GO:0002039 p53 binding; ISO:MGI. # GO_function GO:0003682 chromatin binding; ISS:UniProtKB. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:MGI. # GO_function GO:0008134 transcription factor binding; IPI:BHF-UCL. # GO_function GO:0016491 oxidoreductase activity; ISS:UniProtKB. # GO_function GO:0019899 enzyme binding; IPI:BHF-UCL. # GO_function GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity; ISS:UniProtKB. # GO_function GO:0032451 demethylase activity; ISO:MGI. # GO_function GO:0032452 histone demethylase activity; ISS:BHF-UCL. # GO_function GO:0032453 histone demethylase activity (H3-K4 specific); ISS:UniProtKB. # GO_function GO:0032454 histone demethylase activity (H3-K9 specific); ISS:UniProtKB. # GO_function GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific); ISS:UniProtKB. # GO_function GO:0042162 telomeric DNA binding; ISO:MGI. # GO_function GO:0043426 MRF binding; IPI:BHF-UCL. # GO_function GO:0044212 transcription regulatory region DNA binding; IDA:BHF-UCL. # GO_function GO:0050660 flavin adenine dinucleotide binding; ISS:UniProtKB. # GO_function GO:0050681 androgen receptor binding; ISS:UniProtKB. # GO_function GO:0061752 telomeric repeat-containing RNA binding; ISO:MGI. # GO_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL. # GO_process GO:0000380 alternative mRNA splicing, via spliceosome; IEA:Ensembl. # GO_process GO:0001701 in utero embryonic development; IMP:MGI. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006357 regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB. # GO_process GO:0006482 protein demethylation; ISO:MGI. # GO_process GO:0008283 cell proliferation; IMP:MGI. # GO_process GO:0010569 regulation of double-strand break repair via homologous recombination; ISO:MGI. # GO_process GO:0010725 regulation of primitive erythrocyte differentiation; IMP:UniProtKB. # GO_process GO:0010976 positive regulation of neuron projection development; IEA:Ensembl. # GO_process GO:0021983 pituitary gland development; IMP:MGI. # GO_process GO:0021987 cerebral cortex development; IEA:Ensembl. # GO_process GO:0030851 granulocyte differentiation; IMP:UniProtKB. # GO_process GO:0032091 negative regulation of protein binding; ISO:MGI. # GO_process GO:0033169 histone H3-K9 demethylation; ISS:UniProtKB. # GO_process GO:0033184 positive regulation of histone ubiquitination; ISO:MGI. # GO_process GO:0034644 cellular response to UV; ISO:MGI. # GO_process GO:0034720 histone H3-K4 demethylation; ISS:UniProtKB. # GO_process GO:0035563 positive regulation of chromatin binding; IEA:Ensembl. # GO_process GO:0042551 neuron maturation; IEA:Ensembl. # GO_process GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL. # GO_process GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator; ISO:MGI. # GO_process GO:0045648 positive regulation of erythrocyte differentiation; IMP:UniProtKB. # GO_process GO:0045654 positive regulation of megakaryocyte differentiation; IMP:UniProtKB. # GO_process GO:0045793 positive regulation of cell size; IEA:Ensembl. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; ISS:BHF-UCL. # GO_process GO:0045944 positive regulation of transcription from RNA polymerase II promoter; IMP:MGI. # GO_process GO:0046098 guanine metabolic process; IEA:Ensembl. # GO_process GO:0046886 positive regulation of hormone biosynthetic process; IMP:MGI. # GO_process GO:0050767 regulation of neurogenesis; IGI:MGI. # GO_process GO:0050768 negative regulation of neurogenesis; IDA:MGI. # GO_process GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity; ISO:MGI. # GO_process GO:0051572 negative regulation of histone H3-K4 methylation; IMP:BHF-UCL. # GO_process GO:0051573 negative regulation of histone H3-K9 methylation; IMP:BHF-UCL. # GO_process GO:0055001 muscle cell development; IMP:BHF-UCL. # GO_process GO:0060992 response to fungicide; IEA:Ensembl. # GO_process GO:0071320 cellular response to cAMP; IEA:Ensembl. # GO_process GO:0071480 cellular response to gamma radiation; ISO:MGI. # GO_process GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; ISO:MGI. # GO_process GO:1903758 negative regulation of transcription from RNA polymerase II promoter by histone modification; IC:BHF-UCL. # GO_process GO:1903827 regulation of cellular protein localization; ISO:MGI. # GO_process GO:1990138 neuron projection extension; IMP:MGI. # GO_process GO:2000179 positive regulation of neural precursor cell proliferation; IMP:BHF-UCL. # GO_process GO:2000648 positive regulation of stem cell proliferation; IMP:BHF-UCL. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005634 nucleus # GOslim_component GO:0005654 nucleoplasm # GOslim_component GO:0043234 protein complex # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008134 transcription factor binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0019899 enzyme binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006397 mRNA processing # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0008283 cell proliferation # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0009790 embryo development # GOslim_process GO:0021700 developmental maturation # GOslim_process GO:0030154 cell differentiation # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0040007 growth # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0048856 anatomical structure development # Gene3D 1.10.10.10 -; 1. # Gene3D 3.50.50.60 -; 2. # Genevisible Q6ZQ88 MM # INTERACTION KDM1A_MOUSE Q9CQJ4 Rnf2; NbExp=3; IntAct=EBI-1216284, EBI-927321; # IntAct Q6ZQ88 7 # InterPro IPR002937 Amino_oxidase # InterPro IPR007526 SWIRM # InterPro IPR009057 Homeodomain-like # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR017366 Hist_Lys-spec_deMease # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03036 Chromosome # MGI MGI:1196256 Kdm1a # Organism KDM1A_MOUSE Mus musculus (Mouse) # PIRSF PIRSF038051 Histone_Lys-demethylase # PROSITE PS50934 SWIRM # Pfam PF01593 Amino_oxidase # Pfam PF04433 SWIRM # Proteomes UP000000589 Chromosome 4 # Reactome R-MMU-3214842 HDMs demethylate histones # Reactome R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 # RecName KDM1A_MOUSE Lysine-specific histone demethylase 1A # RefSeq NP_598633 NM_133872.2 # SEQUENCE CAUTION Sequence=AAH59885.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC97980.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the flavin monoamine oxidase family. {ECO 0000305}. # SIMILARITY Contains 1 SWIRM domain. {ECO:0000255|PROSITE- ProRule PRU00247}. # SUBCELLULAR LOCATION KDM1A_MOUSE Nucleus {ECO 0000250}. # SUBUNIT KDM1A_MOUSE Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B, KDM1A, RCOR1 and PHF21A. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, RCOR1 strongly enhances the demethylase activity and protects it from the proteasome while PHF21A inhibits the demethylase activity. Interacts with the androgen receptor (AR) (By similarity). Component of a RCOR/GFI/KDM1A/HDAC complex. Interacts directly with GFI1 and GFI1B. Interacts with ASXL1. Interacts with SNAI1 (via SNAG domain) (By similarity). Interacts with INSM1. {ECO 0000250, ECO 0000269|PubMed 17707228, ECO 0000269|PubMed 24227653}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF51905 SSF51905; 3 # TISSUE SPECIFICITY Ubiquitously expressed. {ECO:0000269|PubMed 16079795}. # UCSC uc008vig mouse # eggNOG ENOG410XSNC LUCA # eggNOG KOG0029 Eukaryota # eggNOG KOG0685 Eukaryota BLAST swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/kblast/swissprot:KDM1A_MOUSE COXPRESdb 99982 http://coxpresdb.jp/data/gene/99982.shtml CleanEx MM_AOF2 http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=MM_AOF2 DIP DIP-38599N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-38599N DOI 10.1016/j.cell.2010.12.001 http://dx.doi.org/10.1016/j.cell.2010.12.001 DOI 10.1016/j.immuni.2008.11.006 http://dx.doi.org/10.1016/j.immuni.2008.11.006 DOI 10.1016/j.molcel.2007.06.039 http://dx.doi.org/10.1016/j.molcel.2007.06.039 DOI 10.1038/nature04020 http://dx.doi.org/10.1038/nature04020 DOI 10.1038/ng.268 http://dx.doi.org/10.1038/ng.268 DOI 10.1093/dnares/10.4.167 http://dx.doi.org/10.1093/dnares/10.4.167 DOI 10.1101/gr.2596504 http://dx.doi.org/10.1101/gr.2596504 DOI 10.1242/dev.097642 http://dx.doi.org/10.1242/dev.097642 DOI 10.1371/journal.pbio.1000112 http://dx.doi.org/10.1371/journal.pbio.1000112 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AK129170 http://www.ebi.ac.uk/ena/data/view/AK129170 EMBL AL671173 http://www.ebi.ac.uk/ena/data/view/AL671173 EMBL BC019417 http://www.ebi.ac.uk/ena/data/view/BC019417 EMBL BC059885 http://www.ebi.ac.uk/ena/data/view/BC059885 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- Ensembl ENSMUST00000116273 http://www.ensembl.org/id/ENSMUST00000116273 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_component GO:0000784 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000784 GO_component GO:0000790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000790 GO_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GO_component GO:0005654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654 GO_component GO:0005667 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005667 GO_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GO_component GO:1990391 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990391 GO_function GO:0001085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001085 GO_function GO:0002039 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002039 GO_function GO:0003682 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003682 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0008134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008134 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GO_function GO:0030374 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030374 GO_function GO:0032451 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032451 GO_function GO:0032452 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032452 GO_function GO:0032453 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032453 GO_function GO:0032454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032454 GO_function GO:0034648 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034648 GO_function GO:0042162 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042162 GO_function GO:0043426 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043426 GO_function GO:0044212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044212 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0050681 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050681 GO_function GO:0061752 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061752 GO_process GO:0000122 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000122 GO_process GO:0000380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000380 GO_process GO:0001701 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001701 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006357 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006357 GO_process GO:0006482 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006482 GO_process GO:0008283 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283 GO_process GO:0010569 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010569 GO_process GO:0010725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010725 GO_process GO:0010976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010976 GO_process GO:0021983 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021983 GO_process GO:0021987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021987 GO_process GO:0030851 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030851 GO_process GO:0032091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032091 GO_process GO:0033169 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033169 GO_process GO:0033184 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033184 GO_process GO:0034644 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034644 GO_process GO:0034720 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034720 GO_process GO:0035563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035563 GO_process GO:0042551 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042551 GO_process GO:0043433 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043433 GO_process GO:0043518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043518 GO_process GO:0045648 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045648 GO_process GO:0045654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045654 GO_process GO:0045793 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045793 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045944 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944 GO_process GO:0046098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046098 GO_process GO:0046886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046886 GO_process GO:0050767 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050767 GO_process GO:0050768 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050768 GO_process GO:0051091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051091 GO_process GO:0051572 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051572 GO_process GO:0051573 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051573 GO_process GO:0055001 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055001 GO_process GO:0060992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060992 GO_process GO:0071320 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071320 GO_process GO:0071480 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071480 GO_process GO:1902166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902166 GO_process GO:1903758 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903758 GO_process GO:1903827 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903827 GO_process GO:1990138 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990138 GO_process GO:2000179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000179 GO_process GO:2000648 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000648 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GOslim_component GO:0005654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008134 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006397 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0008283 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008283 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0009790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009790 GOslim_process GO:0021700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021700 GOslim_process GO:0030154 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0040007 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0048856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 99982 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=99982 GeneTree ENSGT00530000062888 http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00530000062888 HOGENOM HOG000246945 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246945&db=HOGENOM6 InParanoid Q6ZQ88 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6ZQ88 IntAct Q6ZQ88 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q6ZQ88* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR007526 http://www.ebi.ac.uk/interpro/entry/IPR007526 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR017366 http://www.ebi.ac.uk/interpro/entry/IPR017366 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene mmu:99982 http://www.genome.jp/dbget-bin/www_bget?mmu:99982 KEGG_Orthology KO:K11450 http://www.genome.jp/dbget-bin/www_bget?KO:K11450 MGI MGI:1196256 http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1196256 MINT MINT-4100561 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4100561 PROSITE PS50934 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50934 PSORT swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/kpsort/swissprot:KDM1A_MOUSE PSORT-B swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/kpsortb/swissprot:KDM1A_MOUSE PSORT2 swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/kpsort2/swissprot:KDM1A_MOUSE Pfam PF01593 http://pfam.xfam.org/family/PF01593 Pfam PF04433 http://pfam.xfam.org/family/PF04433 Phobius swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/kphobius/swissprot:KDM1A_MOUSE PhylomeDB Q6ZQ88 http://phylomedb.org/?seqid=Q6ZQ88 ProteinModelPortal Q6ZQ88 http://www.proteinmodelportal.org/query/uniprot/Q6ZQ88 PubMed 14621295 http://www.ncbi.nlm.nih.gov/pubmed/14621295 PubMed 15489334 http://www.ncbi.nlm.nih.gov/pubmed/15489334 PubMed 16079795 http://www.ncbi.nlm.nih.gov/pubmed/16079795 PubMed 17707228 http://www.ncbi.nlm.nih.gov/pubmed/17707228 PubMed 19098913 http://www.ncbi.nlm.nih.gov/pubmed/19098913 PubMed 19144319 http://www.ncbi.nlm.nih.gov/pubmed/19144319 PubMed 19468303 http://www.ncbi.nlm.nih.gov/pubmed/19468303 PubMed 21183079 http://www.ncbi.nlm.nih.gov/pubmed/21183079 PubMed 24227653 http://www.ncbi.nlm.nih.gov/pubmed/24227653 Reactome R-MMU-3214842 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3214842 Reactome R-MMU-5625886 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5625886 RefSeq NP_598633 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_598633 SMR Q6ZQ88 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6ZQ88 STRING 10090.ENSMUSP00000111977 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=10090.ENSMUSP00000111977&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UCSC uc008vig http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc008vig&org=rat UniGene Mm.28540 http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Mm.28540 UniProtKB KDM1A_MOUSE http://www.uniprot.org/uniprot/KDM1A_MOUSE UniProtKB-AC Q6ZQ88 http://www.uniprot.org/uniprot/Q6ZQ88 charge swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/charge/swissprot:KDM1A_MOUSE eggNOG ENOG410XSNC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSNC eggNOG KOG0029 http://eggnogapi.embl.de/nog_data/html/tree/KOG0029 eggNOG KOG0685 http://eggnogapi.embl.de/nog_data/html/tree/KOG0685 epestfind swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/epestfind/swissprot:KDM1A_MOUSE garnier swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/garnier/swissprot:KDM1A_MOUSE helixturnhelix swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDM1A_MOUSE hmoment swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/hmoment/swissprot:KDM1A_MOUSE iep swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/iep/swissprot:KDM1A_MOUSE inforesidue swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/inforesidue/swissprot:KDM1A_MOUSE octanol swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/octanol/swissprot:KDM1A_MOUSE pepcoil swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/pepcoil/swissprot:KDM1A_MOUSE pepdigest swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/pepdigest/swissprot:KDM1A_MOUSE pepinfo swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/pepinfo/swissprot:KDM1A_MOUSE pepnet swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/pepnet/swissprot:KDM1A_MOUSE pepstats swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/pepstats/swissprot:KDM1A_MOUSE pepwheel swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/pepwheel/swissprot:KDM1A_MOUSE pepwindow swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/pepwindow/swissprot:KDM1A_MOUSE sigcleave swissprot:KDM1A_MOUSE http://rest.g-language.org/emboss/sigcleave/swissprot:KDM1A_MOUSE ## Database ID URL or Descriptions # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # InterPro IPR002937 Amino_oxidase # InterPro IPR023753 FAD/NAD-binding_dom # Organism A7YEZ7_TRAEU Tragelaphus eurycerus (Bongo) # Pfam PF01593 Amino_oxidase # SUPFAM SSF51905 SSF51905 # SubName A7YEZ7_TRAEU Amine oxidase flavin-containing domain 2 {ECO 0000313|EMBL ABU96085.1} BLAST swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/kblast/swissprot:A7YEZ7_TRAEU EMBL EF674536 http://www.ebi.ac.uk/ena/data/view/EF674536 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 PSORT swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/kpsort/swissprot:A7YEZ7_TRAEU PSORT-B swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/kpsortb/swissprot:A7YEZ7_TRAEU PSORT2 swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/kpsort2/swissprot:A7YEZ7_TRAEU Pfam PF01593 http://pfam.xfam.org/family/PF01593 Phobius swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/kphobius/swissprot:A7YEZ7_TRAEU SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB A7YEZ7_TRAEU http://www.uniprot.org/uniprot/A7YEZ7_TRAEU UniProtKB-AC A7YEZ7 http://www.uniprot.org/uniprot/A7YEZ7 charge swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/charge/swissprot:A7YEZ7_TRAEU epestfind swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/epestfind/swissprot:A7YEZ7_TRAEU garnier swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/garnier/swissprot:A7YEZ7_TRAEU helixturnhelix swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/helixturnhelix/swissprot:A7YEZ7_TRAEU hmoment swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/hmoment/swissprot:A7YEZ7_TRAEU iep swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/iep/swissprot:A7YEZ7_TRAEU inforesidue swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/inforesidue/swissprot:A7YEZ7_TRAEU octanol swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/octanol/swissprot:A7YEZ7_TRAEU pepcoil swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/pepcoil/swissprot:A7YEZ7_TRAEU pepdigest swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/pepdigest/swissprot:A7YEZ7_TRAEU pepinfo swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/pepinfo/swissprot:A7YEZ7_TRAEU pepnet swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/pepnet/swissprot:A7YEZ7_TRAEU pepstats swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/pepstats/swissprot:A7YEZ7_TRAEU pepwheel swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/pepwheel/swissprot:A7YEZ7_TRAEU pepwindow swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/pepwindow/swissprot:A7YEZ7_TRAEU sigcleave swissprot:A7YEZ7_TRAEU http://rest.g-language.org/emboss/sigcleave/swissprot:A7YEZ7_TRAEU ## Database ID URL or Descriptions # COFACTOR A0JMQ3_DANRE Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000256|PIRSR PIRSR038051-1}; # GO_component GO:0005634 nucleus; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0034720 histone H3-K4 demethylation; IEA:InterPro. # GO_process GO:1900052 regulation of retinoic acid biosynthetic process; IGI:ZFIN. # GO_process GO:1903706 regulation of hemopoiesis; IMP:ZFIN. # GOslim_component GO:0005634 nucleus # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0008150 biological_process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.50.50.60 -; 2. # InterPro IPR002937 Amino_oxidase # InterPro IPR007526 SWIRM # InterPro IPR009057 Homeodomain-like # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR017366 Hist_Lys-spec_deMease # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03036 Chromosome # Organism A0JMQ3_DANRE Danio rerio (Zebrafish) (Brachydanio rerio) # PIRSF PIRSF038051 Histone_Lys-demethylase # PROSITE PS50934 SWIRM # Pfam PF01593 Amino_oxidase # Pfam PF04433 SWIRM # RefSeq NP_001229924 NM_001242995.1 # SUPFAM SSF46689 SSF46689 # SUPFAM SSF51905 SSF51905; 3 # SubName A0JMQ3_DANRE Aof2 protein {ECO 0000313|EMBL AAI25966.1} # ZFIN ZDB-GENE-030131-7828 kdm1a # eggNOG ENOG410XSNC LUCA # eggNOG KOG0029 Eukaryota # eggNOG KOG0685 Eukaryota BLAST swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/kblast/swissprot:A0JMQ3_DANRE EMBL BC125965 http://www.ebi.ac.uk/ena/data/view/BC125965 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0034720 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034720 GO_process GO:1900052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900052 GO_process GO:1903706 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903706 GOslim_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 558450 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=558450 HOGENOM HOG000246945 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246945&db=HOGENOM6 HOVERGEN HBG102081 http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG102081&db=HOVERGEN InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR007526 http://www.ebi.ac.uk/interpro/entry/IPR007526 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR017366 http://www.ebi.ac.uk/interpro/entry/IPR017366 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene dre:558450 http://www.genome.jp/dbget-bin/www_bget?dre:558450 KEGG_Orthology KO:K11450 http://www.genome.jp/dbget-bin/www_bget?KO:K11450 PROSITE PS50934 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50934 PSORT swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/kpsort/swissprot:A0JMQ3_DANRE PSORT-B swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/kpsortb/swissprot:A0JMQ3_DANRE PSORT2 swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/kpsort2/swissprot:A0JMQ3_DANRE Pfam PF01593 http://pfam.xfam.org/family/PF01593 Pfam PF04433 http://pfam.xfam.org/family/PF04433 Phobius swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/kphobius/swissprot:A0JMQ3_DANRE PhylomeDB A0JMQ3 http://phylomedb.org/?seqid=A0JMQ3 ProteinModelPortal A0JMQ3 http://www.proteinmodelportal.org/query/uniprot/A0JMQ3 RefSeq NP_001229924 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001229924 STRING 7955.ENSDARP00000080193 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=7955.ENSDARP00000080193&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniGene Dr.105968 http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Dr.105968 UniGene Dr.106569 http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Dr.106569 UniGene Dr.77555 http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Dr.77555 UniProtKB A0JMQ3_DANRE http://www.uniprot.org/uniprot/A0JMQ3_DANRE UniProtKB-AC A0JMQ3 http://www.uniprot.org/uniprot/A0JMQ3 ZFIN ZDB-GENE-030131-7828 http://zfin.org/cgi-bin/webdriver?MIval=aa-markerview.apg&OID=ZDB-GENE-030131-7828 charge swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/charge/swissprot:A0JMQ3_DANRE eggNOG ENOG410XSNC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSNC eggNOG KOG0029 http://eggnogapi.embl.de/nog_data/html/tree/KOG0029 eggNOG KOG0685 http://eggnogapi.embl.de/nog_data/html/tree/KOG0685 epestfind swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/epestfind/swissprot:A0JMQ3_DANRE garnier swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/garnier/swissprot:A0JMQ3_DANRE helixturnhelix swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/helixturnhelix/swissprot:A0JMQ3_DANRE hmoment swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/hmoment/swissprot:A0JMQ3_DANRE iep swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/iep/swissprot:A0JMQ3_DANRE inforesidue swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/inforesidue/swissprot:A0JMQ3_DANRE octanol swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/octanol/swissprot:A0JMQ3_DANRE pepcoil swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/pepcoil/swissprot:A0JMQ3_DANRE pepdigest swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/pepdigest/swissprot:A0JMQ3_DANRE pepinfo swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/pepinfo/swissprot:A0JMQ3_DANRE pepnet swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/pepnet/swissprot:A0JMQ3_DANRE pepstats swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/pepstats/swissprot:A0JMQ3_DANRE pepwheel swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/pepwheel/swissprot:A0JMQ3_DANRE pepwindow swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/pepwindow/swissprot:A0JMQ3_DANRE sigcleave swissprot:A0JMQ3_DANRE http://rest.g-language.org/emboss/sigcleave/swissprot:A0JMQ3_DANRE ## Database ID URL or Descriptions # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 1.10.10.10 -; 1. # Gene3D 3.50.50.60 -; 1. # InterPro IPR002937 Amino_oxidase # InterPro IPR007526 SWIRM # InterPro IPR009057 Homeodomain-like # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR023753 FAD/NAD-binding_dom # Organism A7E385_BOVIN Bos taurus (Bovine) # PROSITE PS50934 SWIRM # Pfam PF01593 Amino_oxidase # Pfam PF04433 SWIRM # SUPFAM SSF46689 SSF46689 # SUPFAM SSF51905 SSF51905 # SubName A7E385_BOVIN AOF2 protein {ECO 0000313|EMBL AAI51757.1} BLAST swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/kblast/swissprot:A7E385_BOVIN EMBL BC151756 http://www.ebi.ac.uk/ena/data/view/BC151756 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 HOGENOM HOG000246945 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246945&db=HOGENOM6 InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR007526 http://www.ebi.ac.uk/interpro/entry/IPR007526 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 PROSITE PS50934 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50934 PSORT swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/kpsort/swissprot:A7E385_BOVIN PSORT-B swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/kpsortb/swissprot:A7E385_BOVIN PSORT2 swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/kpsort2/swissprot:A7E385_BOVIN Pfam PF01593 http://pfam.xfam.org/family/PF01593 Pfam PF04433 http://pfam.xfam.org/family/PF04433 Phobius swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/kphobius/swissprot:A7E385_BOVIN SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniGene Bt.39775 http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Bt.39775 UniProtKB A7E385_BOVIN http://www.uniprot.org/uniprot/A7E385_BOVIN UniProtKB-AC A7E385 http://www.uniprot.org/uniprot/A7E385 charge swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/charge/swissprot:A7E385_BOVIN epestfind swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/epestfind/swissprot:A7E385_BOVIN garnier swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/garnier/swissprot:A7E385_BOVIN helixturnhelix swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/helixturnhelix/swissprot:A7E385_BOVIN hmoment swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/hmoment/swissprot:A7E385_BOVIN iep swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/iep/swissprot:A7E385_BOVIN inforesidue swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/inforesidue/swissprot:A7E385_BOVIN octanol swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/octanol/swissprot:A7E385_BOVIN pepcoil swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/pepcoil/swissprot:A7E385_BOVIN pepdigest swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/pepdigest/swissprot:A7E385_BOVIN pepinfo swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/pepinfo/swissprot:A7E385_BOVIN pepnet swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/pepnet/swissprot:A7E385_BOVIN pepstats swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/pepstats/swissprot:A7E385_BOVIN pepwheel swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/pepwheel/swissprot:A7E385_BOVIN pepwindow swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/pepwindow/swissprot:A7E385_BOVIN sigcleave swissprot:A7E385_BOVIN http://rest.g-language.org/emboss/sigcleave/swissprot:A7E385_BOVIN ## Database ID URL or Descriptions # COFACTOR A8WC97_PIG Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000256|PIRSR PIRSR038051-1}; # GO_component GO:0005634 nucleus; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0034720 histone H3-K4 demethylation; IEA:InterPro. # GOslim_component GO:0005634 nucleus # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0008150 biological_process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.50.50.60 -; 2. # InterPro IPR002937 Amino_oxidase # InterPro IPR007526 SWIRM # InterPro IPR009057 Homeodomain-like # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR017366 Hist_Lys-spec_deMease # InterPro IPR023753 FAD/NAD-binding_dom # Organism A8WC97_PIG Sus scrofa (Pig) # PIRSF PIRSF038051 Histone_Lys-demethylase # PROSITE PS50934 SWIRM # Pfam PF01593 Amino_oxidase # Pfam PF04433 SWIRM # SUPFAM SSF46689 SSF46689 # SUPFAM SSF51905 SSF51905; 3 # SubName A8WC97_PIG Amine oxidase (Flavin containing) domain 2 isoform b {ECO 0000313|EMBL ABX10191.1} # eggNOG ENOG410XSNC LUCA # eggNOG KOG0029 Eukaryota # eggNOG KOG0685 Eukaryota BLAST swissprot:A8WC97_PIG http://rest.g-language.org/emboss/kblast/swissprot:A8WC97_PIG DOI 10.1007/s12010-012-9966-3 http://dx.doi.org/10.1007/s12010-012-9966-3 EMBL EU219916 http://www.ebi.ac.uk/ena/data/view/EU219916 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0034720 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034720 GOslim_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 HOGENOM HOG000246945 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246945&db=HOGENOM6 HOVERGEN HBG102081 http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG102081&db=HOVERGEN InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR007526 http://www.ebi.ac.uk/interpro/entry/IPR007526 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR017366 http://www.ebi.ac.uk/interpro/entry/IPR017366 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 PROSITE PS50934 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50934 PSORT swissprot:A8WC97_PIG http://rest.g-language.org/emboss/kpsort/swissprot:A8WC97_PIG PSORT-B swissprot:A8WC97_PIG http://rest.g-language.org/emboss/kpsortb/swissprot:A8WC97_PIG PSORT2 swissprot:A8WC97_PIG http://rest.g-language.org/emboss/kpsort2/swissprot:A8WC97_PIG Pfam PF01593 http://pfam.xfam.org/family/PF01593 Pfam PF04433 http://pfam.xfam.org/family/PF04433 Phobius swissprot:A8WC97_PIG http://rest.g-language.org/emboss/kphobius/swissprot:A8WC97_PIG ProteinModelPortal A8WC97 http://www.proteinmodelportal.org/query/uniprot/A8WC97 PubMed 23229475 http://www.ncbi.nlm.nih.gov/pubmed/23229475 STRING 9823.ENSSSCP00000003832 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9823.ENSSSCP00000003832&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniGene Ssc.30810 http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Ssc.30810 UniGene Ssc.7578 http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Ssc.7578 UniProtKB A8WC97_PIG http://www.uniprot.org/uniprot/A8WC97_PIG UniProtKB-AC A8WC97 http://www.uniprot.org/uniprot/A8WC97 charge swissprot:A8WC97_PIG http://rest.g-language.org/emboss/charge/swissprot:A8WC97_PIG eggNOG ENOG410XSNC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSNC eggNOG KOG0029 http://eggnogapi.embl.de/nog_data/html/tree/KOG0029 eggNOG KOG0685 http://eggnogapi.embl.de/nog_data/html/tree/KOG0685 epestfind swissprot:A8WC97_PIG http://rest.g-language.org/emboss/epestfind/swissprot:A8WC97_PIG garnier swissprot:A8WC97_PIG http://rest.g-language.org/emboss/garnier/swissprot:A8WC97_PIG helixturnhelix swissprot:A8WC97_PIG http://rest.g-language.org/emboss/helixturnhelix/swissprot:A8WC97_PIG hmoment swissprot:A8WC97_PIG http://rest.g-language.org/emboss/hmoment/swissprot:A8WC97_PIG iep swissprot:A8WC97_PIG http://rest.g-language.org/emboss/iep/swissprot:A8WC97_PIG inforesidue swissprot:A8WC97_PIG http://rest.g-language.org/emboss/inforesidue/swissprot:A8WC97_PIG octanol swissprot:A8WC97_PIG http://rest.g-language.org/emboss/octanol/swissprot:A8WC97_PIG pepcoil swissprot:A8WC97_PIG http://rest.g-language.org/emboss/pepcoil/swissprot:A8WC97_PIG pepdigest swissprot:A8WC97_PIG http://rest.g-language.org/emboss/pepdigest/swissprot:A8WC97_PIG pepinfo swissprot:A8WC97_PIG http://rest.g-language.org/emboss/pepinfo/swissprot:A8WC97_PIG pepnet swissprot:A8WC97_PIG http://rest.g-language.org/emboss/pepnet/swissprot:A8WC97_PIG pepstats swissprot:A8WC97_PIG http://rest.g-language.org/emboss/pepstats/swissprot:A8WC97_PIG pepwheel swissprot:A8WC97_PIG http://rest.g-language.org/emboss/pepwheel/swissprot:A8WC97_PIG pepwindow swissprot:A8WC97_PIG http://rest.g-language.org/emboss/pepwindow/swissprot:A8WC97_PIG sigcleave swissprot:A8WC97_PIG http://rest.g-language.org/emboss/sigcleave/swissprot:A8WC97_PIG ## Database ID URL or Descriptions # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # InterPro IPR002937 Amino_oxidase # InterPro IPR023753 FAD/NAD-binding_dom # Organism A7YF01_ORNAN Ornithorhynchus anatinus (Duckbill platypus) # Pfam PF01593 Amino_oxidase # SUPFAM SSF51905 SSF51905 # SubName A7YF01_ORNAN Amine oxidase flavin-containing domain 2 {ECO 0000313|EMBL ABU96087.1} # eggNOG ENOG410XSNC LUCA # eggNOG KOG0029 Eukaryota BLAST swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/kblast/swissprot:A7YF01_ORNAN EMBL EF674538 http://www.ebi.ac.uk/ena/data/view/EF674538 G-Links AOF2 http://link.g-language.org/AOF2/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 InterPro IPR002937 http://www.ebi.ac.uk/interpro/entry/IPR002937 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 PSORT swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/kpsort/swissprot:A7YF01_ORNAN PSORT-B swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/kpsortb/swissprot:A7YF01_ORNAN PSORT2 swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/kpsort2/swissprot:A7YF01_ORNAN Pfam PF01593 http://pfam.xfam.org/family/PF01593 Phobius swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/kphobius/swissprot:A7YF01_ORNAN STRING 9258.ENSOANP00000006331 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9258.ENSOANP00000006331&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB A7YF01_ORNAN http://www.uniprot.org/uniprot/A7YF01_ORNAN UniProtKB-AC A7YF01 http://www.uniprot.org/uniprot/A7YF01 charge swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/charge/swissprot:A7YF01_ORNAN eggNOG ENOG410XSNC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSNC eggNOG KOG0029 http://eggnogapi.embl.de/nog_data/html/tree/KOG0029 epestfind swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/epestfind/swissprot:A7YF01_ORNAN garnier swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/garnier/swissprot:A7YF01_ORNAN helixturnhelix swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/helixturnhelix/swissprot:A7YF01_ORNAN hmoment swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/hmoment/swissprot:A7YF01_ORNAN iep swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/iep/swissprot:A7YF01_ORNAN inforesidue swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/inforesidue/swissprot:A7YF01_ORNAN octanol swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/octanol/swissprot:A7YF01_ORNAN pepcoil swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/pepcoil/swissprot:A7YF01_ORNAN pepdigest swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/pepdigest/swissprot:A7YF01_ORNAN pepinfo swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/pepinfo/swissprot:A7YF01_ORNAN pepnet swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/pepnet/swissprot:A7YF01_ORNAN pepstats swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/pepstats/swissprot:A7YF01_ORNAN pepwheel swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/pepwheel/swissprot:A7YF01_ORNAN pepwindow swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/pepwindow/swissprot:A7YF01_ORNAN sigcleave swissprot:A7YF01_ORNAN http://rest.g-language.org/emboss/sigcleave/swissprot:A7YF01_ORNAN