PDB:1JM7 PDB:1JNX PDB:1N5O PDB:1OQA PDB:1T15 PDB:1T29 PDB:1T2U PDB:1T2V PDB:1Y98 PDB:2ING PDB:3COJ PDB:3K0H PDB:3K0K PDB:3K15 PDB:3K16 PDB:3PXA PDB:3PXB PDB:3PXC PDB:3PXD PDB:3PXE PDB:4IFI PDB:4IGK PDB:4JLU PDB:4OFB PDB:4U4A PDB:4Y18 PDB:4Y2G Jabion:672 Fanconi anemia pathway Ubiquitin mediated proteolysis PI3K-Akt signaling pathway
DataBaseIDURL or Descriptions
# ALTERNATIVE PRODUCTSBRCA1_HUMANEvent=Alternative splicing, Alternative initiation; Named isoforms=8; Name=1; IsoId=P38398-1; Sequence=Displayed; Name=2; IsoId=P38398-2; Sequence=VSP_047891; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; Synonyms=Delta11b; IsoId=P38398-3; Sequence=VSP_035399, VSP_043797; Name=4; Synonyms=DeltaBRCA1(17aa); IsoId=P38398-4; Sequence=VSP_035396; Note=Produced by alternative initiation at Met-18 of isoform 1.; Name=5; Synonyms=Delta11, Delta772-3095; IsoId=P38398-5; Sequence=VSP_035398; Name=6; IsoId=P38398-6; Sequence=VSP_035399, VSP_043797, VSP_043798; Note=No experimental confirmation available.; Name=7; IsoId=P38398-7; Sequence=VSP_055404; Note=No experimental confirmation available. Ref.8 (AAI15038) sequence is in conflict in position 1461 N->D. {ECO 0000305}; Name=8; IsoId=P38398-8; Sequence=VSP_057569; Note=No experimental confirmation available. The N-terminus is confirmed by several cDNAs. {ECO 0000305};
# AltNameBRCA1_HUMANRING finger protein 53
# AltNameRING-type E3 ubiquitin transferase BRCA1 {ECO0000305}
# BRENDA6.3.2.192681
# BioGrid107140566
# CATALYTIC ACTIVITYBRCA1_HUMANS-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin- conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. {ECO 0000269|PubMed 10500182, ECO 0000269|PubMed 12887909, ECO 0000269|PubMed 12890688, ECO 0000269|PubMed 16818604, ECO 0000269|PubMed 18056443, ECO 0000269|PubMed 20351172}.
# CCDSCCDS11453-. [P38398-1]
# CCDSCCDS11454-. [P38398-3]
# CCDSCCDS11455-. [P38398-6]
# CCDSCCDS11456-. [P38398-7]
# CCDSCCDS11459-. [P38398-8]
# CDDcd00027BRCT; 2
# ChiTaRSBRCA1human
# DISEASEBRCA1_HUMANBreast cancer (BC) [MIM 114480] A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. {ECO 0000269|PubMed 10323242, ECO 0000269|PubMed 12442275, ECO 0000269|PubMed 12938098, ECO 0000269|PubMed 14722926, ECO 0000269|PubMed 18285836, ECO 0000269|PubMed 7545954, ECO 0000269|PubMed 7894491, ECO 0000269|PubMed 7894493, ECO 0000269|PubMed 7939630, ECO 0000269|PubMed 8554067, ECO 0000269|PubMed 8723683, ECO 0000269|PubMed 8776600, ECO 0000269|PubMed 9482581, ECO 0000269|PubMed 9609997, ECO 0000269|PubMed 9760198}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Mutations in BRCA1 are thought to be responsible for 45% of inherited breast cancer. Moreover, BRCA1 carriers have a 4-fold increased risk of colon cancer, whereas male carriers face a 3- fold increased risk of prostate cancer. Cells lacking BRCA1 show defects in DNA repair by homologous recombination.
# DISEASEBRCA1_HUMANBreast-ovarian cancer, familial, 1 (BROVCA1) [MIM 604370] A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate. {ECO 0000269|PubMed 12938098, ECO 0000269|PubMed 14722926, ECO 0000269|PubMed 8968716}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Mutations in BRCA1 are thought to be responsible for more than 80% of inherited breast-ovarian cancer.
# DISEASEBRCA1_HUMANOvarian cancer (OC) [MIM 167000] The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. {ECO 0000269|PubMed 10196379, ECO 0000269|PubMed 10486320, ECO 0000269|PubMed 14746861}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
# DISEASEBRCA1_HUMANPancreatic cancer 4 (PNCA4) [MIM 614320] A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue. {ECO 0000269|PubMed 18762988}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
# DOMAINBRCA1_HUMANThe BRCT domains recognize and bind phosphorylated pSXXF motif on proteins. The interaction with the phosphorylated pSXXF motif of FAM175A/Abraxas, recruits BRCA1 at DNA damage sites. {ECO 0000269|PubMed 20159462}.
# DOMAINBRCA1_HUMANThe RING-type zinc finger domain interacts with BAP1. {ECO 0000269|PubMed 20159462}.
# ENZYME REGULATIONThe E3 ubiquitin-protein ligase activity is inhibited by phosphorylation by AURKA. Activity is increased by phosphatase treatment. {ECO:0000269|PubMed18056443}.
# EnsemblENST00000352993ENSP00000312236; ENSG00000012048. [P38398-5]
# EnsemblENST00000357654ENSP00000350283; ENSG00000012048. [P38398-1]
# EnsemblENST00000461221ENSP00000418548; ENSG00000012048. [P38398-2]
# EnsemblENST00000461798ENSP00000417988; ENSG00000012048. [P38398-2]
# EnsemblENST00000468300ENSP00000417148; ENSG00000012048. [P38398-6]
# EnsemblENST00000471181ENSP00000418960; ENSG00000012048. [P38398-7]
# EnsemblENST00000491747ENSP00000420705; ENSG00000012048. [P38398-3]
# EnsemblENST00000493795ENSP00000418775; ENSG00000012048. [P38398-8]
# ExpressionAtlasP38398baseline and differential
# FUNCTIONBRCA1_HUMANE3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (PubMed 20160719). {ECO 0000269|PubMed 10500182, ECO 0000269|PubMed 10724175, ECO 0000269|PubMed 11836499, ECO 0000269|PubMed 12887909, ECO 0000269|PubMed 12890688, ECO 0000269|PubMed 14976165, ECO 0000269|PubMed 14990569, ECO 0000269|PubMed 16326698, ECO 0000269|PubMed 16818604, ECO 0000269|PubMed 17525340, ECO 0000269|PubMed 18056443, ECO 0000269|PubMed 19261748, ECO 0000269|PubMed 19369211, ECO 0000269|PubMed 20160719, ECO 0000269|PubMed 20351172, ECO 0000269|PubMed 20364141}.
# GO_componentGO:0000151ubiquitin ligase complex; NAS:UniProtKB.
# GO_componentGO:0000800lateral element; IDA:MGI.
# GO_componentGO:0005634nucleus; IDA:UniProtKB.
# GO_componentGO:0005654nucleoplasm; TAS:Reactome.
# GO_componentGO:0005694chromosome; ISS:UniProtKB.
# GO_componentGO:0005737cytoplasm; IDA:UniProtKB.
# GO_componentGO:0005886plasma membrane; IDA:BHF-UCL.
# GO_componentGO:0008274gamma-tubulin ring complex; NAS:UniProtKB.
# GO_componentGO:0030529intracellular ribonucleoprotein complex; IDA:MGI.
# GO_componentGO:0031436BRCA1-BARD1 complex; IDA:UniProtKB.
# GO_componentGO:0043234protein complex; IDA:UniProtKB.
# GO_componentGO:0070531BRCA1-A complex; IDA:UniProtKB.
# GO_functionGO:0003677DNA binding; TAS:ProtInc.
# GO_functionGO:0003684damaged DNA binding; IEA:Ensembl.
# GO_functionGO:0003713transcription coactivator activity; NAS:UniProtKB.
# GO_functionGO:0003723RNA binding; IDA:MGI.
# GO_functionGO:0004842ubiquitin-protein transferase activity; IDA:UniProtKB.
# GO_functionGO:0008270zinc ion binding; TAS:ProtInc.
# GO_functionGO:0015631tubulin binding; NAS:UniProtKB.
# GO_functionGO:0019899enzyme binding; IPI:UniProtKB.
# GO_functionGO:0031625ubiquitin protein ligase binding; IPI:UniProtKB.
# GO_functionGO:0044212transcription regulatory region DNA binding; IDA:BHF-UCL.
# GO_functionGO:0050681androgen receptor binding; NAS:UniProtKB.
# GO_processGO:0000724double-strand break repair via homologous recombination; IDA:HGNC.
# GO_processGO:0000729DNA double-strand break processing; TAS:Reactome.
# GO_processGO:0000731DNA synthesis involved in DNA repair; TAS:Reactome.
# GO_processGO:0000732strand displacement; TAS:Reactome.
# GO_processGO:0006260DNA replication; TAS:Reactome.
# GO_processGO:0006301postreplication repair; IDA:HGNC.
# GO_processGO:0006302double-strand break repair; IMP:UniProtKB.
# GO_processGO:0006303double-strand break repair via nonhomologous end joining; TAS:Reactome.
# GO_processGO:0006349regulation of gene expression by genetic imprinting; IEA:Ensembl.
# GO_processGO:0006351transcription, DNA-templated; IEA:UniProtKB-KW.
# GO_processGO:0006357regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
# GO_processGO:0006359regulation of transcription from RNA polymerase III promoter; TAS:UniProtKB.
# GO_processGO:0006633fatty acid biosynthetic process; IEA:UniProtKB-KW.
# GO_processGO:0006915apoptotic process; TAS:UniProtKB.
# GO_processGO:0006974cellular response to DNA damage stimulus; TAS:ProtInc.
# GO_processGO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; TAS:UniProtKB.
# GO_processGO:0007059chromosome segregation; IMP:UniProtKB.
# GO_processGO:0007098centrosome cycle; IEA:Ensembl.
# GO_processGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage; IDA:MGI.
# GO_processGO:0009048dosage compensation by inactivation of X chromosome; IBA:GO_Central.
# GO_processGO:0010212response to ionizing radiation; IMP:UniProtKB.
# GO_processGO:0010575positive regulation of vascular endothelial growth factor production; IMP:BHF-UCL.
# GO_processGO:0010628positive regulation of gene expression; IMP:BHF-UCL.
# GO_processGO:0016567protein ubiquitination; IDA:HGNC.
# GO_processGO:0016925protein sumoylation; TAS:Reactome.
# GO_processGO:0030521androgen receptor signaling pathway; NAS:UniProtKB.
# GO_processGO:0031052chromosome breakage; IEA:Ensembl.
# GO_processGO:0031398positive regulation of protein ubiquitination; IDA:UniProtKB.
# GO_processGO:0031572G2 DNA damage checkpoint; IMP:UniProtKB.
# GO_processGO:0033147negative regulation of intracellular estrogen receptor signaling pathway; IMP:CACAO.
# GO_processGO:0035066positive regulation of histone acetylation; IDA:BHF-UCL.
# GO_processGO:0035067negative regulation of histone acetylation; IBA:GO_Central.
# GO_processGO:0042127regulation of cell proliferation; TAS:UniProtKB.
# GO_processGO:0042981regulation of apoptotic process; TAS:UniProtKB.
# GO_processGO:0043009chordate embryonic development; IBA:GO_Central.
# GO_processGO:0043627response to estrogen; IDA:UniProtKB.
# GO_processGO:0044030regulation of DNA methylation; IEA:Ensembl.
# GO_processGO:0045717negative regulation of fatty acid biosynthetic process; IMP:UniProtKB.
# GO_processGO:0045739positive regulation of DNA repair; IMP:UniProtKB.
# GO_processGO:0045766positive regulation of angiogenesis; IMP:BHF-UCL.
# GO_processGO:0045892negative regulation of transcription, DNA-templated; IDA:UniProtKB.
# GO_processGO:0045893positive regulation of transcription, DNA-templated; IDA:UniProtKB.
# GO_processGO:0045944positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
# GO_processGO:0046600negative regulation of centriole replication; NAS:UniProtKB.
# GO_processGO:0051571positive regulation of histone H3-K4 methylation; IDA:BHF-UCL.
# GO_processGO:0051572negative regulation of histone H3-K4 methylation; IEA:Ensembl.
# GO_processGO:0051573negative regulation of histone H3-K9 methylation; IDA:BHF-UCL.
# GO_processGO:0051574positive regulation of histone H3-K9 methylation; IEA:Ensembl.
# GO_processGO:0051865protein autoubiquitination; IDA:UniProtKB.
# GO_processGO:0070512positive regulation of histone H4-K20 methylation; IDA:BHF-UCL.
# GO_processGO:0071158positive regulation of cell cycle arrest; IDA:BHF-UCL.
# GO_processGO:0071356cellular response to tumor necrosis factor; IMP:BHF-UCL.
# GO_processGO:0071681cellular response to indole-3-methanol; IDA:UniProtKB.
# GO_processGO:0085020protein K6-linked ubiquitination; IDA:UniProtKB.
# GO_processGO:1901796regulation of signal transduction by p53 class mediator; TAS:Reactome.
# GO_processGO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IMP:BHF-UCL.
# GO_processGO:2000378negative regulation of reactive oxygen species metabolic process; IMP:BHF-UCL.
# GO_processGO:2000617positive regulation of histone H3-K9 acetylation; IDA:BHF-UCL.
# GO_processGO:2000620positive regulation of histone H4-K16 acetylation; IDA:BHF-UCL.
# GOslim_componentGO:0005575cellular_component
# GOslim_componentGO:0005634nucleus
# GOslim_componentGO:0005654nucleoplasm
# GOslim_componentGO:0005694chromosome
# GOslim_componentGO:0005737cytoplasm
# GOslim_componentGO:0005886plasma membrane
# GOslim_componentGO:0043234protein complex
# GOslim_functionGO:0000988transcription factor activity, protein binding
# GOslim_functionGO:0003674molecular_function
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0003723RNA binding
# GOslim_functionGO:0008092cytoskeletal protein binding
# GOslim_functionGO:0019899enzyme binding
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0006464cellular protein modification process
# GOslim_processGO:0006629lipid metabolic process
# GOslim_processGO:0006950response to stress
# GOslim_processGO:0007059chromosome segregation
# GOslim_processGO:0007165signal transduction
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0008219cell death
# GOslim_processGO:0009058biosynthetic process
# GOslim_processGO:0009790embryo development
# GOslim_processGO:0034641cellular nitrogen compound metabolic process
# GOslim_processGO:0044281small molecule metabolic process
# GOslim_processGO:0051276chromosome organization
# Gene3D3.30.40.10-; 1.
# Gene3D3.40.50.10190-; 2.
# GenevisibleP38398HS
# HGNCHGNC:1100BRCA1
# INTERACTIONBRCA1_HUMANQ13085 ACACA; NbExp=2; IntAct=EBI-349905, EBI-717681; Q92560 BAP1; NbExp=3; IntAct=EBI-349905, EBI-1791447; Q99728 BARD1; NbExp=9; IntAct=EBI-349905, EBI-473181; P10415 BCL2; NbExp=6; IntAct=EBI-349905, EBI-77694; Q7Z569 BRAP; NbExp=3; IntAct=EBI-349905, EBI-349900; Q6PJG6 BRAT1; NbExp=6; IntAct=EBI-349905, EBI-10826195; Q9BX63 BRIP1; NbExp=12; IntAct=EBI-349905, EBI-3509650; P24385 CCND1; NbExp=3; IntAct=EBI-349905, EBI-375001; P24864 CCNE1; NbExp=2; IntAct=EBI-349905, EBI-519526; O14757 CHEK1; NbExp=3; IntAct=EBI-349905, EBI-974488; P03372 ESR1; NbExp=12; IntAct=EBI-349905, EBI-78473; Q61188 Ezh2 (xeno); NbExp=5; IntAct=EBI-349905, EBI-904311; Q6UWZ7 FAM175A; NbExp=10; IntAct=EBI-349905, EBI-1263451; Q14192 FHL2; NbExp=6; IntAct=EBI-349905, EBI-701903; P78347 GTF2I; NbExp=5; IntAct=EBI-349905, EBI-359622; P16104 H2AFX; NbExp=4; IntAct=EBI-349905, EBI-494830; P10809 HSPD1; NbExp=2; IntAct=EBI-349905, EBI-352528; Q16666 IFI16; NbExp=9; IntAct=EBI-349905, EBI-2867186; P52292 KPNA2; NbExp=3; IntAct=EBI-349905, EBI-349938; Q8WX92 NELFB; NbExp=5; IntAct=EBI-349905, EBI-347721; P62136 PPP1CA; NbExp=2; IntAct=EBI-349905, EBI-357253; P62140 PPP1CB; NbExp=3; IntAct=EBI-349905, EBI-352350; P36873 PPP1CC; NbExp=2; IntAct=EBI-349905, EBI-356283; Q99708 RBBP8; NbExp=9; IntAct=EBI-349905, EBI-745715; Q9Y4A5 TRRAP; NbExp=8; IntAct=EBI-349905, EBI-399128; Q96RL1 UIMC1; NbExp=9; IntAct=EBI-349905, EBI-725300; Q6NZY4 ZCCHC8; NbExp=2; IntAct=EBI-349905, EBI-1263058; Q9GZX5 ZNF350; NbExp=3; IntAct=EBI-349905, EBI-396421;
# IntActP3839876
# InterProIPR001357BRCT_dom
# InterProIPR001841Znf_RING
# InterProIPR011364BRCA1
# InterProIPR013083Znf_RING/FYVE/PHD
# InterProIPR017907Znf_RING_CS
# InterProIPR018957Znf_C3HC4_RING-type
# InterProIPR025994BRCA1_serine_dom
# InterProIPR031099BRCA1-associated
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko00002 KEGG pathway modules
# KEGG_Briteko03036 Chromosome
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Briteko03400 M00295 BRCA1-associated genome surveillance complex (BASC)
# KEGG_Briteko04121 Ubiquitin system
# KEGG_DiseaseH00027[Cancer] Ovarian cancer
# KEGG_DiseaseH00031[Cancer] Breast cancer
# KEGG_DiseaseH01554[Cancer] Fallopian tube cancer
# KEGG_DiseaseH01665[Cancer] Primary peritoneal carcinoma
# KEGG_Pathwayko03460Fanconi anemia pathway
# KEGG_Pathwayko04120Ubiquitin mediated proteolysis
# KEGG_Pathwayko04151PI3K-Akt signaling pathway
# MIM113705gene
# MIM114480phenotype
# MIM167000phenotype
# MIM604370phenotype
# MIM614320phenotype
# OrganismBRCA1_HUMANHomo sapiens (Human)
# Orphanet1331Familial prostate cancer
# Orphanet1333Familial pancreatic carcinoma
# Orphanet145Hereditary breast and ovarian cancer syndrome
# Orphanet168829Primary peritoneal carcinoma
# Orphanet213524Hereditary site-specific ovarian cancer syndrome
# Orphanet227535Hereditary breast cancer
# PANTHERPTHR13763:SF0PTHR13763:SF0
# PANTHERPTHR13763PTHR13763
# PATHWAYBRCA1_HUMANProtein modification; protein ubiquitination.
# PDB1JM7NMR; -; A=1-110
# PDB1JNXX-ray; 2.50 A; X=1646-1859
# PDB1N5OX-ray; 2.80 A; X=1646-1859
# PDB1OQANMR; -; A=1755-1863
# PDB1T15X-ray; 1.85 A; A=1646-1859
# PDB1T29X-ray; 2.30 A; A=1646-1859
# PDB1T2UX-ray; 2.80 A; A=1646-1859
# PDB1T2VX-ray; 3.30 A; A/B/C/D/E=1646-1859
# PDB1Y98X-ray; 2.50 A; A=1646-1859
# PDB2INGX-ray; 3.60 A; X=1649-1859
# PDB3COJX-ray; 3.21 A; A/B/C/D/E/F/G/X=1646-1859
# PDB3K0HX-ray; 2.70 A; A=1646-1859
# PDB3K0KX-ray; 2.70 A; A=1646-1859
# PDB3K15X-ray; 2.80 A; A=1646-1859
# PDB3K16X-ray; 3.00 A; A=1646-1859
# PDB3PXAX-ray; 2.55 A; A=1646-1859
# PDB3PXBX-ray; 2.50 A; A=1646-1859
# PDB3PXCX-ray; 2.80 A; X=1646-1859
# PDB3PXDX-ray; 2.80 A; A=1646-1859
# PDB3PXEX-ray; 2.85 A; A/B/C/D=1646-1859
# PDB4IFIX-ray; 2.20 A; A=1646-1859
# PDB4IGKX-ray; 1.75 A; A/B=1646-1859
# PDB4JLUX-ray; 3.50 A; A=1649-1859
# PDB4OFBX-ray; 3.05 A; A=1646-1859
# PDB4U4AX-ray; 3.51 A; A/B/C=1646-1859
# PDB4Y18X-ray; 3.50 A; A/B/C/D/E/F/G/H=1646-1859
# PDB4Y2GX-ray; 2.50 A; A=1646-1859
# PIRA58881A58881
# PIRSFPIRSF001734BRCA1
# POLYMORPHISMBRCA1_HUMANThere is evidence that the presence of the rare form of Gln-356-Arg and Leu-871-Pro polymorphisms may be associated with an increased risk for developing ovarian cancer.
# PRINTSPR00493BRSTCANCERI
# PROSITEPS00518ZF_RING_1
# PROSITEPS50089ZF_RING_2
# PROSITEPS50172BRCT; 2
# PTMBRCA1_HUMANAutoubiquitinated, undergoes 'Lys-6'-linked polyubiquitination. 'Lys-6'-linked polyubiquitination does not promote degradation. {ECO 0000269|PubMed 12890688, ECO 0000269|PubMed 20351172}.
# PTMBRCA1_HUMANPhosphorylation at Ser-308 by AURKA is required for normal cell cycle progression from G2 to mitosis. Phosphorylated in response to IR, UV, and various stimuli that cause checkpoint activation, probably by ATM or ATR. Phosphorylation at Ser-988 by CHEK2 regulates mitotic spindle assembly. {ECO 0000269|PubMed 10724175, ECO 0000269|PubMed 11114888, ECO 0000269|PubMed 12183412, ECO 0000269|PubMed 14990569, ECO 0000269|PubMed 18056443, ECO 0000269|PubMed 20364141, ECO 0000269|PubMed 21144835}.
# PfamPF00097zf-C3HC4
# PfamPF00533BRCT; 2
# PfamPF12820BRCT_assoc
# ProteomesUP000005640Chromosome 17
# ReactomeR-HSA-1221632Meiotic synapsis
# ReactomeR-HSA-3108214SUMOylation of DNA damage response and repair proteins
# ReactomeR-HSA-5685938HDR through Single Strand Annealing (SSA)
# ReactomeR-HSA-5685942HDR through Homologous Recombination (HRR)
# ReactomeR-HSA-5689901Metalloprotease DUBs
# ReactomeR-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
# ReactomeR-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
# ReactomeR-HSA-5693568Resolution of D-loop Structures through Holliday Junction Intermediates
# ReactomeR-HSA-5693571Nonhomologous End-Joining (NHEJ)
# ReactomeR-HSA-5693579Homologous DNA Pairing and Strand Exchange
# ReactomeR-HSA-5693607Processing of DNA double-strand break ends
# ReactomeR-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchange
# ReactomeR-HSA-6796648TP53 Regulates Transcription of DNA Repair Genes
# ReactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
# ReactomeR-HSA-69473G2/M DNA damage checkpoint
# ReactomeR-HSA-912446Meiotic recombination
# RecNameBRCA1_HUMANBreast cancer type 1 susceptibility protein
# RefSeqNP_009225NM_007294.3. [P38398-1]
# RefSeqNP_009228NM_007297.3. [P38398-8]
# RefSeqNP_009229NM_007298.3. [P38398-3]
# RefSeqNP_009230NM_007299.3. [P38398-6]
# RefSeqNP_009231NM_007300.3. [P38398-7]
# SEQUENCE CAUTIONSequence=AAB61673.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAI15038.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO0000305}; Sequence=AAI15038.1; Type=Erroneous termination; Positions=526; Note=Translated as Gln.; Evidence={ECO:0000305};
# SIMILARITYContains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRulePRU00175}.
# SIMILARITYContains 2 BRCT domains. {ECO:0000255|PROSITE- ProRulePRU00033}.
# SMARTSM00184RING
# SMARTSM00292BRCT; 2
# SUBCELLULAR LOCATIONBRCA1_HUMANIsoform 3 Cytoplasm.
# SUBCELLULAR LOCATIONBRCA1_HUMANIsoform 5 Cytoplasm {ECO 0000269|PubMed 8972225}.
# SUBCELLULAR LOCATIONBRCA1_HUMANNucleus {ECO 0000269|PubMed 15133502, ECO 0000269|PubMed 17525340, ECO 0000269|PubMed 20160719, ECO 0000269|PubMed 21144835, ECO 0000269|PubMed 26778126, ECO 0000269|PubMed 9528852}. Chromosome {ECO 0000250|UniProtKB P48754}. Cytoplasm {ECO 0000269|PubMed 20160719}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by FAM175A and the BRCA1-A complex (PubMed 26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed 20160719). {ECO 0000269|PubMed 20160719, ECO 0000269|PubMed 26778126}.
# SUBUNITBRCA1_HUMANHeterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Interacts (via the BRCT domains) with FAM175A (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of FAM175A (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, COBRA1, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, AURKA, UBXN1 and KIAA0101/PAF15. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AFX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2 (PubMed 26807646). {ECO 0000269|PubMed 10724175, ECO 0000269|PubMed 10783165, ECO 0000269|PubMed 11239454, ECO 0000269|PubMed 11301010, ECO 0000269|PubMed 11573085, ECO 0000269|PubMed 11739404, ECO 0000269|PubMed 11751867, ECO 0000269|PubMed 11836499, ECO 0000269|PubMed 11877377, ECO 0000269|PubMed 12360400, ECO 0000269|PubMed 12419185, ECO 0000269|PubMed 12890688, ECO 0000269|PubMed 14636569, ECO 0000269|PubMed 14976165, ECO 0000269|PubMed 14990569, ECO 0000269|PubMed 15096610, ECO 0000269|PubMed 15133502, ECO 0000269|PubMed 15456891, ECO 0000269|PubMed 16101277, ECO 0000269|PubMed 16326698, ECO 0000269|PubMed 16698035, ECO 0000269|PubMed 16818604, ECO 0000269|PubMed 17525340, ECO 0000269|PubMed 17643121, ECO 0000269|PubMed 17643122, ECO 0000269|PubMed 18452305, ECO 0000269|PubMed 19261746, ECO 0000269|PubMed 19261748, ECO 0000269|PubMed 19261749, ECO 0000269|PubMed 19369211, ECO 0000269|PubMed 20159462, ECO 0000269|PubMed 20160719, ECO 0000269|PubMed 20351172, ECO 0000269|PubMed 21473589, ECO 0000269|PubMed 21673012, ECO 0000269|PubMed 24316840, ECO 0000269|PubMed 26778126, ECO 0000269|PubMed 26807646, ECO 0000269|PubMed 9528852, ECO 0000269|PubMed 9811458}.
# SUPFAMSSF52113SSF52113; 2
# TISSUE SPECIFICITYBRCA1_HUMANIsoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast and ovarian cancer cell lines.
# UCSCuc002icqhuman. [P38398-1]
# UCSCuc010cyxhuman
# WEB RESOURCEBRCA1_HUMANName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/BRCA1ID163ch17q21.html";
# WEB RESOURCEBRCA1_HUMANName=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/brca1/";
# WEB RESOURCEBRCA1_HUMANName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http //shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=BRCA1";
# WEB RESOURCEBRCA1_HUMANName=Wikipedia; Note=BRCA1 entry; URL="https //en.wikipedia.org/wiki/BRCA1";
# eggNOGENOG410ITQ4Eukaryota
# eggNOGENOG4112BIHLUCA
BLASTswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/kblast/swissprot:BRCA1_HUMAN
BioCycZFISH:ENSG00000012048-MONOMERhttp://biocyc.org/getid?id=ZFISH:ENSG00000012048-MONOMER
COXPRESdb672http://coxpresdb.jp/data/gene/672.shtml
CleanExHS_BRCA1http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_BRCA1
DIPDIP-5971Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-5971N
DOI10.1002/(SICI)1098-1004(1996)7:4<334::AID-HUMU7>3.3.CO3.3.CO>http://dx.doi.org/10.1002/(SICI)1098-1004(1996)7:4<334::AID-HUMU7>3.3.CO
DOI10.1002/(SICI)1098-1004(1998)11:2<166::AID-HUMU10>3.0.CO3.0.CO>http://dx.doi.org/10.1002/(SICI)1098-1004(1998)11:2<166::AID-HUMU10>3.0.CO
DOI10.1002/(SICI)1098-2272(1996)13:6<595::AID-GEPI5>3.3.CO3.3.CO>http://dx.doi.org/10.1002/(SICI)1098-2272(1996)13:6<595::AID-GEPI5>3.3.CO
DOI10.1002/humu.1380080102http://dx.doi.org/10.1002/humu.1380080102
DOI10.1002/humu.21267http://dx.doi.org/10.1002/humu.21267
DOI10.1002/humu.9083http://dx.doi.org/10.1002/humu.9083
DOI10.1002/humu.9084http://dx.doi.org/10.1002/humu.9084
DOI10.1002/humu.9174http://dx.doi.org/10.1002/humu.9174
DOI10.1002/humu.9213http://dx.doi.org/10.1002/humu.9213
DOI10.1002/humu.9275http://dx.doi.org/10.1002/humu.9275
DOI10.1007/s00439-008-0554-0http://dx.doi.org/10.1007/s00439-008-0554-0
DOI10.1007/s004390050799http://dx.doi.org/10.1007/s004390050799
DOI10.1007/s004390050936http://dx.doi.org/10.1007/s004390050936
DOI10.1007/s100380050035http://dx.doi.org/10.1007/s100380050035
DOI10.1016/S0092-8674(01)00304-Xhttp://dx.doi.org/10.1016/S0092-8674(01)00304-X
DOI10.1016/S0960-9822(02)01259-9http://dx.doi.org/10.1016/S0960-9822(02)01259-9
DOI10.1016/S1097-2765(01)00173-3http://dx.doi.org/10.1016/S1097-2765(01)00173-3
DOI10.1016/S1097-2765(03)00281-8http://dx.doi.org/10.1016/S1097-2765(03)00281-8
DOI10.1016/S1097-2765(03)00424-6http://dx.doi.org/10.1016/S1097-2765(03)00424-6
DOI10.1016/j.bbrc.2010.12.005http://dx.doi.org/10.1016/j.bbrc.2010.12.005
DOI10.1016/j.cell.2006.09.026http://dx.doi.org/10.1016/j.cell.2006.09.026
DOI10.1016/j.ejca.2003.09.016http://dx.doi.org/10.1016/j.ejca.2003.09.016
DOI10.1016/j.jmb.2006.04.010http://dx.doi.org/10.1016/j.jmb.2006.04.010
DOI10.1016/j.molcel.2015.12.017http://dx.doi.org/10.1016/j.molcel.2015.12.017
DOI10.1016/j.str.2009.12.008http://dx.doi.org/10.1016/j.str.2009.12.008
DOI10.1021/bi049550qhttp://dx.doi.org/10.1021/bi049550q
DOI10.1021/bi0509651http://dx.doi.org/10.1021/bi0509651
DOI10.1021/bi2003795http://dx.doi.org/10.1021/bi2003795
DOI10.1021/bi800314mhttp://dx.doi.org/10.1021/bi800314m
DOI10.1021/pr300630khttp://dx.doi.org/10.1021/pr300630k
DOI10.1038/35004614http://dx.doi.org/10.1038/35004614
DOI10.1038/ejhg.2008.13http://dx.doi.org/10.1038/ejhg.2008.13
DOI10.1038/nature04689http://dx.doi.org/10.1038/nature04689
DOI10.1038/ncb2051http://dx.doi.org/10.1038/ncb2051
DOI10.1038/ncb3303http://dx.doi.org/10.1038/ncb3303
DOI10.1038/ng1294-387http://dx.doi.org/10.1038/ng1294-387
DOI10.1038/ng1294-399http://dx.doi.org/10.1038/ng1294-399
DOI10.1038/ng837http://dx.doi.org/10.1038/ng837
DOI10.1038/nsb1001-833http://dx.doi.org/10.1038/nsb1001-833
DOI10.1038/nsb1001-838http://dx.doi.org/10.1038/nsb1001-838
DOI10.1038/nsmb.2890http://dx.doi.org/10.1038/nsmb.2890
DOI10.1038/nsmb1277http://dx.doi.org/10.1038/nsmb1277
DOI10.1038/nsmb1279http://dx.doi.org/10.1038/nsmb1279
DOI10.1038/nsmb775http://dx.doi.org/10.1038/nsmb775
DOI10.1038/sj.bjc.6601656http://dx.doi.org/10.1038/sj.bjc.6601656
DOI10.1038/sj.bjc.6605577http://dx.doi.org/10.1038/sj.bjc.6605577
DOI10.1038/sj.onc.1200924http://dx.doi.org/10.1038/sj.onc.1200924
DOI10.1038/sj.onc.1201861http://dx.doi.org/10.1038/sj.onc.1201861
DOI10.1038/sj.onc.1202150http://dx.doi.org/10.1038/sj.onc.1202150
DOI10.1038/sj.onc.1203599http://dx.doi.org/10.1038/sj.onc.1203599
DOI10.1038/sj.onc.1205915http://dx.doi.org/10.1038/sj.onc.1205915
DOI10.1073/pnas.0401847101http://dx.doi.org/10.1073/pnas.0401847101
DOI10.1073/pnas.0805139105http://dx.doi.org/10.1073/pnas.0805139105
DOI10.1073/pnas.0811159106http://dx.doi.org/10.1073/pnas.0811159106
DOI10.1073/pnas.1210303109http://dx.doi.org/10.1073/pnas.1210303109
DOI10.1073/pnas.96.20.11364http://dx.doi.org/10.1073/pnas.96.20.11364
DOI10.1074/jbc.C300249200http://dx.doi.org/10.1074/jbc.C300249200
DOI10.1074/jbc.M110603200http://dx.doi.org/10.1074/jbc.M110603200
DOI10.1074/jbc.M210019200http://dx.doi.org/10.1074/jbc.M210019200
DOI10.1074/jbc.M311780200http://dx.doi.org/10.1074/jbc.M311780200
DOI10.1074/jbc.M504652200http://dx.doi.org/10.1074/jbc.M504652200
DOI10.1074/mcp.O114.044792http://dx.doi.org/10.1074/mcp.O114.044792
DOI10.1083/jcb.200108049http://dx.doi.org/10.1083/jcb.200108049
DOI10.1086/302583http://dx.doi.org/10.1086/302583
DOI10.1086/521032http://dx.doi.org/10.1086/521032
DOI10.1089/10906570260199375http://dx.doi.org/10.1089/10906570260199375
DOI10.1093/hmg/5.6.835http://dx.doi.org/10.1093/hmg/5.6.835
DOI10.1093/hmg/8.5.889http://dx.doi.org/10.1093/hmg/8.5.889
DOI10.1093/hmg/ddh095http://dx.doi.org/10.1093/hmg/ddh095
DOI10.1101/gad.1431006http://dx.doi.org/10.1101/gad.1431006
DOI10.1101/gad.1739609http://dx.doi.org/10.1101/gad.1739609
DOI10.1101/gad.1770309http://dx.doi.org/10.1101/gad.1770309
DOI10.1101/gad.1770609http://dx.doi.org/10.1101/gad.1770609
DOI10.1101/gad.851000http://dx.doi.org/10.1101/gad.851000
DOI10.1101/gad.970702http://dx.doi.org/10.1101/gad.970702
DOI10.1101/gr.2596504http://dx.doi.org/10.1101/gr.2596504
DOI10.1101/gr.6.11.1029http://dx.doi.org/10.1101/gr.6.11.1029
DOI10.1107/S1744309113030649http://dx.doi.org/10.1107/S1744309113030649
DOI10.1126/science.1133427http://dx.doi.org/10.1126/science.1133427
DOI10.1126/science.1139476http://dx.doi.org/10.1126/science.1139476
DOI10.1126/science.1140321http://dx.doi.org/10.1126/science.1140321
DOI10.1126/science.7545954http://dx.doi.org/10.1126/science.7545954
DOI10.1126/science.7939630http://dx.doi.org/10.1126/science.7939630
DOI10.1126/scisignal.2000007http://dx.doi.org/10.1126/scisignal.2000007
DOI10.1126/scisignal.2000475http://dx.doi.org/10.1126/scisignal.2000475
DOI10.1126/scisignal.2001570http://dx.doi.org/10.1126/scisignal.2001570
DOI10.1128/MCB.01056-09http://dx.doi.org/10.1128/MCB.01056-09
DOI10.1128/MCB.17.1.444http://dx.doi.org/10.1128/MCB.17.1.444
DOI10.1128/MCB.24.20.9207-9220.2004http://dx.doi.org/10.1128/MCB.24.20.9207-9220.2004
DOI10.1158/0008-5472.CAN-07-2578http://dx.doi.org/10.1158/0008-5472.CAN-07-2578
DOI10.1158/1541-7786.MCR-10-0503http://dx.doi.org/10.1158/1541-7786.MCR-10-0503
DOI10.1158/2159-8290.CD-13-0094http://dx.doi.org/10.1158/2159-8290.CD-13-0094
DisProtDP00238http://www.disprot.org/protein.php?id=DP00238
EC_numberEC:2.3.2.27 {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:20351172}http://www.genome.jp/dbget-bin/www_bget?EC:2.3.2.27 {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:20351172}
EMBLAC060780http://www.ebi.ac.uk/ena/data/view/AC060780
EMBLAC135721http://www.ebi.ac.uk/ena/data/view/AC135721
EMBLAF005068http://www.ebi.ac.uk/ena/data/view/AF005068
EMBLAY273801http://www.ebi.ac.uk/ena/data/view/AY273801
EMBLBC072418http://www.ebi.ac.uk/ena/data/view/BC072418
EMBLBC115037http://www.ebi.ac.uk/ena/data/view/BC115037
EMBLDQ190450http://www.ebi.ac.uk/ena/data/view/DQ190450
EMBLDQ190451http://www.ebi.ac.uk/ena/data/view/DQ190451
EMBLDQ190452http://www.ebi.ac.uk/ena/data/view/DQ190452
EMBLDQ190453http://www.ebi.ac.uk/ena/data/view/DQ190453
EMBLDQ190454http://www.ebi.ac.uk/ena/data/view/DQ190454
EMBLDQ190455http://www.ebi.ac.uk/ena/data/view/DQ190455
EMBLDQ190456http://www.ebi.ac.uk/ena/data/view/DQ190456
EMBLL78833http://www.ebi.ac.uk/ena/data/view/L78833
EMBLU14680http://www.ebi.ac.uk/ena/data/view/U14680
EMBLU64805http://www.ebi.ac.uk/ena/data/view/U64805
ENZYME2.3.2.27 {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:20351172}http://enzyme.expasy.org/EC/2.3.2.27 {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:20351172}
EnsemblENST00000352993http://www.ensembl.org/id/ENST00000352993
EnsemblENST00000357654http://www.ensembl.org/id/ENST00000357654
EnsemblENST00000461221http://www.ensembl.org/id/ENST00000461221
EnsemblENST00000461798http://www.ensembl.org/id/ENST00000461798
EnsemblENST00000468300http://www.ensembl.org/id/ENST00000468300
EnsemblENST00000471181http://www.ensembl.org/id/ENST00000471181
EnsemblENST00000491747http://www.ensembl.org/id/ENST00000491747
EnsemblENST00000493795http://www.ensembl.org/id/ENST00000493795
G-LinksBRCA1_HUMANhttp://link.g-language.org/BRCA1_HUMAN/format=tsv
GO_componentGO:0000151http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000151
GO_componentGO:0000800http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000800
GO_componentGO:0005634http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_componentGO:0005654http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GO_componentGO:0005694http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694
GO_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_componentGO:0005886http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_componentGO:0008274http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008274
GO_componentGO:0030529http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030529
GO_componentGO:0031436http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031436
GO_componentGO:0043234http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GO_componentGO:0070531http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070531
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003684http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003684
GO_functionGO:0003713http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003713
GO_functionGO:0003723http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GO_functionGO:0004842http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004842
GO_functionGO:0008270http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_functionGO:0015631http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015631
GO_functionGO:0019899http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GO_functionGO:0031625http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031625
GO_functionGO:0044212http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044212
GO_functionGO:0050681http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050681
GO_processGO:0000724http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000724
GO_processGO:0000729http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000729
GO_processGO:0000731http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000731
GO_processGO:0000732http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000732
GO_processGO:0006260http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260
GO_processGO:0006301http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006301
GO_processGO:0006302http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006302
GO_processGO:0006303http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006303
GO_processGO:0006349http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006349
GO_processGO:0006351http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351
GO_processGO:0006357http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006357
GO_processGO:0006359http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006359
GO_processGO:0006633http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633
GO_processGO:0006915http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915
GO_processGO:0006974http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974
GO_processGO:0006978http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006978
GO_processGO:0007059http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059
GO_processGO:0007098http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007098
GO_processGO:0008630http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008630
GO_processGO:0009048http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009048
GO_processGO:0010212http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010212
GO_processGO:0010575http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010575
GO_processGO:0010628http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628
GO_processGO:0016567http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016567
GO_processGO:0016925http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016925
GO_processGO:0030521http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030521
GO_processGO:0031052http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031052
GO_processGO:0031398http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031398
GO_processGO:0031572http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031572
GO_processGO:0033147http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033147
GO_processGO:0035066http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035066
GO_processGO:0035067http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035067
GO_processGO:0042127http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042127
GO_processGO:0042981http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042981
GO_processGO:0043009http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043009
GO_processGO:0043627http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043627
GO_processGO:0044030http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044030
GO_processGO:0045717http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045717
GO_processGO:0045739http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045739
GO_processGO:0045766http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045766
GO_processGO:0045892http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892
GO_processGO:0045893http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893
GO_processGO:0045944http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944
GO_processGO:0046600http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046600
GO_processGO:0051571http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051571
GO_processGO:0051572http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051572
GO_processGO:0051573http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051573
GO_processGO:0051574http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051574
GO_processGO:0051865http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051865
GO_processGO:0070512http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070512
GO_processGO:0071158http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071158
GO_processGO:0071356http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071356
GO_processGO:0071681http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071681
GO_processGO:0085020http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0085020
GO_processGO:1901796http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901796
GO_processGO:1902042http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902042
GO_processGO:2000378http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000378
GO_processGO:2000617http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000617
GO_processGO:2000620http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000620
GOslim_componentGO:0005575http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_componentGO:0005634http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_componentGO:0005654http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654
GOslim_componentGO:0005694http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694
GOslim_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_componentGO:0005886http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_componentGO:0043234http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_functionGO:0000988http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988
GOslim_functionGO:0003674http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0003723http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_functionGO:0008092http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092
GOslim_functionGO:0019899http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0006464http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464
GOslim_processGO:0006629http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629
GOslim_processGO:0006950http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_processGO:0007059http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059
GOslim_processGO:0007165http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0008219http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_processGO:0009790http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009790
GOslim_processGO:0034641http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_processGO:0044281http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281
GOslim_processGO:0051276http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276
Gene3D3.30.40.10http://www.cathdb.info/version/latest/superfamily/3.30.40.10
Gene3D3.40.50.10190http://www.cathdb.info/version/latest/superfamily/3.40.50.10190
GeneCardsBRCA1http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=BRCA1
GeneID672http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=672
GeneTreeENSGT00440000034289http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00440000034289
HGNCHGNC:1100http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1100
HOGENOMHOG000230969http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230969&db=HOGENOM6
HOVERGENHBG050730http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050730&db=HOVERGEN
HPACAB001946http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB001946
HPACAB018369http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB018369
HPAHPA034966http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034966
InParanoidP38398http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38398
IntActP38398http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38398*
IntEnz2.3.2.27 {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:20351172}http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.2.27 {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:20351172}
InterProIPR001357http://www.ebi.ac.uk/interpro/entry/IPR001357
InterProIPR001841http://www.ebi.ac.uk/interpro/entry/IPR001841
InterProIPR011364http://www.ebi.ac.uk/interpro/entry/IPR011364
InterProIPR013083http://www.ebi.ac.uk/interpro/entry/IPR013083
InterProIPR017907http://www.ebi.ac.uk/interpro/entry/IPR017907
InterProIPR018957http://www.ebi.ac.uk/interpro/entry/IPR018957
InterProIPR025994http://www.ebi.ac.uk/interpro/entry/IPR025994
InterProIPR031099http://www.ebi.ac.uk/interpro/entry/IPR031099
Jabion672http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=672
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko00002http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Briteko03036http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Briteko04121http://www.genome.jp/dbget-bin/www_bget?ko04121
KEGG_DiseaseH00027http://www.genome.jp/dbget-bin/www_bget?H00027
KEGG_DiseaseH00031http://www.genome.jp/dbget-bin/www_bget?H00031
KEGG_DiseaseH01554http://www.genome.jp/dbget-bin/www_bget?H01554
KEGG_DiseaseH01665http://www.genome.jp/dbget-bin/www_bget?H01665
KEGG_Genehsa:672http://www.genome.jp/dbget-bin/www_bget?hsa:672
KEGG_OrthologyKO:K10605http://www.genome.jp/dbget-bin/www_bget?KO:K10605
KEGG_Pathwayko03460http://www.genome.jp/kegg-bin/show_pathway?ko03460
KEGG_Pathwayko04120http://www.genome.jp/kegg-bin/show_pathway?ko04120
KEGG_Pathwayko04151http://www.genome.jp/kegg-bin/show_pathway?ko04151
MIM113705http://www.ncbi.nlm.nih.gov/omim/113705
MIM114480http://www.ncbi.nlm.nih.gov/omim/114480
MIM167000http://www.ncbi.nlm.nih.gov/omim/167000
MIM604370http://www.ncbi.nlm.nih.gov/omim/604370
MIM614320http://www.ncbi.nlm.nih.gov/omim/614320
MINTMINT-90433http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-90433
OMAFQHLLFGhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FQHLLFG
Orphanet1331http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1331
Orphanet1333http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1333
Orphanet145http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=145
Orphanet168829http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=168829
Orphanet213524http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=213524
Orphanet227535http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=227535
OrthoDBEOG091G0670http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0670
PANTHERPTHR13763:SF0http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13763:SF0
PANTHERPTHR13763http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13763
PDB1JM7http://www.ebi.ac.uk/pdbe-srv/view/entry/1JM7
PDB1JNXhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1JNX
PDB1N5Ohttp://www.ebi.ac.uk/pdbe-srv/view/entry/1N5O
PDB1OQAhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1OQA
PDB1T15http://www.ebi.ac.uk/pdbe-srv/view/entry/1T15
PDB1T29http://www.ebi.ac.uk/pdbe-srv/view/entry/1T29
PDB1T2Uhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1T2U
PDB1T2Vhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1T2V
PDB1Y98http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y98
PDB2INGhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2ING
PDB3COJhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3COJ
PDB3K0Hhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3K0H
PDB3K0Khttp://www.ebi.ac.uk/pdbe-srv/view/entry/3K0K
PDB3K15http://www.ebi.ac.uk/pdbe-srv/view/entry/3K15
PDB3K16http://www.ebi.ac.uk/pdbe-srv/view/entry/3K16
PDB3PXAhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3PXA
PDB3PXBhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3PXB
PDB3PXChttp://www.ebi.ac.uk/pdbe-srv/view/entry/3PXC
PDB3PXDhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3PXD
PDB3PXEhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3PXE
PDB4IFIhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4IFI
PDB4IGKhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4IGK
PDB4JLUhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4JLU
PDB4OFBhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4OFB
PDB4U4Ahttp://www.ebi.ac.uk/pdbe-srv/view/entry/4U4A
PDB4Y18http://www.ebi.ac.uk/pdbe-srv/view/entry/4Y18
PDB4Y2Ghttp://www.ebi.ac.uk/pdbe-srv/view/entry/4Y2G
PDBsum1JM7http://www.ebi.ac.uk/pdbsum/1JM7
PDBsum1JNXhttp://www.ebi.ac.uk/pdbsum/1JNX
PDBsum1N5Ohttp://www.ebi.ac.uk/pdbsum/1N5O
PDBsum1OQAhttp://www.ebi.ac.uk/pdbsum/1OQA
PDBsum1T15http://www.ebi.ac.uk/pdbsum/1T15
PDBsum1T29http://www.ebi.ac.uk/pdbsum/1T29
PDBsum1T2Uhttp://www.ebi.ac.uk/pdbsum/1T2U
PDBsum1T2Vhttp://www.ebi.ac.uk/pdbsum/1T2V
PDBsum1Y98http://www.ebi.ac.uk/pdbsum/1Y98
PDBsum2INGhttp://www.ebi.ac.uk/pdbsum/2ING
PDBsum3COJhttp://www.ebi.ac.uk/pdbsum/3COJ
PDBsum3K0Hhttp://www.ebi.ac.uk/pdbsum/3K0H
PDBsum3K0Khttp://www.ebi.ac.uk/pdbsum/3K0K
PDBsum3K15http://www.ebi.ac.uk/pdbsum/3K15
PDBsum3K16http://www.ebi.ac.uk/pdbsum/3K16
PDBsum3PXAhttp://www.ebi.ac.uk/pdbsum/3PXA
PDBsum3PXBhttp://www.ebi.ac.uk/pdbsum/3PXB
PDBsum3PXChttp://www.ebi.ac.uk/pdbsum/3PXC
PDBsum3PXDhttp://www.ebi.ac.uk/pdbsum/3PXD
PDBsum3PXEhttp://www.ebi.ac.uk/pdbsum/3PXE
PDBsum4IFIhttp://www.ebi.ac.uk/pdbsum/4IFI
PDBsum4IGKhttp://www.ebi.ac.uk/pdbsum/4IGK
PDBsum4JLUhttp://www.ebi.ac.uk/pdbsum/4JLU
PDBsum4OFBhttp://www.ebi.ac.uk/pdbsum/4OFB
PDBsum4U4Ahttp://www.ebi.ac.uk/pdbsum/4U4A
PDBsum4Y18http://www.ebi.ac.uk/pdbsum/4Y18
PDBsum4Y2Ghttp://www.ebi.ac.uk/pdbsum/4Y2G
PRINTSPR00493http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00493
PROSITEPS00518http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00518
PROSITEPS50089http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50089
PROSITEPS50172http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50172
PSORT-Bswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/kpsortb/swissprot:BRCA1_HUMAN
PSORT2swissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/kpsort2/swissprot:BRCA1_HUMAN
PSORTswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/kpsort/swissprot:BRCA1_HUMAN
PfamPF00097http://pfam.xfam.org/family/PF00097
PfamPF00533http://pfam.xfam.org/family/PF00533
PfamPF12820http://pfam.xfam.org/family/PF12820
PharmGKBPA25411http://www.pharmgkb.org/do/serve?objId=PA25411&objCls=Gene
Phobiusswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/kphobius/swissprot:BRCA1_HUMAN
PhylomeDBP38398http://phylomedb.org/?seqid=P38398
ProteinModelPortalP38398http://www.proteinmodelportal.org/query/uniprot/P38398
PubMed10196379http://www.ncbi.nlm.nih.gov/pubmed/10196379
PubMed10323242http://www.ncbi.nlm.nih.gov/pubmed/10323242
PubMed10486320http://www.ncbi.nlm.nih.gov/pubmed/10486320
PubMed10500182http://www.ncbi.nlm.nih.gov/pubmed/10500182
PubMed10724175http://www.ncbi.nlm.nih.gov/pubmed/10724175
PubMed10783165http://www.ncbi.nlm.nih.gov/pubmed/10783165
PubMed10851077http://www.ncbi.nlm.nih.gov/pubmed/10851077
PubMed11114888http://www.ncbi.nlm.nih.gov/pubmed/11114888
PubMed11239454http://www.ncbi.nlm.nih.gov/pubmed/11239454
PubMed11301010http://www.ncbi.nlm.nih.gov/pubmed/11301010
PubMed11573085http://www.ncbi.nlm.nih.gov/pubmed/11573085
PubMed11573086http://www.ncbi.nlm.nih.gov/pubmed/11573086
PubMed11739404http://www.ncbi.nlm.nih.gov/pubmed/11739404
PubMed11751867http://www.ncbi.nlm.nih.gov/pubmed/11751867
PubMed11836499http://www.ncbi.nlm.nih.gov/pubmed/11836499
PubMed11877377http://www.ncbi.nlm.nih.gov/pubmed/11877377
PubMed12183412http://www.ncbi.nlm.nih.gov/pubmed/12183412
PubMed12215251http://www.ncbi.nlm.nih.gov/pubmed/12215251
PubMed12360400http://www.ncbi.nlm.nih.gov/pubmed/12360400
PubMed12419185http://www.ncbi.nlm.nih.gov/pubmed/12419185
PubMed12427738http://www.ncbi.nlm.nih.gov/pubmed/12427738
PubMed12442274http://www.ncbi.nlm.nih.gov/pubmed/12442274
PubMed12442275http://www.ncbi.nlm.nih.gov/pubmed/12442275
PubMed12887909http://www.ncbi.nlm.nih.gov/pubmed/12887909
PubMed12890688http://www.ncbi.nlm.nih.gov/pubmed/12890688
PubMed12938098http://www.ncbi.nlm.nih.gov/pubmed/12938098
PubMed14636569http://www.ncbi.nlm.nih.gov/pubmed/14636569
PubMed14722926http://www.ncbi.nlm.nih.gov/pubmed/14722926
PubMed14746861http://www.ncbi.nlm.nih.gov/pubmed/14746861
PubMed14976165http://www.ncbi.nlm.nih.gov/pubmed/14976165
PubMed14990569http://www.ncbi.nlm.nih.gov/pubmed/14990569
PubMed15026808http://www.ncbi.nlm.nih.gov/pubmed/15026808
PubMed15096610http://www.ncbi.nlm.nih.gov/pubmed/15096610
PubMed15133502http://www.ncbi.nlm.nih.gov/pubmed/15133502
PubMed15365993http://www.ncbi.nlm.nih.gov/pubmed/15365993
PubMed15456891http://www.ncbi.nlm.nih.gov/pubmed/15456891
PubMed15489334http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed15609993http://www.ncbi.nlm.nih.gov/pubmed/15609993
PubMed16101277http://www.ncbi.nlm.nih.gov/pubmed/16101277
PubMed16326698http://www.ncbi.nlm.nih.gov/pubmed/16326698
PubMed16625196http://www.ncbi.nlm.nih.gov/pubmed/16625196
PubMed16698035http://www.ncbi.nlm.nih.gov/pubmed/16698035
PubMed16818604http://www.ncbi.nlm.nih.gov/pubmed/16818604
PubMed16959974http://www.ncbi.nlm.nih.gov/pubmed/16959974
PubMed17081983http://www.ncbi.nlm.nih.gov/pubmed/17081983
PubMed17525332http://www.ncbi.nlm.nih.gov/pubmed/17525332
PubMed17525340http://www.ncbi.nlm.nih.gov/pubmed/17525340
PubMed17643121http://www.ncbi.nlm.nih.gov/pubmed/17643121
PubMed17643122http://www.ncbi.nlm.nih.gov/pubmed/17643122
PubMed17924331http://www.ncbi.nlm.nih.gov/pubmed/17924331
PubMed18056443http://www.ncbi.nlm.nih.gov/pubmed/18056443
PubMed18285836http://www.ncbi.nlm.nih.gov/pubmed/18285836
PubMed18452305http://www.ncbi.nlm.nih.gov/pubmed/18452305
PubMed18669648http://www.ncbi.nlm.nih.gov/pubmed/18669648
PubMed18762988http://www.ncbi.nlm.nih.gov/pubmed/18762988
PubMed19261746http://www.ncbi.nlm.nih.gov/pubmed/19261746
PubMed19261748http://www.ncbi.nlm.nih.gov/pubmed/19261748
PubMed19261749http://www.ncbi.nlm.nih.gov/pubmed/19261749
PubMed19369211http://www.ncbi.nlm.nih.gov/pubmed/19369211
PubMed19690332http://www.ncbi.nlm.nih.gov/pubmed/19690332
PubMed20068231http://www.ncbi.nlm.nih.gov/pubmed/20068231
PubMed20159462http://www.ncbi.nlm.nih.gov/pubmed/20159462
PubMed20160719http://www.ncbi.nlm.nih.gov/pubmed/20160719
PubMed20351172http://www.ncbi.nlm.nih.gov/pubmed/20351172
PubMed20364141http://www.ncbi.nlm.nih.gov/pubmed/20364141
PubMed20513136http://www.ncbi.nlm.nih.gov/pubmed/20513136
PubMed21144835http://www.ncbi.nlm.nih.gov/pubmed/21144835
PubMed21406692http://www.ncbi.nlm.nih.gov/pubmed/21406692
PubMed21473589http://www.ncbi.nlm.nih.gov/pubmed/21473589
PubMed21673012http://www.ncbi.nlm.nih.gov/pubmed/21673012
PubMed22814378http://www.ncbi.nlm.nih.gov/pubmed/22814378
PubMed23186163http://www.ncbi.nlm.nih.gov/pubmed/23186163
PubMed23867111http://www.ncbi.nlm.nih.gov/pubmed/23867111
PubMed24316840http://www.ncbi.nlm.nih.gov/pubmed/24316840
PubMed25218447http://www.ncbi.nlm.nih.gov/pubmed/25218447
PubMed25755297http://www.ncbi.nlm.nih.gov/pubmed/25755297
PubMed26778126http://www.ncbi.nlm.nih.gov/pubmed/26778126
PubMed26807646http://www.ncbi.nlm.nih.gov/pubmed/26807646
PubMed7545954http://www.ncbi.nlm.nih.gov/pubmed/7545954
PubMed7894491http://www.ncbi.nlm.nih.gov/pubmed/7894491
PubMed7894493http://www.ncbi.nlm.nih.gov/pubmed/7894493
PubMed7939630http://www.ncbi.nlm.nih.gov/pubmed/7939630
PubMed8554067http://www.ncbi.nlm.nih.gov/pubmed/8554067
PubMed8723683http://www.ncbi.nlm.nih.gov/pubmed/8723683
PubMed8776600http://www.ncbi.nlm.nih.gov/pubmed/8776600
PubMed8807330http://www.ncbi.nlm.nih.gov/pubmed/8807330
PubMed8938427http://www.ncbi.nlm.nih.gov/pubmed/8938427
PubMed8968716http://www.ncbi.nlm.nih.gov/pubmed/8968716
PubMed8972225http://www.ncbi.nlm.nih.gov/pubmed/8972225
PubMed9010228http://www.ncbi.nlm.nih.gov/pubmed/9010228
PubMed9482581http://www.ncbi.nlm.nih.gov/pubmed/9482581
PubMed9528852http://www.ncbi.nlm.nih.gov/pubmed/9528852
PubMed9609997http://www.ncbi.nlm.nih.gov/pubmed/9609997
PubMed9760198http://www.ncbi.nlm.nih.gov/pubmed/9760198
PubMed9811458http://www.ncbi.nlm.nih.gov/pubmed/9811458
ReactomeR-HSA-1221632http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1221632
ReactomeR-HSA-3108214http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3108214
ReactomeR-HSA-5685938http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5685938
ReactomeR-HSA-5685942http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5685942
ReactomeR-HSA-5689901http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5689901
ReactomeR-HSA-5693554http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693554
ReactomeR-HSA-5693565http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693565
ReactomeR-HSA-5693568http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693568
ReactomeR-HSA-5693571http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693571
ReactomeR-HSA-5693579http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693579
ReactomeR-HSA-5693607http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693607
ReactomeR-HSA-5693616http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693616
ReactomeR-HSA-6796648http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6796648
ReactomeR-HSA-6804756http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6804756
ReactomeR-HSA-69473http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-69473
ReactomeR-HSA-912446http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-912446
RefSeqNP_009225http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009225
RefSeqNP_009228http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009228
RefSeqNP_009229http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009229
RefSeqNP_009230http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009230
RefSeqNP_009231http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009231
SMARTSM00184http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00184
SMARTSM00292http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00292
SMRP38398http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38398
STRING9606.ENSP00000418960http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000418960&targetmode=cogs
SUPFAMSSF52113http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52113
UCSCuc002icqhttp://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002icq&org=rat
UCSCuc010cyxhttp://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010cyx&org=rat
UniGeneHs.194143http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.194143
UniProtKB-ACP38398http://www.uniprot.org/uniprot/P38398
UniProtKBBRCA1_HUMANhttp://www.uniprot.org/uniprot/BRCA1_HUMAN
chargeswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/charge/swissprot:BRCA1_HUMAN
eggNOGENOG410ITQ4http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ITQ4
eggNOGENOG4112BIHhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4112BIH
epestfindswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/epestfind/swissprot:BRCA1_HUMAN
garnierswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/garnier/swissprot:BRCA1_HUMAN
helixturnhelixswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:BRCA1_HUMAN
hmomentswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/hmoment/swissprot:BRCA1_HUMAN
iepswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/iep/swissprot:BRCA1_HUMAN
inforesidueswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/inforesidue/swissprot:BRCA1_HUMAN
neXtProtNX_P38398http://www.nextprot.org/db/entry/NX_P38398
octanolswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/octanol/swissprot:BRCA1_HUMAN
pepcoilswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/pepcoil/swissprot:BRCA1_HUMAN
pepdigestswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/pepdigest/swissprot:BRCA1_HUMAN
pepinfoswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/pepinfo/swissprot:BRCA1_HUMAN
pepnetswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/pepnet/swissprot:BRCA1_HUMAN
pepstatsswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/pepstats/swissprot:BRCA1_HUMAN
pepwheelswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/pepwheel/swissprot:BRCA1_HUMAN
pepwindowswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/pepwindow/swissprot:BRCA1_HUMAN
sigcleaveswissprot:BRCA1_HUMANhttp://rest.g-language.org/emboss/sigcleave/swissprot:BRCA1_HUMAN