## Database ID URL or Descriptions # ALTERNATIVE PRODUCTS BRCA1_HUMAN Event=Alternative splicing, Alternative initiation; Named isoforms=8; Name=1; IsoId=P38398-1; Sequence=Displayed; Name=2; IsoId=P38398-2; Sequence=VSP_047891; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; Synonyms=Delta11b; IsoId=P38398-3; Sequence=VSP_035399, VSP_043797; Name=4; Synonyms=DeltaBRCA1(17aa); IsoId=P38398-4; Sequence=VSP_035396; Note=Produced by alternative initiation at Met-18 of isoform 1.; Name=5; Synonyms=Delta11, Delta772-3095; IsoId=P38398-5; Sequence=VSP_035398; Name=6; IsoId=P38398-6; Sequence=VSP_035399, VSP_043797, VSP_043798; Note=No experimental confirmation available.; Name=7; IsoId=P38398-7; Sequence=VSP_055404; Note=No experimental confirmation available. Ref.8 (AAI15038) sequence is in conflict in position 1461 N->D. {ECO 0000305}; Name=8; IsoId=P38398-8; Sequence=VSP_057569; Note=No experimental confirmation available. The N-terminus is confirmed by several cDNAs. {ECO 0000305}; # AltName BRCA1_HUMAN RING finger protein 53 # AltName RING-type E3 ubiquitin transferase BRCA1 {ECO 0000305} # BRENDA 6.3.2.19 2681 # BioGrid 107140 566 # CATALYTIC ACTIVITY BRCA1_HUMAN S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin- conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. {ECO 0000269|PubMed 10500182, ECO 0000269|PubMed 12887909, ECO 0000269|PubMed 12890688, ECO 0000269|PubMed 16818604, ECO 0000269|PubMed 18056443, ECO 0000269|PubMed 20351172}. # CCDS CCDS11453 -. [P38398-1] # CCDS CCDS11454 -. [P38398-3] # CCDS CCDS11455 -. [P38398-6] # CCDS CCDS11456 -. [P38398-7] # CCDS CCDS11459 -. [P38398-8] # CDD cd00027 BRCT; 2 # ChiTaRS BRCA1 human # DISEASE BRCA1_HUMAN Breast cancer (BC) [MIM 114480] A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. {ECO 0000269|PubMed 10323242, ECO 0000269|PubMed 12442275, ECO 0000269|PubMed 12938098, ECO 0000269|PubMed 14722926, ECO 0000269|PubMed 18285836, ECO 0000269|PubMed 7545954, ECO 0000269|PubMed 7894491, ECO 0000269|PubMed 7894493, ECO 0000269|PubMed 7939630, ECO 0000269|PubMed 8554067, ECO 0000269|PubMed 8723683, ECO 0000269|PubMed 8776600, ECO 0000269|PubMed 9482581, ECO 0000269|PubMed 9609997, ECO 0000269|PubMed 9760198}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Mutations in BRCA1 are thought to be responsible for 45% of inherited breast cancer. Moreover, BRCA1 carriers have a 4-fold increased risk of colon cancer, whereas male carriers face a 3- fold increased risk of prostate cancer. Cells lacking BRCA1 show defects in DNA repair by homologous recombination. # DISEASE BRCA1_HUMAN Breast-ovarian cancer, familial, 1 (BROVCA1) [MIM 604370] A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate. {ECO 0000269|PubMed 12938098, ECO 0000269|PubMed 14722926, ECO 0000269|PubMed 8968716}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Mutations in BRCA1 are thought to be responsible for more than 80% of inherited breast-ovarian cancer. # DISEASE BRCA1_HUMAN Ovarian cancer (OC) [MIM 167000] The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. {ECO 0000269|PubMed 10196379, ECO 0000269|PubMed 10486320, ECO 0000269|PubMed 14746861}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. # DISEASE BRCA1_HUMAN Pancreatic cancer 4 (PNCA4) [MIM 614320] A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue. {ECO 0000269|PubMed 18762988}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. # DOMAIN BRCA1_HUMAN The BRCT domains recognize and bind phosphorylated pSXXF motif on proteins. The interaction with the phosphorylated pSXXF motif of FAM175A/Abraxas, recruits BRCA1 at DNA damage sites. {ECO 0000269|PubMed 20159462}. # DOMAIN BRCA1_HUMAN The RING-type zinc finger domain interacts with BAP1. {ECO 0000269|PubMed 20159462}. # ENZYME REGULATION The E3 ubiquitin-protein ligase activity is inhibited by phosphorylation by AURKA. Activity is increased by phosphatase treatment. {ECO:0000269|PubMed 18056443}. # Ensembl ENST00000352993 ENSP00000312236; ENSG00000012048. [P38398-5] # Ensembl ENST00000357654 ENSP00000350283; ENSG00000012048. [P38398-1] # Ensembl ENST00000461221 ENSP00000418548; ENSG00000012048. [P38398-2] # Ensembl ENST00000461798 ENSP00000417988; ENSG00000012048. [P38398-2] # Ensembl ENST00000468300 ENSP00000417148; ENSG00000012048. [P38398-6] # Ensembl ENST00000471181 ENSP00000418960; ENSG00000012048. [P38398-7] # Ensembl ENST00000491747 ENSP00000420705; ENSG00000012048. [P38398-3] # Ensembl ENST00000493795 ENSP00000418775; ENSG00000012048. [P38398-8] # ExpressionAtlas P38398 baseline and differential # FUNCTION BRCA1_HUMAN E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (PubMed 20160719). {ECO 0000269|PubMed 10500182, ECO 0000269|PubMed 10724175, ECO 0000269|PubMed 11836499, ECO 0000269|PubMed 12887909, ECO 0000269|PubMed 12890688, ECO 0000269|PubMed 14976165, ECO 0000269|PubMed 14990569, ECO 0000269|PubMed 16326698, ECO 0000269|PubMed 16818604, ECO 0000269|PubMed 17525340, ECO 0000269|PubMed 18056443, ECO 0000269|PubMed 19261748, ECO 0000269|PubMed 19369211, ECO 0000269|PubMed 20160719, ECO 0000269|PubMed 20351172, ECO 0000269|PubMed 20364141}. # GO_component GO:0000151 ubiquitin ligase complex; NAS:UniProtKB. # GO_component GO:0000800 lateral element; IDA:MGI. # GO_component GO:0005634 nucleus; IDA:UniProtKB. # GO_component GO:0005654 nucleoplasm; TAS:Reactome. # GO_component GO:0005694 chromosome; ISS:UniProtKB. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005886 plasma membrane; IDA:BHF-UCL. # GO_component GO:0008274 gamma-tubulin ring complex; NAS:UniProtKB. # GO_component GO:0030529 intracellular ribonucleoprotein complex; IDA:MGI. # GO_component GO:0031436 BRCA1-BARD1 complex; IDA:UniProtKB. # GO_component GO:0043234 protein complex; IDA:UniProtKB. # GO_component GO:0070531 BRCA1-A complex; IDA:UniProtKB. # GO_function GO:0003677 DNA binding; TAS:ProtInc. # GO_function GO:0003684 damaged DNA binding; IEA:Ensembl. # GO_function GO:0003713 transcription coactivator activity; NAS:UniProtKB. # GO_function GO:0003723 RNA binding; IDA:MGI. # GO_function GO:0004842 ubiquitin-protein transferase activity; IDA:UniProtKB. # GO_function GO:0008270 zinc ion binding; TAS:ProtInc. # GO_function GO:0015631 tubulin binding; NAS:UniProtKB. # GO_function GO:0019899 enzyme binding; IPI:UniProtKB. # GO_function GO:0031625 ubiquitin protein ligase binding; IPI:UniProtKB. # GO_function GO:0044212 transcription regulatory region DNA binding; IDA:BHF-UCL. # GO_function GO:0050681 androgen receptor binding; NAS:UniProtKB. # GO_process GO:0000724 double-strand break repair via homologous recombination; IDA:HGNC. # GO_process GO:0000729 DNA double-strand break processing; TAS:Reactome. # GO_process GO:0000731 DNA synthesis involved in DNA repair; TAS:Reactome. # GO_process GO:0000732 strand displacement; TAS:Reactome. # GO_process GO:0006260 DNA replication; TAS:Reactome. # GO_process GO:0006301 postreplication repair; IDA:HGNC. # GO_process GO:0006302 double-strand break repair; IMP:UniProtKB. # GO_process GO:0006303 double-strand break repair via nonhomologous end joining; TAS:Reactome. # GO_process GO:0006349 regulation of gene expression by genetic imprinting; IEA:Ensembl. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006357 regulation of transcription from RNA polymerase II promoter; TAS:ProtInc. # GO_process GO:0006359 regulation of transcription from RNA polymerase III promoter; TAS:UniProtKB. # GO_process GO:0006633 fatty acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0006915 apoptotic process; TAS:UniProtKB. # GO_process GO:0006974 cellular response to DNA damage stimulus; TAS:ProtInc. # GO_process GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; TAS:UniProtKB. # GO_process GO:0007059 chromosome segregation; IMP:UniProtKB. # GO_process GO:0007098 centrosome cycle; IEA:Ensembl. # GO_process GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage; IDA:MGI. # GO_process GO:0009048 dosage compensation by inactivation of X chromosome; IBA:GO_Central. # GO_process GO:0010212 response to ionizing radiation; IMP:UniProtKB. # GO_process GO:0010575 positive regulation of vascular endothelial growth factor production; IMP:BHF-UCL. # GO_process GO:0010628 positive regulation of gene expression; IMP:BHF-UCL. # GO_process GO:0016567 protein ubiquitination; IDA:HGNC. # GO_process GO:0016925 protein sumoylation; TAS:Reactome. # GO_process GO:0030521 androgen receptor signaling pathway; NAS:UniProtKB. # GO_process GO:0031052 chromosome breakage; IEA:Ensembl. # GO_process GO:0031398 positive regulation of protein ubiquitination; IDA:UniProtKB. # GO_process GO:0031572 G2 DNA damage checkpoint; IMP:UniProtKB. # GO_process GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway; IMP:CACAO. # GO_process GO:0035066 positive regulation of histone acetylation; IDA:BHF-UCL. # GO_process GO:0035067 negative regulation of histone acetylation; IBA:GO_Central. # GO_process GO:0042127 regulation of cell proliferation; TAS:UniProtKB. # GO_process GO:0042981 regulation of apoptotic process; TAS:UniProtKB. # GO_process GO:0043009 chordate embryonic development; IBA:GO_Central. # GO_process GO:0043627 response to estrogen; IDA:UniProtKB. # GO_process GO:0044030 regulation of DNA methylation; IEA:Ensembl. # GO_process GO:0045717 negative regulation of fatty acid biosynthetic process; IMP:UniProtKB. # GO_process GO:0045739 positive regulation of DNA repair; IMP:UniProtKB. # GO_process GO:0045766 positive regulation of angiogenesis; IMP:BHF-UCL. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:UniProtKB. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:UniProtKB. # GO_process GO:0045944 positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB. # GO_process GO:0046600 negative regulation of centriole replication; NAS:UniProtKB. # GO_process GO:0051571 positive regulation of histone H3-K4 methylation; IDA:BHF-UCL. # GO_process GO:0051572 negative regulation of histone H3-K4 methylation; IEA:Ensembl. # GO_process GO:0051573 negative regulation of histone H3-K9 methylation; IDA:BHF-UCL. # GO_process GO:0051574 positive regulation of histone H3-K9 methylation; IEA:Ensembl. # GO_process GO:0051865 protein autoubiquitination; IDA:UniProtKB. # GO_process GO:0070512 positive regulation of histone H4-K20 methylation; IDA:BHF-UCL. # GO_process GO:0071158 positive regulation of cell cycle arrest; IDA:BHF-UCL. # GO_process GO:0071356 cellular response to tumor necrosis factor; IMP:BHF-UCL. # GO_process GO:0071681 cellular response to indole-3-methanol; IDA:UniProtKB. # GO_process GO:0085020 protein K6-linked ubiquitination; IDA:UniProtKB. # GO_process GO:1901796 regulation of signal transduction by p53 class mediator; TAS:Reactome. # GO_process GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IMP:BHF-UCL. # GO_process GO:2000378 negative regulation of reactive oxygen species metabolic process; IMP:BHF-UCL. # GO_process GO:2000617 positive regulation of histone H3-K9 acetylation; IDA:BHF-UCL. # GO_process GO:2000620 positive regulation of histone H4-K16 acetylation; IDA:BHF-UCL. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005634 nucleus # GOslim_component GO:0005654 nucleoplasm # GOslim_component GO:0005694 chromosome # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008092 cytoskeletal protein binding # GOslim_function GO:0019899 enzyme binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007059 chromosome segregation # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0008219 cell death # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0009790 embryo development # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051276 chromosome organization # Gene3D 3.30.40.10 -; 1. # Gene3D 3.40.50.10190 -; 2. # Genevisible P38398 HS # HGNC HGNC:1100 BRCA1 # INTERACTION BRCA1_HUMAN Q13085 ACACA; NbExp=2; IntAct=EBI-349905, EBI-717681; Q92560 BAP1; NbExp=3; IntAct=EBI-349905, EBI-1791447; Q99728 BARD1; NbExp=9; IntAct=EBI-349905, EBI-473181; P10415 BCL2; NbExp=6; IntAct=EBI-349905, EBI-77694; Q7Z569 BRAP; NbExp=3; IntAct=EBI-349905, EBI-349900; Q6PJG6 BRAT1; NbExp=6; IntAct=EBI-349905, EBI-10826195; Q9BX63 BRIP1; NbExp=12; IntAct=EBI-349905, EBI-3509650; P24385 CCND1; NbExp=3; IntAct=EBI-349905, EBI-375001; P24864 CCNE1; NbExp=2; IntAct=EBI-349905, EBI-519526; O14757 CHEK1; NbExp=3; IntAct=EBI-349905, EBI-974488; P03372 ESR1; NbExp=12; IntAct=EBI-349905, EBI-78473; Q61188 Ezh2 (xeno); NbExp=5; IntAct=EBI-349905, EBI-904311; Q6UWZ7 FAM175A; NbExp=10; IntAct=EBI-349905, EBI-1263451; Q14192 FHL2; NbExp=6; IntAct=EBI-349905, EBI-701903; P78347 GTF2I; NbExp=5; IntAct=EBI-349905, EBI-359622; P16104 H2AFX; NbExp=4; IntAct=EBI-349905, EBI-494830; P10809 HSPD1; NbExp=2; IntAct=EBI-349905, EBI-352528; Q16666 IFI16; NbExp=9; IntAct=EBI-349905, EBI-2867186; P52292 KPNA2; NbExp=3; IntAct=EBI-349905, EBI-349938; Q8WX92 NELFB; NbExp=5; IntAct=EBI-349905, EBI-347721; P62136 PPP1CA; NbExp=2; IntAct=EBI-349905, EBI-357253; P62140 PPP1CB; NbExp=3; IntAct=EBI-349905, EBI-352350; P36873 PPP1CC; NbExp=2; IntAct=EBI-349905, EBI-356283; Q99708 RBBP8; NbExp=9; IntAct=EBI-349905, EBI-745715; Q9Y4A5 TRRAP; NbExp=8; IntAct=EBI-349905, EBI-399128; Q96RL1 UIMC1; NbExp=9; IntAct=EBI-349905, EBI-725300; Q6NZY4 ZCCHC8; NbExp=2; IntAct=EBI-349905, EBI-1263058; Q9GZX5 ZNF350; NbExp=3; IntAct=EBI-349905, EBI-396421; # IntAct P38398 76 # InterPro IPR001357 BRCT_dom # InterPro IPR001841 Znf_RING # InterPro IPR011364 BRCA1 # InterPro IPR013083 Znf_RING/FYVE/PHD # InterPro IPR017907 Znf_RING_CS # InterPro IPR018957 Znf_C3HC4_RING-type # InterPro IPR025994 BRCA1_serine_dom # InterPro IPR031099 BRCA1-associated # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03036 Chromosome # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Brite ko03400 M00295 BRCA1-associated genome surveillance complex (BASC) # KEGG_Brite ko04121 Ubiquitin system # KEGG_Disease H00027 [Cancer] Ovarian cancer # KEGG_Disease H00031 [Cancer] Breast cancer # KEGG_Disease H01554 [Cancer] Fallopian tube cancer # KEGG_Disease H01665 [Cancer] Primary peritoneal carcinoma # KEGG_Pathway ko03460 Fanconi anemia pathway # KEGG_Pathway ko04120 Ubiquitin mediated proteolysis # KEGG_Pathway ko04151 PI3K-Akt signaling pathway # MIM 113705 gene # MIM 114480 phenotype # MIM 167000 phenotype # MIM 604370 phenotype # MIM 614320 phenotype # Organism BRCA1_HUMAN Homo sapiens (Human) # Orphanet 1331 Familial prostate cancer # Orphanet 1333 Familial pancreatic carcinoma # Orphanet 145 Hereditary breast and ovarian cancer syndrome # Orphanet 168829 Primary peritoneal carcinoma # Orphanet 213524 Hereditary site-specific ovarian cancer syndrome # Orphanet 227535 Hereditary breast cancer # PANTHER PTHR13763 PTHR13763 # PANTHER PTHR13763:SF0 PTHR13763:SF0 # PATHWAY BRCA1_HUMAN Protein modification; protein ubiquitination. # PDB 1JM7 NMR; -; A=1-110 # PDB 1JNX X-ray; 2.50 A; X=1646-1859 # PDB 1N5O X-ray; 2.80 A; X=1646-1859 # PDB 1OQA NMR; -; A=1755-1863 # PDB 1T15 X-ray; 1.85 A; A=1646-1859 # PDB 1T29 X-ray; 2.30 A; A=1646-1859 # PDB 1T2U X-ray; 2.80 A; A=1646-1859 # PDB 1T2V X-ray; 3.30 A; A/B/C/D/E=1646-1859 # PDB 1Y98 X-ray; 2.50 A; A=1646-1859 # PDB 2ING X-ray; 3.60 A; X=1649-1859 # PDB 3COJ X-ray; 3.21 A; A/B/C/D/E/F/G/X=1646-1859 # PDB 3K0H X-ray; 2.70 A; A=1646-1859 # PDB 3K0K X-ray; 2.70 A; A=1646-1859 # PDB 3K15 X-ray; 2.80 A; A=1646-1859 # PDB 3K16 X-ray; 3.00 A; A=1646-1859 # PDB 3PXA X-ray; 2.55 A; A=1646-1859 # PDB 3PXB X-ray; 2.50 A; A=1646-1859 # PDB 3PXC X-ray; 2.80 A; X=1646-1859 # PDB 3PXD X-ray; 2.80 A; A=1646-1859 # PDB 3PXE X-ray; 2.85 A; A/B/C/D=1646-1859 # PDB 4IFI X-ray; 2.20 A; A=1646-1859 # PDB 4IGK X-ray; 1.75 A; A/B=1646-1859 # PDB 4JLU X-ray; 3.50 A; A=1649-1859 # PDB 4OFB X-ray; 3.05 A; A=1646-1859 # PDB 4U4A X-ray; 3.51 A; A/B/C=1646-1859 # PDB 4Y18 X-ray; 3.50 A; A/B/C/D/E/F/G/H=1646-1859 # PDB 4Y2G X-ray; 2.50 A; A=1646-1859 # PIR A58881 A58881 # PIRSF PIRSF001734 BRCA1 # POLYMORPHISM BRCA1_HUMAN There is evidence that the presence of the rare form of Gln-356-Arg and Leu-871-Pro polymorphisms may be associated with an increased risk for developing ovarian cancer. # PRINTS PR00493 BRSTCANCERI # PROSITE PS00518 ZF_RING_1 # PROSITE PS50089 ZF_RING_2 # PROSITE PS50172 BRCT; 2 # PTM BRCA1_HUMAN Autoubiquitinated, undergoes 'Lys-6'-linked polyubiquitination. 'Lys-6'-linked polyubiquitination does not promote degradation. {ECO 0000269|PubMed 12890688, ECO 0000269|PubMed 20351172}. # PTM BRCA1_HUMAN Phosphorylation at Ser-308 by AURKA is required for normal cell cycle progression from G2 to mitosis. Phosphorylated in response to IR, UV, and various stimuli that cause checkpoint activation, probably by ATM or ATR. Phosphorylation at Ser-988 by CHEK2 regulates mitotic spindle assembly. {ECO 0000269|PubMed 10724175, ECO 0000269|PubMed 11114888, ECO 0000269|PubMed 12183412, ECO 0000269|PubMed 14990569, ECO 0000269|PubMed 18056443, ECO 0000269|PubMed 20364141, ECO 0000269|PubMed 21144835}. # Pfam PF00097 zf-C3HC4 # Pfam PF00533 BRCT; 2 # Pfam PF12820 BRCT_assoc # Proteomes UP000005640 Chromosome 17 # Reactome R-HSA-1221632 Meiotic synapsis # Reactome R-HSA-3108214 SUMOylation of DNA damage response and repair proteins # Reactome R-HSA-5685938 HDR through Single Strand Annealing (SSA) # Reactome R-HSA-5685942 HDR through Homologous Recombination (HRR) # Reactome R-HSA-5689901 Metalloprotease DUBs # Reactome R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) # Reactome R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks # Reactome R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates # Reactome R-HSA-5693571 Nonhomologous End-Joining (NHEJ) # Reactome R-HSA-5693579 Homologous DNA Pairing and Strand Exchange # Reactome R-HSA-5693607 Processing of DNA double-strand break ends # Reactome R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange # Reactome R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes # Reactome R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation # Reactome R-HSA-69473 G2/M DNA damage checkpoint # Reactome R-HSA-912446 Meiotic recombination # RecName BRCA1_HUMAN Breast cancer type 1 susceptibility protein # RefSeq NP_009225 NM_007294.3. [P38398-1] # RefSeq NP_009228 NM_007297.3. [P38398-8] # RefSeq NP_009229 NM_007298.3. [P38398-3] # RefSeq NP_009230 NM_007299.3. [P38398-6] # RefSeq NP_009231 NM_007300.3. [P38398-7] # SEQUENCE CAUTION Sequence=AAB61673.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAI15038.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAI15038.1; Type=Erroneous termination; Positions=526; Note=Translated as Gln.; Evidence={ECO:0000305}; # SIMILARITY Contains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule PRU00175}. # SIMILARITY Contains 2 BRCT domains. {ECO:0000255|PROSITE- ProRule PRU00033}. # SMART SM00184 RING # SMART SM00292 BRCT; 2 # SUBCELLULAR LOCATION BRCA1_HUMAN Isoform 3 Cytoplasm. # SUBCELLULAR LOCATION BRCA1_HUMAN Isoform 5 Cytoplasm {ECO 0000269|PubMed 8972225}. # SUBCELLULAR LOCATION BRCA1_HUMAN Nucleus {ECO 0000269|PubMed 15133502, ECO 0000269|PubMed 17525340, ECO 0000269|PubMed 20160719, ECO 0000269|PubMed 21144835, ECO 0000269|PubMed 26778126, ECO 0000269|PubMed 9528852}. Chromosome {ECO 0000250|UniProtKB P48754}. Cytoplasm {ECO 0000269|PubMed 20160719}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by FAM175A and the BRCA1-A complex (PubMed 26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed 20160719). {ECO 0000269|PubMed 20160719, ECO 0000269|PubMed 26778126}. # SUBUNIT BRCA1_HUMAN Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Interacts (via the BRCT domains) with FAM175A (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of FAM175A (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, COBRA1, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, AURKA, UBXN1 and KIAA0101/PAF15. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AFX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2 (PubMed 26807646). {ECO 0000269|PubMed 10724175, ECO 0000269|PubMed 10783165, ECO 0000269|PubMed 11239454, ECO 0000269|PubMed 11301010, ECO 0000269|PubMed 11573085, ECO 0000269|PubMed 11739404, ECO 0000269|PubMed 11751867, ECO 0000269|PubMed 11836499, ECO 0000269|PubMed 11877377, ECO 0000269|PubMed 12360400, ECO 0000269|PubMed 12419185, ECO 0000269|PubMed 12890688, ECO 0000269|PubMed 14636569, ECO 0000269|PubMed 14976165, ECO 0000269|PubMed 14990569, ECO 0000269|PubMed 15096610, ECO 0000269|PubMed 15133502, ECO 0000269|PubMed 15456891, ECO 0000269|PubMed 16101277, ECO 0000269|PubMed 16326698, ECO 0000269|PubMed 16698035, ECO 0000269|PubMed 16818604, ECO 0000269|PubMed 17525340, ECO 0000269|PubMed 17643121, ECO 0000269|PubMed 17643122, ECO 0000269|PubMed 18452305, ECO 0000269|PubMed 19261746, ECO 0000269|PubMed 19261748, ECO 0000269|PubMed 19261749, ECO 0000269|PubMed 19369211, ECO 0000269|PubMed 20159462, ECO 0000269|PubMed 20160719, ECO 0000269|PubMed 20351172, ECO 0000269|PubMed 21473589, ECO 0000269|PubMed 21673012, ECO 0000269|PubMed 24316840, ECO 0000269|PubMed 26778126, ECO 0000269|PubMed 26807646, ECO 0000269|PubMed 9528852, ECO 0000269|PubMed 9811458}. # SUPFAM SSF52113 SSF52113; 2 # TISSUE SPECIFICITY BRCA1_HUMAN Isoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast and ovarian cancer cell lines. # UCSC uc002icq human. [P38398-1] # UCSC uc010cyx human # WEB RESOURCE BRCA1_HUMAN Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http //atlasgeneticsoncology.org/Genes/BRCA1ID163ch17q21.html"; # WEB RESOURCE BRCA1_HUMAN Name=NIEHS-SNPs; URL="http //egp.gs.washington.edu/data/brca1/"; # WEB RESOURCE BRCA1_HUMAN Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http //shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=BRCA1"; # WEB RESOURCE BRCA1_HUMAN Name=Wikipedia; Note=BRCA1 entry; URL="https //en.wikipedia.org/wiki/BRCA1"; # eggNOG ENOG410ITQ4 Eukaryota # eggNOG ENOG4112BIH LUCA BLAST swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/kblast/swissprot:BRCA1_HUMAN BioCyc ZFISH:ENSG00000012048-MONOMER http://biocyc.org/getid?id=ZFISH:ENSG00000012048-MONOMER COXPRESdb 672 http://coxpresdb.jp/data/gene/672.shtml CleanEx HS_BRCA1 http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=HS_BRCA1 DIP DIP-5971N 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http://dx.doi.org/10.1128/MCB.01056-09 DOI 10.1128/MCB.17.1.444 http://dx.doi.org/10.1128/MCB.17.1.444 DOI 10.1128/MCB.24.20.9207-9220.2004 http://dx.doi.org/10.1128/MCB.24.20.9207-9220.2004 DOI 10.1158/0008-5472.CAN-07-2578 http://dx.doi.org/10.1158/0008-5472.CAN-07-2578 DOI 10.1158/1541-7786.MCR-10-0503 http://dx.doi.org/10.1158/1541-7786.MCR-10-0503 DOI 10.1158/2159-8290.CD-13-0094 http://dx.doi.org/10.1158/2159-8290.CD-13-0094 DisProt DP00238 http://www.disprot.org/protein.php?id=DP00238 EC_number EC:2.3.2.27 {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:20351172} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.2.27 {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:20351172} EMBL AC060780 http://www.ebi.ac.uk/ena/data/view/AC060780 EMBL AC135721 http://www.ebi.ac.uk/ena/data/view/AC135721 EMBL AF005068 http://www.ebi.ac.uk/ena/data/view/AF005068 EMBL AY273801 http://www.ebi.ac.uk/ena/data/view/AY273801 EMBL BC072418 http://www.ebi.ac.uk/ena/data/view/BC072418 EMBL BC115037 http://www.ebi.ac.uk/ena/data/view/BC115037 EMBL DQ190450 http://www.ebi.ac.uk/ena/data/view/DQ190450 EMBL DQ190451 http://www.ebi.ac.uk/ena/data/view/DQ190451 EMBL DQ190452 http://www.ebi.ac.uk/ena/data/view/DQ190452 EMBL DQ190453 http://www.ebi.ac.uk/ena/data/view/DQ190453 EMBL DQ190454 http://www.ebi.ac.uk/ena/data/view/DQ190454 EMBL DQ190455 http://www.ebi.ac.uk/ena/data/view/DQ190455 EMBL DQ190456 http://www.ebi.ac.uk/ena/data/view/DQ190456 EMBL L78833 http://www.ebi.ac.uk/ena/data/view/L78833 EMBL U14680 http://www.ebi.ac.uk/ena/data/view/U14680 EMBL U64805 http://www.ebi.ac.uk/ena/data/view/U64805 ENZYME 2.3.2.27 {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:20351172} http://enzyme.expasy.org/EC/2.3.2.27 {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:20351172} Ensembl ENST00000352993 http://www.ensembl.org/id/ENST00000352993 Ensembl ENST00000357654 http://www.ensembl.org/id/ENST00000357654 Ensembl ENST00000461221 http://www.ensembl.org/id/ENST00000461221 Ensembl ENST00000461798 http://www.ensembl.org/id/ENST00000461798 Ensembl ENST00000468300 http://www.ensembl.org/id/ENST00000468300 Ensembl ENST00000471181 http://www.ensembl.org/id/ENST00000471181 Ensembl ENST00000491747 http://www.ensembl.org/id/ENST00000491747 Ensembl ENST00000493795 http://www.ensembl.org/id/ENST00000493795 G-Links BRCA1_HUMAN http://link.g-language.org/BRCA1_HUMAN/format=tsv GO_component GO:0000151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000151 GO_component GO:0000800 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000800 GO_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GO_component GO:0005654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654 GO_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0008274 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008274 GO_component GO:0030529 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030529 GO_component GO:0031436 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031436 GO_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GO_component GO:0070531 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070531 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003684 GO_function GO:0003713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003713 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004842 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004842 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0015631 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015631 GO_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GO_function GO:0031625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031625 GO_function GO:0044212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044212 GO_function GO:0050681 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050681 GO_process GO:0000724 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000724 GO_process GO:0000729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000729 GO_process GO:0000731 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000731 GO_process GO:0000732 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000732 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006301 GO_process GO:0006302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006302 GO_process GO:0006303 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006303 GO_process GO:0006349 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006349 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006357 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006357 GO_process GO:0006359 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006359 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GO_process GO:0006915 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0006978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006978 GO_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GO_process GO:0007098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007098 GO_process GO:0008630 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008630 GO_process GO:0009048 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009048 GO_process GO:0010212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010212 GO_process GO:0010575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010575 GO_process GO:0010628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628 GO_process GO:0016567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016567 GO_process GO:0016925 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016925 GO_process GO:0030521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030521 GO_process GO:0031052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031052 GO_process GO:0031398 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031398 GO_process GO:0031572 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031572 GO_process GO:0033147 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033147 GO_process GO:0035066 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035066 GO_process GO:0035067 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035067 GO_process GO:0042127 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042127 GO_process GO:0042981 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042981 GO_process GO:0043009 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043009 GO_process GO:0043627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043627 GO_process GO:0044030 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044030 GO_process GO:0045717 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045717 GO_process GO:0045739 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045739 GO_process GO:0045766 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045766 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GO_process GO:0045944 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045944 GO_process GO:0046600 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046600 GO_process GO:0051571 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051571 GO_process GO:0051572 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051572 GO_process GO:0051573 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051573 GO_process GO:0051574 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051574 GO_process GO:0051865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051865 GO_process GO:0070512 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070512 GO_process GO:0071158 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071158 GO_process GO:0071356 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071356 GO_process GO:0071681 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071681 GO_process GO:0085020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0085020 GO_process GO:1901796 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901796 GO_process GO:1902042 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902042 GO_process GO:2000378 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000378 GO_process GO:2000617 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000617 GO_process GO:2000620 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000620 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GOslim_component GO:0005654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005654 GOslim_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008092 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0008219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0009790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009790 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 3.30.40.10 http://www.cathdb.info/version/latest/superfamily/3.30.40.10 Gene3D 3.40.50.10190 http://www.cathdb.info/version/latest/superfamily/3.40.50.10190 GeneCards BRCA1 http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=BRCA1 GeneID 672 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=672 GeneTree ENSGT00440000034289 http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00440000034289 HGNC HGNC:1100 http://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:1100 HOGENOM HOG000230969 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230969&db=HOGENOM6 HOVERGEN HBG050730 http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG050730&db=HOVERGEN HPA CAB001946 http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB001946 HPA CAB018369 http://www.proteinatlas.org/tissue_profile.php?antibody_id=CAB018369 HPA HPA034966 http://www.proteinatlas.org/tissue_profile.php?antibody_id=HPA034966 InParanoid P38398 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38398 IntAct P38398 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38398* IntEnz 2.3.2.27 {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:20351172} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.2.27 {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:20351172} InterPro IPR001357 http://www.ebi.ac.uk/interpro/entry/IPR001357 InterPro IPR001841 http://www.ebi.ac.uk/interpro/entry/IPR001841 InterPro IPR011364 http://www.ebi.ac.uk/interpro/entry/IPR011364 InterPro IPR013083 http://www.ebi.ac.uk/interpro/entry/IPR013083 InterPro IPR017907 http://www.ebi.ac.uk/interpro/entry/IPR017907 InterPro IPR018957 http://www.ebi.ac.uk/interpro/entry/IPR018957 InterPro IPR025994 http://www.ebi.ac.uk/interpro/entry/IPR025994 InterPro IPR031099 http://www.ebi.ac.uk/interpro/entry/IPR031099 Jabion 672 http://www.bioportal.jp/genome/cgi-bin/gene_homolog.cgi?org=hs&id=672 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko04121 http://www.genome.jp/dbget-bin/www_bget?ko04121 KEGG_Disease H00027 http://www.genome.jp/dbget-bin/www_bget?H00027 KEGG_Disease H00031 http://www.genome.jp/dbget-bin/www_bget?H00031 KEGG_Disease H01554 http://www.genome.jp/dbget-bin/www_bget?H01554 KEGG_Disease H01665 http://www.genome.jp/dbget-bin/www_bget?H01665 KEGG_Gene hsa:672 http://www.genome.jp/dbget-bin/www_bget?hsa:672 KEGG_Orthology KO:K10605 http://www.genome.jp/dbget-bin/www_bget?KO:K10605 KEGG_Pathway ko03460 http://www.genome.jp/kegg-bin/show_pathway?ko03460 KEGG_Pathway ko04120 http://www.genome.jp/kegg-bin/show_pathway?ko04120 KEGG_Pathway ko04151 http://www.genome.jp/kegg-bin/show_pathway?ko04151 MIM 113705 http://www.ncbi.nlm.nih.gov/omim/113705 MIM 114480 http://www.ncbi.nlm.nih.gov/omim/114480 MIM 167000 http://www.ncbi.nlm.nih.gov/omim/167000 MIM 604370 http://www.ncbi.nlm.nih.gov/omim/604370 MIM 614320 http://www.ncbi.nlm.nih.gov/omim/614320 MINT MINT-90433 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-90433 OMA FQHLLFG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FQHLLFG Orphanet 1331 http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1331 Orphanet 1333 http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=1333 Orphanet 145 http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=145 Orphanet 168829 http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=168829 Orphanet 213524 http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=213524 Orphanet 227535 http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=227535 OrthoDB EOG091G0670 http://cegg.unige.ch/orthodb/results?searchtext=EOG091G0670 PANTHER PTHR13763 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13763 PANTHER PTHR13763:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13763:SF0 PDB 1JM7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JM7 PDB 1JNX http://www.ebi.ac.uk/pdbe-srv/view/entry/1JNX PDB 1N5O http://www.ebi.ac.uk/pdbe-srv/view/entry/1N5O PDB 1OQA http://www.ebi.ac.uk/pdbe-srv/view/entry/1OQA PDB 1T15 http://www.ebi.ac.uk/pdbe-srv/view/entry/1T15 PDB 1T29 http://www.ebi.ac.uk/pdbe-srv/view/entry/1T29 PDB 1T2U http://www.ebi.ac.uk/pdbe-srv/view/entry/1T2U PDB 1T2V http://www.ebi.ac.uk/pdbe-srv/view/entry/1T2V PDB 1Y98 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y98 PDB 2ING http://www.ebi.ac.uk/pdbe-srv/view/entry/2ING PDB 3COJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3COJ PDB 3K0H http://www.ebi.ac.uk/pdbe-srv/view/entry/3K0H PDB 3K0K http://www.ebi.ac.uk/pdbe-srv/view/entry/3K0K PDB 3K15 http://www.ebi.ac.uk/pdbe-srv/view/entry/3K15 PDB 3K16 http://www.ebi.ac.uk/pdbe-srv/view/entry/3K16 PDB 3PXA http://www.ebi.ac.uk/pdbe-srv/view/entry/3PXA PDB 3PXB http://www.ebi.ac.uk/pdbe-srv/view/entry/3PXB PDB 3PXC http://www.ebi.ac.uk/pdbe-srv/view/entry/3PXC PDB 3PXD http://www.ebi.ac.uk/pdbe-srv/view/entry/3PXD PDB 3PXE http://www.ebi.ac.uk/pdbe-srv/view/entry/3PXE PDB 4IFI http://www.ebi.ac.uk/pdbe-srv/view/entry/4IFI PDB 4IGK http://www.ebi.ac.uk/pdbe-srv/view/entry/4IGK PDB 4JLU http://www.ebi.ac.uk/pdbe-srv/view/entry/4JLU PDB 4OFB http://www.ebi.ac.uk/pdbe-srv/view/entry/4OFB PDB 4U4A http://www.ebi.ac.uk/pdbe-srv/view/entry/4U4A PDB 4Y18 http://www.ebi.ac.uk/pdbe-srv/view/entry/4Y18 PDB 4Y2G http://www.ebi.ac.uk/pdbe-srv/view/entry/4Y2G PDBsum 1JM7 http://www.ebi.ac.uk/pdbsum/1JM7 PDBsum 1JNX http://www.ebi.ac.uk/pdbsum/1JNX PDBsum 1N5O http://www.ebi.ac.uk/pdbsum/1N5O PDBsum 1OQA http://www.ebi.ac.uk/pdbsum/1OQA PDBsum 1T15 http://www.ebi.ac.uk/pdbsum/1T15 PDBsum 1T29 http://www.ebi.ac.uk/pdbsum/1T29 PDBsum 1T2U http://www.ebi.ac.uk/pdbsum/1T2U PDBsum 1T2V http://www.ebi.ac.uk/pdbsum/1T2V PDBsum 1Y98 http://www.ebi.ac.uk/pdbsum/1Y98 PDBsum 2ING http://www.ebi.ac.uk/pdbsum/2ING PDBsum 3COJ http://www.ebi.ac.uk/pdbsum/3COJ PDBsum 3K0H http://www.ebi.ac.uk/pdbsum/3K0H PDBsum 3K0K http://www.ebi.ac.uk/pdbsum/3K0K PDBsum 3K15 http://www.ebi.ac.uk/pdbsum/3K15 PDBsum 3K16 http://www.ebi.ac.uk/pdbsum/3K16 PDBsum 3PXA http://www.ebi.ac.uk/pdbsum/3PXA PDBsum 3PXB http://www.ebi.ac.uk/pdbsum/3PXB PDBsum 3PXC http://www.ebi.ac.uk/pdbsum/3PXC PDBsum 3PXD http://www.ebi.ac.uk/pdbsum/3PXD PDBsum 3PXE http://www.ebi.ac.uk/pdbsum/3PXE PDBsum 4IFI http://www.ebi.ac.uk/pdbsum/4IFI PDBsum 4IGK http://www.ebi.ac.uk/pdbsum/4IGK PDBsum 4JLU http://www.ebi.ac.uk/pdbsum/4JLU PDBsum 4OFB http://www.ebi.ac.uk/pdbsum/4OFB PDBsum 4U4A http://www.ebi.ac.uk/pdbsum/4U4A PDBsum 4Y18 http://www.ebi.ac.uk/pdbsum/4Y18 PDBsum 4Y2G http://www.ebi.ac.uk/pdbsum/4Y2G PRINTS PR00493 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00493 PROSITE PS00518 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00518 PROSITE PS50089 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50089 PROSITE PS50172 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50172 PSORT swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/kpsort/swissprot:BRCA1_HUMAN PSORT-B swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/kpsortb/swissprot:BRCA1_HUMAN PSORT2 swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/kpsort2/swissprot:BRCA1_HUMAN Pfam PF00097 http://pfam.xfam.org/family/PF00097 Pfam PF00533 http://pfam.xfam.org/family/PF00533 Pfam PF12820 http://pfam.xfam.org/family/PF12820 PharmGKB PA25411 http://www.pharmgkb.org/do/serve?objId=PA25411&objCls=Gene Phobius swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/kphobius/swissprot:BRCA1_HUMAN PhylomeDB P38398 http://phylomedb.org/?seqid=P38398 ProteinModelPortal P38398 http://www.proteinmodelportal.org/query/uniprot/P38398 PubMed 10196379 http://www.ncbi.nlm.nih.gov/pubmed/10196379 PubMed 10323242 http://www.ncbi.nlm.nih.gov/pubmed/10323242 PubMed 10486320 http://www.ncbi.nlm.nih.gov/pubmed/10486320 PubMed 10500182 http://www.ncbi.nlm.nih.gov/pubmed/10500182 PubMed 10724175 http://www.ncbi.nlm.nih.gov/pubmed/10724175 PubMed 10783165 http://www.ncbi.nlm.nih.gov/pubmed/10783165 PubMed 10851077 http://www.ncbi.nlm.nih.gov/pubmed/10851077 PubMed 11114888 http://www.ncbi.nlm.nih.gov/pubmed/11114888 PubMed 11239454 http://www.ncbi.nlm.nih.gov/pubmed/11239454 PubMed 11301010 http://www.ncbi.nlm.nih.gov/pubmed/11301010 PubMed 11573085 http://www.ncbi.nlm.nih.gov/pubmed/11573085 PubMed 11573086 http://www.ncbi.nlm.nih.gov/pubmed/11573086 PubMed 11739404 http://www.ncbi.nlm.nih.gov/pubmed/11739404 PubMed 11751867 http://www.ncbi.nlm.nih.gov/pubmed/11751867 PubMed 11836499 http://www.ncbi.nlm.nih.gov/pubmed/11836499 PubMed 11877377 http://www.ncbi.nlm.nih.gov/pubmed/11877377 PubMed 12183412 http://www.ncbi.nlm.nih.gov/pubmed/12183412 PubMed 12215251 http://www.ncbi.nlm.nih.gov/pubmed/12215251 PubMed 12360400 http://www.ncbi.nlm.nih.gov/pubmed/12360400 PubMed 12419185 http://www.ncbi.nlm.nih.gov/pubmed/12419185 PubMed 12427738 http://www.ncbi.nlm.nih.gov/pubmed/12427738 PubMed 12442274 http://www.ncbi.nlm.nih.gov/pubmed/12442274 PubMed 12442275 http://www.ncbi.nlm.nih.gov/pubmed/12442275 PubMed 12887909 http://www.ncbi.nlm.nih.gov/pubmed/12887909 PubMed 12890688 http://www.ncbi.nlm.nih.gov/pubmed/12890688 PubMed 12938098 http://www.ncbi.nlm.nih.gov/pubmed/12938098 PubMed 14636569 http://www.ncbi.nlm.nih.gov/pubmed/14636569 PubMed 14722926 http://www.ncbi.nlm.nih.gov/pubmed/14722926 PubMed 14746861 http://www.ncbi.nlm.nih.gov/pubmed/14746861 PubMed 14976165 http://www.ncbi.nlm.nih.gov/pubmed/14976165 PubMed 14990569 http://www.ncbi.nlm.nih.gov/pubmed/14990569 PubMed 15026808 http://www.ncbi.nlm.nih.gov/pubmed/15026808 PubMed 15096610 http://www.ncbi.nlm.nih.gov/pubmed/15096610 PubMed 15133502 http://www.ncbi.nlm.nih.gov/pubmed/15133502 PubMed 15365993 http://www.ncbi.nlm.nih.gov/pubmed/15365993 PubMed 15456891 http://www.ncbi.nlm.nih.gov/pubmed/15456891 PubMed 15489334 http://www.ncbi.nlm.nih.gov/pubmed/15489334 PubMed 15609993 http://www.ncbi.nlm.nih.gov/pubmed/15609993 PubMed 16101277 http://www.ncbi.nlm.nih.gov/pubmed/16101277 PubMed 16326698 http://www.ncbi.nlm.nih.gov/pubmed/16326698 PubMed 16625196 http://www.ncbi.nlm.nih.gov/pubmed/16625196 PubMed 16698035 http://www.ncbi.nlm.nih.gov/pubmed/16698035 PubMed 16818604 http://www.ncbi.nlm.nih.gov/pubmed/16818604 PubMed 16959974 http://www.ncbi.nlm.nih.gov/pubmed/16959974 PubMed 17081983 http://www.ncbi.nlm.nih.gov/pubmed/17081983 PubMed 17525332 http://www.ncbi.nlm.nih.gov/pubmed/17525332 PubMed 17525340 http://www.ncbi.nlm.nih.gov/pubmed/17525340 PubMed 17643121 http://www.ncbi.nlm.nih.gov/pubmed/17643121 PubMed 17643122 http://www.ncbi.nlm.nih.gov/pubmed/17643122 PubMed 17924331 http://www.ncbi.nlm.nih.gov/pubmed/17924331 PubMed 18056443 http://www.ncbi.nlm.nih.gov/pubmed/18056443 PubMed 18285836 http://www.ncbi.nlm.nih.gov/pubmed/18285836 PubMed 18452305 http://www.ncbi.nlm.nih.gov/pubmed/18452305 PubMed 18669648 http://www.ncbi.nlm.nih.gov/pubmed/18669648 PubMed 18762988 http://www.ncbi.nlm.nih.gov/pubmed/18762988 PubMed 19261746 http://www.ncbi.nlm.nih.gov/pubmed/19261746 PubMed 19261748 http://www.ncbi.nlm.nih.gov/pubmed/19261748 PubMed 19261749 http://www.ncbi.nlm.nih.gov/pubmed/19261749 PubMed 19369211 http://www.ncbi.nlm.nih.gov/pubmed/19369211 PubMed 19690332 http://www.ncbi.nlm.nih.gov/pubmed/19690332 PubMed 20068231 http://www.ncbi.nlm.nih.gov/pubmed/20068231 PubMed 20159462 http://www.ncbi.nlm.nih.gov/pubmed/20159462 PubMed 20160719 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http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1221632 Reactome R-HSA-3108214 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3108214 Reactome R-HSA-5685938 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5685938 Reactome R-HSA-5685942 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5685942 Reactome R-HSA-5689901 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5689901 Reactome R-HSA-5693554 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693554 Reactome R-HSA-5693565 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693565 Reactome R-HSA-5693568 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693568 Reactome R-HSA-5693571 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693571 Reactome R-HSA-5693579 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693579 Reactome R-HSA-5693607 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693607 Reactome R-HSA-5693616 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5693616 Reactome R-HSA-6796648 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6796648 Reactome R-HSA-6804756 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6804756 Reactome R-HSA-69473 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-69473 Reactome R-HSA-912446 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-912446 RefSeq NP_009225 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009225 RefSeq NP_009228 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009228 RefSeq NP_009229 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009229 RefSeq NP_009230 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009230 RefSeq NP_009231 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_009231 SMART SM00184 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00184 SMART SM00292 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00292 SMR P38398 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38398 STRING 9606.ENSP00000418960 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=9606.ENSP00000418960&targetmode=cogs SUPFAM SSF52113 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52113 UCSC uc002icq http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc002icq&org=rat UCSC uc010cyx http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc010cyx&org=rat UniGene Hs.194143 http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Hs.194143 UniProtKB BRCA1_HUMAN http://www.uniprot.org/uniprot/BRCA1_HUMAN UniProtKB-AC P38398 http://www.uniprot.org/uniprot/P38398 charge swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/charge/swissprot:BRCA1_HUMAN eggNOG ENOG410ITQ4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ITQ4 eggNOG ENOG4112BIH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112BIH epestfind swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/epestfind/swissprot:BRCA1_HUMAN garnier swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/garnier/swissprot:BRCA1_HUMAN helixturnhelix swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/helixturnhelix/swissprot:BRCA1_HUMAN hmoment swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/hmoment/swissprot:BRCA1_HUMAN iep swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/iep/swissprot:BRCA1_HUMAN inforesidue swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/inforesidue/swissprot:BRCA1_HUMAN neXtProt NX_P38398 http://www.nextprot.org/db/entry/NX_P38398 octanol swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/octanol/swissprot:BRCA1_HUMAN pepcoil swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/pepcoil/swissprot:BRCA1_HUMAN pepdigest swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/pepdigest/swissprot:BRCA1_HUMAN pepinfo swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/pepinfo/swissprot:BRCA1_HUMAN pepnet swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/pepnet/swissprot:BRCA1_HUMAN pepstats swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/pepstats/swissprot:BRCA1_HUMAN pepwheel swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/pepwheel/swissprot:BRCA1_HUMAN pepwindow swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/pepwindow/swissprot:BRCA1_HUMAN sigcleave swissprot:BRCA1_HUMAN http://rest.g-language.org/emboss/sigcleave/swissprot:BRCA1_HUMAN