# DOMAIN | FOXP2_GORGO | The leucine-zipper is required for dimerization and transcriptional repression. {ECO 0000250}. |
# FUNCTION | FOXP2_GORGO | Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). {ECO 0000250}. |
# GO_component | GO:0005634 | nucleus; IEA:UniProtKB-SubCell. |
# GO_function | GO:0003677 | DNA binding; ISS:UniProtKB. |
# GO_function | GO:0003700 | transcription factor activity, sequence-specific DNA binding; IEA:InterPro. |
# GO_function | GO:0042803 | protein homodimerization activity; ISS:UniProtKB. |
# GO_function | GO:0043565 | sequence-specific DNA binding; IEA:InterPro. |
# GO_function | GO:0046872 | metal ion binding; IEA:UniProtKB-KW. |
# GO_process | GO:0006351 | transcription, DNA-templated; IEA:UniProtKB-KW. |
# GO_process | GO:0021757 | caudate nucleus development; ISS:UniProtKB. |
# GO_process | GO:0021758 | putamen development; ISS:UniProtKB. |
# GOslim_component | GO:0005634 | nucleus |
# GOslim_function | GO:0001071 | nucleic acid binding transcription factor activity |
# GOslim_function | GO:0003674 | molecular_function |
# GOslim_function | GO:0003677 | DNA binding |
# GOslim_function | GO:0043167 | ion binding |
# GOslim_process | GO:0009058 | biosynthetic process |
# GOslim_process | GO:0034641 | cellular nitrogen compound metabolic process |
# GOslim_process | GO:0048856 | anatomical structure development |
# Gene3D | 1.10.10.10 | -; 1. |
# InterPro | IPR001766 | Fork_head_dom |
# InterPro | IPR011991 | WHTH_DNA-bd_dom |
# InterPro | IPR030456 | TF_fork_head_CS_2 |
# InterPro | IPR032354 | FOXP-CC |
# Organism | FOXP2_GORGO | Gorilla gorilla gorilla (Western lowland gorilla) |
# PRINTS | PR00053 | FORKHEAD |
# PROSITE | PS00028 | ZINC_FINGER_C2H2_1 |
# PROSITE | PS00658 | FORK_HEAD_2 |
# PROSITE | PS50039 | FORK_HEAD_3 |
# Pfam | PF00250 | Forkhead |
# Pfam | PF16159 | FOXP-CC |
# Proteomes | UP000001519 | Unplaced |
# RecName | FOXP2_GORGO | Forkhead box protein P2 |
# RefSeq | NP_001266466 | NM_001279537.1 |
# SIMILARITY | Contains 1 C2H2-type zinc finger. {ECO | 0000305}. |
# SIMILARITY | Contains 1 fork-head DNA-binding domain. {ECO:0000255|PROSITE-ProRule | PRU00089}. |
# SMART | SM00339 | FH |
# SUBCELLULAR LOCATION | FOXP2_GORGO | Nucleus {ECO 0000305}. |
# SUBUNIT | FOXP2_GORGO | Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Interacts with FOXP1 (By similarity). {ECO 0000250|UniProtKB O15409, ECO 0000250|UniProtKB P58463}. |
# SUPFAM | SSF46785 | SSF46785 |
BLAST | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/kblast/swissprot:FOXP2_GORGO |
DOI | 10.1038/nature01025 | http://dx.doi.org/10.1038/nature01025 |
EMBL | AF512948 | http://www.ebi.ac.uk/ena/data/view/AF512948 |
EMBL | AY064583 | http://www.ebi.ac.uk/ena/data/view/AY064583 |
EMBL | AY064584 | http://www.ebi.ac.uk/ena/data/view/AY064584 |
EMBL | AY064585 | http://www.ebi.ac.uk/ena/data/view/AY064585 |
EMBL | AY064586 | http://www.ebi.ac.uk/ena/data/view/AY064586 |
EMBL | AY064587 | http://www.ebi.ac.uk/ena/data/view/AY064587 |
EMBL | AY064588 | http://www.ebi.ac.uk/ena/data/view/AY064588 |
EMBL | AY064589 | http://www.ebi.ac.uk/ena/data/view/AY064589 |
EMBL | AY064590 | http://www.ebi.ac.uk/ena/data/view/AY064590 |
EMBL | AY064591 | http://www.ebi.ac.uk/ena/data/view/AY064591 |
EMBL | AY064592 | http://www.ebi.ac.uk/ena/data/view/AY064592 |
EMBL | AY064593 | http://www.ebi.ac.uk/ena/data/view/AY064593 |
EMBL | AY064594 | http://www.ebi.ac.uk/ena/data/view/AY064594 |
EMBL | AY064595 | http://www.ebi.ac.uk/ena/data/view/AY064595 |
EMBL | AY064596 | http://www.ebi.ac.uk/ena/data/view/AY064596 |
EMBL | AY064597 | http://www.ebi.ac.uk/ena/data/view/AY064597 |
EMBL | AY143180 | http://www.ebi.ac.uk/ena/data/view/AY143180 |
G-Links | FOXP2_GORGO | http://link.g-language.org/FOXP2_GORGO/format=tsv |
GO_component | GO:0005634 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 |
GO_function | GO:0003677 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 |
GO_function | GO:0003700 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 |
GO_function | GO:0042803 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803 |
GO_function | GO:0043565 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 |
GO_function | GO:0046872 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 |
GO_process | GO:0006351 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 |
GO_process | GO:0021757 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021757 |
GO_process | GO:0021758 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021758 |
GOslim_component | GO:0005634 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 |
GOslim_function | GO:0001071 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 |
GOslim_function | GO:0003674 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 |
GOslim_function | GO:0003677 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 |
GOslim_function | GO:0043167 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 |
GOslim_process | GO:0009058 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 |
GOslim_process | GO:0034641 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 |
GOslim_process | GO:0048856 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856 |
Gene3D | 1.10.10.10 | http://www.cathdb.info/version/latest/superfamily/1.10.10.10 |
GeneID | 101150977 | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=101150977 |
HOVERGEN | HBG051657 | http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051657&db=HOVERGEN |
InParanoid | Q8MJ99 | http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q8MJ99 |
InterPro | IPR001766 | http://www.ebi.ac.uk/interpro/entry/IPR001766 |
InterPro | IPR011991 | http://www.ebi.ac.uk/interpro/entry/IPR011991 |
InterPro | IPR030456 | http://www.ebi.ac.uk/interpro/entry/IPR030456 |
InterPro | IPR032354 | http://www.ebi.ac.uk/interpro/entry/IPR032354 |
PRINTS | PR00053 | http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00053 |
PROSITE | PS00028 | http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00028 |
PROSITE | PS00658 | http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00658 |
PROSITE | PS50039 | http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50039 |
PSORT-B | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/kpsortb/swissprot:FOXP2_GORGO |
PSORT2 | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/kpsort2/swissprot:FOXP2_GORGO |
PSORT | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/kpsort/swissprot:FOXP2_GORGO |
Pfam | PF00250 | http://pfam.xfam.org/family/PF00250 |
Pfam | PF16159 | http://pfam.xfam.org/family/PF16159 |
Phobius | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/kphobius/swissprot:FOXP2_GORGO |
ProteinModelPortal | Q8MJ99 | http://www.proteinmodelportal.org/query/uniprot/Q8MJ99 |
PubMed | 12192408 | http://www.ncbi.nlm.nih.gov/pubmed/12192408 |
PubMed | 12524352 | http://www.ncbi.nlm.nih.gov/pubmed/12524352 |
RefSeq | NP_001266466 | http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001266466 |
SMART | SM00339 | http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00339 |
SUPFAM | SSF46785 | http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 |
UniProtKB-AC | Q8MJ99 | http://www.uniprot.org/uniprot/Q8MJ99 |
UniProtKB | FOXP2_GORGO | http://www.uniprot.org/uniprot/FOXP2_GORGO |
charge | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/charge/swissprot:FOXP2_GORGO |
epestfind | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/epestfind/swissprot:FOXP2_GORGO |
garnier | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/garnier/swissprot:FOXP2_GORGO |
helixturnhelix | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/helixturnhelix/swissprot:FOXP2_GORGO |
hmoment | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/hmoment/swissprot:FOXP2_GORGO |
iep | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/iep/swissprot:FOXP2_GORGO |
inforesidue | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/inforesidue/swissprot:FOXP2_GORGO |
octanol | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/octanol/swissprot:FOXP2_GORGO |
pepcoil | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/pepcoil/swissprot:FOXP2_GORGO |
pepdigest | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/pepdigest/swissprot:FOXP2_GORGO |
pepinfo | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/pepinfo/swissprot:FOXP2_GORGO |
pepnet | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/pepnet/swissprot:FOXP2_GORGO |
pepstats | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/pepstats/swissprot:FOXP2_GORGO |
pepwheel | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/pepwheel/swissprot:FOXP2_GORGO |
pepwindow | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/pepwindow/swissprot:FOXP2_GORGO |
sigcleave | swissprot:FOXP2_GORGO | http://rest.g-language.org/emboss/sigcleave/swissprot:FOXP2_GORGO |