COXPRESdb:114142
DataBaseIDURL or Descriptions
# ALTERNATIVE PRODUCTSFOXP2_MOUSEEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P58463-1; Sequence=Displayed; Name=2; IsoId=P58463-2; Sequence=VSP_011540; Note=May be due to a competing acceptor splice site. No experimental confirmation available.;
# CCDSCCDS19918-. [P58463-1]
# CCDSCCDS71726-. [P58463-2]
# ChiTaRSFoxp2mouse
# DEVELOPMENTAL STAGEFOXP2_MOUSEExpressed in developing lung, neural, intestinal and cardiovascular tissues. Expressed at a high level in the distal airway epithelium and at a low level in the proximal airway epithelium at 12.5 dpc, and restricted to the distal airway epithelium by 14.5 dpc. In the spinal cord, at 12.5 dpc, expressed in a subset of interneurons dorsal to motor neurons. At 16.5 dpc, expression in the brain is observed in the inner intermediate zone of the neopallial cortex and in the developing cerebral hemispheres. In the gastrointestinal system, at 12.5 expressed in the outer mesodermal layer and in the intestinal epithelium. By 16.5 dpc, expression is restricted to the outer longitudinal muscle layer of the intestine and stomach. In the cardiovascular system, at 14.5 dpc, expressed in the outflow tract region of the developing heart. By 16.5 dpc, observed in the outflow tract and atrium, but not in the ventricles. {ECO 0000269|PubMed 11358962, ECO 0000269|PubMed 14516685}.
# DOMAINFOXP2_MOUSEThe leucine-zipper is required for dimerization and transcriptional repression. {ECO 0000269|PubMed 14701752}.
# EnsemblENSMUST00000031545ENSMUSP00000031545; ENSMUSG00000029563. [P58463-1]
# EnsemblENSMUST00000115472ENSMUSP00000111132; ENSMUSG00000029563. [P58463-2]
# EnsemblENSMUST00000115477ENSMUSP00000111137; ENSMUSG00000029563. [P58463-1]
# ExpressionAtlasP58463baseline and differential
# FUNCTIONFOXP2_MOUSETranscriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. {ECO 0000269|PubMed 14701752, ECO 0000269|PubMed 24179158}.
# GO_componentGO:0005634nucleus; IBA:GO_Central.
# GO_functionGO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding; IMP:NTNU_SB.
# GO_functionGO:0001078transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IMP:NTNU_SB.
# GO_functionGO:0003677DNA binding; ISS:UniProtKB.
# GO_functionGO:0003700transcription factor activity, sequence-specific DNA binding; IDA:MGI.
# GO_functionGO:0042803protein homodimerization activity; ISS:UniProtKB.
# GO_functionGO:0046872metal ion binding; IEA:UniProtKB-KW.
# GO_functionGO:0046982protein heterodimerization activity; IPI:MGI.
# GO_processGO:0000122negative regulation of transcription from RNA polymerase II promoter; IMP:NTNU_SB.
# GO_processGO:0002053positive regulation of mesenchymal cell proliferation; IGI:MGI.
# GO_processGO:0006351transcription, DNA-templated; IEA:UniProtKB-KW.
# GO_processGO:0007519skeletal muscle tissue development; IGI:MGI.
# GO_processGO:0009791post-embryonic development; IMP:MGI.
# GO_processGO:0021549cerebellum development; IMP:MGI.
# GO_processGO:0021757caudate nucleus development; ISS:UniProtKB.
# GO_processGO:0021758putamen development; ISS:UniProtKB.
# GO_processGO:0021987cerebral cortex development; IEA:Ensembl.
# GO_processGO:0030324lung development; IGI:MGI.
# GO_processGO:0040007growth; IMP:MGI.
# GO_processGO:0042297vocal learning; IMP:MGI.
# GO_processGO:0043010camera-type eye development; IMP:MGI.
# GO_processGO:0045892negative regulation of transcription, DNA-templated; IDA:MGI.
# GO_processGO:0048286lung alveolus development; IMP:MGI.
# GO_processGO:0048745smooth muscle tissue development; IGI:MGI.
# GO_processGO:0050679positive regulation of epithelial cell proliferation; IGI:MGI.
# GO_processGO:0060013righting reflex; IMP:MGI.
# GO_processGO:0060501positive regulation of epithelial cell proliferation involved in lung morphogenesis; IGI:MGI.
# GOslim_componentGO:0005634nucleus
# GOslim_functionGO:0001071nucleic acid binding transcription factor activity
# GOslim_functionGO:0003674molecular_function
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0009058biosynthetic process
# GOslim_processGO:0034641cellular nitrogen compound metabolic process
# GOslim_processGO:0040007growth
# GOslim_processGO:0048856anatomical structure development
# GOslim_processGO:0050877neurological system process
# Gene3D1.10.10.10-; 1.
# GenevisibleP58463MM
# InterProIPR001766Fork_head_dom
# InterProIPR011991WHTH_DNA-bd_dom
# InterProIPR030456TF_fork_head_CS_2
# InterProIPR032354FOXP-CC
# KEGG_Briteko03000Transcription factors
# MGIMGI:2148705Foxp2
# OrganismFOXP2_MOUSEMus musculus (Mouse)
# PRINTSPR00053FORKHEAD
# PROSITEPS00028ZINC_FINGER_C2H2_1
# PROSITEPS00658FORK_HEAD_2
# PROSITEPS50039FORK_HEAD_3
# PfamPF00250Forkhead
# PfamPF16159FOXP-CC
# ProteomesUP000000589Chromosome 6
# RecNameFOXP2_MOUSEForkhead box protein P2
# RefSeqNP_001273536NM_001286607.1. [P58463-2]
# RefSeqNP_444472NM_053242.4. [P58463-1]
# RefSeqNP_997600NM_212435.1. [P58463-1]
# SIMILARITYContains 1 C2H2-type zinc finger. {ECO0000305}.
# SIMILARITYContains 1 fork-head DNA-binding domain. {ECO:0000255|PROSITE-ProRulePRU00089}.
# SMARTSM00339FH
# SUBCELLULAR LOCATIONFOXP2_MOUSENucleus {ECO 0000305}.
# SUBUNITFOXP2_MOUSEForms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding (By similarity). Interacts with CTBP1 (PubMed 14701752). Interacts with FOXP1 (By similarity). {ECO 0000250|UniProtKB O15409, ECO 0000269|PubMed 14701752}.
# SUPFAMSSF46785SSF46785
# TISSUE SPECIFICITYFOXP2_MOUSEHighest expression in lung. Lower expression in spleen, skeletal muscle, brain, kidney and small intestine.
# UCSCuc009ayymouse. [P58463-1]
# UCSCuc012eiemouse. [P58463-2]
# eggNOGCOG5025LUCA
# eggNOGKOG4385Eukaryota
BLASTswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/kblast/swissprot:FOXP2_MOUSE
COXPRESdb114142http://coxpresdb.jp/data/gene/114142.shtml
CleanExMM_FOXP2http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=MM_FOXP2
DOI10.1016/S0925-4773(03)00116-3http://dx.doi.org/10.1016/S0925-4773(03)00116-3
DOI10.1038/nature01025http://dx.doi.org/10.1038/nature01025
DOI10.1074/jbc.M100636200http://dx.doi.org/10.1074/jbc.M100636200
DOI10.1101/gr.2596504http://dx.doi.org/10.1101/gr.2596504
DOI10.1126/science.1112014http://dx.doi.org/10.1126/science.1112014
DOI10.1126/science.1245079http://dx.doi.org/10.1126/science.1245079
DOI10.1128/MCB.24.2.809-822.2004http://dx.doi.org/10.1128/MCB.24.2.809-822.2004
EMBLAF339106http://www.ebi.ac.uk/ena/data/view/AF339106
EMBLAK082361http://www.ebi.ac.uk/ena/data/view/AK082361
EMBLAY079003http://www.ebi.ac.uk/ena/data/view/AY079003
EMBLBC058960http://www.ebi.ac.uk/ena/data/view/BC058960
EMBLBC062926http://www.ebi.ac.uk/ena/data/view/BC062926
EnsemblENSMUST00000031545http://www.ensembl.org/id/ENSMUST00000031545
EnsemblENSMUST00000115472http://www.ensembl.org/id/ENSMUST00000115472
EnsemblENSMUST00000115477http://www.ensembl.org/id/ENSMUST00000115477
G-LinksFOXP2_MOUSEhttp://link.g-language.org/FOXP2_MOUSE/format=tsv
GO_componentGO:0005634http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GO_functionGO:0000978http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000978
GO_functionGO:0001078http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001078
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003700http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700
GO_functionGO:0042803http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803
GO_functionGO:0046872http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_functionGO:0046982http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982
GO_processGO:0000122http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000122
GO_processGO:0002053http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002053
GO_processGO:0006351http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351
GO_processGO:0007519http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007519
GO_processGO:0009791http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009791
GO_processGO:0021549http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021549
GO_processGO:0021757http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021757
GO_processGO:0021758http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021758
GO_processGO:0021987http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021987
GO_processGO:0030324http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030324
GO_processGO:0040007http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GO_processGO:0042297http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042297
GO_processGO:0043010http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043010
GO_processGO:0045892http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892
GO_processGO:0048286http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048286
GO_processGO:0048745http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048745
GO_processGO:0050679http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050679
GO_processGO:0060013http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060013
GO_processGO:0060501http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060501
GOslim_componentGO:0005634http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634
GOslim_functionGO:0001071http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071
GOslim_functionGO:0003674http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_processGO:0034641http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_processGO:0040007http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007
GOslim_processGO:0048856http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856
GOslim_processGO:0050877http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877
Gene3D1.10.10.10http://www.cathdb.info/version/latest/superfamily/1.10.10.10
GeneID114142http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114142
GeneTreeENSGT00800000124014http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00800000124014
HOGENOMHOG000092089http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000092089&db=HOGENOM6
HOVERGENHBG051657http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051657&db=HOVERGEN
InParanoidP58463http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P58463
InterProIPR001766http://www.ebi.ac.uk/interpro/entry/IPR001766
InterProIPR011991http://www.ebi.ac.uk/interpro/entry/IPR011991
InterProIPR030456http://www.ebi.ac.uk/interpro/entry/IPR030456
InterProIPR032354http://www.ebi.ac.uk/interpro/entry/IPR032354
KEGG_Briteko03000http://www.genome.jp/dbget-bin/www_bget?ko03000
KEGG_Genemmu:114142http://www.genome.jp/dbget-bin/www_bget?mmu:114142
KEGG_OrthologyKO:K09409http://www.genome.jp/dbget-bin/www_bget?KO:K09409
MGIMGI:2148705http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2148705
PRINTSPR00053http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00053
PROSITEPS00028http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00028
PROSITEPS00658http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00658
PROSITEPS50039http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50039
PSORT-Bswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/kpsortb/swissprot:FOXP2_MOUSE
PSORT2swissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/kpsort2/swissprot:FOXP2_MOUSE
PSORTswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/kpsort/swissprot:FOXP2_MOUSE
PfamPF00250http://pfam.xfam.org/family/PF00250
PfamPF16159http://pfam.xfam.org/family/PF16159
Phobiusswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/kphobius/swissprot:FOXP2_MOUSE
PhylomeDBP58463http://phylomedb.org/?seqid=P58463
ProteinModelPortalP58463http://www.proteinmodelportal.org/query/uniprot/P58463
PubMed11358962http://www.ncbi.nlm.nih.gov/pubmed/11358962
PubMed12192408http://www.ncbi.nlm.nih.gov/pubmed/12192408
PubMed14516685http://www.ncbi.nlm.nih.gov/pubmed/14516685
PubMed14701752http://www.ncbi.nlm.nih.gov/pubmed/14701752
PubMed15489334http://www.ncbi.nlm.nih.gov/pubmed/15489334
PubMed16141072http://www.ncbi.nlm.nih.gov/pubmed/16141072
PubMed24179158http://www.ncbi.nlm.nih.gov/pubmed/24179158
RefSeqNP_001273536http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273536
RefSeqNP_444472http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_444472
RefSeqNP_997600http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_997600
SMARTSM00339http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00339
SMRP58463http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P58463
STRING10090.ENSMUSP00000031545http://string-db.org/newstring_cgi/show_network_section.pl?identifier=10090.ENSMUSP00000031545&targetmode=cogs
SUPFAMSSF46785http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785
UCSCuc009ayyhttp://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc009ayy&org=rat
UCSCuc012eiehttp://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc012eie&org=rat
UniGeneMm.332919http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Mm.332919
UniProtKB-ACP58463http://www.uniprot.org/uniprot/P58463
UniProtKBFOXP2_MOUSEhttp://www.uniprot.org/uniprot/FOXP2_MOUSE
chargeswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/charge/swissprot:FOXP2_MOUSE
eggNOGCOG5025http://eggnogapi.embl.de/nog_data/html/tree/COG5025
eggNOGKOG4385http://eggnogapi.embl.de/nog_data/html/tree/KOG4385
epestfindswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/epestfind/swissprot:FOXP2_MOUSE
garnierswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/garnier/swissprot:FOXP2_MOUSE
helixturnhelixswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:FOXP2_MOUSE
hmomentswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/hmoment/swissprot:FOXP2_MOUSE
iepswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/iep/swissprot:FOXP2_MOUSE
inforesidueswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/inforesidue/swissprot:FOXP2_MOUSE
octanolswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/octanol/swissprot:FOXP2_MOUSE
pepcoilswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/pepcoil/swissprot:FOXP2_MOUSE
pepdigestswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/pepdigest/swissprot:FOXP2_MOUSE
pepinfoswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/pepinfo/swissprot:FOXP2_MOUSE
pepnetswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/pepnet/swissprot:FOXP2_MOUSE
pepstatsswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/pepstats/swissprot:FOXP2_MOUSE
pepwheelswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/pepwheel/swissprot:FOXP2_MOUSE
pepwindowswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/pepwindow/swissprot:FOXP2_MOUSE
sigcleaveswissprot:FOXP2_MOUSEhttp://rest.g-language.org/emboss/sigcleave/swissprot:FOXP2_MOUSE