## Database ID URL or Descriptions # ALTERNATIVE PRODUCTS FOXP2_MOUSE Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P58463-1; Sequence=Displayed; Name=2; IsoId=P58463-2; Sequence=VSP_011540; Note=May be due to a competing acceptor splice site. No experimental confirmation available.; # CCDS CCDS19918 -. [P58463-1] # CCDS CCDS71726 -. [P58463-2] # ChiTaRS Foxp2 mouse # DEVELOPMENTAL STAGE FOXP2_MOUSE Expressed in developing lung, neural, intestinal and cardiovascular tissues. Expressed at a high level in the distal airway epithelium and at a low level in the proximal airway epithelium at 12.5 dpc, and restricted to the distal airway epithelium by 14.5 dpc. In the spinal cord, at 12.5 dpc, expressed in a subset of interneurons dorsal to motor neurons. At 16.5 dpc, expression in the brain is observed in the inner intermediate zone of the neopallial cortex and in the developing cerebral hemispheres. In the gastrointestinal system, at 12.5 expressed in the outer mesodermal layer and in the intestinal epithelium. By 16.5 dpc, expression is restricted to the outer longitudinal muscle layer of the intestine and stomach. In the cardiovascular system, at 14.5 dpc, expressed in the outflow tract region of the developing heart. By 16.5 dpc, observed in the outflow tract and atrium, but not in the ventricles. {ECO 0000269|PubMed 11358962, ECO 0000269|PubMed 14516685}. # DOMAIN FOXP2_MOUSE The leucine-zipper is required for dimerization and transcriptional repression. {ECO 0000269|PubMed 14701752}. # Ensembl ENSMUST00000031545 ENSMUSP00000031545; ENSMUSG00000029563. [P58463-1] # Ensembl ENSMUST00000115472 ENSMUSP00000111132; ENSMUSG00000029563. [P58463-2] # Ensembl ENSMUST00000115477 ENSMUSP00000111137; ENSMUSG00000029563. [P58463-1] # ExpressionAtlas P58463 baseline and differential # FUNCTION FOXP2_MOUSE Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. {ECO 0000269|PubMed 14701752, ECO 0000269|PubMed 24179158}. # GO_component GO:0005634 nucleus; IBA:GO_Central. # GO_function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding; IMP:NTNU_SB. # GO_function GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IMP:NTNU_SB. # GO_function GO:0003677 DNA binding; ISS:UniProtKB. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:MGI. # GO_function GO:0042803 protein homodimerization activity; ISS:UniProtKB. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0046982 protein heterodimerization activity; IPI:MGI. # GO_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter; IMP:NTNU_SB. # GO_process GO:0002053 positive regulation of mesenchymal cell proliferation; IGI:MGI. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0007519 skeletal muscle tissue development; IGI:MGI. # GO_process GO:0009791 post-embryonic development; IMP:MGI. # GO_process GO:0021549 cerebellum development; IMP:MGI. # GO_process GO:0021757 caudate nucleus development; ISS:UniProtKB. # GO_process GO:0021758 putamen development; ISS:UniProtKB. # GO_process GO:0021987 cerebral cortex development; IEA:Ensembl. # GO_process GO:0030324 lung development; IGI:MGI. # GO_process GO:0040007 growth; IMP:MGI. # GO_process GO:0042297 vocal learning; IMP:MGI. # GO_process GO:0043010 camera-type eye development; IMP:MGI. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:MGI. # GO_process GO:0048286 lung alveolus development; IMP:MGI. # GO_process GO:0048745 smooth muscle tissue development; IGI:MGI. # GO_process GO:0050679 positive regulation of epithelial cell proliferation; IGI:MGI. # GO_process GO:0060013 righting reflex; IMP:MGI. # GO_process GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis; IGI:MGI. # GOslim_component GO:0005634 nucleus # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0040007 growth # GOslim_process GO:0048856 anatomical structure development # GOslim_process GO:0050877 neurological system process # Gene3D 1.10.10.10 -; 1. # Genevisible P58463 MM # InterPro IPR001766 Fork_head_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR030456 TF_fork_head_CS_2 # InterPro IPR032354 FOXP-CC # KEGG_Brite ko03000 Transcription factors # MGI MGI:2148705 Foxp2 # Organism FOXP2_MOUSE Mus musculus (Mouse) # PRINTS PR00053 FORKHEAD # PROSITE PS00028 ZINC_FINGER_C2H2_1 # PROSITE PS00658 FORK_HEAD_2 # PROSITE PS50039 FORK_HEAD_3 # Pfam PF00250 Forkhead # Pfam PF16159 FOXP-CC # Proteomes UP000000589 Chromosome 6 # RecName FOXP2_MOUSE Forkhead box protein P2 # RefSeq NP_001273536 NM_001286607.1. [P58463-2] # RefSeq NP_444472 NM_053242.4. [P58463-1] # RefSeq NP_997600 NM_212435.1. [P58463-1] # SIMILARITY Contains 1 C2H2-type zinc finger. {ECO 0000305}. # SIMILARITY Contains 1 fork-head DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00089}. # SMART SM00339 FH # SUBCELLULAR LOCATION FOXP2_MOUSE Nucleus {ECO 0000305}. # SUBUNIT FOXP2_MOUSE Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding (By similarity). Interacts with CTBP1 (PubMed 14701752). Interacts with FOXP1 (By similarity). {ECO 0000250|UniProtKB O15409, ECO 0000269|PubMed 14701752}. # SUPFAM SSF46785 SSF46785 # TISSUE SPECIFICITY FOXP2_MOUSE Highest expression in lung. Lower expression in spleen, skeletal muscle, brain, kidney and small intestine. # UCSC uc009ayy mouse. [P58463-1] # UCSC uc012eie mouse. [P58463-2] # eggNOG COG5025 LUCA # eggNOG KOG4385 Eukaryota BLAST swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/kblast/swissprot:FOXP2_MOUSE COXPRESdb 114142 http://coxpresdb.jp/data/gene/114142.shtml CleanEx MM_FOXP2 http://www.cleanex.isb-sib.ch/cgi-bin/get_doc?db=cleanex&format=nice&entry=MM_FOXP2 DOI 10.1016/S0925-4773(03)00116-3 http://dx.doi.org/10.1016/S0925-4773(03)00116-3 DOI 10.1038/nature01025 http://dx.doi.org/10.1038/nature01025 DOI 10.1074/jbc.M100636200 http://dx.doi.org/10.1074/jbc.M100636200 DOI 10.1101/gr.2596504 http://dx.doi.org/10.1101/gr.2596504 DOI 10.1126/science.1112014 http://dx.doi.org/10.1126/science.1112014 DOI 10.1126/science.1245079 http://dx.doi.org/10.1126/science.1245079 DOI 10.1128/MCB.24.2.809-822.2004 http://dx.doi.org/10.1128/MCB.24.2.809-822.2004 EMBL AF339106 http://www.ebi.ac.uk/ena/data/view/AF339106 EMBL AK082361 http://www.ebi.ac.uk/ena/data/view/AK082361 EMBL AY079003 http://www.ebi.ac.uk/ena/data/view/AY079003 EMBL BC058960 http://www.ebi.ac.uk/ena/data/view/BC058960 EMBL BC062926 http://www.ebi.ac.uk/ena/data/view/BC062926 Ensembl ENSMUST00000031545 http://www.ensembl.org/id/ENSMUST00000031545 Ensembl ENSMUST00000115472 http://www.ensembl.org/id/ENSMUST00000115472 Ensembl ENSMUST00000115477 http://www.ensembl.org/id/ENSMUST00000115477 G-Links FOXP2_MOUSE http://link.g-language.org/FOXP2_MOUSE/format=tsv GO_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GO_function GO:0000978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000978 GO_function GO:0001078 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001078 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0042803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0046982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982 GO_process GO:0000122 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000122 GO_process GO:0002053 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002053 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0007519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007519 GO_process GO:0009791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009791 GO_process GO:0021549 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021549 GO_process GO:0021757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021757 GO_process GO:0021758 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021758 GO_process GO:0021987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021987 GO_process GO:0030324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030324 GO_process GO:0040007 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007 GO_process GO:0042297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042297 GO_process GO:0043010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043010 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0048286 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048286 GO_process GO:0048745 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048745 GO_process GO:0050679 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050679 GO_process GO:0060013 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060013 GO_process GO:0060501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060501 GOslim_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0040007 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040007 GOslim_process GO:0048856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856 GOslim_process GO:0050877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050877 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 114142 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114142 GeneTree ENSGT00800000124014 http://asia.ensembl.org/Multi/GeneTree/Image?gt=ENSGT00800000124014 HOGENOM HOG000092089 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000092089&db=HOGENOM6 HOVERGEN HBG051657 http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051657&db=HOVERGEN InParanoid P58463 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P58463 InterPro IPR001766 http://www.ebi.ac.uk/interpro/entry/IPR001766 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR030456 http://www.ebi.ac.uk/interpro/entry/IPR030456 InterPro IPR032354 http://www.ebi.ac.uk/interpro/entry/IPR032354 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene mmu:114142 http://www.genome.jp/dbget-bin/www_bget?mmu:114142 KEGG_Orthology KO:K09409 http://www.genome.jp/dbget-bin/www_bget?KO:K09409 MGI MGI:2148705 http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2148705 PRINTS PR00053 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00053 PROSITE PS00028 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00028 PROSITE PS00658 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00658 PROSITE PS50039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50039 PSORT swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/kpsort/swissprot:FOXP2_MOUSE PSORT-B swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/kpsortb/swissprot:FOXP2_MOUSE PSORT2 swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/kpsort2/swissprot:FOXP2_MOUSE Pfam PF00250 http://pfam.xfam.org/family/PF00250 Pfam PF16159 http://pfam.xfam.org/family/PF16159 Phobius swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/kphobius/swissprot:FOXP2_MOUSE PhylomeDB P58463 http://phylomedb.org/?seqid=P58463 ProteinModelPortal P58463 http://www.proteinmodelportal.org/query/uniprot/P58463 PubMed 11358962 http://www.ncbi.nlm.nih.gov/pubmed/11358962 PubMed 12192408 http://www.ncbi.nlm.nih.gov/pubmed/12192408 PubMed 14516685 http://www.ncbi.nlm.nih.gov/pubmed/14516685 PubMed 14701752 http://www.ncbi.nlm.nih.gov/pubmed/14701752 PubMed 15489334 http://www.ncbi.nlm.nih.gov/pubmed/15489334 PubMed 16141072 http://www.ncbi.nlm.nih.gov/pubmed/16141072 PubMed 24179158 http://www.ncbi.nlm.nih.gov/pubmed/24179158 RefSeq NP_001273536 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001273536 RefSeq NP_444472 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_444472 RefSeq NP_997600 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_997600 SMART SM00339 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00339 SMR P58463 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P58463 STRING 10090.ENSMUSP00000031545 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=10090.ENSMUSP00000031545&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UCSC uc009ayy http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc009ayy&org=rat UCSC uc012eie http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc012eie&org=rat UniGene Mm.332919 http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=At&CID=Mm.332919 UniProtKB FOXP2_MOUSE http://www.uniprot.org/uniprot/FOXP2_MOUSE UniProtKB-AC P58463 http://www.uniprot.org/uniprot/P58463 charge swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/charge/swissprot:FOXP2_MOUSE eggNOG COG5025 http://eggnogapi.embl.de/nog_data/html/tree/COG5025 eggNOG KOG4385 http://eggnogapi.embl.de/nog_data/html/tree/KOG4385 epestfind swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/epestfind/swissprot:FOXP2_MOUSE garnier swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/garnier/swissprot:FOXP2_MOUSE helixturnhelix swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/helixturnhelix/swissprot:FOXP2_MOUSE hmoment swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/hmoment/swissprot:FOXP2_MOUSE iep swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/iep/swissprot:FOXP2_MOUSE inforesidue swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/inforesidue/swissprot:FOXP2_MOUSE octanol swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/octanol/swissprot:FOXP2_MOUSE pepcoil swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/pepcoil/swissprot:FOXP2_MOUSE pepdigest swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/pepdigest/swissprot:FOXP2_MOUSE pepinfo swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/pepinfo/swissprot:FOXP2_MOUSE pepnet swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/pepnet/swissprot:FOXP2_MOUSE pepstats swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/pepstats/swissprot:FOXP2_MOUSE pepwheel swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/pepwheel/swissprot:FOXP2_MOUSE pepwindow swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/pepwindow/swissprot:FOXP2_MOUSE sigcleave swissprot:FOXP2_MOUSE http://rest.g-language.org/emboss/sigcleave/swissprot:FOXP2_MOUSE