| # DOMAIN | FOXP2_PANPA | The leucine-zipper is required for dimerization and transcriptional repression. {ECO 0000250}. |
| # FUNCTION | FOXP2_PANPA | Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). {ECO 0000250}. |
| # GO_component | GO:0005634 | nucleus; IEA:UniProtKB-SubCell. |
| # GO_function | GO:0003677 | DNA binding; ISS:UniProtKB. |
| # GO_function | GO:0003700 | transcription factor activity, sequence-specific DNA binding; IEA:InterPro. |
| # GO_function | GO:0042803 | protein homodimerization activity; ISS:UniProtKB. |
| # GO_function | GO:0043565 | sequence-specific DNA binding; IEA:InterPro. |
| # GO_function | GO:0046872 | metal ion binding; IEA:UniProtKB-KW. |
| # GO_process | GO:0006351 | transcription, DNA-templated; IEA:UniProtKB-KW. |
| # GO_process | GO:0021757 | caudate nucleus development; ISS:UniProtKB. |
| # GO_process | GO:0021758 | putamen development; ISS:UniProtKB. |
| # GOslim_component | GO:0005634 | nucleus |
| # GOslim_function | GO:0001071 | nucleic acid binding transcription factor activity |
| # GOslim_function | GO:0003674 | molecular_function |
| # GOslim_function | GO:0003677 | DNA binding |
| # GOslim_function | GO:0043167 | ion binding |
| # GOslim_process | GO:0009058 | biosynthetic process |
| # GOslim_process | GO:0034641 | cellular nitrogen compound metabolic process |
| # GOslim_process | GO:0048856 | anatomical structure development |
| # Gene3D | 1.10.10.10 | -; 1. |
| # InterPro | IPR001766 | Fork_head_dom |
| # InterPro | IPR011991 | WHTH_DNA-bd_dom |
| # InterPro | IPR030456 | TF_fork_head_CS_2 |
| # InterPro | IPR032354 | FOXP-CC |
| # KEGG_Brite | ko03000 | Transcription factors |
| # Organism | FOXP2_PANPA | Pan paniscus (Pygmy chimpanzee) (Bonobo) |
| # PRINTS | PR00053 | FORKHEAD |
| # PROSITE | PS00028 | ZINC_FINGER_C2H2_1 |
| # PROSITE | PS00658 | FORK_HEAD_2 |
| # PROSITE | PS50039 | FORK_HEAD_3 |
| # Pfam | PF00250 | Forkhead |
| # Pfam | PF16159 | FOXP-CC |
| # RecName | FOXP2_PANPA | Forkhead box protein P2 |
| # RefSeq | NP_001266127 | NM_001279198.1 |
| # SIMILARITY | Contains 1 C2H2-type zinc finger. {ECO | 0000305}. |
| # SIMILARITY | Contains 1 fork-head DNA-binding domain. {ECO:0000255|PROSITE-ProRule | PRU00089}. |
| # SMART | SM00339 | FH |
| # SUBCELLULAR LOCATION | FOXP2_PANPA | Nucleus {ECO 0000305}. |
| # SUBUNIT | FOXP2_PANPA | Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Interacts with FOXP1 (By similarity). {ECO 0000250|UniProtKB O15409, ECO 0000250|UniProtKB P58463}. |
| # SUPFAM | SSF46785 | SSF46785 |
| BLAST | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/kblast/swissprot:FOXP2_PANPA |
| EMBL | AY143179 | http://www.ebi.ac.uk/ena/data/view/AY143179 |
| G-Links | FOXP2_PANPA | http://link.g-language.org/FOXP2_PANPA/format=tsv |
| GO_component | GO:0005634 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 |
| GO_function | GO:0003677 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 |
| GO_function | GO:0003700 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 |
| GO_function | GO:0042803 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803 |
| GO_function | GO:0043565 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 |
| GO_function | GO:0046872 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 |
| GO_process | GO:0006351 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 |
| GO_process | GO:0021757 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021757 |
| GO_process | GO:0021758 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021758 |
| GOslim_component | GO:0005634 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 |
| GOslim_function | GO:0001071 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 |
| GOslim_function | GO:0003674 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 |
| GOslim_function | GO:0003677 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 |
| GOslim_function | GO:0043167 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 |
| GOslim_process | GO:0009058 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 |
| GOslim_process | GO:0034641 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 |
| GOslim_process | GO:0048856 | http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856 |
| Gene3D | 1.10.10.10 | http://www.cathdb.info/version/latest/superfamily/1.10.10.10 |
| GeneID | 100990292 | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100990292 |
| HOVERGEN | HBG051657 | http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051657&db=HOVERGEN |
| InterPro | IPR001766 | http://www.ebi.ac.uk/interpro/entry/IPR001766 |
| InterPro | IPR011991 | http://www.ebi.ac.uk/interpro/entry/IPR011991 |
| InterPro | IPR030456 | http://www.ebi.ac.uk/interpro/entry/IPR030456 |
| InterPro | IPR032354 | http://www.ebi.ac.uk/interpro/entry/IPR032354 |
| KEGG_Brite | ko03000 | http://www.genome.jp/dbget-bin/www_bget?ko03000 |
| KEGG_Gene | pps:100990292 | http://www.genome.jp/dbget-bin/www_bget?pps:100990292 |
| KEGG_Orthology | KO:K09409 | http://www.genome.jp/dbget-bin/www_bget?KO:K09409 |
| OrthoDB | EOG091G08HY | http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HY |
| PRINTS | PR00053 | http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00053 |
| PROSITE | PS00028 | http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00028 |
| PROSITE | PS00658 | http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00658 |
| PROSITE | PS50039 | http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50039 |
| PSORT-B | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/kpsortb/swissprot:FOXP2_PANPA |
| PSORT2 | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/kpsort2/swissprot:FOXP2_PANPA |
| PSORT | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/kpsort/swissprot:FOXP2_PANPA |
| Pfam | PF00250 | http://pfam.xfam.org/family/PF00250 |
| Pfam | PF16159 | http://pfam.xfam.org/family/PF16159 |
| Phobius | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/kphobius/swissprot:FOXP2_PANPA |
| ProteinModelPortal | Q8HZ00 | http://www.proteinmodelportal.org/query/uniprot/Q8HZ00 |
| PubMed | 12524352 | http://www.ncbi.nlm.nih.gov/pubmed/12524352 |
| RefSeq | NP_001266127 | http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001266127 |
| SMART | SM00339 | http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00339 |
| SMR | Q8HZ00 | http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8HZ00 |
| SUPFAM | SSF46785 | http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 |
| UniProtKB-AC | Q8HZ00 | http://www.uniprot.org/uniprot/Q8HZ00 |
| UniProtKB | FOXP2_PANPA | http://www.uniprot.org/uniprot/FOXP2_PANPA |
| charge | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/charge/swissprot:FOXP2_PANPA |
| epestfind | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/epestfind/swissprot:FOXP2_PANPA |
| garnier | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/garnier/swissprot:FOXP2_PANPA |
| helixturnhelix | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/helixturnhelix/swissprot:FOXP2_PANPA |
| hmoment | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/hmoment/swissprot:FOXP2_PANPA |
| iep | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/iep/swissprot:FOXP2_PANPA |
| inforesidue | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/inforesidue/swissprot:FOXP2_PANPA |
| octanol | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/octanol/swissprot:FOXP2_PANPA |
| pepcoil | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/pepcoil/swissprot:FOXP2_PANPA |
| pepdigest | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/pepdigest/swissprot:FOXP2_PANPA |
| pepinfo | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/pepinfo/swissprot:FOXP2_PANPA |
| pepnet | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/pepnet/swissprot:FOXP2_PANPA |
| pepstats | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/pepstats/swissprot:FOXP2_PANPA |
| pepwheel | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/pepwheel/swissprot:FOXP2_PANPA |
| pepwindow | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/pepwindow/swissprot:FOXP2_PANPA |
| sigcleave | swissprot:FOXP2_PANPA | http://rest.g-language.org/emboss/sigcleave/swissprot:FOXP2_PANPA |