## Database ID URL or Descriptions # DOMAIN FOXP2_PANPA The leucine-zipper is required for dimerization and transcriptional repression. {ECO 0000250}. # FUNCTION FOXP2_PANPA Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). {ECO 0000250}. # GO_component GO:0005634 nucleus; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; ISS:UniProtKB. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0042803 protein homodimerization activity; ISS:UniProtKB. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0021757 caudate nucleus development; ISS:UniProtKB. # GO_process GO:0021758 putamen development; ISS:UniProtKB. # GOslim_component GO:0005634 nucleus # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0048856 anatomical structure development # Gene3D 1.10.10.10 -; 1. # InterPro IPR001766 Fork_head_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR030456 TF_fork_head_CS_2 # InterPro IPR032354 FOXP-CC # KEGG_Brite ko03000 Transcription factors # Organism FOXP2_PANPA Pan paniscus (Pygmy chimpanzee) (Bonobo) # PRINTS PR00053 FORKHEAD # PROSITE PS00028 ZINC_FINGER_C2H2_1 # PROSITE PS00658 FORK_HEAD_2 # PROSITE PS50039 FORK_HEAD_3 # Pfam PF00250 Forkhead # Pfam PF16159 FOXP-CC # RecName FOXP2_PANPA Forkhead box protein P2 # RefSeq NP_001266127 NM_001279198.1 # SIMILARITY Contains 1 C2H2-type zinc finger. {ECO 0000305}. # SIMILARITY Contains 1 fork-head DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00089}. # SMART SM00339 FH # SUBCELLULAR LOCATION FOXP2_PANPA Nucleus {ECO 0000305}. # SUBUNIT FOXP2_PANPA Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Interacts with FOXP1 (By similarity). {ECO 0000250|UniProtKB O15409, ECO 0000250|UniProtKB P58463}. # SUPFAM SSF46785 SSF46785 BLAST swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/kblast/swissprot:FOXP2_PANPA EMBL AY143179 http://www.ebi.ac.uk/ena/data/view/AY143179 G-Links FOXP2_PANPA http://link.g-language.org/FOXP2_PANPA/format=tsv GO_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0042803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0021757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021757 GO_process GO:0021758 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021758 GOslim_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0048856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 100990292 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100990292 HOVERGEN HBG051657 http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051657&db=HOVERGEN InterPro IPR001766 http://www.ebi.ac.uk/interpro/entry/IPR001766 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR030456 http://www.ebi.ac.uk/interpro/entry/IPR030456 InterPro IPR032354 http://www.ebi.ac.uk/interpro/entry/IPR032354 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene pps:100990292 http://www.genome.jp/dbget-bin/www_bget?pps:100990292 KEGG_Orthology KO:K09409 http://www.genome.jp/dbget-bin/www_bget?KO:K09409 OrthoDB EOG091G08HY http://cegg.unige.ch/orthodb/results?searchtext=EOG091G08HY PRINTS PR00053 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00053 PROSITE PS00028 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00028 PROSITE PS00658 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00658 PROSITE PS50039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50039 PSORT swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/kpsort/swissprot:FOXP2_PANPA PSORT-B swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/kpsortb/swissprot:FOXP2_PANPA PSORT2 swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/kpsort2/swissprot:FOXP2_PANPA Pfam PF00250 http://pfam.xfam.org/family/PF00250 Pfam PF16159 http://pfam.xfam.org/family/PF16159 Phobius swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/kphobius/swissprot:FOXP2_PANPA ProteinModelPortal Q8HZ00 http://www.proteinmodelportal.org/query/uniprot/Q8HZ00 PubMed 12524352 http://www.ncbi.nlm.nih.gov/pubmed/12524352 RefSeq NP_001266127 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_001266127 SMART SM00339 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00339 SMR Q8HZ00 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q8HZ00 SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB FOXP2_PANPA http://www.uniprot.org/uniprot/FOXP2_PANPA UniProtKB-AC Q8HZ00 http://www.uniprot.org/uniprot/Q8HZ00 charge swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/charge/swissprot:FOXP2_PANPA epestfind swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/epestfind/swissprot:FOXP2_PANPA garnier swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/garnier/swissprot:FOXP2_PANPA helixturnhelix swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/helixturnhelix/swissprot:FOXP2_PANPA hmoment swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/hmoment/swissprot:FOXP2_PANPA iep swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/iep/swissprot:FOXP2_PANPA inforesidue swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/inforesidue/swissprot:FOXP2_PANPA octanol swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/octanol/swissprot:FOXP2_PANPA pepcoil swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/pepcoil/swissprot:FOXP2_PANPA pepdigest swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/pepdigest/swissprot:FOXP2_PANPA pepinfo swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/pepinfo/swissprot:FOXP2_PANPA pepnet swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/pepnet/swissprot:FOXP2_PANPA pepstats swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/pepstats/swissprot:FOXP2_PANPA pepwheel swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/pepwheel/swissprot:FOXP2_PANPA pepwindow swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/pepwindow/swissprot:FOXP2_PANPA sigcleave swissprot:FOXP2_PANPA http://rest.g-language.org/emboss/sigcleave/swissprot:FOXP2_PANPA