## Database ID URL or Descriptions # DOMAIN FOXP2_PONPY The leucine-zipper is required for dimerization and transcriptional repression. {ECO 0000250}. # FUNCTION FOXP2_PONPY Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). {ECO 0000250}. # GO_component GO:0005634 nucleus; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; ISS:UniProtKB. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0042803 protein homodimerization activity; ISS:UniProtKB. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0021757 caudate nucleus development; ISS:UniProtKB. # GO_process GO:0021758 putamen development; ISS:UniProtKB. # GOslim_component GO:0005634 nucleus # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0048856 anatomical structure development # Gene3D 1.10.10.10 -; 1. # InterPro IPR001766 Fork_head_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR030456 TF_fork_head_CS_2 # InterPro IPR032354 FOXP-CC # Organism FOXP2_PONPY Pongo pygmaeus (Bornean orangutan) # PRINTS PR00053 FORKHEAD # PROSITE PS00028 ZINC_FINGER_C2H2_1 # PROSITE PS00658 FORK_HEAD_2 # PROSITE PS50039 FORK_HEAD_3 # Pfam PF00250 Forkhead # Pfam PF16159 FOXP-CC # RecName FOXP2_PONPY Forkhead box protein P2 # SIMILARITY Contains 1 C2H2-type zinc finger. {ECO 0000305}. # SIMILARITY Contains 1 fork-head DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00089}. # SMART SM00339 FH # SUBCELLULAR LOCATION FOXP2_PONPY Nucleus {ECO 0000305}. # SUBUNIT FOXP2_PONPY Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Interacts with FOXP1 (By similarity). {ECO 0000250|UniProtKB O15409, ECO 0000250|UniProtKB P58463}. # SUPFAM SSF46785 SSF46785 BLAST swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/kblast/swissprot:FOXP2_PONPY DOI 10.1038/nature01025 http://dx.doi.org/10.1038/nature01025 EMBL AF512949 http://www.ebi.ac.uk/ena/data/view/AF512949 EMBL AF515053 http://www.ebi.ac.uk/ena/data/view/AF515053 EMBL AY064600 http://www.ebi.ac.uk/ena/data/view/AY064600 EMBL AY064601 http://www.ebi.ac.uk/ena/data/view/AY064601 EMBL AY064602 http://www.ebi.ac.uk/ena/data/view/AY064602 EMBL AY064603 http://www.ebi.ac.uk/ena/data/view/AY064603 EMBL AY064604 http://www.ebi.ac.uk/ena/data/view/AY064604 EMBL AY064605 http://www.ebi.ac.uk/ena/data/view/AY064605 EMBL AY064606 http://www.ebi.ac.uk/ena/data/view/AY064606 EMBL AY064607 http://www.ebi.ac.uk/ena/data/view/AY064607 EMBL AY064608 http://www.ebi.ac.uk/ena/data/view/AY064608 EMBL AY064609 http://www.ebi.ac.uk/ena/data/view/AY064609 EMBL AY064610 http://www.ebi.ac.uk/ena/data/view/AY064610 EMBL AY064611 http://www.ebi.ac.uk/ena/data/view/AY064611 EMBL AY064612 http://www.ebi.ac.uk/ena/data/view/AY064612 EMBL AY064613 http://www.ebi.ac.uk/ena/data/view/AY064613 EMBL AY064614 http://www.ebi.ac.uk/ena/data/view/AY064614 EMBL AY143181 http://www.ebi.ac.uk/ena/data/view/AY143181 EMBL DQ789573 http://www.ebi.ac.uk/ena/data/view/DQ789573 G-Links FOXP2_PONPY http://link.g-language.org/FOXP2_PONPY/format=tsv GO_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0042803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0021757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021757 GO_process GO:0021758 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0021758 GOslim_component GO:0005634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005634 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0048856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 HOGENOM HOG000092089 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000092089&db=HOGENOM6 HOVERGEN HBG051657 http://pbil.univ-lyon1.fr/cgi-bin/acnuc-ac2tree?query=HBG051657&db=HOVERGEN InterPro IPR001766 http://www.ebi.ac.uk/interpro/entry/IPR001766 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR030456 http://www.ebi.ac.uk/interpro/entry/IPR030456 InterPro IPR032354 http://www.ebi.ac.uk/interpro/entry/IPR032354 PRINTS PR00053 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00053 PROSITE PS00028 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00028 PROSITE PS00658 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00658 PROSITE PS50039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50039 PSORT swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/kpsort/swissprot:FOXP2_PONPY PSORT-B swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/kpsortb/swissprot:FOXP2_PONPY PSORT2 swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/kpsort2/swissprot:FOXP2_PONPY Pfam PF00250 http://pfam.xfam.org/family/PF00250 Pfam PF16159 http://pfam.xfam.org/family/PF16159 Phobius swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/kphobius/swissprot:FOXP2_PONPY ProteinModelPortal Q8MJ98 http://www.proteinmodelportal.org/query/uniprot/Q8MJ98 PubMed 12192408 http://www.ncbi.nlm.nih.gov/pubmed/12192408 PubMed 12524352 http://www.ncbi.nlm.nih.gov/pubmed/12524352 SMART SM00339 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00339 SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB FOXP2_PONPY http://www.uniprot.org/uniprot/FOXP2_PONPY UniProtKB-AC Q8MJ98 http://www.uniprot.org/uniprot/Q8MJ98 charge swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/charge/swissprot:FOXP2_PONPY epestfind swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/epestfind/swissprot:FOXP2_PONPY garnier swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/garnier/swissprot:FOXP2_PONPY helixturnhelix swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/helixturnhelix/swissprot:FOXP2_PONPY hmoment swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/hmoment/swissprot:FOXP2_PONPY iep swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/iep/swissprot:FOXP2_PONPY inforesidue swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/inforesidue/swissprot:FOXP2_PONPY octanol swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/octanol/swissprot:FOXP2_PONPY pepcoil swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/pepcoil/swissprot:FOXP2_PONPY pepdigest swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/pepdigest/swissprot:FOXP2_PONPY pepinfo swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/pepinfo/swissprot:FOXP2_PONPY pepnet swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/pepnet/swissprot:FOXP2_PONPY pepstats swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/pepstats/swissprot:FOXP2_PONPY pepwheel swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/pepwheel/swissprot:FOXP2_PONPY pepwindow swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/pepwindow/swissprot:FOXP2_PONPY sigcleave swissprot:FOXP2_PONPY http://rest.g-language.org/emboss/sigcleave/swissprot:FOXP2_PONPY