DataBaseIDURL or Descriptions
# BioGrid4261539146
# CDDcd06571Bac_DnaA_C
# EcoGeneEG10235dnaA
# FUNCTIONDNAA_ECOLIAlso required for replication of plasmid DNA; binds 4 dnaA boxes in the minimal plasmid RK2 replication origin (oriV).
# FUNCTIONDNAA_ECOLIPlays a key role in the initiation and regulation of chromosomal replication. Binds in an ATP-dependent fashion to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex exactly once per cell cycle. Binds the DnaA box (consensus sequence 5'-TTATC[CA]A[CA]A-3'); subsequent binding of DNA polymerase III subunits leads to replisome formation. The DnaA-ATP form converts to DnaA-ADP; once converted to ADP the protein cannot initiate replication, ensuring only 1 round of replication per cell cycle. DnaA can inhibit its own gene expression as well as that of other genes such as dam, rpoH, ftsA and mioC.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_componentGO:0005886plasma membrane; IDA:EcoCyc.
# GO_functionGO:0003677DNA binding; IDA:EcoCyc.
# GO_functionGO:0003688DNA replication origin binding; IMP:EcoCyc.
# GO_functionGO:0005524ATP binding; IEA:UniProtKB-HAMAP.
# GO_functionGO:0043565sequence-specific DNA binding; IDA:EcoliWiki.
# GO_processGO:0006260DNA replication; IMP:EcoliWiki.
# GO_processGO:0006270DNA replication initiation; IBA:GO_Central.
# GO_processGO:0006275regulation of DNA replication; IMP:EcoliWiki.
# GO_processGO:0006351transcription, DNA-templated; IEA:UniProtKB-KW.
# GO_processGO:0006355regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
# GO_processGO:0008156negative regulation of DNA replication; IEA:UniProtKB-KW.
# GOslim_componentGO:0005829cytosol
# GOslim_componentGO:0005886plasma membrane
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0009058biosynthetic process
# GOslim_processGO:0034641cellular nitrogen compound metabolic process
# Gene3D1.10.1750.10-; 1.
# Gene3D3.40.50.300-; 1.
# HAMAPMF_00377DnaA_bact
# INTERACTIONDNAA_ECOLIP66817 diaA; NbExp=5; IntAct=EBI-548951, EBI-1125806; P0ACB0 dnaB; NbExp=4; IntAct=EBI-548951, EBI-548978; P0ABT2 dps; NbExp=2; IntAct=EBI-548951, EBI-549640; P69931 hda; NbExp=2; IntAct=EBI-548951, EBI-545453; P0ACF0 hupA; NbExp=5; IntAct=EBI-548951, EBI-547648; P60422 rplB; NbExp=4; IntAct=EBI-548951, EBI-543515;
# IntActP0300444
# InterProIPR001957Chromosome_initiator_DnaA
# InterProIPR003593AAA+_ATPase
# InterProIPR010921Trp_repressor/repl_initiator
# InterProIPR013159DnaA_C
# InterProIPR013317DnaA
# InterProIPR018312Chromosome_initiator_DnaA_CS
# InterProIPR020591Chromosome_initiator_DnaA-like
# InterProIPR024633DnaA_N_dom
# InterProIPR027417P-loop_NTPase
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03036 Chromosome
# KEGG_Pathwayko02020Two-component system
# KEGG_Pathwayko04112Cell cycle - Caulobacter
# MISCELLANEOUSDNAA_ECOLIAt least 4 systems specifically target DnaA to prevent more than 1 round of replication initiation per cell cycle. 1 SeqA binds to and sequesters hemimethylated oriC, preventing DnaA binding. 2 ATP-DnaA binds to the chromosomal datA locus, sequestering ATP-DnaA. 3 ATP-DnaA binds to its own promoter, repressing transcription. 4 RIDA (regulatory inactivation of DnaA) via Hda and the DNA-loaded beta clamp hydrolyzes ATP-DnaA to ADP-DnaA.
# OrganismDNAA_ECOLIEscherichia coli (strain K12)
# PATRIC32122901VBIEscCol129921_3826
# PDB1J1VX-ray; 2.10 A; A=374-467
# PDB2E0GNMR; -; A=2-108
# PIRG65172IQECDA
# PRINTSPR00051DNAA
# PROSITEPS01008DNAA
# PfamPF00308Bac_DnaA
# PfamPF08299Bac_DnaA_C
# PfamPF11638DnaA_N
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDNAA_ECOLIChromosomal replication initiator protein DnaA
# RefSeqNP_418157NC_000913.3
# RefSeqWP_000059111NZ_LN832404.1
# SEQUENCE CAUTIONSequence=AAA62053.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO0000305};
# SIMILARITYBelongs to the DnaA family. {ECO0000305}.
# SMARTSM00382AAA
# SMARTSM00760Bac_DnaA_C
# SUBCELLULAR LOCATIONDNAA_ECOLICytoplasm.
# SUBUNITDNAA_ECOLISome 20 DnaA protein molecules bind their sites in oriC. Forms the RIDA (regulatory inactivation of DnaA) complex with ATP- DnaA, ADP-Hda and the DNA-loaded sliding beta clamp (dnaN). Interacts with DiaA; this stimulates the association of DnaA with the origin of replication. {ECO 0000269|PubMed 17699754, ECO 0000269|PubMed 18977760}.
# SUPFAMSSF48295SSF48295
# SUPFAMSSF52540SSF52540
# TIGRFAMsTIGR00362DnaA
# eggNOGCOG0593LUCA
# eggNOGENOG4105CI4Bacteria
BLASTswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:DNAA_ECOLI
BioCycECOL316407:JW3679-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW3679-MONOMER
BioCycEcoCyc:PD03831http://biocyc.org/getid?id=EcoCyc:PD03831
COGCOG0593http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0593
DIPDIP-9455Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9455N
DOI10.1002/elps.1150180805http://dx.doi.org/10.1002/elps.1150180805
DOI10.1006/geno.1993.1230http://dx.doi.org/10.1006/geno.1993.1230
DOI10.1016/0168-9525(89)90118-2http://dx.doi.org/10.1016/0168-9525(89)90118-2
DOI10.1016/0378-1119(84)90253-1http://dx.doi.org/10.1016/0378-1119(84)90253-1
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1074/jbc.272.32.20173http://dx.doi.org/10.1074/jbc.272.32.20173
DOI10.1074/jbc.M803158200http://dx.doi.org/10.1074/jbc.M803158200
DOI10.1093/nar/10.22.7373http://dx.doi.org/10.1093/nar/10.22.7373
DOI10.1093/nar/gkg309http://dx.doi.org/10.1093/nar/gkg309
DOI10.1101/gad.1561207http://dx.doi.org/10.1101/gad.1561207
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
DOI10.1128/JB.187.16.5605-5613.2005http://dx.doi.org/10.1128/JB.187.16.5605-5613.2005
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLJ01602http://www.ebi.ac.uk/ena/data/view/J01602
EMBLL10328http://www.ebi.ac.uk/ena/data/view/L10328
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLX01861http://www.ebi.ac.uk/ena/data/view/X01861
EchoBASEEB0231http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0231
EcoGeneEG10235http://www.ecogene.org/geneInfo.php?eg_id=EG10235
EnsemblBacteriaAAC76725http://www.ensemblgenomes.org/id/AAC76725
EnsemblBacteriaAAC76725http://www.ensemblgenomes.org/id/AAC76725
EnsemblBacteriaBAE77592http://www.ensemblgenomes.org/id/BAE77592
EnsemblBacteriaBAE77592http://www.ensemblgenomes.org/id/BAE77592
EnsemblBacteriaBAE77592http://www.ensemblgenomes.org/id/BAE77592
EnsemblBacteriab3702http://www.ensemblgenomes.org/id/b3702
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_componentGO:0005886http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003688http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003688
GO_functionGO:0005524http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_functionGO:0043565http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565
GO_processGO:0006260http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260
GO_processGO:0006270http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006270
GO_processGO:0006275http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006275
GO_processGO:0006351http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351
GO_processGO:0006355http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355
GO_processGO:0008156http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008156
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_componentGO:0005886http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_processGO:0034641http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
Gene3D1.10.1750.10http://www.cathdb.info/version/latest/superfamily/1.10.1750.10
Gene3D3.40.50.300http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneID948217http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948217
HAMAPMF_00377http://hamap.expasy.org/unirule/MF_00377
HOGENOMHOG000235659http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000235659&db=HOGENOM6
InParanoidP03004http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P03004
IntActP03004http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P03004*
InterProIPR001957http://www.ebi.ac.uk/interpro/entry/IPR001957
InterProIPR003593http://www.ebi.ac.uk/interpro/entry/IPR003593
InterProIPR010921http://www.ebi.ac.uk/interpro/entry/IPR010921
InterProIPR013159http://www.ebi.ac.uk/interpro/entry/IPR013159
InterProIPR013317http://www.ebi.ac.uk/interpro/entry/IPR013317
InterProIPR018312http://www.ebi.ac.uk/interpro/entry/IPR018312
InterProIPR020591http://www.ebi.ac.uk/interpro/entry/IPR020591
InterProIPR024633http://www.ebi.ac.uk/interpro/entry/IPR024633
InterProIPR027417http://www.ebi.ac.uk/interpro/entry/IPR027417
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03036http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Geneecj:JW3679http://www.genome.jp/dbget-bin/www_bget?ecj:JW3679
KEGG_Geneeco:b3702http://www.genome.jp/dbget-bin/www_bget?eco:b3702
KEGG_OrthologyKO:K02313http://www.genome.jp/dbget-bin/www_bget?KO:K02313
KEGG_Pathwayko02020http://www.genome.jp/kegg-bin/show_pathway?ko02020
KEGG_Pathwayko04112http://www.genome.jp/kegg-bin/show_pathway?ko04112
MINTMINT-207293http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-207293
OMAQSKTRKRhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QSKTRKR
PDB1J1Vhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1J1V
PDB2E0Ghttp://www.ebi.ac.uk/pdbe-srv/view/entry/2E0G
PDBsum1J1Vhttp://www.ebi.ac.uk/pdbsum/1J1V
PDBsum2E0Ghttp://www.ebi.ac.uk/pdbsum/2E0G
PRINTSPR00051http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00051
PROSITEPS01008http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01008
PSORT-Bswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:DNAA_ECOLI
PSORT2swissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:DNAA_ECOLI
PSORTswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:DNAA_ECOLI
PfamPF00308http://pfam.xfam.org/family/PF00308
PfamPF08299http://pfam.xfam.org/family/PF08299
PfamPF11638http://pfam.xfam.org/family/PF11638
Phobiusswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:DNAA_ECOLI
PhylomeDBP03004http://phylomedb.org/?seqid=P03004
ProteinModelPortalP03004http://www.proteinmodelportal.org/query/uniprot/P03004
PubMed12682358http://www.ncbi.nlm.nih.gov/pubmed/12682358
PubMed16077105http://www.ncbi.nlm.nih.gov/pubmed/16077105
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed17699754http://www.ncbi.nlm.nih.gov/pubmed/17699754
PubMed18977760http://www.ncbi.nlm.nih.gov/pubmed/18977760
PubMed2558436http://www.ncbi.nlm.nih.gov/pubmed/2558436
PubMed6234204http://www.ncbi.nlm.nih.gov/pubmed/6234204
PubMed6296774http://www.ncbi.nlm.nih.gov/pubmed/6296774
PubMed6329723http://www.ncbi.nlm.nih.gov/pubmed/6329723
PubMed7686882http://www.ncbi.nlm.nih.gov/pubmed/7686882
PubMed9242693http://www.ncbi.nlm.nih.gov/pubmed/9242693
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9298644http://www.ncbi.nlm.nih.gov/pubmed/9298644
RefSeqNP_418157http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418157
RefSeqWP_000059111http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000059111
SMARTSM00382http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMARTSM00760http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00760
SMRP03004http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P03004
STRING511145.b3702http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3702&targetmode=cogs
STRINGCOG0593http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0593&targetmode=cogs
SUPFAMSSF48295http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48295
SUPFAMSSF52540http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TIGRFAMsTIGR00362http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00362
UniProtKB-ACP03004http://www.uniprot.org/uniprot/P03004
UniProtKBDNAA_ECOLIhttp://www.uniprot.org/uniprot/DNAA_ECOLI
chargeswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:DNAA_ECOLI
eggNOGCOG0593http://eggnogapi.embl.de/nog_data/html/tree/COG0593
eggNOGENOG4105CI4http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CI4
epestfindswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:DNAA_ECOLI
garnierswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:DNAA_ECOLI
helixturnhelixswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:DNAA_ECOLI
hmomentswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:DNAA_ECOLI
iepswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:DNAA_ECOLI
inforesidueswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:DNAA_ECOLI
octanolswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:DNAA_ECOLI
pepcoilswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:DNAA_ECOLI
pepdigestswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:DNAA_ECOLI
pepinfoswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:DNAA_ECOLI
pepnetswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:DNAA_ECOLI
pepstatsswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:DNAA_ECOLI
pepwheelswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:DNAA_ECOLI
pepwindowswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:DNAA_ECOLI
sigcleaveswissprot:DNAA_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:DNAA_ECOLI
DataBaseIDURL or Descriptions
# AltNameDCM_ECOLIM.EcoDcm
# BioGrid4260865162
# CATALYTIC ACTIVITYS-adenosyl-L-methionine + DNA = S-adenosyl-L- homocysteine + DNA containing 5-methylcytosine. {ECO:0000255|PROSITE-ProRulePRU10018}.
# EcoGeneEG10211dcm
# FUNCTIONDCM_ECOLIThis methylase recognizes the double-stranded sequence CCWGG, causes specific methylation on C-2 on both strands.
# GO_functionGO:0003886DNA (cytosine-5-)-methyltransferase activity; IDA:EcoCyc.
# GO_processGO:0009307DNA restriction-modification system; IEA:UniProtKB-KW.
# GO_processGO:0090116C-5 methylation of cytosine; IMP:EcoCyc.
# GOslim_functionGO:0008168methyltransferase activity
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0006950response to stress
# Gene3D3.40.50.150-; 1.
# INTERACTIONDCM_ECOLIP06959 aceF; NbExp=2; IntAct=EBI-548525, EBI-542707;
# IntActP0AED921
# InterProIPR001525C5_MeTfrase
# InterProIPR018117C5_DNA_meth_AS
# InterProIPR029063SAM-dependent_MTases
# InterProIPR031303C5_meth_CS
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko00002 KEGG pathway modules
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03036 Chromosome
# KEGG_Pathwayko00270Cysteine and methionine metabolism
# OrganismDCM_ECOLIEscherichia coli (strain K12)
# PATRIC32119251VBIEscCol129921_2040
# PIRA37754JS0263
# PRINTSPR00105C5METTRFRASE
# PROSITEPS00094C5_MTASE_1
# PROSITEPS00095C5_MTASE_2
# PROSITEPS51679SAM_MT_C5
# PfamPF00145DNA_methylase
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# REBASE2397M.EcoKDcm
# RecNameDCM_ECOLIDNA-cytosine methyltransferase
# RefSeqNP_416470NC_000913.3
# RefSeqWP_001157239NZ_LN832404.1
# SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. {ECO:0000255|PROSITE-ProRulePRU01016}.
# SIMILARITYContains 1 SAM-dependent MTase C5-type domain. {ECO:0000255|PROSITE-ProRulePRU01016}.
# SUPFAMSSF53335SSF53335
# TIGRFAMsTIGR00675dcm
# eggNOGCOG0270LUCA
# eggNOGENOG4105DVFBacteria
BLASTswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:DCM_ECOLI
BioCycECOL316407:JW1944-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW1944-MONOMER
BioCycEcoCyc:EG10211-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10211-MONOMER
BioCycMetaCyc:EG10211-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG10211-MONOMER
COGCOG0270http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0270
DIPDIP-47858Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47858N
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1093/dnares/3.6.379http://dx.doi.org/10.1093/dnares/3.6.379
DOI10.1093/nar/17.14.5844http://dx.doi.org/10.1093/nar/17.14.5844
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:2.1.1.37http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.37
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLM32307http://www.ebi.ac.uk/ena/data/view/M32307
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLX13330http://www.ebi.ac.uk/ena/data/view/X13330
ENZYME2.1.1.37http://enzyme.expasy.org/EC/2.1.1.37
EchoBASEEB0207http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0207
EcoGeneEG10211http://www.ecogene.org/geneInfo.php?eg_id=EG10211
EnsemblBacteriaAAC75027http://www.ensemblgenomes.org/id/AAC75027
EnsemblBacteriaAAC75027http://www.ensemblgenomes.org/id/AAC75027
EnsemblBacteriaBAA15788http://www.ensemblgenomes.org/id/BAA15788
EnsemblBacteriaBAA15788http://www.ensemblgenomes.org/id/BAA15788
EnsemblBacteriaBAA15788http://www.ensemblgenomes.org/id/BAA15788
EnsemblBacteriab1961http://www.ensemblgenomes.org/id/b1961
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_functionGO:0003886http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003886
GO_processGO:0009307http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009307
GO_processGO:0090116http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090116
GOslim_functionGO:0008168http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0006950http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
Gene3D3.40.50.150http://www.cathdb.info/version/latest/superfamily/3.40.50.150
GeneID946479http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946479
HOGENOMHOG000225506http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225506&db=HOGENOM6
InParanoidP0AED9http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AED9
IntActP0AED9http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AED9*
IntEnz2.1.1.37http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.37
InterProIPR001525http://www.ebi.ac.uk/interpro/entry/IPR001525
InterProIPR018117http://www.ebi.ac.uk/interpro/entry/IPR018117
InterProIPR029063http://www.ebi.ac.uk/interpro/entry/IPR029063
InterProIPR031303http://www.ebi.ac.uk/interpro/entry/IPR031303
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko00002http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03036http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Geneecj:JW1944http://www.genome.jp/dbget-bin/www_bget?ecj:JW1944
KEGG_Geneeco:b1961http://www.genome.jp/dbget-bin/www_bget?eco:b1961
KEGG_OrthologyKO:K00558http://www.genome.jp/dbget-bin/www_bget?KO:K00558
KEGG_Pathwayko00270http://www.genome.jp/kegg-bin/show_pathway?ko00270
KEGG_Reactionrn:R04858http://www.genome.jp/dbget-bin/www_bget?rn:R04858
MINTMINT-1237420http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1237420
OMAYLYRYARhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLYRYAR
PRINTSPR00105http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00105
PROSITEPS00094http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00094
PROSITEPS00095http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00095
PROSITEPS51679http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51679
PSORT-Bswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:DCM_ECOLI
PSORT2swissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:DCM_ECOLI
PSORTswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:DCM_ECOLI
PfamPF00145http://pfam.xfam.org/family/PF00145
Phobiusswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:DCM_ECOLI
PhylomeDBP0AED9http://phylomedb.org/?seqid=P0AED9
ProteinModelPortalP0AED9http://www.proteinmodelportal.org/query/uniprot/P0AED9
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed2198248http://www.ncbi.nlm.nih.gov/pubmed/2198248
PubMed2527357http://www.ncbi.nlm.nih.gov/pubmed/2527357
PubMed9097040http://www.ncbi.nlm.nih.gov/pubmed/9097040
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
REBASE2397http://rebase.neb.com/rebase/enz/2397.html
RefSeqNP_416470http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416470
RefSeqWP_001157239http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001157239
SMRP0AED9http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AED9
STRING511145.b1961http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1961&targetmode=cogs
STRINGCOG0270http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0270&targetmode=cogs
SUPFAMSSF53335http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335
TIGRFAMsTIGR00675http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00675
UniProtKB-ACP0AED9http://www.uniprot.org/uniprot/P0AED9
UniProtKBDCM_ECOLIhttp://www.uniprot.org/uniprot/DCM_ECOLI
chargeswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:DCM_ECOLI
eggNOGCOG0270http://eggnogapi.embl.de/nog_data/html/tree/COG0270
eggNOGENOG4105DVFhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DVF
epestfindswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:DCM_ECOLI
garnierswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:DCM_ECOLI
helixturnhelixswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:DCM_ECOLI
hmomentswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:DCM_ECOLI
iepswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:DCM_ECOLI
inforesidueswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:DCM_ECOLI
octanolswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:DCM_ECOLI
pepcoilswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:DCM_ECOLI
pepdigestswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:DCM_ECOLI
pepinfoswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:DCM_ECOLI
pepnetswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:DCM_ECOLI
pepstatsswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:DCM_ECOLI
pepwheelswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:DCM_ECOLI
pepwindowswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:DCM_ECOLI
sigcleaveswissprot:DCM_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:DCM_ECOLI
DataBaseIDURL or Descriptions
# AltNameDBHB_ECOLIHU-1
# AltNameDBHB_ECOLINS1
# BioGrid426073344
# EcoGeneEG10467hupB
# FUNCTIONDBHB_ECOLIHistone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_functionGO:0003677DNA binding; IEA:UniProtKB-KW.
# GO_processGO:0006351transcription, DNA-templated; IDA:EcoCyc.
# GO_processGO:0030261chromosome condensation; IEA:UniProtKB-KW.
# GO_processGO:0045892negative regulation of transcription, DNA-templated; IDA:EcoCyc.
# GO_processGO:0045893positive regulation of transcription, DNA-templated; IDA:EcoCyc.
# GOslim_componentGO:0005829cytosol
# GOslim_functionGO:0003677DNA binding
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0009058biosynthetic process
# GOslim_processGO:0034641cellular nitrogen compound metabolic process
# GOslim_processGO:0051276chromosome organization
# Gene3D4.10.520.10-; 1.
# INTERACTIONDBHB_ECOLISelf; NbExp=2; IntAct=EBI-370411, EBI-370411; P0ACF0 hupA; NbExp=6; IntAct=EBI-370411, EBI-547648;
# IntActP0ACF468
# InterProIPR000119Hist_DNA-bd
# InterProIPR010992IHF-like_DNA-bd_dom
# InterProIPR020816Histone-like_DNA-bd_CS
# KEGG_Briteko03032DNA replication proteins
# KEGG_Briteko03036 Chromosome
# KEGG_Briteko03400 DNA repair and recombination proteins
# OrganismDBHB_ECOLIEscherichia coli (strain K12)
# PATRIC32116033VBIEscCol129921_0458
# PDB2O97X-ray; 2.45 A; B=1-90
# PDB4P3VX-ray; 1.25 A; A=1-90
# PIRS06880DNECS1
# PRINTSPR01727DNABINDINGHU
# PROSITEPS00045HISTONE_LIKE
# PfamPF00216Bac_DNA_binding
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDBHB_ECOLIDNA-binding protein HU-beta
# RefSeqNP_414974NC_000913.3
# RefSeqWP_001043542NZ_LN832404.1
# SIMILARITYBelongs to the bacterial histone-like protein family. {ECO0000305}.
# SMARTSM00411BHL
# SUBUNITHeterodimer of an alpha and a beta chain. {ECO:0000269|PubMed227733}.
# SUPFAMSSF47729SSF47729
# eggNOGCOG0776LUCA
# eggNOGENOG4105K70Bacteria
BLASTswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:DBHB_ECOLI
BioCycECOL316407:JW0430-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW0430-MONOMER
BioCycEcoCyc:EG10467-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10467-MONOMER
COGCOG0776http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0776
DIPDIP-31833Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31833N
DOI10.1002/elps.1150180805http://dx.doi.org/10.1002/elps.1150180805
DOI10.1002/elps.1150180807http://dx.doi.org/10.1002/elps.1150180807
DOI10.1007/BF00425687http://dx.doi.org/10.1007/BF00425687
DOI10.1016/0014-5793(78)80446-3http://dx.doi.org/10.1016/0014-5793(78)80446-3
DOI10.1016/0014-5793(78)80535-3http://dx.doi.org/10.1016/0014-5793(78)80535-3
DOI10.1016/0014-5793(79)80518-9http://dx.doi.org/10.1016/0014-5793(79)80518-9
DOI10.1016/0378-1119(90)90355-Uhttp://dx.doi.org/10.1016/0378-1119(90)90355-U
DOI10.1016/S0022-2836(05)80119-6http://dx.doi.org/10.1016/S0022-2836(05)80119-6
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1111/j.1432-1033.1980.tb05968.xhttp://dx.doi.org/10.1111/j.1432-1033.1980.tb05968.x
DOI10.1111/j.1574-6968.1998.tb13343.xhttp://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLD82943http://www.ebi.ac.uk/ena/data/view/D82943
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU82664http://www.ebi.ac.uk/ena/data/view/U82664
EMBLX16540http://www.ebi.ac.uk/ena/data/view/X16540
EMBLX53241http://www.ebi.ac.uk/ena/data/view/X53241
EchoBASEEB0462http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0462
EcoGeneEG10467http://www.ecogene.org/geneInfo.php?eg_id=EG10467
EnsemblBacteriaAAC73543http://www.ensemblgenomes.org/id/AAC73543
EnsemblBacteriaAAC73543http://www.ensemblgenomes.org/id/AAC73543
EnsemblBacteriaBAE76220http://www.ensemblgenomes.org/id/BAE76220
EnsemblBacteriaBAE76220http://www.ensemblgenomes.org/id/BAE76220
EnsemblBacteriaBAE76220http://www.ensemblgenomes.org/id/BAE76220
EnsemblBacteriab0440http://www.ensemblgenomes.org/id/b0440
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_processGO:0006351http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351
GO_processGO:0030261http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030261
GO_processGO:0045892http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892
GO_processGO:0045893http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_processGO:0034641http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_processGO:0051276http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276
Gene3D4.10.520.10http://www.cathdb.info/version/latest/superfamily/4.10.520.10
GeneID949095http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949095
HOGENOMHOG000043828http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000043828&db=HOGENOM6
InParanoidP0ACF4http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACF4
IntActP0ACF4http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACF4*
InterProIPR000119http://www.ebi.ac.uk/interpro/entry/IPR000119
InterProIPR010992http://www.ebi.ac.uk/interpro/entry/IPR010992
InterProIPR020816http://www.ebi.ac.uk/interpro/entry/IPR020816
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03036http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW0430http://www.genome.jp/dbget-bin/www_bget?ecj:JW0430
KEGG_Geneeco:b0440http://www.genome.jp/dbget-bin/www_bget?eco:b0440
KEGG_OrthologyKO:K03530http://www.genome.jp/dbget-bin/www_bget?KO:K03530
MINTMINT-1236756http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1236756
OMAGSWSVSKhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSWSVSK
PDB2O97http://www.ebi.ac.uk/pdbe-srv/view/entry/2O97
PDB4P3Vhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4P3V
PDBsum2O97http://www.ebi.ac.uk/pdbsum/2O97
PDBsum4P3Vhttp://www.ebi.ac.uk/pdbsum/4P3V
PRINTSPR01727http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01727
PROSITEPS00045http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00045
PSORT-Bswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:DBHB_ECOLI
PSORT2swissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:DBHB_ECOLI
PSORTswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:DBHB_ECOLI
PfamPF00216http://pfam.xfam.org/family/PF00216
Phobiusswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:DBHB_ECOLI
PhylomeDBP0ACF4http://phylomedb.org/?seqid=P0ACF4
ProteinModelPortalP0ACF4http://www.proteinmodelportal.org/query/uniprot/P0ACF4
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed215461http://www.ncbi.nlm.nih.gov/pubmed/215461
PubMed2187099http://www.ncbi.nlm.nih.gov/pubmed/2187099
PubMed2265752http://www.ncbi.nlm.nih.gov/pubmed/2265752
PubMed227733http://www.ncbi.nlm.nih.gov/pubmed/227733
PubMed3003540http://www.ncbi.nlm.nih.gov/pubmed/3003540
PubMed350619http://www.ncbi.nlm.nih.gov/pubmed/350619
PubMed6987059http://www.ncbi.nlm.nih.gov/pubmed/6987059
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9298644http://www.ncbi.nlm.nih.gov/pubmed/9298644
PubMed9298646http://www.ncbi.nlm.nih.gov/pubmed/9298646
PubMed9868784http://www.ncbi.nlm.nih.gov/pubmed/9868784
RefSeqNP_414974http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414974
RefSeqWP_001043542http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001043542
SMARTSM00411http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00411
SMRP0ACF4http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACF4
STRING511145.b0440http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0440&targetmode=cogs
STRINGCOG0776http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0776&targetmode=cogs
SUPFAMSSF47729http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47729
UniProtKB-ACP0ACF4http://www.uniprot.org/uniprot/P0ACF4
UniProtKBDBHB_ECOLIhttp://www.uniprot.org/uniprot/DBHB_ECOLI
chargeswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:DBHB_ECOLI
eggNOGCOG0776http://eggnogapi.embl.de/nog_data/html/tree/COG0776
eggNOGENOG4105K70http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K70
epestfindswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:DBHB_ECOLI
garnierswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:DBHB_ECOLI
helixturnhelixswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:DBHB_ECOLI
hmomentswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:DBHB_ECOLI
iepswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:DBHB_ECOLI
inforesidueswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:DBHB_ECOLI
octanolswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:DBHB_ECOLI
pepcoilswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:DBHB_ECOLI
pepdigestswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:DBHB_ECOLI
pepinfoswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:DBHB_ECOLI
pepnetswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:DBHB_ECOLI
pepstatsswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:DBHB_ECOLI
pepwheelswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:DBHB_ECOLI
pepwindowswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:DBHB_ECOLI
sigcleaveswissprot:DBHB_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:DBHB_ECOLI
DataBaseIDURL or Descriptions
# BioGrid4262132260
# CATALYTIC ACTIVITYGYRA_ECOLIATP-dependent breakage, passage and rejoining of double-stranded DNA. {ECO 0000255|HAMAP-Rule MF_01897, ECO 0000269|PubMed 12051842, ECO 0000269|PubMed 18642932, ECO 0000269|PubMed 186775, ECO 0000269|PubMed 19965760, ECO 0000269|PubMed 9278055}.
# DOMAINGYRA_ECOLIAn N-terminal fragment (residues 1-523) can be reconstituted with GyrB, but the complex no longer has negative supercoiling or ATP-independent DNA relaxation activities, although it is capable of DNA cleavage; ATP-dependent relaxation is inhibited by novobiocin and non-hydrolyzable ATP analogs (PubMed 8962066). The fragment has ATP-dependent DNA relaxation and 30-fold improved decatenation activities, unlike holoenzyme it preferentially binds supercoiled DNA (PubMed 8962066). This N- terminal fragment becomes a topoisomerase IV-like enzyme; it poorly complements a temperature-sensitive parC mutation (parC is the topoisomerase IV paralog of gyrA) (PubMed 8962066). {ECO 0000269|PubMed 8962066}.
# DOMAINGYRA_ECOLIThe C-terminal domain (CTD, approximately residues 535- 841) contains 6 tandemly repeated subdomains known as blades, each of which is composed of a 4-stranded antiparallel beta-sheet (PubMed 15897198). The blades form a circular-shaped beta-pinwheel fold arranged in a spiral around a screw axis, to which DNA probably binds, inducing strong positive superhelicity (about 0.8 links/protein) (PubMed 15897198). The non-conserved, C-terminal acidic tail (residues 842-875) regulates wrapping and DNA-binding by the CTD; deletions within the tail show it is autoinhibitory for DNA wrapping and binding, and couples ATP hydrolysis to DNA strand passage (PubMed 22457353). The GyrA-box is a 7 amino acid motif found in the first blade of the CTD which is discriminative for gyrase versus topoisomerase IV activity (PubMed 9426128). The GyrA-box is required for wrapping of DNA around gyrase, and thus is essential for the DNA supercoiling activity but not DNA relaxation or decatenation activities of gyrase (PubMed 16332690). {ECO 0000269|PubMed 15897198, ECO 0000269|PubMed 16332690, ECO 0000269|PubMed 22457353, ECO 0000305|PubMed 9426128}.
# DrugBankDB00537Ciprofloxacin
# ENZYME REGULATIONGYRA_ECOLIGyrase is the target of many classes of inhibitors, including coumarins, cyclothialidines, pyrrolopyrimidines, pyrazolthiazoles and (fluoro)quinolones. Quinolones bind GyrA when the enzyme is complexed with DNA and trap the enzyme in a covalent reaction intermediate with DNA (PubMed 3031051, PubMed 12051842). Coumarins bind to GyrB and are competitive inhibitors of its ATPase activity (PubMed 7811004). Cyclothialidines also bind GyrB and are ATPase competitive inhibitors; they seem to act differently from coumarins (PubMed 7811004). Pyrrolopyrimidines inhibit both GyrB and its paralog in topoisomerase IV (parE) (PubMed 23294697). Pyrazolthiazoles also inhibit the ATPase activity of GyrB (PubMed 20356737). DNA supercoiling and relaxation are both inhibited by oxolinic acid (PubMed 337300). Acriflavine inhibits supercoiling activity and DNA-stimulated ATPase activity (PubMed 9148951). DNA supercoiling activity is protected from fluoroquinolone inhibition by QnrB4; QnrB4 has no effect on supercoiling activity alone (PubMed 19060136). {ECO 0000269|PubMed 19060136, ECO 0000269|PubMed 20356737, ECO 0000269|PubMed 23294697, ECO 0000269|PubMed 337300, ECO 0000269|PubMed 7811004, ECO 0000269|PubMed 9148951}.
# EcoGeneEG10423gyrA
# FUNCTIONGYRA_ECOLIA type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state (PubMed 3031051, PubMed 186775, PubMed 7811004, PubMed 9148951, PubMed 12051842, PubMed 18642932, PubMed 19060136, PubMed 20356737, PubMed 22457353, PubMed 23294697, PubMed 19965760). This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli (PubMed 9334322). Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes (PubMed 22457352). Relaxes negatively supercoiled DNA in an ATP-independent manner (PubMed 337300). E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations E.coli gyrase introduces more supercoils faster than M.tuberculosis gyrase, while M.tuberculosis gyrase has higher decatenation than supercoiling activity compared to E.coli (PubMed 22457352). E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB subunit is toxic in E.coli, while the E.coli copy can be expressed in S.typhimurium even though the 2 subunits have 777/804 residues identical (PubMed 17400739). The enzymatic differences between E.coli gyrase and topoisomerase IV are largely due to the GyrA C- terminal domain (approximately residues 524-841) and specifically the GyrA-box (PubMed 8962066, PubMed 16332690). {ECO 0000269|PubMed 12051842, ECO 0000269|PubMed 16332690, ECO 0000269|PubMed 17400739, ECO 0000269|PubMed 18642932, ECO 0000269|PubMed 186775, ECO 0000269|PubMed 19060136, ECO 0000269|PubMed 19965760, ECO 0000269|PubMed 20356737, ECO 0000269|PubMed 22457352, ECO 0000269|PubMed 22457353, ECO 0000269|PubMed 23294697, ECO 0000269|PubMed 3031051, ECO 0000269|PubMed 337300, ECO 0000269|PubMed 7811004, ECO 0000269|PubMed 8962066, ECO 0000269|PubMed 9148951, ECO 0000269|PubMed 9334322}.
# FUNCTIONGYRA_ECOLINegative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
# GO_componentGO:0005694chromosome; IEA:InterPro.
# GO_componentGO:0005737cytoplasm; IDA:UniProtKB.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_componentGO:0009295nucleoid; IBA:GO_Central.
# GO_componentGO:0009330DNA topoisomerase complex (ATP-hydrolyzing); IBA:GO_Central.
# GO_componentGO:0016020membrane; IDA:UniProtKB.
# GO_functionGO:0003677DNA binding; IDA:EcoliWiki.
# GO_functionGO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activity; IDA:CACAO.
# GO_functionGO:0005524ATP binding; IEA:UniProtKB-HAMAP.
# GO_functionGO:0008094DNA-dependent ATPase activity; IDA:EcoliWiki.
# GO_functionGO:0034335DNA supercoiling activity; IDA:UniProtKB.
# GO_processGO:0006265DNA topological change; IMP:EcoliWiki.
# GO_processGO:0006268DNA unwinding involved in DNA replication; IBA:GO_Central.
# GO_processGO:0006351transcription, DNA-templated; IDA:EcoliWiki.
# GO_processGO:0007059chromosome segregation; IBA:GO_Central.
# GO_processGO:0042493response to drug; IMP:EcoliWiki.
# GO_processGO:0046677response to antibiotic; IEA:UniProtKB-KW.
# GOslim_componentGO:0005575cellular_component
# GOslim_componentGO:0005694chromosome
# GOslim_componentGO:0005737cytoplasm
# GOslim_componentGO:0005829cytosol
# GOslim_componentGO:0043234protein complex
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0016853isomerase activity
# GOslim_functionGO:0016887ATPase activity
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0007059chromosome segregation
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0009058biosynthetic process
# GOslim_processGO:0034641cellular nitrogen compound metabolic process
# GOslim_processGO:0051276chromosome organization
# Gene3D1.10.268.10-; 1.
# Gene3D3.30.1360.40-; 1.
# Gene3D3.90.199.10-; 1.
# HAMAPMF_01897GyrA
# INTERACTIONGYRA_ECOLISelf; NbExp=2; IntAct=EBI-547129, EBI-547129; P0AES6 gyrB; NbExp=5; IntAct=EBI-547129, EBI-541911; P27245 marR; NbExp=2; IntAct=EBI-547129, EBI-6409744;
# IntActP0AES451
# InterProIPR002205Topo_IIA_A/C
# InterProIPR005743GyrA
# InterProIPR006691GyrA/parC_pinwhl
# InterProIPR013757Topo_IIA_A_a
# InterProIPR013758Topo_IIA_A/C_ab
# InterProIPR013760Topo_IIA-like_dom
# InterProIPR024946Arg_repress_C-like
# KEGG_Briteko01000Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03400 DNA repair and recombination proteins
# MISCELLANEOUSGYRA_ECOLIFew gyrases are as efficient as E.coli at forming negative supercoils (PubMed 22457352, PubMed 17400739). Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes. {ECO 0000255|HAMAP-Rule MF_01897, ECO 0000269|PubMed 17400739, ECO 0000269|PubMed 22457352}.
# MISCELLANEOUSGYRA_ECOLIWhen the enzyme transiently cleaves DNA a phosphotyrosine bond is formed between GyrA and DNA (PubMed 3031051). In the presence of quinolones this intermediate can be trapped and is used as an indicator of drug toxicity (PubMed 12051842). The enzyme-DNA intermediate is also the target of a number of topoisomerase poisons, including toxin CcdB (PubMed 1324324, PubMed 8254658). {ECO 0000269|PubMed 1324324, ECO 0000269|PubMed 3031051, ECO 0000269|PubMed 8254658, ECO 0000305|PubMed 12051842}.
# OrganismGYRA_ECOLIEscherichia coli (strain K12)
# PATRIC32119821VBIEscCol129921_2320
# PDB1AB4X-ray; 2.80 A; A=30-522
# PDB1X75X-ray; 2.80 A; A/B=363-494
# PDB1ZI0X-ray; 2.60 A; A/B=535-841
# PDB2Y3PX-ray; 2.62 A; A/B=2-523
# PDB3NUHX-ray; 3.10 A; A=1-525
# PDB4ELYX-ray; 1.93 A; A/B=363-497
# PIRS02340ITECAP
# PfamPF00521DNA_topoisoIV
# PfamPF03989DNA_gyraseA_C; 6
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDNA gyrase subunit A {ECO:0000255|HAMAP-RuleMF_01897}
# RefSeqNP_416734NC_000913.3
# RefSeqWP_001281242NZ_LN832404.1
# SIMILARITYBelongs to the type II topoisomerase GyrA/ParC subunit family. {ECO:0000255|HAMAP-RuleMF_01897}.
# SMARTSM00434TOP4c
# SUBCELLULAR LOCATIONGYRA_ECOLICytoplasm {ECO 0000255|HAMAP-Rule MF_01897}.
# SUBUNITGYRA_ECOLIHeterotetramer, composed of two GyrA and two GyrB chains (PubMed 9148951, PubMed 12051842). In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with the DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis (PubMed 12051842, PubMed 18642932, PubMed 19965760, PubMed 9148951). Can form a 2 2 complex with toxin CcdB in which GyrA is inactive; rejuvenation of GyrA(2)CcdB(2) is effected by CcdA (PubMed 15854646, PubMed 1324324, PubMed 8254658, PubMed 8604132). {ECO 0000269|PubMed 12051842, ECO 0000269|PubMed 1324324, ECO 0000269|PubMed 15854646, ECO 0000269|PubMed 18642932, ECO 0000269|PubMed 19965760, ECO 0000269|PubMed 8254658, ECO 0000269|PubMed 8604132, ECO 0000269|PubMed 9148951}.
# SUPFAMSSF56719SSF56719
# eggNOGCOG0188LUCA
# eggNOGENOG4105C24Bacteria
BLASTswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:GYRA_ECOLI
BioCycECOL316407:JW2225-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW2225-MONOMER
BioCycEcoCyc:EG10423-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10423-MONOMER
BioCycMetaCyc:EG10423-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG10423-MONOMER
COGCOG0188http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0188
DIPDIP-36179Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36179N
DOI10.1002/elps.1150180805http://dx.doi.org/10.1002/elps.1150180805
DOI10.1006/jmbi.1993.1609http://dx.doi.org/10.1006/jmbi.1993.1609
DOI10.1006/jmbi.1996.0102http://dx.doi.org/10.1006/jmbi.1996.0102
DOI10.1007/BF00338386http://dx.doi.org/10.1007/BF00338386
DOI10.1016/0022-2836(87)90479-7http://dx.doi.org/10.1016/0022-2836(87)90479-7
DOI10.1016/0022-2836(92)90629-Xhttp://dx.doi.org/10.1016/0022-2836(92)90629-X
DOI10.1016/S0022-2836(02)00048-7http://dx.doi.org/10.1016/S0022-2836(02)00048-7
DOI10.1016/j.bmcl.2010.03.052http://dx.doi.org/10.1016/j.bmcl.2010.03.052
DOI10.1016/j.bmcl.2012.11.073http://dx.doi.org/10.1016/j.bmcl.2012.11.073
DOI10.1016/j.jmb.2005.03.049http://dx.doi.org/10.1016/j.jmb.2005.03.049
DOI10.1021/bi800480jhttp://dx.doi.org/10.1021/bi800480j
DOI10.1038/42294http://dx.doi.org/10.1038/42294
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1046/j.1365-2958.1997.6242005.xhttp://dx.doi.org/10.1046/j.1365-2958.1997.6242005.x
DOI10.1073/pnas.73.11.3872http://dx.doi.org/10.1073/pnas.73.11.3872
DOI10.1073/pnas.74.11.4772http://dx.doi.org/10.1073/pnas.74.11.4772
DOI10.1073/pnas.93.25.14416http://dx.doi.org/10.1073/pnas.93.25.14416
DOI10.1074/jbc.272.20.13302http://dx.doi.org/10.1074/jbc.272.20.13302
DOI10.1074/jbc.M112.345678http://dx.doi.org/10.1074/jbc.M112.345678
DOI10.1074/jbc.M112.345736http://dx.doi.org/10.1074/jbc.M112.345736
DOI10.1074/jbc.M502838200http://dx.doi.org/10.1074/jbc.M502838200
DOI10.1074/jbc.M511160200http://dx.doi.org/10.1074/jbc.M511160200
DOI10.1093/dnares/4.2.91http://dx.doi.org/10.1093/dnares/4.2.91
DOI10.1101/gad.11.19.2580http://dx.doi.org/10.1101/gad.11.19.2580
DOI10.1111/j.1365-2958.1987.tb01932.xhttp://dx.doi.org/10.1111/j.1365-2958.1987.tb01932.x
DOI10.1126/science.1179123http://dx.doi.org/10.1126/science.1179123
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
DOI10.1128/AAC.33.6.886http://dx.doi.org/10.1128/AAC.33.6.886
DOI10.1128/AAC.34.6.1271http://dx.doi.org/10.1128/AAC.34.6.1271
DOI10.1128/AAC.35.2.335http://dx.doi.org/10.1128/AAC.35.2.335
DOI10.1128/AAC.35.2.387http://dx.doi.org/10.1128/AAC.35.2.387
DOI10.1128/AAC.38.9.1966http://dx.doi.org/10.1128/AAC.38.9.1966
DOI10.1128/JB.00083-07http://dx.doi.org/10.1128/JB.00083-07
DOI10.1128/JB.01205-08http://dx.doi.org/10.1128/JB.01205-08
DrugBankDB00537http://www.drugbank.ca/drugs/DB00537
EC_numberEC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01897, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760, ECO:0000269|PubMed:9278055}http://www.genome.jp/dbget-bin/www_bget?EC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01897, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760, ECO:0000269|PubMed:9278055}
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLM15631http://www.ebi.ac.uk/ena/data/view/M15631
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLX06373http://www.ebi.ac.uk/ena/data/view/X06373
EMBLX06744http://www.ebi.ac.uk/ena/data/view/X06744
EMBLY00544http://www.ebi.ac.uk/ena/data/view/Y00544
ENZYME5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01897, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760, ECO:0000269|PubMed:9278055}http://enzyme.expasy.org/EC/5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01897, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760, ECO:0000269|PubMed:9278055}
EchoBASEEB0418http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0418
EcoGeneEG10423http://www.ecogene.org/geneInfo.php?eg_id=EG10423
EnsemblBacteriaAAC75291http://www.ensemblgenomes.org/id/AAC75291
EnsemblBacteriaAAC75291http://www.ensemblgenomes.org/id/AAC75291
EnsemblBacteriaBAA16048http://www.ensemblgenomes.org/id/BAA16048
EnsemblBacteriaBAA16048http://www.ensemblgenomes.org/id/BAA16048
EnsemblBacteriaBAA16048http://www.ensemblgenomes.org/id/BAA16048
EnsemblBacteriab2231http://www.ensemblgenomes.org/id/b2231
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005694http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694
GO_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_componentGO:0009295http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295
GO_componentGO:0009330http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009330
GO_componentGO:0016020http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003918http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003918
GO_functionGO:0005524http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_functionGO:0008094http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008094
GO_functionGO:0034335http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034335
GO_processGO:0006265http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006265
GO_processGO:0006268http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006268
GO_processGO:0006351http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351
GO_processGO:0007059http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059
GO_processGO:0042493http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_processGO:0046677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677
GOslim_componentGO:0005575http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_componentGO:0005694http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694
GOslim_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_componentGO:0043234http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0016853http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853
GOslim_functionGO:0016887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0007059http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_processGO:0034641http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_processGO:0051276http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276
Gene3D1.10.268.10http://www.cathdb.info/version/latest/superfamily/1.10.268.10
Gene3D3.30.1360.40http://www.cathdb.info/version/latest/superfamily/3.30.1360.40
Gene3D3.90.199.10http://www.cathdb.info/version/latest/superfamily/3.90.199.10
GeneID946614http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946614
HAMAPMF_01897http://hamap.expasy.org/unirule/MF_01897
HOGENOMHOG000076278http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076278&db=HOGENOM6
InParanoidP0AES4http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AES4
IntActP0AES4http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AES4*
IntEnz5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01897, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760, ECO:0000269|PubMed:9278055}http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01897, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760, ECO:0000269|PubMed:9278055}
InterProIPR002205http://www.ebi.ac.uk/interpro/entry/IPR002205
InterProIPR005743http://www.ebi.ac.uk/interpro/entry/IPR005743
InterProIPR006691http://www.ebi.ac.uk/interpro/entry/IPR006691
InterProIPR013757http://www.ebi.ac.uk/interpro/entry/IPR013757
InterProIPR013758http://www.ebi.ac.uk/interpro/entry/IPR013758
InterProIPR013760http://www.ebi.ac.uk/interpro/entry/IPR013760
InterProIPR024946http://www.ebi.ac.uk/interpro/entry/IPR024946
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW2225http://www.genome.jp/dbget-bin/www_bget?ecj:JW2225
KEGG_Geneeco:b2231http://www.genome.jp/dbget-bin/www_bget?eco:b2231
KEGG_OrthologyKO:K02469http://www.genome.jp/dbget-bin/www_bget?KO:K02469
MINTMINT-201682http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-201682
OMAEMKSAYIhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMKSAYI
PDB1AB4http://www.ebi.ac.uk/pdbe-srv/view/entry/1AB4
PDB1X75http://www.ebi.ac.uk/pdbe-srv/view/entry/1X75
PDB1ZI0http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZI0
PDB2Y3Phttp://www.ebi.ac.uk/pdbe-srv/view/entry/2Y3P
PDB3NUHhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3NUH
PDB4ELYhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4ELY
PDBsum1AB4http://www.ebi.ac.uk/pdbsum/1AB4
PDBsum1X75http://www.ebi.ac.uk/pdbsum/1X75
PDBsum1ZI0http://www.ebi.ac.uk/pdbsum/1ZI0
PDBsum2Y3Phttp://www.ebi.ac.uk/pdbsum/2Y3P
PDBsum3NUHhttp://www.ebi.ac.uk/pdbsum/3NUH
PDBsum4ELYhttp://www.ebi.ac.uk/pdbsum/4ELY
PSORT-Bswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:GYRA_ECOLI
PSORT2swissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:GYRA_ECOLI
PSORTswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:GYRA_ECOLI
PfamPF00521http://pfam.xfam.org/family/PF00521
PfamPF03989http://pfam.xfam.org/family/PF03989
Phobiusswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:GYRA_ECOLI
PhylomeDBP0AES4http://phylomedb.org/?seqid=P0AES4
ProteinModelPortalP0AES4http://www.proteinmodelportal.org/query/uniprot/P0AES4
PubMed12051842http://www.ncbi.nlm.nih.gov/pubmed/12051842
PubMed1324324http://www.ncbi.nlm.nih.gov/pubmed/1324324
PubMed15854646http://www.ncbi.nlm.nih.gov/pubmed/15854646
PubMed15897198http://www.ncbi.nlm.nih.gov/pubmed/15897198
PubMed16332690http://www.ncbi.nlm.nih.gov/pubmed/16332690
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed17400739http://www.ncbi.nlm.nih.gov/pubmed/17400739
PubMed1850970http://www.ncbi.nlm.nih.gov/pubmed/1850970
PubMed1850972http://www.ncbi.nlm.nih.gov/pubmed/1850972
PubMed18642932http://www.ncbi.nlm.nih.gov/pubmed/18642932
PubMed186775http://www.ncbi.nlm.nih.gov/pubmed/186775
PubMed19060136http://www.ncbi.nlm.nih.gov/pubmed/19060136
PubMed19965760http://www.ncbi.nlm.nih.gov/pubmed/19965760
PubMed20356737http://www.ncbi.nlm.nih.gov/pubmed/20356737
PubMed2168148http://www.ncbi.nlm.nih.gov/pubmed/2168148
PubMed22457352http://www.ncbi.nlm.nih.gov/pubmed/22457352
PubMed22457353http://www.ncbi.nlm.nih.gov/pubmed/22457353
PubMed23294697http://www.ncbi.nlm.nih.gov/pubmed/23294697
PubMed2548439http://www.ncbi.nlm.nih.gov/pubmed/2548439
PubMed2828631http://www.ncbi.nlm.nih.gov/pubmed/2828631
PubMed2830458http://www.ncbi.nlm.nih.gov/pubmed/2830458
PubMed2834621http://www.ncbi.nlm.nih.gov/pubmed/2834621
PubMed3029031http://www.ncbi.nlm.nih.gov/pubmed/3029031
PubMed3031051http://www.ncbi.nlm.nih.gov/pubmed/3031051
PubMed337300http://www.ncbi.nlm.nih.gov/pubmed/337300
PubMed7811004http://www.ncbi.nlm.nih.gov/pubmed/7811004
PubMed8254658http://www.ncbi.nlm.nih.gov/pubmed/8254658
PubMed8604132http://www.ncbi.nlm.nih.gov/pubmed/8604132
PubMed8962066http://www.ncbi.nlm.nih.gov/pubmed/8962066
PubMed9148951http://www.ncbi.nlm.nih.gov/pubmed/9148951
PubMed9205837http://www.ncbi.nlm.nih.gov/pubmed/9205837
PubMed9278055http://www.ncbi.nlm.nih.gov/pubmed/9278055
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9298644http://www.ncbi.nlm.nih.gov/pubmed/9298644
PubMed9334322http://www.ncbi.nlm.nih.gov/pubmed/9334322
PubMed9426128http://www.ncbi.nlm.nih.gov/pubmed/9426128
RefSeqNP_416734http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416734
RefSeqWP_001281242http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001281242
SMARTSM00434http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00434
SMRP0AES4http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AES4
STRING511145.b2231http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2231&targetmode=cogs
STRINGCOG0188http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0188&targetmode=cogs
SUPFAMSSF56719http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56719
SWISS-2DPAGEP0AES4http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AES4
UniProtKB-ACP0AES4http://www.uniprot.org/uniprot/P0AES4
UniProtKBGYRA_ECOLIhttp://www.uniprot.org/uniprot/GYRA_ECOLI
chargeswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:GYRA_ECOLI
eggNOGCOG0188http://eggnogapi.embl.de/nog_data/html/tree/COG0188
eggNOGENOG4105C24http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C24
epestfindswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:GYRA_ECOLI
garnierswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:GYRA_ECOLI
helixturnhelixswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:GYRA_ECOLI
hmomentswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:GYRA_ECOLI
iepswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:GYRA_ECOLI
inforesidueswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:GYRA_ECOLI
octanolswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:GYRA_ECOLI
pepcoilswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:GYRA_ECOLI
pepdigestswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:GYRA_ECOLI
pepinfoswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:GYRA_ECOLI
pepnetswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:GYRA_ECOLI
pepstatsswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:GYRA_ECOLI
pepwheelswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:GYRA_ECOLI
pepwindowswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:GYRA_ECOLI
sigcleaveswissprot:GYRA_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:GYRA_ECOLI
DataBaseIDURL or Descriptions
# AltNameHDA_ECOLIDnaA paralog
# BioGrid4261436149
# DISRUPTION PHENOTYPEHDA_ECOLIEssential in strain C600. Disruption in MG1655 confers cold-sensitivity with asynchronously replicating DNA, which is quickly suppressed. Increased levels of plasmid IncP-alpha RK2 in strain BL21-DE3, increased plasmid replication in vitro. {ECO 0000269|PubMed 11483528, ECO 0000269|PubMed 12618445, ECO 0000269|PubMed 22716942}.
# EcoGeneEG14201hda
# FUNCTIONHDA_ECOLIMediates the interactions of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA. ADP-binding activates Hda to hydrolyze DnaA-ATP; Hda monomers bind to ADP with about 200-fold greater affinity than for ATP. RIDA function can be genetically separated from viability, suggesting this protein has another function as well.
# FUNCTIONHDA_ECOLISuppresses the toxic effect of overexpressing a TrfA N- terminal 163 residue fragment. Inhibits inner membrane-associated plasmid IncP-alpha RK2 replication probably by interacting with plasmid-encoded TrfA.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_componentGO:0005886plasma membrane; IEA:UniProtKB-SubCell.
# GO_componentGO:0016020membrane; IDA:EcoCyc.
# GO_functionGO:0000166nucleotide binding; IEA:UniProtKB-KW.
# GO_functionGO:0043565sequence-specific DNA binding; IBA:GO_Central.
# GO_processGO:0006260DNA replication; IEA:UniProtKB-HAMAP.
# GO_processGO:0032297negative regulation of DNA-dependent DNA replication initiation; IMP:EcoCyc.
# GOslim_componentGO:0005575cellular_component
# GOslim_componentGO:0005829cytosol
# GOslim_componentGO:0005886plasma membrane
# GOslim_functionGO:0003674molecular_function
# GOslim_functionGO:0003677DNA binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0009058biosynthetic process
# Gene3D3.40.50.300-; 1.
# HAMAPMF_01158Hda
# INTERACTIONHDA_ECOLISelf; NbExp=2; IntAct=EBI-545453, EBI-545453; P06134 ada; NbExp=3; IntAct=EBI-545453, EBI-1119501; P03004 dnaA; NbExp=2; IntAct=EBI-545453, EBI-548951; P0A988 dnaN; NbExp=8; IntAct=EBI-545453, EBI-542385;
# IntActP6993114
# InterProIPR013317DnaA
# InterProIPR017788Hda
# InterProIPR020591Chromosome_initiator_DnaA-like
# InterProIPR022864Hda_Enterobact
# InterProIPR027417P-loop_NTPase
# KEGG_Briteko03032DNA replication proteins
# MISCELLANEOUSHDA_ECOLIStarts with a CTG codon.
# MISCELLANEOUSHDA_ECOLIThere are about 50 homodimers per cell in strains C600 and K12 / MG1655.
# OrganismHDA_ECOLIEscherichia coli (strain K12)
# PATRIC32120379VBIEscCol129921_2592
# PIRG65025G65025
# PRINTSPR00051DNAA
# PfamPF00308Bac_DnaA
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameHDA_ECOLIDnaA regulatory inactivator Hda
# RefSeqNP_416991NC_000913.3
# SIMILARITYBelongs to the DnaA family. HdA subfamily. {ECO0000305}.
# SUBCELLULAR LOCATIONHDA_ECOLICell inner membrane {ECO 0000269|PubMed 12618445}. Note=More protein is found in the inner than outer membrane fractions.
# SUBUNITHDA_ECOLIThe active form seems to be an ADP-bound monomer; apo-Hda forms homo-multimers that do not hydrolzye DnaA-bound ATP. Forms the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and the DNA-loaded beta sliding clamp (dnaN). Interacts with plasmid IncP-alpha RK2-encoded protein TrfA in strain B / BL21-DE3. {ECO 0000269|PubMed 12618445, ECO 0000269|PubMed 15150238, ECO 0000269|PubMed 15611053, ECO 0000269|PubMed 18977760}.
# SUPFAMSSF52540SSF52540
# TIGRFAMsTIGR03420DnaA_homol_Hda
# eggNOGCOG0593LUCA
# eggNOGENOG4108KZ1Bacteria
BLASTswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:HDA_ECOLI
BioCycECOL316407:JW5397-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW5397-MONOMER
BioCycEcoCyc:G7313-MONOMERhttp://biocyc.org/getid?id=EcoCyc:G7313-MONOMER
COGCOG0593http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0593
DIPDIP-48006Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48006N
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1074/jbc.M412060200http://dx.doi.org/10.1074/jbc.M412060200
DOI10.1074/jbc.M803158200http://dx.doi.org/10.1074/jbc.M803158200
DOI10.1093/dnares/4.2.91http://dx.doi.org/10.1093/dnares/4.2.91
DOI10.1093/emboj/20.15.4253http://dx.doi.org/10.1093/emboj/20.15.4253
DOI10.1111/j.1365-2958.2012.08129.xhttp://dx.doi.org/10.1111/j.1365-2958.2012.08129.x
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
DOI10.1128/JB.185.10.3244-3248.2003http://dx.doi.org/10.1128/JB.185.10.3244-3248.2003
DOI10.1128/JB.185.6.1817-1824.2003http://dx.doi.org/10.1128/JB.185.6.1817-1824.2003
DOI10.1128/JB.186.11.3508-3515.2004http://dx.doi.org/10.1128/JB.186.11.3508-3515.2004
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EchoBASEEB3953http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3953
EcoGeneEG14201http://www.ecogene.org/geneInfo.php?eg_id=EG14201
EnsemblBacteriaAAC75549http://www.ensemblgenomes.org/id/AAC75549
EnsemblBacteriaAAC75549http://www.ensemblgenomes.org/id/AAC75549
EnsemblBacteriaBAA16384http://www.ensemblgenomes.org/id/BAA16384
EnsemblBacteriaBAA16384http://www.ensemblgenomes.org/id/BAA16384
EnsemblBacteriaBAA16384http://www.ensemblgenomes.org/id/BAA16384
EnsemblBacteriab2496http://www.ensemblgenomes.org/id/b2496
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_componentGO:0005886http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GO_componentGO:0016020http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_functionGO:0000166http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166
GO_functionGO:0043565http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565
GO_processGO:0006260http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260
GO_processGO:0032297http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032297
GOslim_componentGO:0005575http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_componentGO:0005886http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886
GOslim_functionGO:0003674http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
Gene3D3.40.50.300http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneID946977http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946977
HAMAPMF_01158http://hamap.expasy.org/unirule/MF_01158
HOGENOMHOG000256538http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256538&db=HOGENOM6
InParanoidP69931http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69931
IntActP69931http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69931*
InterProIPR013317http://www.ebi.ac.uk/interpro/entry/IPR013317
InterProIPR017788http://www.ebi.ac.uk/interpro/entry/IPR017788
InterProIPR020591http://www.ebi.ac.uk/interpro/entry/IPR020591
InterProIPR022864http://www.ebi.ac.uk/interpro/entry/IPR022864
InterProIPR027417http://www.ebi.ac.uk/interpro/entry/IPR027417
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Geneecj:JW5397http://www.genome.jp/dbget-bin/www_bget?ecj:JW5397
KEGG_Geneeco:b2496http://www.genome.jp/dbget-bin/www_bget?eco:b2496
KEGG_OrthologyKO:K10763http://www.genome.jp/dbget-bin/www_bget?KO:K10763
PRINTSPR00051http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00051
PSORT-Bswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:HDA_ECOLI
PSORT2swissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:HDA_ECOLI
PSORTswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:HDA_ECOLI
PfamPF00308http://pfam.xfam.org/family/PF00308
Phobiusswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:HDA_ECOLI
PhylomeDBP69931http://phylomedb.org/?seqid=P69931
ProteinModelPortalP69931http://www.proteinmodelportal.org/query/uniprot/P69931
PubMed11483528http://www.ncbi.nlm.nih.gov/pubmed/11483528
PubMed12618445http://www.ncbi.nlm.nih.gov/pubmed/12618445
PubMed12730188http://www.ncbi.nlm.nih.gov/pubmed/12730188
PubMed15150238http://www.ncbi.nlm.nih.gov/pubmed/15150238
PubMed15611053http://www.ncbi.nlm.nih.gov/pubmed/15611053
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed18977760http://www.ncbi.nlm.nih.gov/pubmed/18977760
PubMed22716942http://www.ncbi.nlm.nih.gov/pubmed/22716942
PubMed9205837http://www.ncbi.nlm.nih.gov/pubmed/9205837
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
RefSeqNP_416991http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416991
SMRP69931http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69931
STRING511145.b2496http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2496&targetmode=cogs
STRINGCOG0593http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0593&targetmode=cogs
SUPFAMSSF52540http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TIGRFAMsTIGR03420http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03420
UniProtKB-ACP69931http://www.uniprot.org/uniprot/P69931
UniProtKBHDA_ECOLIhttp://www.uniprot.org/uniprot/HDA_ECOLI
chargeswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:HDA_ECOLI
eggNOGCOG0593http://eggnogapi.embl.de/nog_data/html/tree/COG0593
eggNOGENOG4108KZ1http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KZ1
epestfindswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:HDA_ECOLI
garnierswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:HDA_ECOLI
helixturnhelixswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:HDA_ECOLI
hmomentswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:HDA_ECOLI
iepswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:HDA_ECOLI
inforesidueswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:HDA_ECOLI
octanolswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:HDA_ECOLI
pepcoilswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:HDA_ECOLI
pepdigestswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:HDA_ECOLI
pepinfoswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:HDA_ECOLI
pepnetswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:HDA_ECOLI
pepstatsswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:HDA_ECOLI
pepwheelswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:HDA_ECOLI
pepwindowswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:HDA_ECOLI
sigcleaveswissprot:HDA_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:HDA_ECOLI
DataBaseIDURL or Descriptions
# BioGrid426025485
# EcoGeneEG11038tus
# FUNCTIONTUS_ECOLITrans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
# GO_componentGO:0005737cytoplasm; IEA:UniProtKB-SubCell.
# GO_functionGO:0043565sequence-specific DNA binding; IDA:EcoCyc.
# GO_processGO:0006274DNA replication termination; IDA:EcoCyc.
# GO_processGO:0071807replication fork arrest involved in DNA replication termination; IDA:EcoCyc.
# GOslim_componentGO:0005737cytoplasm
# GOslim_functionGO:0003677DNA binding
# GOslim_processGO:0006259DNA metabolic process
# Gene3D3.50.14.10-; 2.
# HAMAPMF_00483Rep_term_Tus
# IntActP165252
# InterProIPR008865DNA_replication_term_site-bd
# KEGG_Briteko03032DNA replication proteins
# OrganismTUS_ECOLIEscherichia coli (strain K12)
# PATRIC32118522VBIEscCol129921_1681
# PDB1ECRX-ray; 2.70 A; A=1-309
# PDB1SUTNMR; -; A=223-244
# PDB2EWJX-ray; 2.70 A; A=1-309
# PDB2I05X-ray; 2.60 A; A=1-309
# PDB2I06X-ray; 2.20 A; A=1-309
# PDB4XR0X-ray; 2.80 A; A=1-309
# PDB4XR1X-ray; 2.40 A; A=1-309
# PDB4XR2X-ray; 2.35 A; A=1-309
# PDB4XR3X-ray; 2.70 A; A=1-309
# PIRB32161DNECTS
# PfamPF05472Ter
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDNA replication terminus site-binding protein {ECO:0000255|HAMAP-RuleMF_00483}
# RefSeqNP_416127NC_000913.3
# RefSeqWP_000135181NZ_LN832404.1
# SIMILARITYBelongs to the Tus family. {ECO:0000255|HAMAP- RuleMF_00483}.
# SUBCELLULAR LOCATIONTUS_ECOLICytoplasm.
# SUBUNITTUS_ECOLIMonomer.
# SUPFAMSSF56596SSF56596
# TIGRFAMsTIGR02648rep_term_tus
# eggNOGENOG4105KR1Bacteria
# eggNOGENOG410XSWRLUCA
BLASTswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:TUS_ECOLI
BioCycECOL316407:JW1602-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW1602-MONOMER
BioCycEcoCyc:EG11038-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG11038-MONOMER
DIPDIP-11056Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11056N
DOI10.1021/bi952419lhttp://dx.doi.org/10.1021/bi952419l
DOI10.1038/383598a0http://dx.doi.org/10.1038/383598a0
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1042/bj2370547http://dx.doi.org/10.1042/bj2370547
DOI10.1073/pnas.86.5.1593http://dx.doi.org/10.1073/pnas.86.5.1593
DOI10.1093/dnares/3.6.363http://dx.doi.org/10.1093/dnares/3.6.363
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLD90037http://www.ebi.ac.uk/ena/data/view/D90037
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU41101http://www.ebi.ac.uk/ena/data/view/U41101
EMBLX04065http://www.ebi.ac.uk/ena/data/view/X04065
EchoBASEEB1031http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1031
EcoGeneEG11038http://www.ecogene.org/geneInfo.php?eg_id=EG11038
EnsemblBacteriaAAC74682http://www.ensemblgenomes.org/id/AAC74682
EnsemblBacteriaAAC74682http://www.ensemblgenomes.org/id/AAC74682
EnsemblBacteriaBAA15348http://www.ensemblgenomes.org/id/BAA15348
EnsemblBacteriaBAA15348http://www.ensemblgenomes.org/id/BAA15348
EnsemblBacteriaBAA15348http://www.ensemblgenomes.org/id/BAA15348
EnsemblBacteriab1610http://www.ensemblgenomes.org/id/b1610
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_functionGO:0043565http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565
GO_processGO:0006274http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006274
GO_processGO:0071807http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071807
GOslim_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
Gene3D3.50.14.10http://www.cathdb.info/version/latest/superfamily/3.50.14.10
GeneID945135http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945135
HAMAPMF_00483http://hamap.expasy.org/unirule/MF_00483
HOGENOMHOG000280323http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280323&db=HOGENOM6
IntActP16525http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16525*
InterProIPR008865http://www.ebi.ac.uk/interpro/entry/IPR008865
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Geneecj:JW1602http://www.genome.jp/dbget-bin/www_bget?ecj:JW1602
KEGG_Geneeco:b1610http://www.genome.jp/dbget-bin/www_bget?eco:b1610
KEGG_OrthologyKO:K10748http://www.genome.jp/dbget-bin/www_bget?KO:K10748
MINTMINT-584635http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-584635
OMAQVQYACPhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QVQYACP
PDB1ECRhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1ECR
PDB1SUThttp://www.ebi.ac.uk/pdbe-srv/view/entry/1SUT
PDB2EWJhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2EWJ
PDB2I05http://www.ebi.ac.uk/pdbe-srv/view/entry/2I05
PDB2I06http://www.ebi.ac.uk/pdbe-srv/view/entry/2I06
PDB4XR0http://www.ebi.ac.uk/pdbe-srv/view/entry/4XR0
PDB4XR1http://www.ebi.ac.uk/pdbe-srv/view/entry/4XR1
PDB4XR2http://www.ebi.ac.uk/pdbe-srv/view/entry/4XR2
PDB4XR3http://www.ebi.ac.uk/pdbe-srv/view/entry/4XR3
PDBsum1ECRhttp://www.ebi.ac.uk/pdbsum/1ECR
PDBsum1SUThttp://www.ebi.ac.uk/pdbsum/1SUT
PDBsum2EWJhttp://www.ebi.ac.uk/pdbsum/2EWJ
PDBsum2I05http://www.ebi.ac.uk/pdbsum/2I05
PDBsum2I06http://www.ebi.ac.uk/pdbsum/2I06
PDBsum4XR0http://www.ebi.ac.uk/pdbsum/4XR0
PDBsum4XR1http://www.ebi.ac.uk/pdbsum/4XR1
PDBsum4XR2http://www.ebi.ac.uk/pdbsum/4XR2
PDBsum4XR3http://www.ebi.ac.uk/pdbsum/4XR3
PSORT-Bswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:TUS_ECOLI
PSORT2swissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:TUS_ECOLI
PSORTswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:TUS_ECOLI
PfamPF05472http://pfam.xfam.org/family/PF05472
Phobiusswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:TUS_ECOLI
ProteinModelPortalP16525http://www.proteinmodelportal.org/query/uniprot/P16525
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed2646639http://www.ncbi.nlm.nih.gov/pubmed/2646639
PubMed2687269http://www.ncbi.nlm.nih.gov/pubmed/2687269
PubMed3541901http://www.ncbi.nlm.nih.gov/pubmed/3541901
PubMed8547250http://www.ncbi.nlm.nih.gov/pubmed/8547250
PubMed8857533http://www.ncbi.nlm.nih.gov/pubmed/8857533
PubMed9097039http://www.ncbi.nlm.nih.gov/pubmed/9097039
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
RefSeqNP_416127http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416127
RefSeqWP_000135181http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000135181
SMRP16525http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16525
STRING511145.b1610http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1610&targetmode=cogs
SUPFAMSSF56596http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56596
TIGRFAMsTIGR02648http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02648
UniProtKB-ACP16525http://www.uniprot.org/uniprot/P16525
UniProtKBTUS_ECOLIhttp://www.uniprot.org/uniprot/TUS_ECOLI
chargeswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:TUS_ECOLI
eggNOGENOG4105KR1http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KR1
eggNOGENOG410XSWRhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSWR
epestfindswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:TUS_ECOLI
garnierswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:TUS_ECOLI
helixturnhelixswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:TUS_ECOLI
hmomentswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:TUS_ECOLI
iepswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:TUS_ECOLI
inforesidueswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:TUS_ECOLI
octanolswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:TUS_ECOLI
pepcoilswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:TUS_ECOLI
pepdigestswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:TUS_ECOLI
pepinfoswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:TUS_ECOLI
pepnetswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:TUS_ECOLI
pepstatsswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:TUS_ECOLI
pepwheelswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:TUS_ECOLI
pepwindowswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:TUS_ECOLI
sigcleaveswissprot:TUS_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:TUS_ECOLI
DataBaseIDURL or Descriptions
# AltNameTopoisomerase IV subunit A {ECO:0000255|HAMAP-RuleMF_00936}
# CATALYTIC ACTIVITYPARC_ECOLIATP-dependent breakage, passage and rejoining of double-stranded DNA. {ECO 0000255|HAMAP-Rule MF_00936, ECO 0000269|PubMed 12269820, ECO 0000269|PubMed 16023670, ECO 0000269|PubMed 21300644}.
# DrugBankDB00817Rosoxacin
# ENZYME REGULATIONInhibited by quinolones. {ECO:0000269|PubMed12269820}.
# EcoGeneEG10686parC
# FUNCTIONPARC_ECOLITopoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes (PubMed 9334322). It relaxes supercoiled DNA (PubMed 12269820, PuMed 16023670, PubMed 21300644). MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation (PubMed 20921377). {ECO 0000269|PubMed 12269820, ECO 0000269|PubMed 16023670, ECO 0000269|PubMed 20921377, ECO 0000269|PubMed 21300644, ECO 0000269|PubMed 9334322}.
# GO_componentGO:0005694chromosome; IEA:InterPro.
# GO_componentGO:0005737cytoplasm; IDA:EcoliWiki.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_componentGO:0009295nucleoid; IBA:GO_Central.
# GO_componentGO:0009330DNA topoisomerase complex (ATP-hydrolyzing); IDA:EcoliWiki.
# GO_componentGO:0019897extrinsic component of plasma membrane; IDA:EcoliWiki.
# GO_functionGO:0003677DNA binding; IDA:EcoliWiki.
# GO_functionGO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activity; IEA:UniProtKB-HAMAP.
# GO_functionGO:0005524ATP binding; IEA:InterPro.
# GO_processGO:0006265DNA topological change; IDA:EcoliWiki.
# GO_processGO:0006268DNA unwinding involved in DNA replication; IBA:GO_Central.
# GO_processGO:0007059chromosome segregation; IDA:EcoliWiki.
# GO_processGO:0007062sister chromatid cohesion; IMP:EcoliWiki.
# GO_processGO:0030541plasmid partitioning; IDA:EcoliWiki.
# GOslim_componentGO:0005575cellular_component
# GOslim_componentGO:0005694chromosome
# GOslim_componentGO:0005737cytoplasm
# GOslim_componentGO:0005829cytosol
# GOslim_componentGO:0043234protein complex
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0016853isomerase activity
# GOslim_functionGO:0016887ATPase activity
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0007059chromosome segregation
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0051276chromosome organization
# Gene3D3.30.1360.40-; 1.
# Gene3D3.90.199.10-; 2.
# HAMAPMF_00936ParC_type1
# INTERACTIONPARC_ECOLIP22523 mukB; NbExp=7; IntAct=EBI-878544, EBI-542943;
# IntActP0AFI223
# InterProIPR002205Topo_IIA_A/C
# InterProIPR005742TopoIV_A_Gneg
# InterProIPR006691GyrA/parC_pinwhl
# InterProIPR013758Topo_IIA_A/C_ab
# InterProIPR013760Topo_IIA-like_dom
# InterProIPR024946Arg_repress_C-like
# KEGG_Briteko01000Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03036 Chromosome
# OrganismPARC_ECOLIEscherichia coli (strain K12)
# PATRIC32121452VBIEscCol129921_3113
# PDB1ZVTX-ray; 1.70 A; A/B=497-752
# PDB1ZVUX-ray; 3.00 A; A=27-742
# PDB4MN4X-ray; 2.30 A; A/B=497-752
# PIRA65089A65089
# PfamPF00521DNA_topoisoIV
# PfamPF03989DNA_gyraseA_C; 2
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDNA topoisomerase 4 subunit A {ECO:0000255|HAMAP-RuleMF_00936}
# RefSeqNP_417491NC_000913.3
# RefSeqWP_001281881NZ_LN832404.1
# SEQUENCE CAUTIONSequence=AAA24297.1; Type=Frameshift; Positions=10; Evidence={ECO0000305};
# SIMILARITYBelongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. {ECO:0000255|HAMAP-RuleMF_00936}.
# SMARTSM00434TOP4c
# SUBCELLULAR LOCATIONPARC_ECOLICell membrane; Peripheral membrane protein.
# SUBUNITPARC_ECOLIHeterotetramer composed of ParC and ParE. Interacts with MukB. {ECO 0000255|HAMAP-Rule MF_00936, ECO 0000269|PubMed 16023670, ECO 0000269|PubMed 20921377, ECO 0000269|PubMed 21300644, ECO 0000269|PubMed 8227000}.
# SUPFAMSSF56719SSF56719
# eggNOGCOG0188LUCA
# eggNOGENOG4105C24Bacteria
BLASTswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:PARC_ECOLI
BioCycECOL316407:JW2987-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW2987-MONOMER
BioCycEcoCyc:EG10686-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10686-MONOMER
COGCOG0188http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0188
DIPDIP-36030Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36030N
DOI10.1016/0092-8674(90)90172-Bhttp://dx.doi.org/10.1016/0092-8674(90)90172-B
DOI10.1016/j.jmb.2005.06.029http://dx.doi.org/10.1016/j.jmb.2005.06.029
DOI10.1021/bi026352vhttp://dx.doi.org/10.1021/bi026352v
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1073/pnas.1008678107http://dx.doi.org/10.1073/pnas.1008678107
DOI10.1093/nar/gkr018http://dx.doi.org/10.1093/nar/gkr018
DOI10.1101/gad.11.19.2580http://dx.doi.org/10.1101/gad.11.19.2580
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
DrugBankDB00817http://www.drugbank.ca/drugs/DB00817
EC_numberEC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00936}http://www.genome.jp/dbget-bin/www_bget?EC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00936}
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLL22025http://www.ebi.ac.uk/ena/data/view/L22025
EMBLM58408http://www.ebi.ac.uk/ena/data/view/M58408
EMBLM63491http://www.ebi.ac.uk/ena/data/view/M63491
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU28377http://www.ebi.ac.uk/ena/data/view/U28377
ENZYME5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00936}http://enzyme.expasy.org/EC/5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00936}
EchoBASEEB0680http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0680
EcoGeneEG10686http://www.ecogene.org/geneInfo.php?eg_id=EG10686
EnsemblBacteriaAAC76055http://www.ensemblgenomes.org/id/AAC76055
EnsemblBacteriaAAC76055http://www.ensemblgenomes.org/id/AAC76055
EnsemblBacteriaBAE77075http://www.ensemblgenomes.org/id/BAE77075
EnsemblBacteriaBAE77075http://www.ensemblgenomes.org/id/BAE77075
EnsemblBacteriaBAE77075http://www.ensemblgenomes.org/id/BAE77075
EnsemblBacteriab3019http://www.ensemblgenomes.org/id/b3019
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005694http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694
GO_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_componentGO:0009295http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295
GO_componentGO:0009330http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009330
GO_componentGO:0019897http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019897
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003918http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003918
GO_functionGO:0005524http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_processGO:0006265http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006265
GO_processGO:0006268http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006268
GO_processGO:0007059http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059
GO_processGO:0007062http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007062
GO_processGO:0030541http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030541
GOslim_componentGO:0005575http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_componentGO:0005694http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694
GOslim_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_componentGO:0043234http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0016853http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853
GOslim_functionGO:0016887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0007059http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0051276http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276
Gene3D3.30.1360.40http://www.cathdb.info/version/latest/superfamily/3.30.1360.40
Gene3D3.90.199.10http://www.cathdb.info/version/latest/superfamily/3.90.199.10
GeneID947499http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947499
HAMAPMF_00936http://hamap.expasy.org/unirule/MF_00936
HOGENOMHOG000076277http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076277&db=HOGENOM6
InParanoidP0AFI2http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFI2
IntActP0AFI2http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFI2*
IntEnz5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00936}http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00936}
InterProIPR002205http://www.ebi.ac.uk/interpro/entry/IPR002205
InterProIPR005742http://www.ebi.ac.uk/interpro/entry/IPR005742
InterProIPR006691http://www.ebi.ac.uk/interpro/entry/IPR006691
InterProIPR013758http://www.ebi.ac.uk/interpro/entry/IPR013758
InterProIPR013760http://www.ebi.ac.uk/interpro/entry/IPR013760
InterProIPR024946http://www.ebi.ac.uk/interpro/entry/IPR024946
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03036http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Geneecj:JW2987http://www.genome.jp/dbget-bin/www_bget?ecj:JW2987
KEGG_Geneeco:b3019http://www.genome.jp/dbget-bin/www_bget?eco:b3019
KEGG_OrthologyKO:K02621http://www.genome.jp/dbget-bin/www_bget?KO:K02621
MINTMINT-1227290http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227290
OMARFTEDAYhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFTEDAY
PDB1ZVThttp://www.ebi.ac.uk/pdbe-srv/view/entry/1ZVT
PDB1ZVUhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1ZVU
PDB4MN4http://www.ebi.ac.uk/pdbe-srv/view/entry/4MN4
PDBsum1ZVThttp://www.ebi.ac.uk/pdbsum/1ZVT
PDBsum1ZVUhttp://www.ebi.ac.uk/pdbsum/1ZVU
PDBsum4MN4http://www.ebi.ac.uk/pdbsum/4MN4
PSORT-Bswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:PARC_ECOLI
PSORT2swissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:PARC_ECOLI
PSORTswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:PARC_ECOLI
PfamPF00521http://pfam.xfam.org/family/PF00521
PfamPF03989http://pfam.xfam.org/family/PF03989
Phobiusswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:PARC_ECOLI
PhylomeDBP0AFI2http://phylomedb.org/?seqid=P0AFI2
ProteinModelPortalP0AFI2http://www.proteinmodelportal.org/query/uniprot/P0AFI2
PubMed12269820http://www.ncbi.nlm.nih.gov/pubmed/12269820
PubMed1557036http://www.ncbi.nlm.nih.gov/pubmed/1557036
PubMed16023670http://www.ncbi.nlm.nih.gov/pubmed/16023670
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed20921377http://www.ncbi.nlm.nih.gov/pubmed/20921377
PubMed21300644http://www.ncbi.nlm.nih.gov/pubmed/21300644
PubMed2170028http://www.ncbi.nlm.nih.gov/pubmed/2170028
PubMed8227000http://www.ncbi.nlm.nih.gov/pubmed/8227000
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9334322http://www.ncbi.nlm.nih.gov/pubmed/9334322
RefSeqNP_417491http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417491
RefSeqWP_001281881http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001281881
SMARTSM00434http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00434
SMRP0AFI2http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFI2
STRING511145.b3019http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3019&targetmode=cogs
STRINGCOG0188http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0188&targetmode=cogs
SUPFAMSSF56719http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56719
UniProtKB-ACP0AFI2http://www.uniprot.org/uniprot/P0AFI2
UniProtKBPARC_ECOLIhttp://www.uniprot.org/uniprot/PARC_ECOLI
chargeswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:PARC_ECOLI
eggNOGCOG0188http://eggnogapi.embl.de/nog_data/html/tree/COG0188
eggNOGENOG4105C24http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C24
epestfindswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:PARC_ECOLI
garnierswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:PARC_ECOLI
helixturnhelixswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:PARC_ECOLI
hmomentswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:PARC_ECOLI
iepswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:PARC_ECOLI
inforesidueswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:PARC_ECOLI
octanolswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:PARC_ECOLI
pepcoilswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:PARC_ECOLI
pepdigestswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:PARC_ECOLI
pepinfoswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:PARC_ECOLI
pepnetswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:PARC_ECOLI
pepstatsswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:PARC_ECOLI
pepwheelswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:PARC_ECOLI
pepwindowswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:PARC_ECOLI
sigcleaveswissprot:PARC_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:PARC_ECOLI
DataBaseIDURL or Descriptions
# AltNameGYRB_ECOLIType IIA topoisomerase subunit GyrB
# BRENDA5.99.12026
# BioGrid4259537154
# CATALYTIC ACTIVITYGYRB_ECOLIATP-dependent breakage, passage and rejoining of double-stranded DNA. {ECO 0000255|HAMAP-Rule MF_01898, ECO 0000269|PubMed 12051842, ECO 0000269|PubMed 12051843, ECO 0000269|PubMed 18642932, ECO 0000269|PubMed 186775, ECO 0000269|PubMed 19965760, ECO 0000269|PubMed 20675723, ECO 0000269|PubMed 22731783}.
# COFACTORGYRB_ECOLIName=K(+); Xref=ChEBI CHEBI 29103; Evidence={ECO 0000269|PubMed 25849408}; Note=Binds one K(+) per subunit which interacts with the alpha- phosphate of ATP analog and stimulates ATPase activity of the N- terminal fragment; Na(+) or water bind less well (PubMed 25849408). {ECO 0000269|PubMed 25849408};
# COFACTORGYRB_ECOLIName=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01898, ECO 0000269|PubMed 12051843, ECO 0000269|PubMed 18642932}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_01898, ECO 0000269|PubMed 12051843, ECO 0000269|PubMed 18642932}; Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000255|HAMAP-Rule MF_01898, ECO 0000269|PubMed 12051843, ECO 0000269|PubMed 18642932}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+) (PubMed 12051843, PubMed 18642932). {ECO 0000255|HAMAP-Rule MF_01898, ECO 0000269|PubMed 12051843, ECO 0000269|PubMed 18642932};
# COFACTORGYRB_ECOLIName=Na(+); Xref=ChEBI CHEBI 29101; Evidence={ECO 0000269|PubMed 25849408}; Note=Binds one Na(+) per subunit, with 4 ligands provided by water; may be able to bind K(+), the functional significance of this ion is unclear (PubMed 25849408). {ECO 0000269|PubMed 25849408};
# DOMAINGYRB_ECOLIConsists of 3 domains; the ATPase domain (residues 1-220), the transducer domain (221-392) and the toprim domain (393-804) (PubMed 1646964, PubMed 10734094). ATP-binding is cooperative, and both subunits must be wild-type at residue 103 for supercoiling to occur (PubMed 8621650). Non-hydrolyzable ATP analogs (and ATP- binding) induce dimerization and enhance ATPase activity (PubMed 10734094, PubMed 9657678). ATP hydrolysis induces domain shifts that are probably part of the mechanism of DNA cleavage and rejoining (PubMed 25202966). {ECO 0000269|PubMed 10734094, ECO 0000269|PubMed 1646964, ECO 0000269|PubMed 8621650, ECO 0000305|PubMed 25202966, ECO 0000305|PubMed 9657678}.
# DrugBankDB00817Rosoxacin
# ENZYME REGULATIONGYRB_ECOLIGyrase is the target of many classes of inhibitors, including coumarins, cyclothialidines, pyrrolopyrimidines, pyrazolthiazoles and (fluoro)quinolones. Coumarins bind to GyrB and are competitive inhibitors of its ATPase activity (PubMed 7811004). Cyclothialidines also bind GyrB and are ATPase competitive inhibitors; they seem to act differently from coumarins (PubMed 7811004, PubMed 8635474). Pyrrolopyrimidines inhibit both GyrB and its paralog in topoisomerase 4 (parE) (PubMed 23294697, PubMed 23352267, PubMed 24386374). Pyrazolthiazoles also inhibit the ATPase activity of GyrB (PubMed 20356737). Quinolones bind GyrA when the enzyme is complexed with DNA and trap the enzyme in a covalent reaction intermediate with DNA (PubMed 3031051, PubMed 12051842, PubMed 337300). Acriflavine inhibits DNA supercoiling and DNA- stimulated ATPase activity (PubMed 9148951). DNA supercoiling activity is protected from fluoroquinolone inhibition by QnrB4; QnrB4 has no effect on supercoiling activity alone (PubMed 19060136). {ECO 0000269|PubMed 19060136, ECO 0000269|PubMed 20356737, ECO 0000269|PubMed 23294697, ECO 0000269|PubMed 23352267, ECO 0000269|PubMed 24386374, ECO 0000269|PubMed 3031051, ECO 0000269|PubMed 337300, ECO 0000269|PubMed 7811004, ECO 0000269|PubMed 8635474, ECO 0000269|PubMed 9148951, ECO 0000305|PubMed 12051842}.
# EcoGeneEG10424gyrB
# FUNCTIONGYRB_ECOLIDNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state (PubMed 186775, PubMed 3031051, PubMed 1323022, PubMed 8248233, PubMed 7811004, PubMed 8621650, PubMed 9657678, PubMed 12051842, PubMed 12051843, PubMed 18642932, PubMed 19060136, PubMed 19965760, PubMed 22457353, PubMed 23294697, PubMed 20356737, PubMed 20675723, PubMed 23352267, PubMed 24386374, PubMed 25202966, PubMed 25849408). This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli (PubMed 9334322). Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes (PubMed 22457352). Relaxes negatively supercoiled DNA in an ATP-independent manner (PubMed 337300). E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations E.coli gyrase introduces more supercoils faster than M.tuberculosis gyrase, while M.tuberculosis gyrase has higher decatenation than supercoiling activity compared to E.coli (PubMed 22457352). E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB subunit is toxic in E.coli, while the E.coli copy can be expressed in S.typhimurium even though the 2 subunits have 777/804 residues identical (PubMed 17400739). The enzymatic differences between E.coli gyrase and topoisomerase IV are largely due to the GyrA C- terminal domain (approximately residues 524-841) and specifically the GyrA-box (PubMed 8962066, PubMed 16332690). {ECO 0000269|PubMed 12051842, ECO 0000269|PubMed 12051843, ECO 0000269|PubMed 1323022, ECO 0000269|PubMed 16332690, ECO 0000269|PubMed 17400739, ECO 0000269|PubMed 18642932, ECO 0000269|PubMed 186775, ECO 0000269|PubMed 19060136, ECO 0000269|PubMed 19965760, ECO 0000269|PubMed 20356737, ECO 0000269|PubMed 20675723, ECO 0000269|PubMed 22457352, ECO 0000269|PubMed 22457353, ECO 0000269|PubMed 23294697, ECO 0000269|PubMed 23352267, ECO 0000269|PubMed 24386374, ECO 0000269|PubMed 25202966, ECO 0000269|PubMed 25849408, ECO 0000269|PubMed 3031051, ECO 0000269|PubMed 337300, ECO 0000269|PubMed 7811004, ECO 0000269|PubMed 8248233, ECO 0000269|PubMed 8621650, ECO 0000269|PubMed 8962066, ECO 0000269|PubMed 9148951, ECO 0000269|PubMed 9334322, ECO 0000269|PubMed 9657678}.
# GO_componentGO:0005694chromosome; IEA:InterPro.
# GO_componentGO:0005737cytoplasm; IDA:EcoliWiki.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_componentGO:0009295nucleoid; IBA:GO_Central.
# GO_componentGO:0009330DNA topoisomerase complex (ATP-hydrolyzing); IDA:EcoliWiki.
# GO_functionGO:0000287magnesium ion binding; IEA:UniProtKB-HAMAP.
# GO_functionGO:0003677DNA binding; IDA:EcoliWiki.
# GO_functionGO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activity; IDA:EcoliWiki.
# GO_functionGO:0005524ATP binding; IDA:EcoliWiki.
# GO_functionGO:0008094DNA-dependent ATPase activity; IDA:EcoliWiki.
# GO_functionGO:0034335DNA supercoiling activity; IDA:UniProtKB.
# GO_processGO:0006265DNA topological change; IMP:EcoliWiki.
# GO_processGO:0006268DNA unwinding involved in DNA replication; IBA:GO_Central.
# GO_processGO:0006351transcription, DNA-templated; IMP:EcoliWiki.
# GO_processGO:0007059chromosome segregation; IBA:GO_Central.
# GO_processGO:0042493response to drug; IDA:EcoliWiki.
# GO_processGO:0046677response to antibiotic; IEA:UniProtKB-KW.
# GOslim_componentGO:0005575cellular_component
# GOslim_componentGO:0005694chromosome
# GOslim_componentGO:0005737cytoplasm
# GOslim_componentGO:0005829cytosol
# GOslim_componentGO:0043234protein complex
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0016853isomerase activity
# GOslim_functionGO:0016887ATPase activity
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0007059chromosome segregation
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0009058biosynthetic process
# GOslim_processGO:0034641cellular nitrogen compound metabolic process
# GOslim_processGO:0051276chromosome organization
# Gene3D3.30.230.10-; 1.
# Gene3D3.30.565.10-; 1.
# Gene3D3.40.50.670-; 2.
# HAMAPMF_01898GyrB
# INTERACTIONGYRB_ECOLIP0AES4 gyrA; NbExp=5; IntAct=EBI-541911, EBI-547129;
# IntActP0AES618
# InterProIPR001241Topo_IIA
# InterProIPR002288DNA_gyrase_B_C
# InterProIPR003594HATPase_C
# InterProIPR006171Toprim_domain
# InterProIPR011557GyrB
# InterProIPR013506Topo_IIA_bsu_dom2
# InterProIPR013759Topo_IIA_cen_dom
# InterProIPR013760Topo_IIA-like_dom
# InterProIPR014721Ribosomal_S5_D2-typ_fold_subgr
# InterProIPR018522TopoIIA_CS
# InterProIPR020568Ribosomal_S5_D2-typ_fold
# KEGG_Briteko01000Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03400 DNA repair and recombination proteins
# MISCELLANEOUSGYRB_ECOLIWhen the enzyme transiently cleaves DNA a phosphotyrosine bond is formed between GyrA and DNA in an ATP- independent manner (PubMed 3031051). In the presence of quinolones this intermediate can be trapped and is used as an indicator of drug toxicity (PubMed 12051842). {ECO 0000269|PubMed 3031051, ECO 0000305|PubMed 12051842}.
# OrganismGYRB_ECOLIEscherichia coli (strain K12)
# PATRIC32122895VBIEscCol129921_3823
# PDB1AJ6X-ray; 2.30 A; A=2-220
# PDB1EI1X-ray; 2.30 A; A/B=2-392
# PDB1KZNX-ray; 2.30 A; A=15-219
# PDB3G7EX-ray; 2.20 A; A=15-217
# PDB3NUHX-ray; 3.10 A; B=389-804
# PDB4DUHX-ray; 1.50 A; A/B=1-220
# PDB4HYPX-ray; 2.60 A; A/B/C/D=15-220
# PDB4KFGX-ray; 1.60 A; A/B=15-220
# PDB4PRVX-ray; 2.00 A; A=2-392
# PDB4PRXX-ray; 1.80 A; A=2-392
# PDB4PU9X-ray; 2.40 A; A=2-392
# PDB4WUBX-ray; 1.75 A; A=2-393
# PDB4WUCX-ray; 1.90 A; A=2-393
# PDB4WUDX-ray; 1.95 A; A=2-393
# PDB4XTJX-ray; 1.92 A; A=2-392
# PDB4ZVIX-ray; 2.20 A; A=16-392
# PDB5L3JX-ray; 2.83 A; A=15-392
# PIRD65172ISECTB
# PRINTSPR00418TPI2FAMILY
# PROSITEPS00177TOPOISOMERASE_II
# PROSITEPS50880TOPRIM
# PfamPF00204DNA_gyraseB
# PfamPF00986DNA_gyraseB_C
# PfamPF01751Toprim
# PfamPF02518HATPase_c
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDNA gyrase subunit B {ECO:0000255|HAMAP-RuleMF_01898}
# RefSeqWP_000072067NZ_LN832404.1
# RefSeqYP_026241NC_000913.3
# SIMILARITYBelongs to the type II topoisomerase family. {ECO:0000255|HAMAP-RuleMF_01898}.
# SIMILARITYContains 1 Toprim domain. {ECO:0000255|HAMAP- RuleMF_01898}.
# SMARTSM00387HATPase_c
# SMARTSM00433TOP2c
# SUBCELLULAR LOCATIONGYRB_ECOLICytoplasm {ECO 0000255|HAMAP-Rule MF_01898}.
# SUBUNITGYRB_ECOLIHeterotetramer, composed of two GyrA and two GyrB chains (PubMed 9148951, PubMed 12051842). In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with the DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis (PubMed 12051843, PubMed 18642932, PubMed 20675723, PubMed 19965760). {ECO 0000255|HAMAP- Rule MF_01898, ECO 0000269|PubMed 12051842, ECO 0000269|PubMed 12051843, ECO 0000269|PubMed 18642932, ECO 0000269|PubMed 19965760, ECO 0000269|PubMed 20675723, ECO 0000269|PubMed 9148951}.
# SUPFAMSSF54211SSF54211
# SUPFAMSSF55874SSF55874
# SUPFAMSSF56719SSF56719; 2
# TIGRFAMsTIGR01059gyrB
# eggNOGCOG0187LUCA
# eggNOGENOG4105C7DBacteria
BLASTswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:GYRB_ECOLI
BioCycECOL316407:JW5625-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW5625-MONOMER
BioCycEcoCyc:EG10424-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10424-MONOMER
BioCycMetaCyc:EG10424-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG10424-MONOMER
COGCOG0187http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0187
DIPDIP-48005Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48005N
DOI10.1002/(SICI)1097-0134(199705)28:1<41::AID-PROT4>3.3.CO3.3.CO>http://dx.doi.org/10.1002/(SICI)1097-0134(199705)28:1<41::AID-PROT4>3.3.CO
DOI10.1002/elps.1150180805http://dx.doi.org/10.1002/elps.1150180805
DOI10.1006/geno.1993.1230http://dx.doi.org/10.1006/geno.1993.1230
DOI10.1007/BF00331012http://dx.doi.org/10.1007/BF00331012
DOI10.1016/S0022-2836(02)00048-7http://dx.doi.org/10.1016/S0022-2836(02)00048-7
DOI10.1016/S0022-2836(02)00049-9http://dx.doi.org/10.1016/S0022-2836(02)00049-9
DOI10.1016/j.bmcl.2010.03.052http://dx.doi.org/10.1016/j.bmcl.2010.03.052
DOI10.1016/j.bmcl.2012.11.032http://dx.doi.org/10.1016/j.bmcl.2012.11.032
DOI10.1016/j.bmcl.2012.11.073http://dx.doi.org/10.1016/j.bmcl.2012.11.073
DOI10.1021/bi0159837http://dx.doi.org/10.1021/bi0159837
DOI10.1021/bi800480jhttp://dx.doi.org/10.1021/bi800480j
DOI10.1021/bi970294+http://dx.doi.org/10.1021/bi970294+
DOI10.1021/bi9801309http://dx.doi.org/10.1021/bi9801309
DOI10.1021/jm300395dhttp://dx.doi.org/10.1021/jm300395d
DOI10.1038/351624a0http://dx.doi.org/10.1038/351624a0
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1073/pnas.73.11.3872http://dx.doi.org/10.1073/pnas.73.11.3872
DOI10.1073/pnas.74.11.4772http://dx.doi.org/10.1073/pnas.74.11.4772
DOI10.1073/pnas.90.23.11232http://dx.doi.org/10.1073/pnas.90.23.11232
DOI10.1073/pnas.93.25.14416http://dx.doi.org/10.1073/pnas.93.25.14416
DOI10.1074/jbc.271.16.9723http://dx.doi.org/10.1074/jbc.271.16.9723
DOI10.1074/jbc.272.20.13302http://dx.doi.org/10.1074/jbc.272.20.13302
DOI10.1074/jbc.275.13.9468http://dx.doi.org/10.1074/jbc.275.13.9468
DOI10.1074/jbc.M112.345678http://dx.doi.org/10.1074/jbc.M112.345678
DOI10.1074/jbc.M112.345736http://dx.doi.org/10.1074/jbc.M112.345736
DOI10.1074/jbc.M511160200http://dx.doi.org/10.1074/jbc.M511160200
DOI10.1093/nar/12.16.6389http://dx.doi.org/10.1093/nar/12.16.6389
DOI10.1093/nar/15.2.771http://dx.doi.org/10.1093/nar/15.2.771
DOI10.1093/nar/gkj405http://dx.doi.org/10.1093/nar/gkj405
DOI10.1093/nar/gkq665http://dx.doi.org/10.1093/nar/gkq665
DOI10.1101/gad.11.19.2580http://dx.doi.org/10.1101/gad.11.19.2580
DOI10.1107/S1399004715002916http://dx.doi.org/10.1107/S1399004715002916
DOI10.1111/j.1365-2958.1992.tb00886.xhttp://dx.doi.org/10.1111/j.1365-2958.1992.tb00886.x
DOI10.1126/science.1179123http://dx.doi.org/10.1126/science.1179123
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
DOI10.1128/AAC.35.8.1647http://dx.doi.org/10.1128/AAC.35.8.1647
DOI10.1128/AAC.38.9.1966http://dx.doi.org/10.1128/AAC.38.9.1966
DOI10.1128/JB.00083-07http://dx.doi.org/10.1128/JB.00083-07
DOI10.1128/JB.01205-08http://dx.doi.org/10.1128/JB.01205-08
DOI10.1371/journal.pone.0084409http://dx.doi.org/10.1371/journal.pone.0084409
DOI10.1371/journal.pone.0107289http://dx.doi.org/10.1371/journal.pone.0107289
DrugBankDB00817http://www.drugbank.ca/drugs/DB00817
EC_numberEC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01898, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:12051843, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760}http://www.genome.jp/dbget-bin/www_bget?EC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01898, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:12051843, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760}
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLD87842http://www.ebi.ac.uk/ena/data/view/D87842
EMBLL10328http://www.ebi.ac.uk/ena/data/view/L10328
EMBLM15548http://www.ebi.ac.uk/ena/data/view/M15548
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLX04341http://www.ebi.ac.uk/ena/data/view/X04341
ENZYME5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01898, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:12051843, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760}http://enzyme.expasy.org/EC/5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01898, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:12051843, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760}
EchoBASEEB0419http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0419
EcoGeneEG10424http://www.ecogene.org/geneInfo.php?eg_id=EG10424
EnsemblBacteriaAAT48201http://www.ensemblgenomes.org/id/AAT48201
EnsemblBacteriaAAT48201http://www.ensemblgenomes.org/id/AAT48201
EnsemblBacteriaBAE77595http://www.ensemblgenomes.org/id/BAE77595
EnsemblBacteriaBAE77595http://www.ensemblgenomes.org/id/BAE77595
EnsemblBacteriaBAE77595http://www.ensemblgenomes.org/id/BAE77595
EnsemblBacteriab3699http://www.ensemblgenomes.org/id/b3699
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005694http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694
GO_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_componentGO:0009295http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295
GO_componentGO:0009330http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009330
GO_functionGO:0000287http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003918http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003918
GO_functionGO:0005524http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_functionGO:0008094http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008094
GO_functionGO:0034335http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034335
GO_processGO:0006265http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006265
GO_processGO:0006268http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006268
GO_processGO:0006351http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351
GO_processGO:0007059http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059
GO_processGO:0042493http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493
GO_processGO:0046677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677
GOslim_componentGO:0005575http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_componentGO:0005694http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694
GOslim_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_componentGO:0043234http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0016853http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853
GOslim_functionGO:0016887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0007059http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_processGO:0034641http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_processGO:0051276http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276
Gene3D3.30.230.10http://www.cathdb.info/version/latest/superfamily/3.30.230.10
Gene3D3.30.565.10http://www.cathdb.info/version/latest/superfamily/3.30.565.10
Gene3D3.40.50.670http://www.cathdb.info/version/latest/superfamily/3.40.50.670
GeneID948211http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948211
HAMAPMF_01898http://hamap.expasy.org/unirule/MF_01898
HOGENOMHOG000075155http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000075155&db=HOGENOM6
InParanoidP0AES6http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AES6
IntActP0AES6http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AES6*
IntEnz5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01898, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:12051843, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760}http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01898, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:12051843, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760}
InterProIPR001241http://www.ebi.ac.uk/interpro/entry/IPR001241
InterProIPR002288http://www.ebi.ac.uk/interpro/entry/IPR002288
InterProIPR003594http://www.ebi.ac.uk/interpro/entry/IPR003594
InterProIPR006171http://www.ebi.ac.uk/interpro/entry/IPR006171
InterProIPR011557http://www.ebi.ac.uk/interpro/entry/IPR011557
InterProIPR013506http://www.ebi.ac.uk/interpro/entry/IPR013506
InterProIPR013759http://www.ebi.ac.uk/interpro/entry/IPR013759
InterProIPR013760http://www.ebi.ac.uk/interpro/entry/IPR013760
InterProIPR014721http://www.ebi.ac.uk/interpro/entry/IPR014721
InterProIPR018522http://www.ebi.ac.uk/interpro/entry/IPR018522
InterProIPR020568http://www.ebi.ac.uk/interpro/entry/IPR020568
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW5625http://www.genome.jp/dbget-bin/www_bget?ecj:JW5625
KEGG_Geneeco:b3699http://www.genome.jp/dbget-bin/www_bget?eco:b3699
KEGG_OrthologyKO:K02470http://www.genome.jp/dbget-bin/www_bget?KO:K02470
OMAIKNMITAhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKNMITA
PDB1AJ6http://www.ebi.ac.uk/pdbe-srv/view/entry/1AJ6
PDB1EI1http://www.ebi.ac.uk/pdbe-srv/view/entry/1EI1
PDB1KZNhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1KZN
PDB3G7Ehttp://www.ebi.ac.uk/pdbe-srv/view/entry/3G7E
PDB3NUHhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3NUH
PDB4DUHhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4DUH
PDB4HYPhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4HYP
PDB4KFGhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4KFG
PDB4PRVhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4PRV
PDB4PRXhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4PRX
PDB4PU9http://www.ebi.ac.uk/pdbe-srv/view/entry/4PU9
PDB4WUBhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4WUB
PDB4WUChttp://www.ebi.ac.uk/pdbe-srv/view/entry/4WUC
PDB4WUDhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4WUD
PDB4XTJhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4XTJ
PDB4ZVIhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4ZVI
PDB5L3Jhttp://www.ebi.ac.uk/pdbe-srv/view/entry/5L3J
PDBsum1AJ6http://www.ebi.ac.uk/pdbsum/1AJ6
PDBsum1EI1http://www.ebi.ac.uk/pdbsum/1EI1
PDBsum1KZNhttp://www.ebi.ac.uk/pdbsum/1KZN
PDBsum3G7Ehttp://www.ebi.ac.uk/pdbsum/3G7E
PDBsum3NUHhttp://www.ebi.ac.uk/pdbsum/3NUH
PDBsum4DUHhttp://www.ebi.ac.uk/pdbsum/4DUH
PDBsum4HYPhttp://www.ebi.ac.uk/pdbsum/4HYP
PDBsum4KFGhttp://www.ebi.ac.uk/pdbsum/4KFG
PDBsum4PRVhttp://www.ebi.ac.uk/pdbsum/4PRV
PDBsum4PRXhttp://www.ebi.ac.uk/pdbsum/4PRX
PDBsum4PU9http://www.ebi.ac.uk/pdbsum/4PU9
PDBsum4WUBhttp://www.ebi.ac.uk/pdbsum/4WUB
PDBsum4WUChttp://www.ebi.ac.uk/pdbsum/4WUC
PDBsum4WUDhttp://www.ebi.ac.uk/pdbsum/4WUD
PDBsum4XTJhttp://www.ebi.ac.uk/pdbsum/4XTJ
PDBsum4ZVIhttp://www.ebi.ac.uk/pdbsum/4ZVI
PDBsum5L3Jhttp://www.ebi.ac.uk/pdbsum/5L3J
PRINTSPR00418http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00418
PROSITEPS00177http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00177
PROSITEPS50880http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50880
PSORT-Bswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:GYRB_ECOLI
PSORT2swissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:GYRB_ECOLI
PSORTswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:GYRB_ECOLI
PfamPF00204http://pfam.xfam.org/family/PF00204
PfamPF00986http://pfam.xfam.org/family/PF00986
PfamPF01751http://pfam.xfam.org/family/PF01751
PfamPF02518http://pfam.xfam.org/family/PF02518
Phobiusswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:GYRB_ECOLI
PhylomeDBP0AES6http://phylomedb.org/?seqid=P0AES6
ProteinModelPortalP0AES6http://www.proteinmodelportal.org/query/uniprot/P0AES6
PubMed10734094http://www.ncbi.nlm.nih.gov/pubmed/10734094
PubMed12044152http://www.ncbi.nlm.nih.gov/pubmed/12044152
PubMed12051842http://www.ncbi.nlm.nih.gov/pubmed/12051842
PubMed12051843http://www.ncbi.nlm.nih.gov/pubmed/12051843
PubMed1323022http://www.ncbi.nlm.nih.gov/pubmed/1323022
PubMed16332690http://www.ncbi.nlm.nih.gov/pubmed/16332690
PubMed16397293http://www.ncbi.nlm.nih.gov/pubmed/16397293
PubMed1646964http://www.ncbi.nlm.nih.gov/pubmed/1646964
PubMed1656869http://www.ncbi.nlm.nih.gov/pubmed/1656869
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed17400739http://www.ncbi.nlm.nih.gov/pubmed/17400739
PubMed1846808http://www.ncbi.nlm.nih.gov/pubmed/1846808
PubMed18642932http://www.ncbi.nlm.nih.gov/pubmed/18642932
PubMed186775http://www.ncbi.nlm.nih.gov/pubmed/186775
PubMed19060136http://www.ncbi.nlm.nih.gov/pubmed/19060136
PubMed19965760http://www.ncbi.nlm.nih.gov/pubmed/19965760
PubMed20356737http://www.ncbi.nlm.nih.gov/pubmed/20356737
PubMed20675723http://www.ncbi.nlm.nih.gov/pubmed/20675723
PubMed2174443http://www.ncbi.nlm.nih.gov/pubmed/2174443
PubMed22457352http://www.ncbi.nlm.nih.gov/pubmed/22457352
PubMed22457353http://www.ncbi.nlm.nih.gov/pubmed/22457353
PubMed22731783http://www.ncbi.nlm.nih.gov/pubmed/22731783
PubMed23294697http://www.ncbi.nlm.nih.gov/pubmed/23294697
PubMed23352267http://www.ncbi.nlm.nih.gov/pubmed/23352267
PubMed24386374http://www.ncbi.nlm.nih.gov/pubmed/24386374
PubMed25202966http://www.ncbi.nlm.nih.gov/pubmed/25202966
PubMed25849408http://www.ncbi.nlm.nih.gov/pubmed/25849408
PubMed3020376http://www.ncbi.nlm.nih.gov/pubmed/3020376
PubMed3029031http://www.ncbi.nlm.nih.gov/pubmed/3029031
PubMed3029692http://www.ncbi.nlm.nih.gov/pubmed/3029692
PubMed3031051http://www.ncbi.nlm.nih.gov/pubmed/3031051
PubMed337300http://www.ncbi.nlm.nih.gov/pubmed/337300
PubMed6089112http://www.ncbi.nlm.nih.gov/pubmed/6089112
PubMed7686882http://www.ncbi.nlm.nih.gov/pubmed/7686882
PubMed7811004http://www.ncbi.nlm.nih.gov/pubmed/7811004
PubMed8248233http://www.ncbi.nlm.nih.gov/pubmed/8248233
PubMed8621650http://www.ncbi.nlm.nih.gov/pubmed/8621650
PubMed8635474http://www.ncbi.nlm.nih.gov/pubmed/8635474
PubMed8962066http://www.ncbi.nlm.nih.gov/pubmed/8962066
PubMed9144789http://www.ncbi.nlm.nih.gov/pubmed/9144789
PubMed9148951http://www.ncbi.nlm.nih.gov/pubmed/9148951
PubMed9245398http://www.ncbi.nlm.nih.gov/pubmed/9245398
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9298644http://www.ncbi.nlm.nih.gov/pubmed/9298644
PubMed9334322http://www.ncbi.nlm.nih.gov/pubmed/9334322
PubMed9657678http://www.ncbi.nlm.nih.gov/pubmed/9657678
RefSeqWP_000072067http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000072067
RefSeqYP_026241http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026241
SMARTSM00387http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387
SMARTSM00433http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00433
SMRP0AES6http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AES6
STRING511145.b3699http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3699&targetmode=cogs
STRINGCOG0187http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0187&targetmode=cogs
SUPFAMSSF54211http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211
SUPFAMSSF55874http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874
SUPFAMSSF56719http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56719
TIGRFAMsTIGR01059http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01059
UniProtKB-ACP0AES6http://www.uniprot.org/uniprot/P0AES6
UniProtKBGYRB_ECOLIhttp://www.uniprot.org/uniprot/GYRB_ECOLI
chargeswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:GYRB_ECOLI
eggNOGCOG0187http://eggnogapi.embl.de/nog_data/html/tree/COG0187
eggNOGENOG4105C7Dhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7D
epestfindswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:GYRB_ECOLI
garnierswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:GYRB_ECOLI
helixturnhelixswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:GYRB_ECOLI
hmomentswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:GYRB_ECOLI
iepswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:GYRB_ECOLI
inforesidueswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:GYRB_ECOLI
octanolswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:GYRB_ECOLI
pepcoilswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:GYRB_ECOLI
pepdigestswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:GYRB_ECOLI
pepinfoswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:GYRB_ECOLI
pepnetswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:GYRB_ECOLI
pepstatsswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:GYRB_ECOLI
pepwheelswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:GYRB_ECOLI
pepwindowswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:GYRB_ECOLI
sigcleaveswissprot:GYRB_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:GYRB_ECOLI
DataBaseIDURL or Descriptions
# EcoGeneEG10237dnaC
# FUNCTIONDNAC_ECOLIThis protein is required for chromosomal replication. It forms, in concert with DnaB protein and other prepriming proteins DnaT, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.
# GO_componentGO:1990077primosome complex; IEA:UniProtKB-KW.
# GO_functionGO:0005524ATP binding; IEA:UniProtKB-KW.
# GO_functionGO:0043565sequence-specific DNA binding; IBA:GO_Central.
# GO_processGO:0006269DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW.
# GO_processGO:0006271DNA strand elongation involved in DNA replication; IGI:EcoCyc.
# GOslim_componentGO:0005575cellular_component
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0009058biosynthetic process
# Gene3D3.40.50.300-; 1.
# INDUCTIONInduced by hydroxyurea. {ECO:0000269|PubMed20005847}.
# INTERACTIONDNAC_ECOLIP0ACB0 dnaB; NbExp=9; IntAct=EBI-549012, EBI-548978;
# IntActP0AEF013
# InterProIPR002611IstB_ATP-bd
# InterProIPR003593AAA+_ATPase
# InterProIPR027417P-loop_NTPase
# InterProIPR028350DNAC/ATP-binding
# KEGG_Briteko03032DNA replication proteins
# OrganismDNAC_ECOLIEscherichia coli (strain K12)
# PATRIC32124330VBIEscCol129921_4508
# PIRA28484XMECNC
# PIRSFPIRSF003073DNAC_TnpB_IstB
# PfamPF01695IstB_IS21
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDNAC_ECOLIDNA replication protein DnaC
# RefSeqNP_418781NC_000913.3
# RefSeqWP_000799911NZ_LN832404.1
# SIMILARITYBelongs to the DnaC family. {ECO0000305}.
# SMARTSM00382AAA
# SUPFAMSSF52540SSF52540
# eggNOGCOG1484LUCA
# eggNOGENOG4106CVFBacteria
BLASTswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:DNAC_ECOLI
BioCycECOL316407:JW4325-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW4325-MONOMER
BioCycEcoCyc:EG10237-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10237-MONOMER
COGCOG1484http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1484
DIPDIP-9457Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9457N
DOI10.1002/elps.1150180805http://dx.doi.org/10.1002/elps.1150180805
DOI10.1016/j.molcel.2009.11.024http://dx.doi.org/10.1016/j.molcel.2009.11.024
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1073/pnas.83.5.1256http://dx.doi.org/10.1073/pnas.83.5.1256
DOI10.1093/nar/23.12.2105http://dx.doi.org/10.1093/nar/23.12.2105
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLJ04030http://www.ebi.ac.uk/ena/data/view/J04030
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU14003http://www.ebi.ac.uk/ena/data/view/U14003
EchoBASEEB0233http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0233
EcoGeneEG10237http://www.ecogene.org/geneInfo.php?eg_id=EG10237
EnsemblBacteriaAAC77317http://www.ensemblgenomes.org/id/AAC77317
EnsemblBacteriaAAC77317http://www.ensemblgenomes.org/id/AAC77317
EnsemblBacteriaBAE78351http://www.ensemblgenomes.org/id/BAE78351
EnsemblBacteriaBAE78351http://www.ensemblgenomes.org/id/BAE78351
EnsemblBacteriaBAE78351http://www.ensemblgenomes.org/id/BAE78351
EnsemblBacteriab4361http://www.ensemblgenomes.org/id/b4361
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:1990077http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990077
GO_functionGO:0005524http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_functionGO:0043565http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565
GO_processGO:0006269http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006269
GO_processGO:0006271http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006271
GOslim_componentGO:0005575http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
Gene3D3.40.50.300http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneID948864http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948864
HOGENOMHOG000120230http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120230&db=HOGENOM6
InParanoidP0AEF0http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEF0
IntActP0AEF0http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEF0*
InterProIPR002611http://www.ebi.ac.uk/interpro/entry/IPR002611
InterProIPR003593http://www.ebi.ac.uk/interpro/entry/IPR003593
InterProIPR027417http://www.ebi.ac.uk/interpro/entry/IPR027417
InterProIPR028350http://www.ebi.ac.uk/interpro/entry/IPR028350
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Geneecj:JW4325http://www.genome.jp/dbget-bin/www_bget?ecj:JW4325
KEGG_Geneeco:b4361http://www.genome.jp/dbget-bin/www_bget?eco:b4361
KEGG_OrthologyKO:K02315http://www.genome.jp/dbget-bin/www_bget?KO:K02315
MINTMINT-1276712http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1276712
OMAVGDLMKRhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VGDLMKR
PSORT-Bswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:DNAC_ECOLI
PSORT2swissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:DNAC_ECOLI
PSORTswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:DNAC_ECOLI
PfamPF01695http://pfam.xfam.org/family/PF01695
Phobiusswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:DNAC_ECOLI
PhylomeDBP0AEF0http://phylomedb.org/?seqid=P0AEF0
ProteinModelPortalP0AEF0http://www.proteinmodelportal.org/query/uniprot/P0AEF0
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed20005847http://www.ncbi.nlm.nih.gov/pubmed/20005847
PubMed2844800http://www.ncbi.nlm.nih.gov/pubmed/2844800
PubMed3006041http://www.ncbi.nlm.nih.gov/pubmed/3006041
PubMed3301836http://www.ncbi.nlm.nih.gov/pubmed/3301836
PubMed7610040http://www.ncbi.nlm.nih.gov/pubmed/7610040
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9298644http://www.ncbi.nlm.nih.gov/pubmed/9298644
RefSeqNP_418781http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418781
RefSeqWP_000799911http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000799911
SMARTSM00382http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
STRING511145.b4361http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4361&targetmode=cogs
STRINGCOG1484http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1484&targetmode=cogs
SUPFAMSSF52540http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
UniProtKB-ACP0AEF0http://www.uniprot.org/uniprot/P0AEF0
UniProtKBDNAC_ECOLIhttp://www.uniprot.org/uniprot/DNAC_ECOLI
chargeswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:DNAC_ECOLI
eggNOGCOG1484http://eggnogapi.embl.de/nog_data/html/tree/COG1484
eggNOGENOG4106CVFhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4106CVF
epestfindswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:DNAC_ECOLI
garnierswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:DNAC_ECOLI
helixturnhelixswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:DNAC_ECOLI
hmomentswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:DNAC_ECOLI
iepswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:DNAC_ECOLI
inforesidueswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:DNAC_ECOLI
octanolswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:DNAC_ECOLI
pepcoilswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:DNAC_ECOLI
pepdigestswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:DNAC_ECOLI
pepinfoswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:DNAC_ECOLI
pepnetswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:DNAC_ECOLI
pepstatsswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:DNAC_ECOLI
pepwheelswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:DNAC_ECOLI
pepwindowswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:DNAC_ECOLI
sigcleaveswissprot:DNAC_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:DNAC_ECOLI
DataBaseIDURL or Descriptions
# BioGrid4262146193
# COFACTORDNAG_ECOLIName=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00974}; Note=Binds two Mg(2+) per subunit. {ECO 0000255|HAMAP- Rule MF_00974};
# COFACTORDNAG_ECOLIName=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_00974, ECO 0000269|PubMed 1511009, ECO 0000269|PubMed 8679581}; Note=Binds 1 zinc ion per monomer. {ECO 0000255|HAMAP- Rule MF_00974, ECO 0000269|PubMed 1511009, ECO 0000269|PubMed 8679581};
# DOMAINDNAG_ECOLIContains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB- binding domain. {ECO 0000255|HAMAP-Rule MF_00974, ECO 0000269|PubMed 10741967, ECO 0000269|PubMed 15649896, ECO 0000269|PubMed 17010164}.
# ENZYME REGULATIONActivity can be regulated by an intermolecular trans association between the zinc-binding domain and the catalytic core domain of two different primase molecules. {ECO:0000269|PubMed16285921}.
# EcoGeneEG10239dnaG
# FUNCTIONDNAG_ECOLIRNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. {ECO 0000255|HAMAP-Rule MF_00974, ECO 0000269|PubMed 1511009, ECO 0000269|PubMed 340457}.
# GO_componentGO:0005737cytoplasm; IDA:EcoliWiki.
# GO_componentGO:1990077primosome complex; IEA:UniProtKB-KW.
# GO_functionGO:0000287magnesium ion binding; IEA:UniProtKB-HAMAP.
# GO_functionGO:0003677DNA binding; IEA:UniProtKB-KW.
# GO_functionGO:0003896DNA primase activity; IDA:EcoliWiki.
# GO_functionGO:0008270zinc ion binding; IDA:EcoliWiki.
# GO_processGO:0006269DNA replication, synthesis of RNA primer; IMP:CACAO.
# GOslim_componentGO:0005575cellular_component
# GOslim_componentGO:0005737cytoplasm
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0016779nucleotidyltransferase activity
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0009058biosynthetic process
# Gene3D1.10.860.10-; 1.
# Gene3D3.90.580.10-; 1.
# Gene3D3.90.980.10-; 1.
# HAMAPMF_00974DNA_primase_DnaG
# INTERACTIONDNAG_ECOLIP0ACB0 dnaB; NbExp=3; IntAct=EBI-549259, EBI-548978; P0AGE0 ssb; NbExp=2; IntAct=EBI-549259, EBI-1118620;
# IntActP0ABS517
# InterProIPR002694Znf_CHC2
# InterProIPR006171Toprim_domain
# InterProIPR006295DNA_primase_DnaG
# InterProIPR013173DNA_primase_DnaG_DnaB-bd_dom
# InterProIPR013264DNA_primase_core_N
# InterProIPR016136DNA_helicase_N/primase_C
# InterProIPR019475DNA_primase_DnaB-bd
# InterProIPR030846DnaG_bac
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Pathwayko03030DNA replication
# OrganismDNAG_ECOLIEscherichia coli (strain K12)
# PATRIC32121546VBIEscCol129921_3160
# PDB1DD9X-ray; 1.60 A; A=111-433
# PDB1DDEX-ray; 1.70 A; A=111-433
# PDB1EQNX-ray; 2.90 A; A/B/C/D/E=111-429
# PDB1T3WX-ray; 2.80 A; A/B=434-581
# PDB2HAJNMR; -; A=434-581
# PDB3B39X-ray; 2.35 A; A/B=111-429
# PIRA03423RYEC2
# PIRSFPIRSF002811DnaG
# PROSITEPS50880TOPRIM
# PfamPF01807zf-CHC2
# PfamPF08275Toprim_N
# PfamPF08278DnaG_DnaB_bind
# PfamPF10410DnaB_bind
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDNA primase {ECO:0000255|HAMAP-RuleMF_00974}
# RefSeqNP_417538NC_000913.3
# RefSeqWP_000918827NZ_LN832404.1
# SEQUENCE CAUTIONSequence=CAA23531.1; Type=Frameshift; Positions=106, 169; Evidence={ECO0000305};
# SIMILARITYBelongs to the DnaG primase family. {ECO:0000255|HAMAP-RuleMF_00974}.
# SIMILARITYContains 1 Toprim domain. {ECO:0000255|HAMAP- RuleMF_00974}.
# SMARTSM00400ZnF_CHCC
# SMARTSM00493TOPRIM
# SMARTSM00766DnaG_DnaB_bind
# SUBUNITDNAG_ECOLIMonomer. Interacts with DnaB. The primase-helicase complex is composed of up to three DnaG bound to one DnaB hexamer. {ECO 0000255|HAMAP-Rule MF_00974, ECO 0000269|PubMed 14557266, ECO 0000269|PubMed 1511009, ECO 0000269|PubMed 15649896, ECO 0000269|PubMed 17010164, ECO 0000269|PubMed 340457, ECO 0000269|PubMed 8917517}.
# TIGRFAMsTIGR01391dnaG
# eggNOGCOG0358LUCA
# eggNOGENOG4105C9GBacteria
BLASTswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:DNAG_ECOLI
BioCycECOL316407:JW3038-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW3038-MONOMER
BioCycEcoCyc:EG10239-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10239-MONOMER
BioCycMetaCyc:EG10239-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG10239-MONOMER
COGCOG0358http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0358
DIPDIP-47954Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47954N
DOI10.1002/elps.1150180805http://dx.doi.org/10.1002/elps.1150180805
DOI10.1006/jmbi.2000.3844http://dx.doi.org/10.1006/jmbi.2000.3844
DOI10.1007/BF00326054http://dx.doi.org/10.1007/BF00326054
DOI10.1016/0092-8674(83)90453-1http://dx.doi.org/10.1016/0092-8674(83)90453-1
DOI10.1016/0167-4781(92)90047-4http://dx.doi.org/10.1016/0167-4781(92)90047-4
DOI10.1016/j.molcel.2005.09.004http://dx.doi.org/10.1016/j.molcel.2005.09.004
DOI10.1021/bi952948phttp://dx.doi.org/10.1021/bi952948p
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1038/nsmb.1373http://dx.doi.org/10.1038/nsmb.1373
DOI10.1073/pnas.79.15.4550http://dx.doi.org/10.1073/pnas.79.15.4550
DOI10.1073/pnas.93.23.12902http://dx.doi.org/10.1073/pnas.93.23.12902
DOI10.1074/jbc.M308956200http://dx.doi.org/10.1074/jbc.M308956200
DOI10.1074/jbc.M412645200http://dx.doi.org/10.1074/jbc.M412645200
DOI10.1111/j.1742-4658.2006.05495.xhttp://dx.doi.org/10.1111/j.1742-4658.2006.05495.x
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
DOI10.1126/science.287.5462.2482http://dx.doi.org/10.1126/science.287.5462.2482
EC_numberEC:2.7.7.- {ECO:0000255|HAMAP-Rule:MF_00974}http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.- {ECO:0000255|HAMAP-Rule:MF_00974}
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLJ01687http://www.ebi.ac.uk/ena/data/view/J01687
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU28379http://www.ebi.ac.uk/ena/data/view/U28379
EMBLV00274http://www.ebi.ac.uk/ena/data/view/V00274
EMBLV00346http://www.ebi.ac.uk/ena/data/view/V00346
ENZYME2.7.7.- {ECO:0000255|HAMAP-Rule:MF_00974}http://enzyme.expasy.org/EC/2.7.7.- {ECO:0000255|HAMAP-Rule:MF_00974}
EchoBASEEB0235http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0235
EcoGeneEG10239http://www.ecogene.org/geneInfo.php?eg_id=EG10239
EnsemblBacteriaAAC76102http://www.ensemblgenomes.org/id/AAC76102
EnsemblBacteriaAAC76102http://www.ensemblgenomes.org/id/AAC76102
EnsemblBacteriaBAE77117http://www.ensemblgenomes.org/id/BAE77117
EnsemblBacteriaBAE77117http://www.ensemblgenomes.org/id/BAE77117
EnsemblBacteriaBAE77117http://www.ensemblgenomes.org/id/BAE77117
EnsemblBacteriab3066http://www.ensemblgenomes.org/id/b3066
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_componentGO:1990077http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990077
GO_functionGO:0000287http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003896http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003896
GO_functionGO:0008270http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270
GO_processGO:0006269http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006269
GOslim_componentGO:0005575http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0016779http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
Gene3D1.10.860.10http://www.cathdb.info/version/latest/superfamily/1.10.860.10
Gene3D3.90.580.10http://www.cathdb.info/version/latest/superfamily/3.90.580.10
Gene3D3.90.980.10http://www.cathdb.info/version/latest/superfamily/3.90.980.10
GeneID947570http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947570
HAMAPMF_00974http://hamap.expasy.org/unirule/MF_00974
HOGENOMHOG000014483http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000014483&db=HOGENOM6
InParanoidP0ABS5http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABS5
IntActP0ABS5http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABS5*
IntEnz2.7.7.- {ECO:0000255|HAMAP-Rule:MF_00974}http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.- {ECO:0000255|HAMAP-Rule:MF_00974}
InterProIPR002694http://www.ebi.ac.uk/interpro/entry/IPR002694
InterProIPR006171http://www.ebi.ac.uk/interpro/entry/IPR006171
InterProIPR006295http://www.ebi.ac.uk/interpro/entry/IPR006295
InterProIPR013173http://www.ebi.ac.uk/interpro/entry/IPR013173
InterProIPR013264http://www.ebi.ac.uk/interpro/entry/IPR013264
InterProIPR016136http://www.ebi.ac.uk/interpro/entry/IPR016136
InterProIPR019475http://www.ebi.ac.uk/interpro/entry/IPR019475
InterProIPR030846http://www.ebi.ac.uk/interpro/entry/IPR030846
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Geneecj:JW3038http://www.genome.jp/dbget-bin/www_bget?ecj:JW3038
KEGG_Geneeco:b3066http://www.genome.jp/dbget-bin/www_bget?eco:b3066
KEGG_OrthologyKO:K02316http://www.genome.jp/dbget-bin/www_bget?KO:K02316
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
MINTMINT-1222307http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222307
OMAEHYRGTKhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EHYRGTK
PDB1DD9http://www.ebi.ac.uk/pdbe-srv/view/entry/1DD9
PDB1DDEhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1DDE
PDB1EQNhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1EQN
PDB1T3Whttp://www.ebi.ac.uk/pdbe-srv/view/entry/1T3W
PDB2HAJhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2HAJ
PDB3B39http://www.ebi.ac.uk/pdbe-srv/view/entry/3B39
PDBsum1DD9http://www.ebi.ac.uk/pdbsum/1DD9
PDBsum1DDEhttp://www.ebi.ac.uk/pdbsum/1DDE
PDBsum1EQNhttp://www.ebi.ac.uk/pdbsum/1EQN
PDBsum1T3Whttp://www.ebi.ac.uk/pdbsum/1T3W
PDBsum2HAJhttp://www.ebi.ac.uk/pdbsum/2HAJ
PDBsum3B39http://www.ebi.ac.uk/pdbsum/3B39
PROSITEPS50880http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50880
PSORT-Bswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:DNAG_ECOLI
PSORT2swissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:DNAG_ECOLI
PSORTswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:DNAG_ECOLI
PfamPF01807http://pfam.xfam.org/family/PF01807
PfamPF08275http://pfam.xfam.org/family/PF08275
PfamPF08278http://pfam.xfam.org/family/PF08278
PfamPF10410http://pfam.xfam.org/family/PF10410
Phobiusswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:DNAG_ECOLI
PhylomeDBP0ABS5http://phylomedb.org/?seqid=P0ABS5
ProteinModelPortalP0ABS5http://www.proteinmodelportal.org/query/uniprot/P0ABS5
PubMed10741967http://www.ncbi.nlm.nih.gov/pubmed/10741967
PubMed10873470http://www.ncbi.nlm.nih.gov/pubmed/10873470
PubMed14557266http://www.ncbi.nlm.nih.gov/pubmed/14557266
PubMed1511009http://www.ncbi.nlm.nih.gov/pubmed/1511009
PubMed15649896http://www.ncbi.nlm.nih.gov/pubmed/15649896
PubMed16285921http://www.ncbi.nlm.nih.gov/pubmed/16285921
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed17010164http://www.ncbi.nlm.nih.gov/pubmed/17010164
PubMed18193061http://www.ncbi.nlm.nih.gov/pubmed/18193061
PubMed340457http://www.ncbi.nlm.nih.gov/pubmed/340457
PubMed6186393http://www.ncbi.nlm.nih.gov/pubmed/6186393
PubMed6222240http://www.ncbi.nlm.nih.gov/pubmed/6222240
PubMed6750604http://www.ncbi.nlm.nih.gov/pubmed/6750604
PubMed8679581http://www.ncbi.nlm.nih.gov/pubmed/8679581
PubMed8917517http://www.ncbi.nlm.nih.gov/pubmed/8917517
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9298644http://www.ncbi.nlm.nih.gov/pubmed/9298644
RefSeqNP_417538http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417538
RefSeqWP_000918827http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000918827
SMARTSM00400http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00400
SMARTSM00493http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00493
SMARTSM00766http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00766
SMRP0ABS5http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABS5
STRING511145.b3066http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3066&targetmode=cogs
STRINGCOG0358http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0358&targetmode=cogs
TIGRFAMsTIGR01391http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01391
UniProtKB-ACP0ABS5http://www.uniprot.org/uniprot/P0ABS5
UniProtKBDNAG_ECOLIhttp://www.uniprot.org/uniprot/DNAG_ECOLI
chargeswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:DNAG_ECOLI
eggNOGCOG0358http://eggnogapi.embl.de/nog_data/html/tree/COG0358
eggNOGENOG4105C9Ghttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9G
epestfindswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:DNAG_ECOLI
garnierswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:DNAG_ECOLI
helixturnhelixswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:DNAG_ECOLI
hmomentswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:DNAG_ECOLI
iepswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:DNAG_ECOLI
inforesidueswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:DNAG_ECOLI
octanolswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:DNAG_ECOLI
pepcoilswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:DNAG_ECOLI
pepdigestswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:DNAG_ECOLI
pepinfoswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:DNAG_ECOLI
pepnetswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:DNAG_ECOLI
pepstatsswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:DNAG_ECOLI
pepwheelswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:DNAG_ECOLI
pepwindowswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:DNAG_ECOLI
sigcleaveswissprot:DNAG_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:DNAG_ECOLI
DataBaseIDURL or Descriptions
# BRENDA3.1.262026
# BioGrid426158583
# CATALYTIC ACTIVITYRNH2_ECOLIEndonucleolytic cleavage to 5'- phosphomonoester.
# CDDcd07182RNase_HII_bacteria_HII_like
# COFACTORRNH2_ECOLIName=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250}; Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. {ECO 0000250};
# EcoGeneEG10861rnhB
# FUNCTIONRNH2_ECOLIEndonuclease that specifically degrades the RNA of RNA- DNA hybrids. {ECO 0000250, ECO 0000269|PubMed 2172991}.
# GO_componentGO:0005737cytoplasm; IEA:UniProtKB-SubCell.
# GO_componentGO:0032299ribonuclease H2 complex; IBA:GO_Central.
# GO_functionGO:0003723RNA binding; IEA:InterPro.
# GO_functionGO:0004523RNA-DNA hybrid ribonuclease activity; IDA:EcoCyc.
# GO_functionGO:0030145manganese ion binding; IEA:UniProtKB-HAMAP.
# GO_processGO:0006298mismatch repair; IBA:GO_Central.
# GO_processGO:0043137DNA replication, removal of RNA primer; IBA:GO_Central.
# GOslim_componentGO:0005737cytoplasm
# GOslim_componentGO:0043234protein complex
# GOslim_functionGO:0003723RNA binding
# GOslim_functionGO:0004518nuclease activity
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0006950response to stress
# GOslim_processGO:0034655nucleobase-containing compound catabolic process
# Gene3D3.30.420.10-; 1.
# HAMAPMF_00052_BRNase_HII_B
# IntActP104425
# InterProIPR001352RNase_HII/HIII
# InterProIPR012337RNaseH-like_dom
# InterProIPR022898RNase_HII
# InterProIPR024567RNase_HII/HIII_dom
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Pathwayko03030DNA replication
# OrganismRNH2_ECOLIEscherichia coli (strain K12)
# PANTHERPTHR10954PTHR10954
# PATRIC32115477VBIEscCol129921_0190
# PIRG64742QQECBE
# PfamPF01351RNase_HII
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameRNH2_ECOLIRibonuclease HII
# RefSeqNP_414725NC_000913.3
# RefSeqWP_000569430NZ_LN832404.1
# SIMILARITYBelongs to the RNase HII family. {ECO0000305}.
# SUBCELLULAR LOCATIONRNH2_ECOLICytoplasm {ECO 0000305}.
# SUPFAMSSF53098SSF53098
# eggNOGCOG0164LUCA
# eggNOGENOG4108UH2Bacteria
BLASTswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:RNH2_ECOLI
BioCycECOL316407:JW0178-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW0178-MONOMER
BioCycEcoCyc:EG10861-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10861-MONOMER
BioCycMetaCyc:EG10861-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG10861-MONOMER
COGCOG0164http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0164
DOI10.1021/bi982207zhttp://dx.doi.org/10.1021/bi982207z
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1073/pnas.87.21.8587http://dx.doi.org/10.1073/pnas.87.21.8587
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:3.1.26.4http://www.genome.jp/dbget-bin/www_bget?EC:3.1.26.4
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLM19334http://www.ebi.ac.uk/ena/data/view/M19334
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU70214http://www.ebi.ac.uk/ena/data/view/U70214
ENZYME3.1.26.4http://enzyme.expasy.org/EC/3.1.26.4
EchoBASEEB0854http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0854
EcoGeneEG10861http://www.ecogene.org/geneInfo.php?eg_id=EG10861
EnsemblBacteriaAAC73294http://www.ensemblgenomes.org/id/AAC73294
EnsemblBacteriaAAC73294http://www.ensemblgenomes.org/id/AAC73294
EnsemblBacteriaBAA77858http://www.ensemblgenomes.org/id/BAA77858
EnsemblBacteriaBAA77858http://www.ensemblgenomes.org/id/BAA77858
EnsemblBacteriaBAA77858http://www.ensemblgenomes.org/id/BAA77858
EnsemblBacteriab0183http://www.ensemblgenomes.org/id/b0183
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_componentGO:0032299http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032299
GO_functionGO:0003723http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GO_functionGO:0004523http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004523
GO_functionGO:0030145http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145
GO_processGO:0006298http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006298
GO_processGO:0043137http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043137
GOslim_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_componentGO:0043234http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_functionGO:0003723http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723
GOslim_functionGO:0004518http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0006950http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_processGO:0034655http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655
Gene3D3.30.420.10http://www.cathdb.info/version/latest/superfamily/3.30.420.10
GeneID944852http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944852
HAMAPMF_00052_Bhttp://hamap.expasy.org/unirule/MF_00052_B
HOGENOMHOG000100288http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000100288&db=HOGENOM6
InParanoidP10442http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10442
IntActP10442http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10442*
IntEnz3.1.26.4http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.26.4
InterProIPR001352http://www.ebi.ac.uk/interpro/entry/IPR001352
InterProIPR012337http://www.ebi.ac.uk/interpro/entry/IPR012337
InterProIPR022898http://www.ebi.ac.uk/interpro/entry/IPR022898
InterProIPR024567http://www.ebi.ac.uk/interpro/entry/IPR024567
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Geneecj:JW0178http://www.genome.jp/dbget-bin/www_bget?ecj:JW0178
KEGG_Geneeco:b0183http://www.genome.jp/dbget-bin/www_bget?eco:b0183
KEGG_OrthologyKO:K03470http://www.genome.jp/dbget-bin/www_bget?KO:K03470
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
OMALSWAYLDhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LSWAYLD
PANTHERPTHR10954http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10954
PSORT-Bswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:RNH2_ECOLI
PSORT2swissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:RNH2_ECOLI
PSORTswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:RNH2_ECOLI
PfamPF01351http://pfam.xfam.org/family/PF01351
Phobiusswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:RNH2_ECOLI
PhylomeDBP10442http://phylomedb.org/?seqid=P10442
ProteinModelPortalP10442http://www.proteinmodelportal.org/query/uniprot/P10442
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed2172991http://www.ncbi.nlm.nih.gov/pubmed/2172991
PubMed3316192http://www.ncbi.nlm.nih.gov/pubmed/3316192
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9888800http://www.ncbi.nlm.nih.gov/pubmed/9888800
RefSeqNP_414725http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414725
RefSeqWP_000569430http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000569430
SMRP10442http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10442
STRING511145.b0183http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0183&targetmode=cogs
STRINGCOG0164http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0164&targetmode=cogs
SUPFAMSSF53098http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098
UniProtKB-ACP10442http://www.uniprot.org/uniprot/P10442
UniProtKBRNH2_ECOLIhttp://www.uniprot.org/uniprot/RNH2_ECOLI
chargeswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:RNH2_ECOLI
eggNOGCOG0164http://eggnogapi.embl.de/nog_data/html/tree/COG0164
eggNOGENOG4108UH2http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UH2
epestfindswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:RNH2_ECOLI
garnierswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:RNH2_ECOLI
helixturnhelixswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:RNH2_ECOLI
hmomentswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:RNH2_ECOLI
iepswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:RNH2_ECOLI
inforesidueswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:RNH2_ECOLI
octanolswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:RNH2_ECOLI
pepcoilswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:RNH2_ECOLI
pepdigestswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:RNH2_ECOLI
pepinfoswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:RNH2_ECOLI
pepnetswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:RNH2_ECOLI
pepstatsswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:RNH2_ECOLI
pepwheelswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:RNH2_ECOLI
pepwindowswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:RNH2_ECOLI
sigcleaveswissprot:RNH2_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:RNH2_ECOLI
DataBaseIDURL or Descriptions
# AltNameDNA topoisomerase III {ECO:0000255|HAMAP-RuleMF_00953}
# BRENDA5.99.12026
# BioGrid425913756
# CATALYTIC ACTIVITYTOP3_ECOLIATP-independent breakage of single-stranded DNA, followed by passage and rejoining. {ECO 0000255|HAMAP- Rule MF_00953, ECO 0000269|PubMed 6326814}.
# CDDcd00186TOP1Ac
# COFACTORTOP3_ECOLIName=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00953, ECO 0000269|PubMed 6326814}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_00953, ECO 0000269|PubMed 6326814}; Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000255|HAMAP-Rule MF_00953, ECO 0000269|PubMed 6326814}; Note=Binds two Mg(2+) ions per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO 0000255|HAMAP-Rule MF_00953, ECO 0000269|PubMed 6326814};
# EcoGeneEG11014topB
# FUNCTIONTOP3_ECOLIReleases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. TOP3 is a potent decatenase. {ECO 0000255|HAMAP-Rule MF_00953, ECO 0000269|PubMed 2553698, ECO 0000269|PubMed 6326814}.
# GO_componentGO:0005829cytosol; IBA:GO_Central.
# GO_functionGO:0000287magnesium ion binding; IEA:UniProtKB-HAMAP.
# GO_functionGO:0003677DNA binding; IEA:UniProtKB-KW.
# GO_functionGO:0003917DNA topoisomerase type I activity; IDA:EcoliWiki.
# GO_processGO:0006265DNA topological change; IBA:GO_Central.
# GO_processGO:0006310DNA recombination; IMP:EcoliWiki.
# GO_processGO:0051304chromosome separation; IMP:EcoliWiki.
# GOslim_componentGO:0005829cytosol
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0016853isomerase activity
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0051276chromosome organization
# Gene3D1.10.460.10-; 2.
# Gene3D2.70.20.10-; 2.
# Gene3D3.40.50.140-; 1.
# HAMAPMF_00953Topoisom_3_prok
# IntActP1429439
# InterProIPR000380Topo_IA
# InterProIPR003601Topo_IA_2
# InterProIPR003602Topo_IA_DNA-bd_dom
# InterProIPR005738TopoIII
# InterProIPR006171Toprim_domain
# InterProIPR013497Topo_IA_cen
# InterProIPR013824Topo_IA_cen_sub1
# InterProIPR013825Topo_IA_cen_sub2
# InterProIPR023405Topo_IA_core_domain
# InterProIPR023406Topo_IA_AS
# KEGG_Briteko01000Enzymes
# KEGG_Briteko03032 DNA replication proteins
# OrganismTOP3_ECOLIEscherichia coli (strain K12)
# PANTHERPTHR11390PTHR11390; 2
# PATRIC32118837VBIEscCol129921_1836
# PDB1D6MX-ray; 3.00 A; A=1-653
# PDB1I7DX-ray; 2.05 A; A=1-653
# PDB2O19X-ray; 2.45 A; A/B=1-653
# PDB2O54X-ray; 2.50 A; A/B=1-653
# PDB2O59X-ray; 2.50 A; A/B=1-653
# PDB2O5CX-ray; 2.35 A; A/B=1-653
# PDB2O5EX-ray; 2.50 A; A/B=1-653
# PIRJV0049JV0049
# PRINTSPR00417PRTPISMRASEI
# PROSITEPS00396TOPOISOMERASE_I_PROK
# PROSITEPS50880TOPRIM
# PfamPF01131Topoisom_bac
# PfamPF01751Toprim
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDNA topoisomerase 3 {ECO:0000255|HAMAP-RuleMF_00953}
# RefSeqNP_416277NC_000913.3
# RefSeqWP_001235800NZ_LN832404.1
# SIMILARITYBelongs to the type IA topoisomerase family. {ECO:0000255|HAMAP-RuleMF_00953}.
# SIMILARITYContains 1 Toprim domain. {ECO:0000255|HAMAP- RuleMF_00953}.
# SMARTSM00436TOP1Bc
# SMARTSM00437TOP1Ac
# SMARTSM00493TOPRIM
# SUPFAMSSF56712SSF56712
# TIGRFAMsTIGR01056topB
# eggNOGCOG0550LUCA
# eggNOGENOG4105C73Bacteria
BLASTswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:TOP3_ECOLI
BioCycECOL316407:JW1752-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW1752-MONOMER
BioCycEcoCyc:EG11014-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG11014-MONOMER
BioCycMetaCyc:EG11014-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG11014-MONOMER
COGCOG0550http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0550
DIPDIP-11012Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11012N
DOI10.1016/S0969-2126(00)80027-1http://dx.doi.org/10.1016/S0969-2126(00)80027-1
DOI10.1016/j.jmb.2007.01.065http://dx.doi.org/10.1016/j.jmb.2007.01.065
DOI10.1021/bi00304a002http://dx.doi.org/10.1021/bi00304a002
DOI10.1038/35082615http://dx.doi.org/10.1038/35082615
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1093/dnares/3.6.363http://dx.doi.org/10.1093/dnares/3.6.363
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00953}http://www.genome.jp/dbget-bin/www_bget?EC:5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00953}
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLJ05076http://www.ebi.ac.uk/ena/data/view/J05076
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
ENZYME5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00953}http://enzyme.expasy.org/EC/5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00953}
EchoBASEEB1007http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1007
EcoGeneEG11014http://www.ecogene.org/geneInfo.php?eg_id=EG11014
EnsemblBacteriaAAC74833http://www.ensemblgenomes.org/id/AAC74833
EnsemblBacteriaAAC74833http://www.ensemblgenomes.org/id/AAC74833
EnsemblBacteriaBAA15551http://www.ensemblgenomes.org/id/BAA15551
EnsemblBacteriaBAA15551http://www.ensemblgenomes.org/id/BAA15551
EnsemblBacteriaBAA15551http://www.ensemblgenomes.org/id/BAA15551
EnsemblBacteriab1763http://www.ensemblgenomes.org/id/b1763
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_functionGO:0000287http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003917http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003917
GO_processGO:0006265http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006265
GO_processGO:0006310http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310
GO_processGO:0051304http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051304
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0016853http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0051276http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276
Gene3D1.10.460.10http://www.cathdb.info/version/latest/superfamily/1.10.460.10
Gene3D2.70.20.10http://www.cathdb.info/version/latest/superfamily/2.70.20.10
Gene3D3.40.50.140http://www.cathdb.info/version/latest/superfamily/3.40.50.140
GeneID946141http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946141
HAMAPMF_00953http://hamap.expasy.org/unirule/MF_00953
HOGENOMHOG000086848http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000086848&db=HOGENOM6
InParanoidP14294http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14294
IntActP14294http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P14294*
IntEnz5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00953}http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00953}
InterProIPR000380http://www.ebi.ac.uk/interpro/entry/IPR000380
InterProIPR003601http://www.ebi.ac.uk/interpro/entry/IPR003601
InterProIPR003602http://www.ebi.ac.uk/interpro/entry/IPR003602
InterProIPR005738http://www.ebi.ac.uk/interpro/entry/IPR005738
InterProIPR006171http://www.ebi.ac.uk/interpro/entry/IPR006171
InterProIPR013497http://www.ebi.ac.uk/interpro/entry/IPR013497
InterProIPR013824http://www.ebi.ac.uk/interpro/entry/IPR013824
InterProIPR013825http://www.ebi.ac.uk/interpro/entry/IPR013825
InterProIPR023405http://www.ebi.ac.uk/interpro/entry/IPR023405
InterProIPR023406http://www.ebi.ac.uk/interpro/entry/IPR023406
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Geneecj:JW1752http://www.genome.jp/dbget-bin/www_bget?ecj:JW1752
KEGG_Geneeco:b1763http://www.genome.jp/dbget-bin/www_bget?eco:b1763
KEGG_OrthologyKO:K03169http://www.genome.jp/dbget-bin/www_bget?KO:K03169
MINTMINT-1224249http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224249
OMARRFRGIVhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RRFRGIV
PANTHERPTHR11390http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11390
PDB1D6Mhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1D6M
PDB1I7Dhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1I7D
PDB2O19http://www.ebi.ac.uk/pdbe-srv/view/entry/2O19
PDB2O54http://www.ebi.ac.uk/pdbe-srv/view/entry/2O54
PDB2O59http://www.ebi.ac.uk/pdbe-srv/view/entry/2O59
PDB2O5Chttp://www.ebi.ac.uk/pdbe-srv/view/entry/2O5C
PDB2O5Ehttp://www.ebi.ac.uk/pdbe-srv/view/entry/2O5E
PDBsum1D6Mhttp://www.ebi.ac.uk/pdbsum/1D6M
PDBsum1I7Dhttp://www.ebi.ac.uk/pdbsum/1I7D
PDBsum2O19http://www.ebi.ac.uk/pdbsum/2O19
PDBsum2O54http://www.ebi.ac.uk/pdbsum/2O54
PDBsum2O59http://www.ebi.ac.uk/pdbsum/2O59
PDBsum2O5Chttp://www.ebi.ac.uk/pdbsum/2O5C
PDBsum2O5Ehttp://www.ebi.ac.uk/pdbsum/2O5E
PRINTSPR00417http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00417
PROSITEPS00396http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00396
PROSITEPS50880http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50880
PSORT-Bswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:TOP3_ECOLI
PSORT2swissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:TOP3_ECOLI
PSORTswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:TOP3_ECOLI
PfamPF01131http://pfam.xfam.org/family/PF01131
PfamPF01751http://pfam.xfam.org/family/PF01751
Phobiusswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:TOP3_ECOLI
PhylomeDBP14294http://phylomedb.org/?seqid=P14294
ProteinModelPortalP14294http://www.proteinmodelportal.org/query/uniprot/P14294
PubMed10574789http://www.ncbi.nlm.nih.gov/pubmed/10574789
PubMed11429611http://www.ncbi.nlm.nih.gov/pubmed/11429611
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed17331537http://www.ncbi.nlm.nih.gov/pubmed/17331537
PubMed2553698http://www.ncbi.nlm.nih.gov/pubmed/2553698
PubMed6326814http://www.ncbi.nlm.nih.gov/pubmed/6326814
PubMed9097039http://www.ncbi.nlm.nih.gov/pubmed/9097039
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
RefSeqNP_416277http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416277
RefSeqWP_001235800http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001235800
SMARTSM00436http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00436
SMARTSM00437http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00437
SMARTSM00493http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00493
SMRP14294http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P14294
STRING511145.b1763http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1763&targetmode=cogs
STRINGCOG0550http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0550&targetmode=cogs
SUPFAMSSF56712http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56712
TIGRFAMsTIGR01056http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01056
UniProtKB-ACP14294http://www.uniprot.org/uniprot/P14294
UniProtKBTOP3_ECOLIhttp://www.uniprot.org/uniprot/TOP3_ECOLI
chargeswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:TOP3_ECOLI
eggNOGCOG0550http://eggnogapi.embl.de/nog_data/html/tree/COG0550
eggNOGENOG4105C73http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C73
epestfindswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:TOP3_ECOLI
garnierswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:TOP3_ECOLI
helixturnhelixswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:TOP3_ECOLI
hmomentswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:TOP3_ECOLI
iepswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:TOP3_ECOLI
inforesidueswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:TOP3_ECOLI
octanolswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:TOP3_ECOLI
pepcoilswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:TOP3_ECOLI
pepdigestswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:TOP3_ECOLI
pepinfoswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:TOP3_ECOLI
pepnetswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:TOP3_ECOLI
pepstatsswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:TOP3_ECOLI
pepwheelswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:TOP3_ECOLI
pepwindowswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:TOP3_ECOLI
sigcleaveswissprot:TOP3_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:TOP3_ECOLI
DataBaseIDURL or Descriptions
# BioGrid426190782
# DOMAINSEQA_ECOLIThe N-terminal domain is required for multimerization. The C-terminal domain is involved in DNA-binding. {ECO 0000269|PubMed 12379844, ECO 0000269|PubMed 12507506, ECO 0000269|PubMed 19304745}.
# EcoGeneEG12197seqA
# FUNCTIONSEQA_ECOLINegative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. Can also bind to hemimethylated GATC sequences outside of oriC region. Binds, with less affinity, to fully methylated GATC sites and affects timing of replication. May play a role in chromosome organization and gene regulation. {ECO 0000255|HAMAP-Rule MF_00908, ECO 0000269|PubMed 10931282, ECO 0000269|PubMed 11080170, ECO 0000269|PubMed 20689753, ECO 0000269|PubMed 7553853, ECO 0000269|PubMed 7891562, ECO 0000269|PubMed 8011018}.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_componentGO:1990097SeqA-DNA complex; IDA:EcoCyc.
# GO_functionGO:0003688DNA replication origin binding; IDA:EcoCyc.
# GO_functionGO:0010385double-stranded methylated DNA binding; IDA:EcoCyc.
# GO_functionGO:0042802identical protein binding; IPI:IntAct.
# GO_functionGO:0044729hemi-methylated DNA-binding; IDA:EcoCyc.
# GO_processGO:0006355regulation of transcription, DNA-templated; IEA:InterPro.
# GO_processGO:0007062sister chromatid cohesion; IGI:EcoCyc.
# GO_processGO:0032297negative regulation of DNA-dependent DNA replication initiation; IMP:EcoCyc.
# GO_processGO:0051289protein homotetramerization; IDA:EcoCyc.
# GO_processGO:0090143nucleoid organization; IGI:EcoCyc.
# GOslim_componentGO:0005575cellular_component
# GOslim_componentGO:0005829cytosol
# GOslim_functionGO:0003674molecular_function
# GOslim_functionGO:0003677DNA binding
# GOslim_processGO:0006461protein complex assembly
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0051276chromosome organization
# Gene3D1.10.1220.10-; 1.
# Gene3D1.20.1380.10-; 1.
# HAMAPMF_00908SeqA
# INTERACTIONSEQA_ECOLISelf; NbExp=13; IntAct=EBI-552553, EBI-552553; P0A8F8 uvrB; NbExp=2; IntAct=EBI-552553, EBI-552176;
# IntActP0AFY83
# InterProIPR005621SeqA
# InterProIPR010985Ribbon_hlx_hlx
# InterProIPR013321Arc_rbn_hlx_hlx
# InterProIPR026577SeqA_DNA-bd_C
# InterProIPR033761SeqA_N
# KEGG_Briteko03032DNA replication proteins
# KEGG_Briteko03036 Chromosome
# OrganismSEQA_ECOLIEscherichia coli (strain K12)
# PATRIC32116567VBIEscCol129921_0716
# PDB1IU3X-ray; 3.00 A; C/F=71-181
# PDB1J3EX-ray; 2.50 A; A=71-181
# PDB1LRRX-ray; 2.65 A; A/D=51-181
# PDB1XRXX-ray; 2.15 A; A/B/C/D=1-50
# PDB2CH3Model; -; A=1-181
# PDB3FMTX-ray; 2.98 A; A/B/E/F=1-181
# PIRA54296A54296
# PIRSFPIRSF019401SeqA
# PfamPF03925SeqA
# PfamPF17206SeqA_N
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameNegative modulator of initiation of replication {ECO:0000255|HAMAP-RuleMF_00908}
# RefSeqNP_415213NC_000913.3
# RefSeqWP_000848387NZ_LN832404.1
# SIMILARITYBelongs to the SeqA family. {ECO:0000255|HAMAP- RuleMF_00908}.
# SUBCELLULAR LOCATIONSEQA_ECOLICytoplasm {ECO 0000255|HAMAP-Rule MF_00908, ECO 0000269|PubMed 9660922}. Note=Localization is cell cycle- dependent. Localizes at midcell in newborn cells, then migrates in opposite directions toward cell quarter sites and remains tethered there until the cell divides.
# SUBUNITSEQA_ECOLIHomodimer. Polymerizes to form helical filaments. Dimerization is sufficient for DNA-binding, but oligomerization is essential for function. {ECO 0000255|HAMAP-Rule MF_00908, ECO 0000269|PubMed 12379844, ECO 0000269|PubMed 14704346, ECO 0000269|PubMed 15933720, ECO 0000269|PubMed 19304745}.
# SUPFAMSSF47598SSF47598
# SUPFAMSSF82808SSF82808
# eggNOGCOG3057LUCA
# eggNOGENOG4107CDUBacteria
BLASTswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:SEQA_ECOLI
BioCycECOL316407:JW0674-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW0674-MONOMER
BioCycEcoCyc:EG12197-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG12197-MONOMER
COGCOG3057http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3057
DIPDIP-48017Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48017N
DOI10.1016/0092-8674(94)90156-2http://dx.doi.org/10.1016/0092-8674(94)90156-2
DOI10.1016/0092-8674(95)90272-4http://dx.doi.org/10.1016/0092-8674(95)90272-4
DOI10.1016/S0006-291X(02)02891-7http://dx.doi.org/10.1016/S0006-291X(02)02891-7
DOI10.1016/S0960-9822(00)00214-1http://dx.doi.org/10.1016/S0960-9822(00)00214-1
DOI10.1016/S1097-2765(00)80038-6http://dx.doi.org/10.1016/S1097-2765(00)80038-6
DOI10.1016/j.patbio.2008.03.013http://dx.doi.org/10.1016/j.patbio.2008.03.013
DOI10.1016/j.plasmid.2009.02.004http://dx.doi.org/10.1016/j.plasmid.2009.02.004
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1038/nsb857http://dx.doi.org/10.1038/nsb857
DOI10.1038/sj.emboj.7600634http://dx.doi.org/10.1038/sj.emboj.7600634
DOI10.1046/j.1365-2958.2000.01943.xhttp://dx.doi.org/10.1046/j.1365-2958.2000.01943.x
DOI10.1073/pnas.95.19.11117http://dx.doi.org/10.1073/pnas.95.19.11117
DOI10.1093/dnares/3.3.137http://dx.doi.org/10.1093/dnares/3.3.137
DOI10.1093/emboj/19.22.6249http://dx.doi.org/10.1093/emboj/19.22.6249
DOI10.1093/nar/gkh173http://dx.doi.org/10.1093/nar/gkh173
DOI10.1093/nar/gkp151http://dx.doi.org/10.1093/nar/gkp151
DOI10.1111/j.1365-2958.1994.tb01313.xhttp://dx.doi.org/10.1111/j.1365-2958.1994.tb01313.x
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
DOI10.1128/mBio.00012-10http://dx.doi.org/10.1128/mBio.00012-10
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU07651http://www.ebi.ac.uk/ena/data/view/U07651
EchoBASEEB2114http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2114
EcoGeneEG12197http://www.ecogene.org/geneInfo.php?eg_id=EG12197
EnsemblBacteriaAAC73781http://www.ensemblgenomes.org/id/AAC73781
EnsemblBacteriaAAC73781http://www.ensemblgenomes.org/id/AAC73781
EnsemblBacteriaBAA35336http://www.ensemblgenomes.org/id/BAA35336
EnsemblBacteriaBAA35336http://www.ensemblgenomes.org/id/BAA35336
EnsemblBacteriaBAA35336http://www.ensemblgenomes.org/id/BAA35336
EnsemblBacteriab0687http://www.ensemblgenomes.org/id/b0687
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_componentGO:1990097http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990097
GO_functionGO:0003688http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003688
GO_functionGO:0010385http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010385
GO_functionGO:0042802http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_functionGO:0044729http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044729
GO_processGO:0006355http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355
GO_processGO:0007062http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007062
GO_processGO:0032297http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032297
GO_processGO:0051289http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289
GO_processGO:0090143http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090143
GOslim_componentGO:0005575http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_functionGO:0003674http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_processGO:0006461http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0051276http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276
Gene3D1.10.1220.10http://www.cathdb.info/version/latest/superfamily/1.10.1220.10
Gene3D1.20.1380.10http://www.cathdb.info/version/latest/superfamily/1.20.1380.10
GeneID945272http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945272
HAMAPMF_00908http://hamap.expasy.org/unirule/MF_00908
HOGENOMHOG000275226http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275226&db=HOGENOM6
IntActP0AFY8http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFY8*
InterProIPR005621http://www.ebi.ac.uk/interpro/entry/IPR005621
InterProIPR010985http://www.ebi.ac.uk/interpro/entry/IPR010985
InterProIPR013321http://www.ebi.ac.uk/interpro/entry/IPR013321
InterProIPR026577http://www.ebi.ac.uk/interpro/entry/IPR026577
InterProIPR033761http://www.ebi.ac.uk/interpro/entry/IPR033761
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03036http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Geneecj:JW0674http://www.genome.jp/dbget-bin/www_bget?ecj:JW0674
KEGG_Geneeco:b0687http://www.genome.jp/dbget-bin/www_bget?eco:b0687
KEGG_OrthologyKO:K03645http://www.genome.jp/dbget-bin/www_bget?KO:K03645
MINTMINT-1238758http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238758
OMARTRTYFAhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTRTYFA
PDB1IU3http://www.ebi.ac.uk/pdbe-srv/view/entry/1IU3
PDB1J3Ehttp://www.ebi.ac.uk/pdbe-srv/view/entry/1J3E
PDB1LRRhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1LRR
PDB1XRXhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1XRX
PDB2CH3http://www.ebi.ac.uk/pdbe-srv/view/entry/2CH3
PDB3FMThttp://www.ebi.ac.uk/pdbe-srv/view/entry/3FMT
PDBsum1IU3http://www.ebi.ac.uk/pdbsum/1IU3
PDBsum1J3Ehttp://www.ebi.ac.uk/pdbsum/1J3E
PDBsum1LRRhttp://www.ebi.ac.uk/pdbsum/1LRR
PDBsum1XRXhttp://www.ebi.ac.uk/pdbsum/1XRX
PDBsum2CH3http://www.ebi.ac.uk/pdbsum/2CH3
PDBsum3FMThttp://www.ebi.ac.uk/pdbsum/3FMT
PSORT-Bswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:SEQA_ECOLI
PSORT2swissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:SEQA_ECOLI
PSORTswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:SEQA_ECOLI
PfamPF03925http://pfam.xfam.org/family/PF03925
PfamPF17206http://pfam.xfam.org/family/PF17206
Phobiusswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:SEQA_ECOLI
ProteinModelPortalP0AFY8http://www.proteinmodelportal.org/query/uniprot/P0AFY8
PubMed10931282http://www.ncbi.nlm.nih.gov/pubmed/10931282
PubMed11080170http://www.ncbi.nlm.nih.gov/pubmed/11080170
PubMed12379844http://www.ncbi.nlm.nih.gov/pubmed/12379844
PubMed12507506http://www.ncbi.nlm.nih.gov/pubmed/12507506
PubMed14704346http://www.ncbi.nlm.nih.gov/pubmed/14704346
PubMed15933720http://www.ncbi.nlm.nih.gov/pubmed/15933720
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed18849124http://www.ncbi.nlm.nih.gov/pubmed/18849124
PubMed19254745http://www.ncbi.nlm.nih.gov/pubmed/19254745
PubMed19304745http://www.ncbi.nlm.nih.gov/pubmed/19304745
PubMed20689753http://www.ncbi.nlm.nih.gov/pubmed/20689753
PubMed7553853http://www.ncbi.nlm.nih.gov/pubmed/7553853
PubMed7850437http://www.ncbi.nlm.nih.gov/pubmed/7850437
PubMed7891562http://www.ncbi.nlm.nih.gov/pubmed/7891562
PubMed8011018http://www.ncbi.nlm.nih.gov/pubmed/8011018
PubMed8905232http://www.ncbi.nlm.nih.gov/pubmed/8905232
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9660922http://www.ncbi.nlm.nih.gov/pubmed/9660922
PubMed9736699http://www.ncbi.nlm.nih.gov/pubmed/9736699
RefSeqNP_415213http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415213
RefSeqWP_000848387http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000848387
SMRP0AFY8http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFY8
STRING511145.b0687http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0687&targetmode=cogs
STRINGCOG3057http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3057&targetmode=cogs
SUPFAMSSF47598http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47598
SUPFAMSSF82808http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82808
UniProtKB-ACP0AFY8http://www.uniprot.org/uniprot/P0AFY8
UniProtKBSEQA_ECOLIhttp://www.uniprot.org/uniprot/SEQA_ECOLI
chargeswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:SEQA_ECOLI
eggNOGCOG3057http://eggnogapi.embl.de/nog_data/html/tree/COG3057
eggNOGENOG4107CDUhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4107CDU
epestfindswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:SEQA_ECOLI
garnierswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:SEQA_ECOLI
helixturnhelixswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:SEQA_ECOLI
hmomentswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:SEQA_ECOLI
iepswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:SEQA_ECOLI
inforesidueswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:SEQA_ECOLI
octanolswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:SEQA_ECOLI
pepcoilswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:SEQA_ECOLI
pepdigestswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:SEQA_ECOLI
pepinfoswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:SEQA_ECOLI
pepnetswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:SEQA_ECOLI
pepstatsswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:SEQA_ECOLI
pepwheelswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:SEQA_ECOLI
pepwindowswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:SEQA_ECOLI
sigcleaveswissprot:SEQA_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:SEQA_ECOLI
DataBaseIDURL or Descriptions
# BioGrid426036141
# CATALYTIC ACTIVITYHOLE_ECOLIDeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
# EcoGeneEG11505holE
# FUNCTIONHOLE_ECOLIDNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
# FUNCTIONHOLE_ECOLIThe exact function of the theta subunit is unknown.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_componentGO:0044776DNA polymerase III, core complex; IDA:EcoCyc.
# GO_functionGO:0003677DNA binding; IEA:InterPro.
# GO_functionGO:0003887DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
# GO_processGO:0006260DNA replication; IEA:UniProtKB-KW.
# GOslim_componentGO:0005829cytosol
# GOslim_componentGO:0043234protein complex
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0016779nucleotidyltransferase activity
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0009058biosynthetic process
# Gene3D1.10.1110.10-; 1.
# INTERACTIONHOLE_ECOLIP03007 dnaQ; NbExp=11; IntAct=EBI-549182, EBI-549131;
# IntActP0ABS828
# InterProIPR009052DNA_pol_III_theta_bac
# InterProIPR011325DNA_pol_III_theta_core_bac
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko00002 KEGG pathway modules
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03032 M00260 DNA polymerase III complex, bacteria
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Briteko03400 M00260 DNA polymerase III complex, bacteria
# KEGG_Pathwayko00230Purine metabolism
# KEGG_Pathwayko00240Pyrimidine metabolism
# KEGG_Pathwayko03030DNA replication
# KEGG_Pathwayko03430Mismatch repair
# KEGG_Pathwayko03440Homologous recombination
# OrganismHOLE_ECOLIEscherichia coli (strain K12)
# PATRIC32119005VBIEscCol129921_1920
# PDB1DU2NMR; -; A=1-76
# PDB2AE9NMR; -; A=1-76
# PDB2AXDNMR; -; S=1-76
# PDB2XY8NMR; -; B=1-76
# PIRS34951S34951
# PfamPF06440DNA_pol3_theta
# ProDomPD057609DNA_pol_III_theta_bac
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameHOLE_ECOLIDNA polymerase III subunit theta
# RefSeqNP_416356NC_000913.3
# RefSeqWP_000916763NZ_LN832404.1
# SUBUNITThe DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4].
# SUPFAMSSF46575SSF46575
# eggNOGENOG4105MPKBacteria
# eggNOGENOG4111UZCLUCA
BLASTswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:HOLE_ECOLI
BioCycECOL316407:JW1831-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW1831-MONOMER
BioCycEcoCyc:EG11505-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG11505-MONOMER
BioCycMetaCyc:EG11505-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG11505-MONOMER
DIPDIP-39982Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-39982N
DOI10.1002/bies.950140206http://dx.doi.org/10.1002/bies.950140206
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1093/dnares/3.6.379http://dx.doi.org/10.1093/dnares/3.6.379
DOI10.1093/nar/21.14.3281http://dx.doi.org/10.1093/nar/21.14.3281
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:2.7.7.7http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLL04572http://www.ebi.ac.uk/ena/data/view/L04572
EMBLL05381http://www.ebi.ac.uk/ena/data/view/L05381
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
ENZYME2.7.7.7http://enzyme.expasy.org/EC/2.7.7.7
EchoBASEEB1468http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1468
EcoGeneEG11505http://www.ecogene.org/geneInfo.php?eg_id=EG11505
EnsemblBacteriaAAC74912http://www.ensemblgenomes.org/id/AAC74912
EnsemblBacteriaAAC74912http://www.ensemblgenomes.org/id/AAC74912
EnsemblBacteriaBAA15650http://www.ensemblgenomes.org/id/BAA15650
EnsemblBacteriaBAA15650http://www.ensemblgenomes.org/id/BAA15650
EnsemblBacteriaBAA15650http://www.ensemblgenomes.org/id/BAA15650
EnsemblBacteriab1842http://www.ensemblgenomes.org/id/b1842
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_componentGO:0044776http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044776
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887
GO_processGO:0006260http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_componentGO:0043234http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0016779http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
Gene3D1.10.1110.10http://www.cathdb.info/version/latest/superfamily/1.10.1110.10
GeneID947471http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947471
HOGENOMHOG000219272http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219272&db=HOGENOM6
IntActP0ABS8http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABS8*
IntEnz2.7.7.7http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7
InterProIPR009052http://www.ebi.ac.uk/interpro/entry/IPR009052
InterProIPR011325http://www.ebi.ac.uk/interpro/entry/IPR011325
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko00002http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW1831http://www.genome.jp/dbget-bin/www_bget?ecj:JW1831
KEGG_Geneeco:b1842http://www.genome.jp/dbget-bin/www_bget?eco:b1842
KEGG_OrthologyKO:K02345http://www.genome.jp/dbget-bin/www_bget?KO:K02345
KEGG_Pathwayko00230http://www.genome.jp/kegg-bin/show_pathway?ko00230
KEGG_Pathwayko00240http://www.genome.jp/kegg-bin/show_pathway?ko00240
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
KEGG_Pathwayko03430http://www.genome.jp/kegg-bin/show_pathway?ko03430
KEGG_Pathwayko03440http://www.genome.jp/kegg-bin/show_pathway?ko03440
KEGG_Reactionrn:R00375http://www.genome.jp/dbget-bin/www_bget?rn:R00375
KEGG_Reactionrn:R00376http://www.genome.jp/dbget-bin/www_bget?rn:R00376
KEGG_Reactionrn:R00377http://www.genome.jp/dbget-bin/www_bget?rn:R00377
KEGG_Reactionrn:R00378http://www.genome.jp/dbget-bin/www_bget?rn:R00378
MINTMINT-1223798http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223798
OMAFRERYNMhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRERYNM
PDB1DU2http://www.ebi.ac.uk/pdbe-srv/view/entry/1DU2
PDB2AE9http://www.ebi.ac.uk/pdbe-srv/view/entry/2AE9
PDB2AXDhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2AXD
PDB2XY8http://www.ebi.ac.uk/pdbe-srv/view/entry/2XY8
PDBsum1DU2http://www.ebi.ac.uk/pdbsum/1DU2
PDBsum2AE9http://www.ebi.ac.uk/pdbsum/2AE9
PDBsum2AXDhttp://www.ebi.ac.uk/pdbsum/2AXD
PDBsum2XY8http://www.ebi.ac.uk/pdbsum/2XY8
PSORT-Bswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:HOLE_ECOLI
PSORT2swissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:HOLE_ECOLI
PSORTswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:HOLE_ECOLI
PfamPF06440http://pfam.xfam.org/family/PF06440
Phobiusswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:HOLE_ECOLI
ProteinModelPortalP0ABS8http://www.proteinmodelportal.org/query/uniprot/P0ABS8
PubMed1575709http://www.ncbi.nlm.nih.gov/pubmed/1575709
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed8341603http://www.ncbi.nlm.nih.gov/pubmed/8341603
PubMed8505306http://www.ncbi.nlm.nih.gov/pubmed/8505306
PubMed9097040http://www.ncbi.nlm.nih.gov/pubmed/9097040
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
RefSeqNP_416356http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416356
RefSeqWP_000916763http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000916763
SMRP0ABS8http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABS8
STRING511145.b1842http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1842&targetmode=cogs
SUPFAMSSF46575http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46575
UniProtKB-ACP0ABS8http://www.uniprot.org/uniprot/P0ABS8
UniProtKBHOLE_ECOLIhttp://www.uniprot.org/uniprot/HOLE_ECOLI
chargeswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:HOLE_ECOLI
eggNOGENOG4105MPKhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MPK
eggNOGENOG4111UZChttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4111UZC
epestfindswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:HOLE_ECOLI
garnierswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:HOLE_ECOLI
helixturnhelixswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:HOLE_ECOLI
hmomentswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:HOLE_ECOLI
iepswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:HOLE_ECOLI
inforesidueswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:HOLE_ECOLI
octanolswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:HOLE_ECOLI
pepcoilswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:HOLE_ECOLI
pepdigestswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:HOLE_ECOLI
pepinfoswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:HOLE_ECOLI
pepnetswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:HOLE_ECOLI
pepstatsswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:HOLE_ECOLI
pepwheelswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:HOLE_ECOLI
pepwindowswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:HOLE_ECOLI
sigcleaveswissprot:HOLE_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:HOLE_ECOLI
DataBaseIDURL or Descriptions
# BioGrid426212163
# CATALYTIC ACTIVITYDPO3E_ECOLIDeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
# CDDcd06131DNA_pol_III_epsilon_Ecoli_like
# COFACTORDPO3E_ECOLIName=Mg(2+); Xref=ChEBI CHEBI 18420; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Note=Binds 2 divalent metal cations. Magnesium or manganese.;
# EcoGeneEG10243dnaQ
# FUNCTIONDPO3E_ECOLIDNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.
# GO_componentGO:0044776DNA polymerase III, core complex; IDA:EcoCyc.
# GO_functionGO:0003677DNA binding; IEA:InterPro.
# GO_functionGO:0003887DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
# GO_functionGO:0004527exonuclease activity; IDA:EcoCyc.
# GO_functionGO:0046872metal ion binding; IEA:UniProtKB-KW.
# GO_processGO:0045004DNA replication proofreading; IMP:EcoCyc.
# GOslim_componentGO:0043234protein complex
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0004518nuclease activity
# GOslim_functionGO:0016779nucleotidyltransferase activity
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0006950response to stress
# Gene3D3.30.420.10-; 1.
# INTERACTIONDPO3E_ECOLIP10443 dnaE; NbExp=20; IntAct=EBI-549131, EBI-549111; P0A988 dnaN; NbExp=6; IntAct=EBI-549131, EBI-542385; P06710 dnaX; NbExp=4; IntAct=EBI-549131, EBI-549140; P0ABS8 holE; NbExp=11; IntAct=EBI-549131, EBI-549182;
# IntActP0300728
# InterProIPR006054DnaQ
# InterProIPR006309DnaQ_proteo
# InterProIPR012337RNaseH-like_dom
# InterProIPR013520Exonuclease_RNaseT/DNA_pol3
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko00002 KEGG pathway modules
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03032 M00260 DNA polymerase III complex, bacteria
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Briteko03400 M00260 DNA polymerase III complex, bacteria
# KEGG_Pathwayko00230Purine metabolism
# KEGG_Pathwayko00240Pyrimidine metabolism
# KEGG_Pathwayko03030DNA replication
# KEGG_Pathwayko03430Mismatch repair
# KEGG_Pathwayko03440Homologous recombination
# OrganismDPO3E_ECOLIEscherichia coli (strain K12)
# PANTHERPTHR30231:SF0PTHR30231:SF0
# PATRIC32115543VBIEscCol129921_0217
# PDB1J53X-ray; 1.80 A; A=1-186
# PDB1J54X-ray; 1.70 A; A=1-186
# PDB1MGZModel; -; A=1-186
# PDB2GUIX-ray; 1.60 A; A=2-186
# PDB2IDOX-ray; 2.10 A; A/C=1-186
# PDB2XY8NMR; -; A=1-186
# PDB4GX8X-ray; 1.70 A; A/B/C/D=209-243
# PDB4GX9X-ray; 2.15 A; A/B/C/D=200-243
# PDB5FKUEM; 8.34 A; D=1-243
# PDB5FKVEM; 8.00 A; D=1-243
# PDB5FKWEM; 7.30 A; D=1-243
# PIRA64746IQECQ
# PfamPF00929RNase_T
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDPO3E_ECOLIDNA polymerase III subunit epsilon
# RefSeqNP_414751NC_000913.3
# SEQUENCE CAUTIONSequence=AAB08637.1; Type=Erroneous initiation; Evidence={ECO0000305};
# SMARTSM00479EXOIII
# SUBUNITDPO3E_ECOLIThe DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4]. {ECO 0000269|PubMed 11937058}.
# SUPFAMSSF53098SSF53098
# TIGRFAMsTIGR00573dnaq
# TIGRFAMsTIGR01406dnaQ_proteo
# eggNOGCOG0847LUCA
# eggNOGENOG4107RZZBacteria
BLASTswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:DPO3E_ECOLI
BioCycECOL316407:JW0205-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW0205-MONOMER
BioCycEcoCyc:EG10243-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10243-MONOMER
BioCycMetaCyc:EG10243-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG10243-MONOMER
COGCOG0847http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0847
DIPDIP-9462Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9462N
DOI10.1002/bies.950140206http://dx.doi.org/10.1002/bies.950140206
DOI10.1002/elps.1150180805http://dx.doi.org/10.1002/elps.1150180805
DOI10.1007/BF02428026http://dx.doi.org/10.1007/BF02428026
DOI10.1016/0022-2836(86)90080-Xhttp://dx.doi.org/10.1016/0022-2836(86)90080-X
DOI10.1016/S0969-2126(02)00738-4http://dx.doi.org/10.1016/S0969-2126(02)00738-4
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1073/pnas.80.23.7137http://dx.doi.org/10.1073/pnas.80.23.7137
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:2.7.7.7http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLK00985http://www.ebi.ac.uk/ena/data/view/K00985
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU70214http://www.ebi.ac.uk/ena/data/view/U70214
EMBLX04027http://www.ebi.ac.uk/ena/data/view/X04027
ENZYME2.7.7.7http://enzyme.expasy.org/EC/2.7.7.7
EchoBASEEB0239http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0239
EcoGeneEG10243http://www.ecogene.org/geneInfo.php?eg_id=EG10243
EnsemblBacteriaAAC73320http://www.ensemblgenomes.org/id/AAC73320
EnsemblBacteriaAAC73320http://www.ensemblgenomes.org/id/AAC73320
EnsemblBacteriaBAA77886http://www.ensemblgenomes.org/id/BAA77886
EnsemblBacteriaBAA77886http://www.ensemblgenomes.org/id/BAA77886
EnsemblBacteriaBAA77886http://www.ensemblgenomes.org/id/BAA77886
EnsemblBacteriab0215http://www.ensemblgenomes.org/id/b0215
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0044776http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044776
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887
GO_functionGO:0004527http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004527
GO_functionGO:0046872http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_processGO:0045004http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045004
GOslim_componentGO:0043234http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0004518http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518
GOslim_functionGO:0016779http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0006950http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
Gene3D3.30.420.10http://www.cathdb.info/version/latest/superfamily/3.30.420.10
GeneID946441http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946441
HOGENOMHOG000258616http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258616&db=HOGENOM6
InParanoidP03007http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P03007
IntActP03007http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P03007*
IntEnz2.7.7.7http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7
InterProIPR006054http://www.ebi.ac.uk/interpro/entry/IPR006054
InterProIPR006309http://www.ebi.ac.uk/interpro/entry/IPR006309
InterProIPR012337http://www.ebi.ac.uk/interpro/entry/IPR012337
InterProIPR013520http://www.ebi.ac.uk/interpro/entry/IPR013520
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko00002http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW0205http://www.genome.jp/dbget-bin/www_bget?ecj:JW0205
KEGG_Geneeco:b0215http://www.genome.jp/dbget-bin/www_bget?eco:b0215
KEGG_OrthologyKO:K02342http://www.genome.jp/dbget-bin/www_bget?KO:K02342
KEGG_Pathwayko00230http://www.genome.jp/kegg-bin/show_pathway?ko00230
KEGG_Pathwayko00240http://www.genome.jp/kegg-bin/show_pathway?ko00240
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
KEGG_Pathwayko03430http://www.genome.jp/kegg-bin/show_pathway?ko03430
KEGG_Pathwayko03440http://www.genome.jp/kegg-bin/show_pathway?ko03440
KEGG_Reactionrn:R00375http://www.genome.jp/dbget-bin/www_bget?rn:R00375
KEGG_Reactionrn:R00376http://www.genome.jp/dbget-bin/www_bget?rn:R00376
KEGG_Reactionrn:R00377http://www.genome.jp/dbget-bin/www_bget?rn:R00377
KEGG_Reactionrn:R00378http://www.genome.jp/dbget-bin/www_bget?rn:R00378
MINTMINT-1222832http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222832
OMAFHVYLNPhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHVYLNP
PANTHERPTHR30231:SF0http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30231:SF0
PDB1J53http://www.ebi.ac.uk/pdbe-srv/view/entry/1J53
PDB1J54http://www.ebi.ac.uk/pdbe-srv/view/entry/1J54
PDB1MGZhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1MGZ
PDB2GUIhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2GUI
PDB2IDOhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2IDO
PDB2XY8http://www.ebi.ac.uk/pdbe-srv/view/entry/2XY8
PDB4GX8http://www.ebi.ac.uk/pdbe-srv/view/entry/4GX8
PDB4GX9http://www.ebi.ac.uk/pdbe-srv/view/entry/4GX9
PDB5FKUhttp://www.ebi.ac.uk/pdbe-srv/view/entry/5FKU
PDB5FKVhttp://www.ebi.ac.uk/pdbe-srv/view/entry/5FKV
PDB5FKWhttp://www.ebi.ac.uk/pdbe-srv/view/entry/5FKW
PDBsum1J53http://www.ebi.ac.uk/pdbsum/1J53
PDBsum1J54http://www.ebi.ac.uk/pdbsum/1J54
PDBsum1MGZhttp://www.ebi.ac.uk/pdbsum/1MGZ
PDBsum2GUIhttp://www.ebi.ac.uk/pdbsum/2GUI
PDBsum2IDOhttp://www.ebi.ac.uk/pdbsum/2IDO
PDBsum2XY8http://www.ebi.ac.uk/pdbsum/2XY8
PDBsum4GX8http://www.ebi.ac.uk/pdbsum/4GX8
PDBsum4GX9http://www.ebi.ac.uk/pdbsum/4GX9
PDBsum5FKUhttp://www.ebi.ac.uk/pdbsum/5FKU
PDBsum5FKVhttp://www.ebi.ac.uk/pdbsum/5FKV
PDBsum5FKWhttp://www.ebi.ac.uk/pdbsum/5FKW
PSORT-Bswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:DPO3E_ECOLI
PSORT2swissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:DPO3E_ECOLI
PSORTswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:DPO3E_ECOLI
PfamPF00929http://pfam.xfam.org/family/PF00929
Phobiusswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:DPO3E_ECOLI
PhylomeDBP03007http://phylomedb.org/?seqid=P03007
ProteinModelPortalP03007http://www.proteinmodelportal.org/query/uniprot/P03007
PubMed11937058http://www.ncbi.nlm.nih.gov/pubmed/11937058
PubMed1575709http://www.ncbi.nlm.nih.gov/pubmed/1575709
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed3023634http://www.ncbi.nlm.nih.gov/pubmed/3023634
PubMed3540531http://www.ncbi.nlm.nih.gov/pubmed/3540531
PubMed6316347http://www.ncbi.nlm.nih.gov/pubmed/6316347
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9298644http://www.ncbi.nlm.nih.gov/pubmed/9298644
RefSeqNP_414751http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414751
SMARTSM00479http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00479
SMRP03007http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P03007
STRING511145.b0215http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0215&targetmode=cogs
STRINGCOG0847http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0847&targetmode=cogs
SUPFAMSSF53098http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098
SWISS-2DPAGEP03007http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P03007
TIGRFAMsTIGR00573http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00573
TIGRFAMsTIGR01406http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01406
UniProtKB-ACP03007http://www.uniprot.org/uniprot/P03007
UniProtKBDPO3E_ECOLIhttp://www.uniprot.org/uniprot/DPO3E_ECOLI
chargeswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:DPO3E_ECOLI
eggNOGCOG0847http://eggnogapi.embl.de/nog_data/html/tree/COG0847
eggNOGENOG4107RZZhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RZZ
epestfindswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:DPO3E_ECOLI
garnierswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:DPO3E_ECOLI
helixturnhelixswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:DPO3E_ECOLI
hmomentswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:DPO3E_ECOLI
iepswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:DPO3E_ECOLI
inforesidueswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:DPO3E_ECOLI
octanolswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:DPO3E_ECOLI
pepcoilswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:DPO3E_ECOLI
pepdigestswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:DPO3E_ECOLI
pepinfoswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:DPO3E_ECOLI
pepnetswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:DPO3E_ECOLI
pepstatsswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:DPO3E_ECOLI
pepwheelswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:DPO3E_ECOLI
pepwindowswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:DPO3E_ECOLI
sigcleaveswissprot:DPO3E_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:DPO3E_ECOLI
DataBaseIDURL or Descriptions
# AltNameDBHA_ECOLIHU-2
# AltNameDBHA_ECOLINS2
# BioGrid4263459132
# EcoGeneEG10466hupA
# FUNCTIONDBHA_ECOLIHistone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_componentGO:0016020membrane; IDA:UniProtKB.
# GO_componentGO:1990178HU-DNA complex; IDA:CACAO.
# GO_functionGO:0003677DNA binding; IDA:EcoliWiki.
# GO_processGO:0006351transcription, DNA-templated; IDA:EcoCyc.
# GO_processGO:0006974cellular response to DNA damage stimulus; IEP:EcoliWiki.
# GO_processGO:0030261chromosome condensation; IEA:UniProtKB-KW.
# GO_processGO:0045893positive regulation of transcription, DNA-templated; IDA:EcoCyc.
# GOslim_componentGO:0005575cellular_component
# GOslim_componentGO:0005829cytosol
# GOslim_functionGO:0003677DNA binding
# GOslim_processGO:0006950response to stress
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0009058biosynthetic process
# GOslim_processGO:0034641cellular nitrogen compound metabolic process
# GOslim_processGO:0051276chromosome organization
# Gene3D4.10.520.10-; 1.
# INTERACTIONDBHA_ECOLISelf; NbExp=2; IntAct=EBI-547648, EBI-547648; P03004 dnaA; NbExp=5; IntAct=EBI-547648, EBI-548951; P0ACF4 hupB; NbExp=6; IntAct=EBI-547648, EBI-370411;
# IntActP0ACF066
# InterProIPR000119Hist_DNA-bd
# InterProIPR010992IHF-like_DNA-bd_dom
# InterProIPR020816Histone-like_DNA-bd_CS
# KEGG_Briteko03032DNA replication proteins
# KEGG_Briteko03036 Chromosome
# KEGG_Briteko03400 DNA repair and recombination proteins
# OrganismDBHA_ECOLIEscherichia coli (strain K12)
# PATRIC32123523VBIEscCol129921_4114
# PDB1MULX-ray; 2.30 A; A=1-90
# PDB2O97X-ray; 2.45 A; A=1-90
# PDB4YEWX-ray; 2.68 A; C=1-90
# PDB4YEXX-ray; 3.20 A; A/C=1-90
# PDB4YEYX-ray; 3.35 A; A/C=1-90
# PDB4YF0X-ray; 2.79 A; A/B=1-90
# PDB4YFHX-ray; 3.49 A; A/B=1-90
# PDB4YFTX-ray; 2.91 A; C=1-90
# PIRS06269DNECS2
# PRINTSPR01727DNABINDINGHU
# PROSITEPS00045HISTONE_LIKE
# PfamPF00216Bac_DNA_binding
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDBHA_ECOLIDNA-binding protein HU-alpha
# RefSeqNP_418428NC_000913.3
# RefSeqWP_001044513NZ_LN832404.1
# SIMILARITYBelongs to the bacterial histone-like protein family. {ECO0000305}.
# SMARTSM00411BHL
# SUBCELLULAR LOCATIONDBHA_ECOLICytoplasm, nucleoid {ECO 0000269|PubMed 21903814}. Note=Scattered throughout the nucleoid (PubMed 21903814). {ECO 0000269|PubMed 21903814}.
# SUBUNITHeterodimer of an alpha and a beta chain. {ECO:0000269|PubMed227733}.
# SUPFAMSSF47729SSF47729
# eggNOGCOG0776LUCA
# eggNOGENOG4105K70Bacteria
BLASTswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:DBHA_ECOLI
BioCycECOL316407:JW3964-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW3964-MONOMER
BioCycEcoCyc:EG10466-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10466-MONOMER
COGCOG0776http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0776
DIPDIP-35892Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35892N
DOI10.1002/elps.1150180805http://dx.doi.org/10.1002/elps.1150180805
DOI10.1002/elps.1150180807http://dx.doi.org/10.1002/elps.1150180807
DOI10.1007/BF00329674http://dx.doi.org/10.1007/BF00329674
DOI10.1016/0014-5793(78)80446-3http://dx.doi.org/10.1016/0014-5793(78)80446-3
DOI10.1016/0014-5793(78)80535-3http://dx.doi.org/10.1016/0014-5793(78)80535-3
DOI10.1016/0014-5793(79)80518-9http://dx.doi.org/10.1016/0014-5793(79)80518-9
DOI10.1016/S0022-2836(05)80119-6http://dx.doi.org/10.1016/S0022-2836(05)80119-6
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1093/nar/21.23.5408http://dx.doi.org/10.1093/nar/21.23.5408
DOI10.1111/j.1432-1033.1980.tb05968.xhttp://dx.doi.org/10.1111/j.1432-1033.1980.tb05968.x
DOI10.1111/j.1574-6968.1998.tb13343.xhttp://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x
DOI10.1126/science.1204697http://dx.doi.org/10.1126/science.1204697
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLD12624http://www.ebi.ac.uk/ena/data/view/D12624
EMBLU00006http://www.ebi.ac.uk/ena/data/view/U00006
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLX05994http://www.ebi.ac.uk/ena/data/view/X05994
EMBLX54555http://www.ebi.ac.uk/ena/data/view/X54555
EchoBASEEB0461http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0461
EcoGeneEG10466http://www.ecogene.org/geneInfo.php?eg_id=EG10466
EnsemblBacteriaAAC76974http://www.ensemblgenomes.org/id/AAC76974
EnsemblBacteriaAAC76974http://www.ensemblgenomes.org/id/AAC76974
EnsemblBacteriaBAE77319http://www.ensemblgenomes.org/id/BAE77319
EnsemblBacteriaBAE77319http://www.ensemblgenomes.org/id/BAE77319
EnsemblBacteriaBAE77319http://www.ensemblgenomes.org/id/BAE77319
EnsemblBacteriab4000http://www.ensemblgenomes.org/id/b4000
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_componentGO:0016020http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020
GO_componentGO:1990178http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990178
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_processGO:0006351http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351
GO_processGO:0006974http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974
GO_processGO:0030261http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030261
GO_processGO:0045893http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893
GOslim_componentGO:0005575http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_processGO:0006950http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_processGO:0034641http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
GOslim_processGO:0051276http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276
Gene3D4.10.520.10http://www.cathdb.info/version/latest/superfamily/4.10.520.10
GeneID948499http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948499
HOGENOMHOG000043828http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000043828&db=HOGENOM6
InParanoidP0ACF0http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACF0
IntActP0ACF0http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACF0*
InterProIPR000119http://www.ebi.ac.uk/interpro/entry/IPR000119
InterProIPR010992http://www.ebi.ac.uk/interpro/entry/IPR010992
InterProIPR020816http://www.ebi.ac.uk/interpro/entry/IPR020816
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03036http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW3964http://www.genome.jp/dbget-bin/www_bget?ecj:JW3964
KEGG_Geneeco:b4000http://www.genome.jp/dbget-bin/www_bget?eco:b4000
KEGG_OrthologyKO:K05787http://www.genome.jp/dbget-bin/www_bget?KO:K05787
MINTMINT-1244407http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1244407
OMAMNSITYEhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNSITYE
PDB1MULhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1MUL
PDB2O97http://www.ebi.ac.uk/pdbe-srv/view/entry/2O97
PDB4YEWhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4YEW
PDB4YEXhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4YEX
PDB4YEYhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4YEY
PDB4YF0http://www.ebi.ac.uk/pdbe-srv/view/entry/4YF0
PDB4YFHhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4YFH
PDB4YFThttp://www.ebi.ac.uk/pdbe-srv/view/entry/4YFT
PDBsum1MULhttp://www.ebi.ac.uk/pdbsum/1MUL
PDBsum2O97http://www.ebi.ac.uk/pdbsum/2O97
PDBsum4YEWhttp://www.ebi.ac.uk/pdbsum/4YEW
PDBsum4YEXhttp://www.ebi.ac.uk/pdbsum/4YEX
PDBsum4YEYhttp://www.ebi.ac.uk/pdbsum/4YEY
PDBsum4YF0http://www.ebi.ac.uk/pdbsum/4YF0
PDBsum4YFHhttp://www.ebi.ac.uk/pdbsum/4YFH
PDBsum4YFThttp://www.ebi.ac.uk/pdbsum/4YFT
PRINTSPR01727http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01727
PROSITEPS00045http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00045
PSORT-Bswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:DBHA_ECOLI
PSORT2swissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:DBHA_ECOLI
PSORTswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:DBHA_ECOLI
PfamPF00216http://pfam.xfam.org/family/PF00216
Phobiusswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:DBHA_ECOLI
PhylomeDBP0ACF0http://phylomedb.org/?seqid=P0ACF0
ProteinModelPortalP0ACF0http://www.proteinmodelportal.org/query/uniprot/P0ACF0
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed215461http://www.ncbi.nlm.nih.gov/pubmed/215461
PubMed2187099http://www.ncbi.nlm.nih.gov/pubmed/2187099
PubMed21903814http://www.ncbi.nlm.nih.gov/pubmed/21903814
PubMed227733http://www.ncbi.nlm.nih.gov/pubmed/227733
PubMed3312963http://www.ncbi.nlm.nih.gov/pubmed/3312963
PubMed350619http://www.ncbi.nlm.nih.gov/pubmed/350619
PubMed6987059http://www.ncbi.nlm.nih.gov/pubmed/6987059
PubMed8265357http://www.ncbi.nlm.nih.gov/pubmed/8265357
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9298644http://www.ncbi.nlm.nih.gov/pubmed/9298644
PubMed9298646http://www.ncbi.nlm.nih.gov/pubmed/9298646
PubMed9868784http://www.ncbi.nlm.nih.gov/pubmed/9868784
RefSeqNP_418428http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418428
RefSeqWP_001044513http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001044513
SMARTSM00411http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00411
SMRP0ACF0http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACF0
STRING511145.b4000http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4000&targetmode=cogs
STRINGCOG0776http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0776&targetmode=cogs
SUPFAMSSF47729http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47729
UniProtKB-ACP0ACF0http://www.uniprot.org/uniprot/P0ACF0
UniProtKBDBHA_ECOLIhttp://www.uniprot.org/uniprot/DBHA_ECOLI
chargeswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:DBHA_ECOLI
eggNOGCOG0776http://eggnogapi.embl.de/nog_data/html/tree/COG0776
eggNOGENOG4105K70http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K70
epestfindswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:DBHA_ECOLI
garnierswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:DBHA_ECOLI
helixturnhelixswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:DBHA_ECOLI
hmomentswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:DBHA_ECOLI
iepswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:DBHA_ECOLI
inforesidueswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:DBHA_ECOLI
octanolswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:DBHA_ECOLI
pepcoilswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:DBHA_ECOLI
pepdigestswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:DBHA_ECOLI
pepinfoswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:DBHA_ECOLI
pepnetswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:DBHA_ECOLI
pepstatsswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:DBHA_ECOLI
pepwheelswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:DBHA_ECOLI
pepwindowswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:DBHA_ECOLI
sigcleaveswissprot:DBHA_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:DBHA_ECOLI
DataBaseIDURL or Descriptions
# AltNameSSB_ECOLIHelix-destabilizing protein
# BioGrid4262671106
# ENZYME REGULATIONThe C-terminal tail exerts an inhibitory effect on ssDNA binding. {ECO:0000269|PubMed20360609}.
# EcoGeneEG10976ssb
# FUNCTIONSSB_ECOLIPlays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. Acts as a sliding platform that migrates on DNA via reptation. {ECO 0000255|HAMAP-Rule MF_00984, ECO 0000269|PubMed 18937104, ECO 0000269|PubMed 20360609, ECO 0000269|PubMed 21784244}.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_functionGO:0003697single-stranded DNA binding; IDA:EcoCyc.
# GO_functionGO:0008047enzyme activator activity; IMP:UniProtKB.
# GO_functionGO:0042802identical protein binding; IDA:EcoCyc.
# GO_processGO:0000725recombinational repair; TAS:EcoCyc.
# GO_processGO:0006260DNA replication; IEA:UniProtKB-HAMAP.
# GO_processGO:0006298mismatch repair; TAS:EcoCyc.
# GO_processGO:0009432SOS response; TAS:EcoCyc.
# GO_processGO:0043085positive regulation of catalytic activity; IMP:UniProtKB.
# GOslim_componentGO:0005829cytosol
# GOslim_functionGO:0003674molecular_function
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0030234enzyme regulator activity
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0006950response to stress
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0009058biosynthetic process
# HAMAPMF_00984SSB
# INTERACTIONSSB_ECOLIP27296 dinG; NbExp=2; IntAct=EBI-1118620, EBI-1114590; P0ABS5 dnaG; NbExp=2; IntAct=EBI-1118620, EBI-549259; P06710 dnaX; NbExp=2; IntAct=EBI-1118620, EBI-549140; P28905 holC; NbExp=9; IntAct=EBI-1118620, EBI-549169; P17888 priA; NbExp=2; IntAct=EBI-1118620, EBI-552050;
# IntActP0AGE012
# InterProIPR000424Primosome_PriB/ssb
# InterProIPR011344ssDNA-bd
# InterProIPR012340NA-bd_OB-fold
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Pathwayko03030DNA replication
# KEGG_Pathwayko03430Mismatch repair
# KEGG_Pathwayko03440Homologous recombination
# OrganismSSB_ECOLIEscherichia coli (strain K12)
# PANTHERPTHR10302PTHR10302
# PATRIC32123663VBIEscCol129921_4180
# PDB1EQQX-ray; 3.20 A; A/B/C/D=1-178
# PDB1EYGX-ray; 2.80 A; A/B/C/D=1-116
# PDB1KAWX-ray; 2.90 A; A/B/C/D=2-136
# PDB1QVCX-ray; 2.20 A; A/B/C/D=2-146
# PDB1SRUX-ray; 3.30 A; A/B/C/D=1-113
# PDB3C94X-ray; 2.70 A; B/C=170-178
# PDB3SXUX-ray; 1.85 A; C=175-178
# PDB3UF7X-ray; 1.20 A; B/C=170-178
# PDB4MZ9X-ray; 2.20 A; A/B/C/D=1-178
# PDB4Z0UX-ray; 2.00 A; D/E=170-178
# PIRB65214DDEC
# PIRSFPIRSF002070SSB
# PROSITEPS50935SSB
# PTMSSB_ECOLIPhosphorylated on tyrosine residue(s). {ECO 0000269|PubMed 16549871}.
# PfamPF00436SSB
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameSingle-stranded DNA-binding protein {ECO:0000255|HAMAP-RuleMF_00984}
# RefSeqNP_418483NC_000913.3
# RefSeqWP_000168305NZ_LN832404.1
# SIMILARITYContains 1 SSB domain. {ECO:0000255|HAMAP- RuleMF_00984}.
# SUBUNITSSB_ECOLIHomotetramer. Interacts, via its C-terminus, with several proteins involved in DNA metabolism such as DnaG, HolC, PriA, PriB, RecO, RecQ and SbcB. {ECO 0000255|HAMAP-Rule MF_00984, ECO 0000269|PubMed 10782989, ECO 0000269|PubMed 10932248, ECO 0000269|PubMed 15576682, ECO 0000269|PubMed 17483090, ECO 0000269|PubMed 18591666, ECO 0000269|PubMed 20018747, ECO 0000269|PubMed 23430154, ECO 0000269|PubMed 23963891, ECO 0000269|PubMed 7962001, ECO 0000269|PubMed 9192620, ECO 0000269|PubMed 9545254}.
# SUPFAMSSF50249SSF50249
# TIGRFAMsTIGR00621ssb
# eggNOGCOG0629LUCA
# eggNOGENOG4108UUMBacteria
BLASTswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:SSB_ECOLI
BioCycECOL316407:JW4020-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW4020-MONOMER
BioCycEcoCyc:EG10976-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10976-MONOMER
COGCOG0629http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0629
DIPDIP-35980Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35980N
DOI10.1002/elps.1150180805http://dx.doi.org/10.1002/elps.1150180805
DOI10.1007/s10930-013-9509-yhttp://dx.doi.org/10.1007/s10930-013-9509-y
DOI10.1016/0014-5793(87)80844-Xhttp://dx.doi.org/10.1016/0014-5793(87)80844-X
DOI10.1016/0022-2836(91)90611-9http://dx.doi.org/10.1016/0022-2836(91)90611-9
DOI10.1016/j.cell.2011.06.036http://dx.doi.org/10.1016/j.cell.2011.06.036
DOI10.1038/77943http://dx.doi.org/10.1038/77943
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1073/pnas.0800741105http://dx.doi.org/10.1073/pnas.0800741105
DOI10.1073/pnas.0909191107http://dx.doi.org/10.1073/pnas.0909191107
DOI10.1073/pnas.78.7.4274http://dx.doi.org/10.1073/pnas.78.7.4274
DOI10.1073/pnas.80.18.5480http://dx.doi.org/10.1073/pnas.80.18.5480
DOI10.1073/pnas.94.13.6652http://dx.doi.org/10.1073/pnas.94.13.6652
DOI10.1074/jbc.M110.118273http://dx.doi.org/10.1074/jbc.M110.118273
DOI10.1074/jbc.M608011200http://dx.doi.org/10.1074/jbc.M608011200
DOI10.1080/10409230802341296 http://dx.doi.org/10.1080/10409230802341296
DOI10.1093/emboj/17.8.2436http://dx.doi.org/10.1093/emboj/17.8.2436
DOI10.1093/nar/21.23.5408http://dx.doi.org/10.1093/nar/21.23.5408
DOI10.1093/nar/gkh980http://dx.doi.org/10.1093/nar/gkh980
DOI10.1093/nar/gkj514http://dx.doi.org/10.1093/nar/gkj514
DOI10.1093/nar/gkt107http://dx.doi.org/10.1093/nar/gkt107
DOI10.1111/j.1432-1033.1982.tb19784.xhttp://dx.doi.org/10.1111/j.1432-1033.1982.tb19784.x
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
DOI10.1515/BC.2000.025http://dx.doi.org/10.1515/BC.2000.025
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLJ01704http://www.ebi.ac.uk/ena/data/view/J01704
EMBLU00006http://www.ebi.ac.uk/ena/data/view/U00006
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EchoBASEEB0969http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0969
EcoGeneEG10976http://www.ecogene.org/geneInfo.php?eg_id=EG10976
EnsemblBacteriaAAC77029http://www.ensemblgenomes.org/id/AAC77029
EnsemblBacteriaAAC77029http://www.ensemblgenomes.org/id/AAC77029
EnsemblBacteriaBAE78061http://www.ensemblgenomes.org/id/BAE78061
EnsemblBacteriaBAE78061http://www.ensemblgenomes.org/id/BAE78061
EnsemblBacteriaBAE78061http://www.ensemblgenomes.org/id/BAE78061
EnsemblBacteriab4059http://www.ensemblgenomes.org/id/b4059
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_functionGO:0003697http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697
GO_functionGO:0008047http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008047
GO_functionGO:0042802http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_processGO:0000725http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000725
GO_processGO:0006260http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260
GO_processGO:0006298http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006298
GO_processGO:0009432http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432
GO_processGO:0043085http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043085
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_functionGO:0003674http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0030234http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0006950http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GeneID948570http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948570
HAMAPMF_00984http://hamap.expasy.org/unirule/MF_00984
HOGENOMHOG000106483http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000106483&db=HOGENOM6
InParanoidP0AGE0http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGE0
IntActP0AGE0http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGE0*
InterProIPR000424http://www.ebi.ac.uk/interpro/entry/IPR000424
InterProIPR011344http://www.ebi.ac.uk/interpro/entry/IPR011344
InterProIPR012340http://www.ebi.ac.uk/interpro/entry/IPR012340
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW4020http://www.genome.jp/dbget-bin/www_bget?ecj:JW4020
KEGG_Geneeco:b4059http://www.genome.jp/dbget-bin/www_bget?eco:b4059
KEGG_OrthologyKO:K03111http://www.genome.jp/dbget-bin/www_bget?KO:K03111
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
KEGG_Pathwayko03430http://www.genome.jp/kegg-bin/show_pathway?ko03430
KEGG_Pathwayko03440http://www.genome.jp/kegg-bin/show_pathway?ko03440
MINTMINT-8298796http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8298796
OMAQQYNEPPhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QQYNEPP
PANTHERPTHR10302http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10302
PDB1EQQhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1EQQ
PDB1EYGhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1EYG
PDB1KAWhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1KAW
PDB1QVChttp://www.ebi.ac.uk/pdbe-srv/view/entry/1QVC
PDB1SRUhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1SRU
PDB3C94http://www.ebi.ac.uk/pdbe-srv/view/entry/3C94
PDB3SXUhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3SXU
PDB3UF7http://www.ebi.ac.uk/pdbe-srv/view/entry/3UF7
PDB4MZ9http://www.ebi.ac.uk/pdbe-srv/view/entry/4MZ9
PDB4Z0Uhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4Z0U
PDBsum1EQQhttp://www.ebi.ac.uk/pdbsum/1EQQ
PDBsum1EYGhttp://www.ebi.ac.uk/pdbsum/1EYG
PDBsum1KAWhttp://www.ebi.ac.uk/pdbsum/1KAW
PDBsum1QVChttp://www.ebi.ac.uk/pdbsum/1QVC
PDBsum1SRUhttp://www.ebi.ac.uk/pdbsum/1SRU
PDBsum3C94http://www.ebi.ac.uk/pdbsum/3C94
PDBsum3SXUhttp://www.ebi.ac.uk/pdbsum/3SXU
PDBsum3UF7http://www.ebi.ac.uk/pdbsum/3UF7
PDBsum4MZ9http://www.ebi.ac.uk/pdbsum/4MZ9
PDBsum4Z0Uhttp://www.ebi.ac.uk/pdbsum/4Z0U
PROSITEPS50935http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50935
PSORT-Bswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:SSB_ECOLI
PSORT2swissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:SSB_ECOLI
PSORTswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:SSB_ECOLI
PfamPF00436http://pfam.xfam.org/family/PF00436
Phobiusswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:SSB_ECOLI
PhylomeDBP0AGE0http://phylomedb.org/?seqid=P0AGE0
ProteinModelPortalP0AGE0http://www.proteinmodelportal.org/query/uniprot/P0AGE0
PubMed10782989http://www.ncbi.nlm.nih.gov/pubmed/10782989
PubMed10932248http://www.ncbi.nlm.nih.gov/pubmed/10932248
PubMed15576682http://www.ncbi.nlm.nih.gov/pubmed/15576682
PubMed16549871http://www.ncbi.nlm.nih.gov/pubmed/16549871
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed17483090http://www.ncbi.nlm.nih.gov/pubmed/17483090
PubMed18591666http://www.ncbi.nlm.nih.gov/pubmed/18591666
PubMed18937104http://www.ncbi.nlm.nih.gov/pubmed/18937104
PubMed1988680http://www.ncbi.nlm.nih.gov/pubmed/1988680
PubMed20018747http://www.ncbi.nlm.nih.gov/pubmed/20018747
PubMed20360609http://www.ncbi.nlm.nih.gov/pubmed/20360609
PubMed2087220http://www.ncbi.nlm.nih.gov/pubmed/2087220
PubMed21784244http://www.ncbi.nlm.nih.gov/pubmed/21784244
PubMed23430154http://www.ncbi.nlm.nih.gov/pubmed/23430154
PubMed23963891http://www.ncbi.nlm.nih.gov/pubmed/23963891
PubMed3301414http://www.ncbi.nlm.nih.gov/pubmed/3301414
PubMed6270666http://www.ncbi.nlm.nih.gov/pubmed/6270666
PubMed6351061http://www.ncbi.nlm.nih.gov/pubmed/6351061
PubMed6363409http://www.ncbi.nlm.nih.gov/pubmed/6363409
PubMed6384214http://www.ncbi.nlm.nih.gov/pubmed/6384214
PubMed7042342http://www.ncbi.nlm.nih.gov/pubmed/7042342
PubMed7962001http://www.ncbi.nlm.nih.gov/pubmed/7962001
PubMed8265357http://www.ncbi.nlm.nih.gov/pubmed/8265357
PubMed9139905http://www.ncbi.nlm.nih.gov/pubmed/9139905
PubMed9192620http://www.ncbi.nlm.nih.gov/pubmed/9192620
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9298644http://www.ncbi.nlm.nih.gov/pubmed/9298644
PubMed9545254http://www.ncbi.nlm.nih.gov/pubmed/9545254
RefSeqNP_418483http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418483
RefSeqWP_000168305http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000168305
SMRP0AGE0http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGE0
STRING511145.b4059http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4059&targetmode=cogs
STRINGCOG0629http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0629&targetmode=cogs
SUPFAMSSF50249http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249
SWISS-2DPAGEP0AGE0http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AGE0
TIGRFAMsTIGR00621http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00621
UniProtKB-ACP0AGE0http://www.uniprot.org/uniprot/P0AGE0
UniProtKBSSB_ECOLIhttp://www.uniprot.org/uniprot/SSB_ECOLI
chargeswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:SSB_ECOLI
eggNOGCOG0629http://eggnogapi.embl.de/nog_data/html/tree/COG0629
eggNOGENOG4108UUMhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UUM
epestfindswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:SSB_ECOLI
garnierswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:SSB_ECOLI
helixturnhelixswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:SSB_ECOLI
hmomentswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:SSB_ECOLI
iepswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:SSB_ECOLI
inforesidueswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:SSB_ECOLI
octanolswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:SSB_ECOLI
pepcoilswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:SSB_ECOLI
pepdigestswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:SSB_ECOLI
pepinfoswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:SSB_ECOLI
pepnetswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:SSB_ECOLI
pepstatsswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:SSB_ECOLI
pepwheelswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:SSB_ECOLI
pepwindowswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:SSB_ECOLI
sigcleaveswissprot:SSB_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:SSB_ECOLI
DataBaseIDURL or Descriptions
# BioGrid4263061174
# EcoGeneEG10441ihfB
# FUNCTIONIHFB_ECOLIHas an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site. Relaxosome formation requires binding of IHF and TraY to the oriT region, which then faciliates binding of TraI.
# FUNCTIONIHFB_ECOLIOne of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
# FUNCTIONIHFB_ECOLIPlays a crucial role in the lysogenic life cycle of bacteriophage lambda, as it is required not only in the recombination reaction, which inserts lambda DNA into the E.coli chromosome, but also for the synthesis of int and cI repressor, two phage proteins necessary for DNA insertion and repression, respectively. The synthesis of int and cI proteins is regulated indirectly by IHF via translational control of the lambda cII protein.
# GO_componentGO:0005694chromosome; IEA:InterPro.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_functionGO:0003677DNA binding; IEA:UniProtKB-HAMAP.
# GO_processGO:0000746conjugation; IEA:UniProtKB-KW.
# GO_processGO:0006310DNA recombination; IEA:UniProtKB-HAMAP.
# GO_processGO:0006351transcription, DNA-templated; IDA:EcoCyc.
# GO_processGO:0006417regulation of translation; IEA:UniProtKB-HAMAP.
# GO_processGO:0045892negative regulation of transcription, DNA-templated; IDA:EcoCyc.
# GO_processGO:0045893positive regulation of transcription, DNA-templated; IDA:EcoCyc.
# GOslim_componentGO:0005694chromosome
# GOslim_componentGO:0005829cytosol
# GOslim_functionGO:0003677DNA binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0009058biosynthetic process
# GOslim_processGO:0034641cellular nitrogen compound metabolic process
# Gene3D4.10.520.10-; 1.
# HAMAPMF_00381IHF_beta
# IntActP0A6Y134
# InterProIPR000119Hist_DNA-bd
# InterProIPR005685IHF_beta
# InterProIPR010992IHF-like_DNA-bd_dom
# InterProIPR020816Histone-like_DNA-bd_CS
# KEGG_Briteko03032DNA replication proteins
# KEGG_Briteko03036 Chromosome
# KEGG_Briteko03400 DNA repair and recombination proteins
# OrganismIHFB_ECOLIEscherichia coli (strain K12)
# PATRIC32117037VBIEscCol129921_0943
# PDB1IHFX-ray; 2.20 A; B=1-94
# PDB1OUZX-ray; 2.41 A; B=1-94
# PDB1OWFX-ray; 1.95 A; B=1-94
# PDB1OWGX-ray; 2.10 A; B=1-94
# PDB2HT0X-ray; 2.00 A; B=1-94
# PDB2IIEX-ray; 2.41 A; A=2-94
# PDB2IIFX-ray; 2.72 A; A=2-94
# PIRG64830IQECAB
# PRINTSPR01727DNABINDINGHU
# PROSITEPS00045HISTONE_LIKE
# PfamPF00216Bac_DNA_binding
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameIHFB_ECOLIIntegration host factor subunit beta
# RefSeqNP_415432NC_000913.3
# RefSeqWP_000167336NZ_LN832404.1
# SIMILARITYBelongs to the bacterial histone-like protein family. {ECO0000305}.
# SMARTSM00411BHL
# SUBCELLULAR LOCATIONIHFB_ECOLICytoplasm.
# SUBUNITIHFB_ECOLIHeterodimer of an alpha and a beta chain. Part of the relaxosome, a complex composed of plasmid-encoded TraI, TraM, TraY and host-encoded IHF bound to the F plasmid origin of transfer (oriT). {ECO 0000269|PubMed 17238924, ECO 0000269|PubMed 7499340}.
# SUPFAMSSF47729SSF47729
# TIGRFAMsTIGR00988hip
# eggNOGCOG0776LUCA
# eggNOGENOG41080YABacteria
BLASTswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:IHFB_ECOLI
BioCycECOL316407:JW0895-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW0895-MONOMER
BioCycEcoCyc:PD00348http://biocyc.org/getid?id=EcoCyc:PD00348
COGCOG0776http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0776
DIPDIP-41099Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-41099N
DOI10.1016/0022-2836(85)90206-2http://dx.doi.org/10.1016/0022-2836(85)90206-2
DOI10.1016/S0092-8674(00)81824-3http://dx.doi.org/10.1016/S0092-8674(00)81824-3
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1074/jbc.270.47.28374http://dx.doi.org/10.1074/jbc.270.47.28374
DOI10.1074/jbc.270.47.28381http://dx.doi.org/10.1074/jbc.270.47.28381
DOI10.1093/dnares/3.3.137http://dx.doi.org/10.1093/dnares/3.3.137
DOI10.1111/j.1365-2958.2006.05576.xhttp://dx.doi.org/10.1111/j.1365-2958.2006.05576.x
DOI10.1111/j.1574-6968.1998.tb13343.xhttp://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLX04864http://www.ebi.ac.uk/ena/data/view/X04864
EchoBASEEB0436http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0436
EcoGeneEG10441http://www.ecogene.org/geneInfo.php?eg_id=EG10441
EnsemblBacteriaAAC73998http://www.ensemblgenomes.org/id/AAC73998
EnsemblBacteriaAAC73998http://www.ensemblgenomes.org/id/AAC73998
EnsemblBacteriaBAA35656http://www.ensemblgenomes.org/id/BAA35656
EnsemblBacteriaBAA35656http://www.ensemblgenomes.org/id/BAA35656
EnsemblBacteriaBAA35656http://www.ensemblgenomes.org/id/BAA35656
EnsemblBacteriab0912http://www.ensemblgenomes.org/id/b0912
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005694http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_processGO:0000746http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746
GO_processGO:0006310http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310
GO_processGO:0006351http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351
GO_processGO:0006417http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006417
GO_processGO:0045892http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892
GO_processGO:0045893http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893
GOslim_componentGO:0005694http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GOslim_processGO:0034641http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641
Gene3D4.10.520.10http://www.cathdb.info/version/latest/superfamily/4.10.520.10
GeneID945533http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945533
HAMAPMF_00381http://hamap.expasy.org/unirule/MF_00381
HOGENOMHOG000043828http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000043828&db=HOGENOM6
InParanoidP0A6Y1http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6Y1
IntActP0A6Y1http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6Y1*
InterProIPR000119http://www.ebi.ac.uk/interpro/entry/IPR000119
InterProIPR005685http://www.ebi.ac.uk/interpro/entry/IPR005685
InterProIPR010992http://www.ebi.ac.uk/interpro/entry/IPR010992
InterProIPR020816http://www.ebi.ac.uk/interpro/entry/IPR020816
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03036http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW0895http://www.genome.jp/dbget-bin/www_bget?ecj:JW0895
KEGG_Geneeco:b0912http://www.genome.jp/dbget-bin/www_bget?eco:b0912
KEGG_OrthologyKO:K05788http://www.genome.jp/dbget-bin/www_bget?KO:K05788
MINTMINT-365163http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-365163
OMARDRVNIYhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDRVNIY
PDB1IHFhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1IHF
PDB1OUZhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1OUZ
PDB1OWFhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1OWF
PDB1OWGhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1OWG
PDB2HT0http://www.ebi.ac.uk/pdbe-srv/view/entry/2HT0
PDB2IIEhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2IIE
PDB2IIFhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2IIF
PDBsum1IHFhttp://www.ebi.ac.uk/pdbsum/1IHF
PDBsum1OUZhttp://www.ebi.ac.uk/pdbsum/1OUZ
PDBsum1OWFhttp://www.ebi.ac.uk/pdbsum/1OWF
PDBsum1OWGhttp://www.ebi.ac.uk/pdbsum/1OWG
PDBsum2HT0http://www.ebi.ac.uk/pdbsum/2HT0
PDBsum2IIEhttp://www.ebi.ac.uk/pdbsum/2IIE
PDBsum2IIFhttp://www.ebi.ac.uk/pdbsum/2IIF
PRINTSPR01727http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01727
PROSITEPS00045http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00045
PSORT-Bswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:IHFB_ECOLI
PSORT2swissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:IHFB_ECOLI
PSORTswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:IHFB_ECOLI
PfamPF00216http://pfam.xfam.org/family/PF00216
Phobiusswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:IHFB_ECOLI
PhylomeDBP0A6Y1http://phylomedb.org/?seqid=P0A6Y1
ProteinModelPortalP0A6Y1http://www.proteinmodelportal.org/query/uniprot/P0A6Y1
PubMed1531459http://www.ncbi.nlm.nih.gov/pubmed/1531459
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed17238924http://www.ncbi.nlm.nih.gov/pubmed/17238924
PubMed1917861http://www.ncbi.nlm.nih.gov/pubmed/1917861
PubMed3159903http://www.ncbi.nlm.nih.gov/pubmed/3159903
PubMed7499339http://www.ncbi.nlm.nih.gov/pubmed/7499339
PubMed7499340http://www.ncbi.nlm.nih.gov/pubmed/7499340
PubMed8905232http://www.ncbi.nlm.nih.gov/pubmed/8905232
PubMed8980235http://www.ncbi.nlm.nih.gov/pubmed/8980235
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9868784http://www.ncbi.nlm.nih.gov/pubmed/9868784
RefSeqNP_415432http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415432
RefSeqWP_000167336http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000167336
SMARTSM00411http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00411
SMRP0A6Y1http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6Y1
STRING511145.b0912http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0912&targetmode=cogs
STRINGCOG0776http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0776&targetmode=cogs
SUPFAMSSF47729http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47729
TIGRFAMsTIGR00988http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00988
UniProtKB-ACP0A6Y1http://www.uniprot.org/uniprot/P0A6Y1
UniProtKBIHFB_ECOLIhttp://www.uniprot.org/uniprot/IHFB_ECOLI
chargeswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:IHFB_ECOLI
eggNOGCOG0776http://eggnogapi.embl.de/nog_data/html/tree/COG0776
eggNOGENOG41080YAhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG41080YA
epestfindswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:IHFB_ECOLI
garnierswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:IHFB_ECOLI
helixturnhelixswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:IHFB_ECOLI
hmomentswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:IHFB_ECOLI
iepswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:IHFB_ECOLI
inforesidueswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:IHFB_ECOLI
octanolswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:IHFB_ECOLI
pepcoilswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:IHFB_ECOLI
pepdigestswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:IHFB_ECOLI
pepinfoswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:IHFB_ECOLI
pepnetswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:IHFB_ECOLI
pepstatsswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:IHFB_ECOLI
pepwheelswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:IHFB_ECOLI
pepwindowswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:IHFB_ECOLI
sigcleaveswissprot:IHFB_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:IHFB_ECOLI
DataBaseIDURL or Descriptions
# AltNameDNLJ_ECOLIPolydeoxyribonucleotide synthase [NAD(+)]
# BRENDA6.5.12026
# BioGrid4259672128
# CATALYTIC ACTIVITYNAD(+) + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + beta-nicotinamide D- ribonucleotide + (deoxyribonucleotide)(n+m). {ECO:0000269|PubMed11781321}.
# CDDcd00027BRCT
# COFACTORDNLJ_ECOLIName=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 11781321};
# EcoGeneEG10534ligA
# FUNCTIONDNLJ_ECOLIDNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_functionGO:0003677DNA binding; IDA:EcoCyc.
# GO_functionGO:0003911DNA ligase (NAD+) activity; IDA:EcoliWiki.
# GO_functionGO:0046872metal ion binding; IEA:UniProtKB-KW.
# GO_functionGO:0070403NAD+ binding; IMP:EcoCyc.
# GO_processGO:0006260DNA replication; IEA:UniProtKB-KW.
# GO_processGO:0006266DNA ligation; IDA:EcoCyc.
# GO_processGO:0006288base-excision repair, DNA ligation; IDA:EcoCyc.
# GOslim_componentGO:0005829cytosol
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0016874ligase activity
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0009058biosynthetic process
# Gene3D3.40.50.10190-; 1.
# HAMAPMF_01588DNA_ligase_A
# IntActP1504220
# InterProIPR001357BRCT_dom
# InterProIPR001679DNAligase
# InterProIPR003583Hlx-hairpin-Hlx_DNA-bd_motif
# InterProIPR004149Znf_DNAligase_C4
# InterProIPR004150NAD_DNA_ligase_OB
# InterProIPR010994RuvA_2-like
# InterProIPR012340NA-bd_OB-fold
# InterProIPR013839DNAligase_adenylation
# InterProIPR013840DNAligase_N
# InterProIPR018239DNA_ligase_AS
# InterProIPR033136DNA_ligase_CS
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Pathwayko03030DNA replication
# KEGG_Pathwayko03410Base excision repair
# KEGG_Pathwayko03420Nucleotide excision repair
# KEGG_Pathwayko03430Mismatch repair
# OrganismDNLJ_ECOLIEscherichia coli (strain K12)
# PATRIC32120205VBIEscCol129921_2505
# PDB2OWOX-ray; 2.30 A; A=1-671
# PDB4GLXX-ray; 1.90 A; A=1-586
# PIRB65015LQECC6
# PIRSFPIRSF001604LigA
# PROSITEPS01055DNA_LIGASE_N1
# PROSITEPS01056DNA_LIGASE_N2
# PROSITEPS50172BRCT
# PfamPF00533BRCT
# PfamPF01653DNA_ligase_aden
# PfamPF03119DNA_ligase_ZBD
# PfamPF03120DNA_ligase_OB
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDNLJ_ECOLIDNA ligase
# RefSeqNP_416906NC_000913.3
# RefSeqWP_000443661NZ_LN832404.1
# SIMILARITYBelongs to the NAD-dependent DNA ligase family. LigA subfamily. {ECO0000305}.
# SIMILARITYContains 1 BRCT domain. {ECO0000305}.
# SMARTSM00278HhH1; 4
# SMARTSM00292BRCT
# SMARTSM00532LIGANc
# SUPFAMSSF47781SSF47781
# SUPFAMSSF50249SSF50249
# SUPFAMSSF52113SSF52113
# TIGRFAMsTIGR00575dnlj
# eggNOGCOG0272LUCA
# eggNOGENOG4105C77Bacteria
BLASTswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:DNLJ_ECOLI
BioCycECOL316407:JW2403-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW2403-MONOMER
BioCycEcoCyc:EG10534-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10534-MONOMER
BioCycMetaCyc:EG10534-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG10534-MONOMER
COGCOG0272http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0272
DIPDIP-10098Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10098N
DOI10.1007/BF00330179http://dx.doi.org/10.1007/BF00330179
DOI10.1016/S0092-8674(00)81838-3http://dx.doi.org/10.1016/S0092-8674(00)81838-3
DOI10.1016/j.molcel.2007.02.026http://dx.doi.org/10.1016/j.molcel.2007.02.026
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1074/jbc.M111164200http://dx.doi.org/10.1074/jbc.M111164200
DOI10.1074/jbc.M413685200http://dx.doi.org/10.1074/jbc.M413685200
DOI10.1074/jbc.M802945200http://dx.doi.org/10.1074/jbc.M802945200
DOI10.1093/dnares/4.2.91http://dx.doi.org/10.1093/dnares/4.2.91
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:6.5.1.2http://www.genome.jp/dbget-bin/www_bget?EC:6.5.1.2
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLM24278http://www.ebi.ac.uk/ena/data/view/M24278
EMBLM30255http://www.ebi.ac.uk/ena/data/view/M30255
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU74650http://www.ebi.ac.uk/ena/data/view/U74650
ENZYME6.5.1.2http://enzyme.expasy.org/EC/6.5.1.2
EchoBASEEB0529http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0529
EcoGeneEG10534http://www.ecogene.org/geneInfo.php?eg_id=EG10534
EnsemblBacteriaAAC75464http://www.ensemblgenomes.org/id/AAC75464
EnsemblBacteriaAAC75464http://www.ensemblgenomes.org/id/AAC75464
EnsemblBacteriaBAA16282http://www.ensemblgenomes.org/id/BAA16282
EnsemblBacteriaBAA16282http://www.ensemblgenomes.org/id/BAA16282
EnsemblBacteriaBAA16282http://www.ensemblgenomes.org/id/BAA16282
EnsemblBacteriab2411http://www.ensemblgenomes.org/id/b2411
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003911http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003911
GO_functionGO:0046872http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872
GO_functionGO:0070403http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070403
GO_processGO:0006260http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260
GO_processGO:0006266http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006266
GO_processGO:0006288http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006288
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0016874http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
Gene3D3.40.50.10190http://www.cathdb.info/version/latest/superfamily/3.40.50.10190
GeneID946885http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946885
HAMAPMF_01588http://hamap.expasy.org/unirule/MF_01588
HOGENOMHOG000218459http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218459&db=HOGENOM6
InParanoidP15042http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15042
IntActP15042http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15042*
IntEnz6.5.1.2http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.5.1.2
InterProIPR001357http://www.ebi.ac.uk/interpro/entry/IPR001357
InterProIPR001679http://www.ebi.ac.uk/interpro/entry/IPR001679
InterProIPR003583http://www.ebi.ac.uk/interpro/entry/IPR003583
InterProIPR004149http://www.ebi.ac.uk/interpro/entry/IPR004149
InterProIPR004150http://www.ebi.ac.uk/interpro/entry/IPR004150
InterProIPR010994http://www.ebi.ac.uk/interpro/entry/IPR010994
InterProIPR012340http://www.ebi.ac.uk/interpro/entry/IPR012340
InterProIPR013839http://www.ebi.ac.uk/interpro/entry/IPR013839
InterProIPR013840http://www.ebi.ac.uk/interpro/entry/IPR013840
InterProIPR018239http://www.ebi.ac.uk/interpro/entry/IPR018239
InterProIPR033136http://www.ebi.ac.uk/interpro/entry/IPR033136
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW2403http://www.genome.jp/dbget-bin/www_bget?ecj:JW2403
KEGG_Geneeco:b2411http://www.genome.jp/dbget-bin/www_bget?eco:b2411
KEGG_OrthologyKO:K01972http://www.genome.jp/dbget-bin/www_bget?KO:K01972
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
KEGG_Pathwayko03410http://www.genome.jp/kegg-bin/show_pathway?ko03410
KEGG_Pathwayko03420http://www.genome.jp/kegg-bin/show_pathway?ko03420
KEGG_Pathwayko03430http://www.genome.jp/kegg-bin/show_pathway?ko03430
MINTMINT-204717http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-204717
OMAFTAKSPRhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTAKSPR
PDB2OWOhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2OWO
PDB4GLXhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4GLX
PDBsum2OWOhttp://www.ebi.ac.uk/pdbsum/2OWO
PDBsum4GLXhttp://www.ebi.ac.uk/pdbsum/4GLX
PROSITEPS01055http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01055
PROSITEPS01056http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01056
PROSITEPS50172http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50172
PSORT-Bswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:DNLJ_ECOLI
PSORT2swissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:DNLJ_ECOLI
PSORTswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:DNLJ_ECOLI
PfamPF00533http://pfam.xfam.org/family/PF00533
PfamPF01653http://pfam.xfam.org/family/PF01653
PfamPF03119http://pfam.xfam.org/family/PF03119
PfamPF03120http://pfam.xfam.org/family/PF03120
Phobiusswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:DNLJ_ECOLI
PhylomeDBP15042http://phylomedb.org/?seqid=P15042
ProteinModelPortalP15042http://www.proteinmodelportal.org/query/uniprot/P15042
PubMed11781321http://www.ncbi.nlm.nih.gov/pubmed/11781321
PubMed15671015http://www.ncbi.nlm.nih.gov/pubmed/15671015
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed17466627http://www.ncbi.nlm.nih.gov/pubmed/17466627
PubMed18515356http://www.ncbi.nlm.nih.gov/pubmed/18515356
PubMed3018436http://www.ncbi.nlm.nih.gov/pubmed/3018436
PubMed9008158http://www.ncbi.nlm.nih.gov/pubmed/9008158
PubMed9205837http://www.ncbi.nlm.nih.gov/pubmed/9205837
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
RefSeqNP_416906http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416906
RefSeqWP_000443661http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000443661
SMARTSM00278http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00278
SMARTSM00292http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00292
SMARTSM00532http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00532
SMRP15042http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15042
STRING511145.b2411http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2411&targetmode=cogs
STRINGCOG0272http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0272&targetmode=cogs
SUPFAMSSF47781http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47781
SUPFAMSSF50249http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249
SUPFAMSSF52113http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52113
TIGRFAMsTIGR00575http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00575
UniProtKB-ACP15042http://www.uniprot.org/uniprot/P15042
UniProtKBDNLJ_ECOLIhttp://www.uniprot.org/uniprot/DNLJ_ECOLI
chargeswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:DNLJ_ECOLI
eggNOGCOG0272http://eggnogapi.embl.de/nog_data/html/tree/COG0272
eggNOGENOG4105C77http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C77
epestfindswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:DNLJ_ECOLI
garnierswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:DNLJ_ECOLI
helixturnhelixswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:DNLJ_ECOLI
hmomentswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:DNLJ_ECOLI
iepswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:DNLJ_ECOLI
inforesidueswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:DNLJ_ECOLI
octanolswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:DNLJ_ECOLI
pepcoilswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:DNLJ_ECOLI
pepdigestswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:DNLJ_ECOLI
pepinfoswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:DNLJ_ECOLI
pepnetswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:DNLJ_ECOLI
pepstatsswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:DNLJ_ECOLI
pepwheelswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:DNLJ_ECOLI
pepwindowswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:DNLJ_ECOLI
sigcleaveswissprot:DNLJ_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:DNLJ_ECOLI
DataBaseIDURL or Descriptions
# AltNameDPO3B_ECOLIBeta sliding clamp
# BioGrid4259535176
# CATALYTIC ACTIVITYDPO3B_ECOLIDeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
# CDDcd00140beta_clamp
# EcoGeneEG10242dnaN
# FUNCTIONDPO3B_ECOLIDNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication; once it is clamped onto DNA it slides freely (bidirectional and ATP- independent) along duplex DNA. Coordinates protein traffic at the replication fork, where it interacts with multiple DNA polymerases. {ECO 0000269|PubMed 15466025, ECO 0000269|PubMed 22716942}.
# GO_componentGO:0005829cytosol; IDA:UniProtKB.
# GO_componentGO:0009360DNA polymerase III complex; IEA:InterPro.
# GO_functionGO:0003677DNA binding; IEA:InterPro.
# GO_functionGO:0003887DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
# GO_functionGO:00084083'-5' exonuclease activity; IEA:InterPro.
# GO_functionGO:0042802identical protein binding; IPI:IntAct.
# GO_processGO:0006271DNA strand elongation involved in DNA replication; IDA:EcoCyc.
# GO_processGO:0006974cellular response to DNA damage stimulus; IEP:EcoliWiki.
# GOslim_componentGO:0005575cellular_component
# GOslim_componentGO:0005829cytosol
# GOslim_functionGO:0003674molecular_function
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0004518nuclease activity
# GOslim_functionGO:0016779nucleotidyltransferase activity
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0006950response to stress
# INDUCTIONInduced 1.5-fold by hydroxyurea. {ECO:0000269|PubMed20005847}.
# INTERACTIONDPO3B_ECOLISelf; NbExp=9; IntAct=EBI-542385, EBI-542385; Q47155 dinB; NbExp=2; IntAct=EBI-542385, EBI-1037359; P10443 dnaE; NbExp=17; IntAct=EBI-542385, EBI-549111; P03007 dnaQ; NbExp=6; IntAct=EBI-542385, EBI-549131; P06710 dnaX; NbExp=4; IntAct=EBI-542385, EBI-549140; P69931 hda; NbExp=8; IntAct=EBI-542385, EBI-545453; P28630 holA; NbExp=10; IntAct=EBI-542385, EBI-549153; P0AG07 rpe; NbExp=3; IntAct=EBI-542385, EBI-546020; P05845 tnsE (xeno); NbExp=4; IntAct=EBI-542385, EBI-2434514;
# IntActP0A98838
# InterProIPR001001DNA_polIII_beta
# InterProIPR022634DNA_polIII_beta_N
# InterProIPR022635DNA_polIII_beta_C
# InterProIPR022637DNA_polIII_beta_cen
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko00002 KEGG pathway modules
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03032 M00260 DNA polymerase III complex, bacteria
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Briteko03400 M00260 DNA polymerase III complex, bacteria
# KEGG_Pathwayko00230Purine metabolism
# KEGG_Pathwayko00240Pyrimidine metabolism
# KEGG_Pathwayko03030DNA replication
# KEGG_Pathwayko03430Mismatch repair
# KEGG_Pathwayko03440Homologous recombination
# MISCELLANEOUSDPO3B_ECOLIThe temperature- and UV-sensitive allele dnaN159 does not grow at higher than 37 degrees Celsius. The global SOS response is chronically induced. The UV-sensitivity of dnaN159 is dependent upon pol IV (dinB), it has an enhanced Pol V-dependent mutation rate (umuC, umuD), and is absolutely dependent on the polymerase activity of Pol I (polA) for viability.
# OrganismDPO3B_ECOLIEscherichia coli (strain K12)
# PATRIC32122899VBIEscCol129921_3825
# PDB1JQJX-ray; 2.90 A; A/B=1-366
# PDB1JQLX-ray; 2.50 A; A=1-366
# PDB1MMIX-ray; 1.85 A; A/B=1-366
# PDB1OK7X-ray; 1.65 A; A/B=1-366
# PDB1UNNX-ray; 1.90 A; A/B=1-366
# PDB1WAIModel; -; A/B=1-366
# PDB2POLX-ray; 2.50 A; A/B=1-366
# PDB2XURX-ray; 1.90 A; A/B=1-366
# PDB3BEPX-ray; 1.92 A; A/B=1-366
# PDB3D1EX-ray; 1.90 A; A/B=1-366
# PDB3D1FX-ray; 2.00 A; A/B=1-366
# PDB3D1GX-ray; 1.64 A; A/B=1-366
# PDB3F1VX-ray; 1.77 A; A/B=1-366
# PDB3PWEX-ray; 2.20 A; A/B=1-366
# PDB3Q4JX-ray; 2.30 A; A/B/C/D/E/F=1-366
# PDB3Q4KX-ray; 2.60 A; A/B=1-366
# PDB3Q4LX-ray; 1.95 A; A/B=1-366
# PDB3QSBX-ray; 1.90 A; A/B=1-366
# PDB4K3KX-ray; 1.85 A; A/B=1-366
# PDB4K3LX-ray; 1.50 A; A/B=1-366
# PDB4K3MX-ray; 1.85 A; A/B=1-366
# PDB4K3OX-ray; 2.00 A; A/B=1-366
# PDB4K3PX-ray; 2.15 A; A/B=1-366
# PDB4K3QX-ray; 1.85 A; A/B=1-366
# PDB4K3RX-ray; 1.86 A; A/B=1-366
# PDB4K3SX-ray; 1.75 A; A/B=1-366
# PDB4MJPX-ray; 1.86 A; A/B=1-366
# PDB4MJQX-ray; 1.73 A; A/B=1-366
# PDB4MJRX-ray; 1.62 A; A/B=1-366
# PDB4N94X-ray; 1.73 A; A/B=1-366
# PDB4N95X-ray; 1.80 A; A/B=1-366
# PDB4N96X-ray; 1.70 A; A/B=1-366
# PDB4N97X-ray; 1.97 A; A/B=1-366
# PDB4N98X-ray; 1.70 A; A/B=1-366
# PDB4N99X-ray; 2.30 A; A/B=1-366
# PDB4N9AX-ray; 1.90 A; A/B=1-366
# PDB5FKUEM; 8.34 A; B/C=1-366
# PDB5FKVEM; 8.00 A; B/C=1-366
# PDB5FKWEM; 7.30 A; B/C=1-366
# PIRA91510DJEC3B
# PIRSFPIRSF000804DNA_pol_III_b
# PfamPF00712DNA_pol3_beta
# PfamPF02767DNA_pol3_beta_2
# PfamPF02768DNA_pol3_beta_3
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDPO3B_ECOLIDNA polymerase III subunit beta
# RefSeqNP_418156NC_000913.3
# RefSeqWP_000673464NZ_LN832404.1
# SMARTSM00480POL3Bc
# SUBCELLULAR LOCATIONDPO3B_ECOLICytoplasm {ECO 0000269|PubMed 23994470}. Note=Localizes to midcell position when chromosomes are condensed during DNA replication.
# SUBUNITDPO3B_ECOLIThe DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha, epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the beta sliding clamp processivity factor (this entry). The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4]. The beta chain is a homodimer when not associated with the other components. Can also be part of the RIDA complex (regulatory inactivation of DnaA), consisting of ATP-DnaA, ADP-Hda and DNA-loaded beta clamp. Probably also interacts with components of DNA polymerases I, II, IV and V. Binds to CrfC homooligomers at the midcell position during DNA replication. {ECO 0000269|PubMed 14592985, ECO 0000269|PubMed 15150238, ECO 0000269|PubMed 15466025, ECO 0000269|PubMed 18977760, ECO 0000269|PubMed 23994470}.
# TIGRFAMsTIGR00663dnan
# eggNOGCOG0592LUCA
# eggNOGENOG4105CZ8Bacteria
BLASTswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:DPO3B_ECOLI
BioCycECOL316407:JW3678-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW3678-MONOMER
BioCycEcoCyc:EG10242-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10242-MONOMER
BioCycMetaCyc:EG10242-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG10242-MONOMER
COGCOG0592http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0592
DIPDIP-36038Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36038N
DOI10.1002/bies.950140206http://dx.doi.org/10.1002/bies.950140206
DOI10.1002/elps.1150180805http://dx.doi.org/10.1002/elps.1150180805
DOI10.1006/geno.1993.1230http://dx.doi.org/10.1006/geno.1993.1230
DOI10.1016/0092-8674(92)90445-Ihttp://dx.doi.org/10.1016/0092-8674(92)90445-I
DOI10.1016/0378-1119(84)90253-1http://dx.doi.org/10.1016/0378-1119(84)90253-1
DOI10.1016/0378-1119(86)90206-4http://dx.doi.org/10.1016/0378-1119(86)90206-4
DOI10.1016/j.celrep.2013.07.040http://dx.doi.org/10.1016/j.celrep.2013.07.040
DOI10.1016/j.molcel.2009.11.024http://dx.doi.org/10.1016/j.molcel.2009.11.024
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1073/pnas.81.15.4622http://dx.doi.org/10.1073/pnas.81.15.4622
DOI10.1074/jbc.M803158200http://dx.doi.org/10.1074/jbc.M803158200
DOI10.1093/emboj/cdg568http://dx.doi.org/10.1093/emboj/cdg568
DOI10.1093/nar/12.16.6389http://dx.doi.org/10.1093/nar/12.16.6389
DOI10.1107/S0907444903009958http://dx.doi.org/10.1107/S0907444903009958
DOI10.1111/j.1365-2958.2012.08129.xhttp://dx.doi.org/10.1111/j.1365-2958.2012.08129.x
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
DOI10.1128/JB.186.11.3508-3515.2004http://dx.doi.org/10.1128/JB.186.11.3508-3515.2004
DOI10.1128/JB.186.20.6738-6748.2004http://dx.doi.org/10.1128/JB.186.20.6738-6748.2004
EC_numberEC:2.7.7.7http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLJ01602http://www.ebi.ac.uk/ena/data/view/J01602
EMBLK02179http://www.ebi.ac.uk/ena/data/view/K02179
EMBLL10328http://www.ebi.ac.uk/ena/data/view/L10328
EMBLM13822http://www.ebi.ac.uk/ena/data/view/M13822
EMBLM19876http://www.ebi.ac.uk/ena/data/view/M19876
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLX04341http://www.ebi.ac.uk/ena/data/view/X04341
ENZYME2.7.7.7http://enzyme.expasy.org/EC/2.7.7.7
EchoBASEEB0238http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0238
EcoGeneEG10242http://www.ecogene.org/geneInfo.php?eg_id=EG10242
EnsemblBacteriaAAC76724http://www.ensemblgenomes.org/id/AAC76724
EnsemblBacteriaAAC76724http://www.ensemblgenomes.org/id/AAC76724
EnsemblBacteriaBAE77593http://www.ensemblgenomes.org/id/BAE77593
EnsemblBacteriaBAE77593http://www.ensemblgenomes.org/id/BAE77593
EnsemblBacteriaBAE77593http://www.ensemblgenomes.org/id/BAE77593
EnsemblBacteriab3701http://www.ensemblgenomes.org/id/b3701
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_componentGO:0009360http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009360
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887
GO_functionGO:0008408http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008408
GO_functionGO:0042802http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_processGO:0006271http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006271
GO_processGO:0006974http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974
GOslim_componentGO:0005575http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_functionGO:0003674http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0004518http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518
GOslim_functionGO:0016779http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0006950http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GeneID948218http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948218
HOGENOMHOG000071791http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000071791&db=HOGENOM6
InParanoidP0A988http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A988
IntActP0A988http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A988*
IntEnz2.7.7.7http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7
InterProIPR001001http://www.ebi.ac.uk/interpro/entry/IPR001001
InterProIPR022634http://www.ebi.ac.uk/interpro/entry/IPR022634
InterProIPR022635http://www.ebi.ac.uk/interpro/entry/IPR022635
InterProIPR022637http://www.ebi.ac.uk/interpro/entry/IPR022637
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko00002http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW3678http://www.genome.jp/dbget-bin/www_bget?ecj:JW3678
KEGG_Geneeco:b3701http://www.genome.jp/dbget-bin/www_bget?eco:b3701
KEGG_OrthologyKO:K02338http://www.genome.jp/dbget-bin/www_bget?KO:K02338
KEGG_Pathwayko00230http://www.genome.jp/kegg-bin/show_pathway?ko00230
KEGG_Pathwayko00240http://www.genome.jp/kegg-bin/show_pathway?ko00240
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
KEGG_Pathwayko03430http://www.genome.jp/kegg-bin/show_pathway?ko03430
KEGG_Pathwayko03440http://www.genome.jp/kegg-bin/show_pathway?ko03440
KEGG_Reactionrn:R00375http://www.genome.jp/dbget-bin/www_bget?rn:R00375
KEGG_Reactionrn:R00376http://www.genome.jp/dbget-bin/www_bget?rn:R00376
KEGG_Reactionrn:R00377http://www.genome.jp/dbget-bin/www_bget?rn:R00377
KEGG_Reactionrn:R00378http://www.genome.jp/dbget-bin/www_bget?rn:R00378
OMATHQIRLKhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THQIRLK
PDB1JQJhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1JQJ
PDB1JQLhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1JQL
PDB1MMIhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1MMI
PDB1OK7http://www.ebi.ac.uk/pdbe-srv/view/entry/1OK7
PDB1UNNhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1UNN
PDB1WAIhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1WAI
PDB2POLhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2POL
PDB2XURhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2XUR
PDB3BEPhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3BEP
PDB3D1Ehttp://www.ebi.ac.uk/pdbe-srv/view/entry/3D1E
PDB3D1Fhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3D1F
PDB3D1Ghttp://www.ebi.ac.uk/pdbe-srv/view/entry/3D1G
PDB3F1Vhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3F1V
PDB3PWEhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3PWE
PDB3Q4Jhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3Q4J
PDB3Q4Khttp://www.ebi.ac.uk/pdbe-srv/view/entry/3Q4K
PDB3Q4Lhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3Q4L
PDB3QSBhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3QSB
PDB4K3Khttp://www.ebi.ac.uk/pdbe-srv/view/entry/4K3K
PDB4K3Lhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4K3L
PDB4K3Mhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4K3M
PDB4K3Ohttp://www.ebi.ac.uk/pdbe-srv/view/entry/4K3O
PDB4K3Phttp://www.ebi.ac.uk/pdbe-srv/view/entry/4K3P
PDB4K3Qhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4K3Q
PDB4K3Rhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4K3R
PDB4K3Shttp://www.ebi.ac.uk/pdbe-srv/view/entry/4K3S
PDB4MJPhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4MJP
PDB4MJQhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4MJQ
PDB4MJRhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4MJR
PDB4N94http://www.ebi.ac.uk/pdbe-srv/view/entry/4N94
PDB4N95http://www.ebi.ac.uk/pdbe-srv/view/entry/4N95
PDB4N96http://www.ebi.ac.uk/pdbe-srv/view/entry/4N96
PDB4N97http://www.ebi.ac.uk/pdbe-srv/view/entry/4N97
PDB4N98http://www.ebi.ac.uk/pdbe-srv/view/entry/4N98
PDB4N99http://www.ebi.ac.uk/pdbe-srv/view/entry/4N99
PDB4N9Ahttp://www.ebi.ac.uk/pdbe-srv/view/entry/4N9A
PDB5FKUhttp://www.ebi.ac.uk/pdbe-srv/view/entry/5FKU
PDB5FKVhttp://www.ebi.ac.uk/pdbe-srv/view/entry/5FKV
PDB5FKWhttp://www.ebi.ac.uk/pdbe-srv/view/entry/5FKW
PDBsum1JQJhttp://www.ebi.ac.uk/pdbsum/1JQJ
PDBsum1JQLhttp://www.ebi.ac.uk/pdbsum/1JQL
PDBsum1MMIhttp://www.ebi.ac.uk/pdbsum/1MMI
PDBsum1OK7http://www.ebi.ac.uk/pdbsum/1OK7
PDBsum1UNNhttp://www.ebi.ac.uk/pdbsum/1UNN
PDBsum1WAIhttp://www.ebi.ac.uk/pdbsum/1WAI
PDBsum2POLhttp://www.ebi.ac.uk/pdbsum/2POL
PDBsum2XURhttp://www.ebi.ac.uk/pdbsum/2XUR
PDBsum3BEPhttp://www.ebi.ac.uk/pdbsum/3BEP
PDBsum3D1Ehttp://www.ebi.ac.uk/pdbsum/3D1E
PDBsum3D1Fhttp://www.ebi.ac.uk/pdbsum/3D1F
PDBsum3D1Ghttp://www.ebi.ac.uk/pdbsum/3D1G
PDBsum3F1Vhttp://www.ebi.ac.uk/pdbsum/3F1V
PDBsum3PWEhttp://www.ebi.ac.uk/pdbsum/3PWE
PDBsum3Q4Jhttp://www.ebi.ac.uk/pdbsum/3Q4J
PDBsum3Q4Khttp://www.ebi.ac.uk/pdbsum/3Q4K
PDBsum3Q4Lhttp://www.ebi.ac.uk/pdbsum/3Q4L
PDBsum3QSBhttp://www.ebi.ac.uk/pdbsum/3QSB
PDBsum4K3Khttp://www.ebi.ac.uk/pdbsum/4K3K
PDBsum4K3Lhttp://www.ebi.ac.uk/pdbsum/4K3L
PDBsum4K3Mhttp://www.ebi.ac.uk/pdbsum/4K3M
PDBsum4K3Ohttp://www.ebi.ac.uk/pdbsum/4K3O
PDBsum4K3Phttp://www.ebi.ac.uk/pdbsum/4K3P
PDBsum4K3Qhttp://www.ebi.ac.uk/pdbsum/4K3Q
PDBsum4K3Rhttp://www.ebi.ac.uk/pdbsum/4K3R
PDBsum4K3Shttp://www.ebi.ac.uk/pdbsum/4K3S
PDBsum4MJPhttp://www.ebi.ac.uk/pdbsum/4MJP
PDBsum4MJQhttp://www.ebi.ac.uk/pdbsum/4MJQ
PDBsum4MJRhttp://www.ebi.ac.uk/pdbsum/4MJR
PDBsum4N94http://www.ebi.ac.uk/pdbsum/4N94
PDBsum4N95http://www.ebi.ac.uk/pdbsum/4N95
PDBsum4N96http://www.ebi.ac.uk/pdbsum/4N96
PDBsum4N97http://www.ebi.ac.uk/pdbsum/4N97
PDBsum4N98http://www.ebi.ac.uk/pdbsum/4N98
PDBsum4N99http://www.ebi.ac.uk/pdbsum/4N99
PDBsum4N9Ahttp://www.ebi.ac.uk/pdbsum/4N9A
PDBsum5FKUhttp://www.ebi.ac.uk/pdbsum/5FKU
PDBsum5FKVhttp://www.ebi.ac.uk/pdbsum/5FKV
PDBsum5FKWhttp://www.ebi.ac.uk/pdbsum/5FKW
PSORT-Bswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:DPO3B_ECOLI
PSORT2swissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:DPO3B_ECOLI
PSORTswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:DPO3B_ECOLI
PfamPF00712http://pfam.xfam.org/family/PF00712
PfamPF02767http://pfam.xfam.org/family/PF02767
PfamPF02768http://pfam.xfam.org/family/PF02768
Phobiusswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:DPO3B_ECOLI
PhylomeDBP0A988http://phylomedb.org/?seqid=P0A988
ProteinModelPortalP0A988http://www.proteinmodelportal.org/query/uniprot/P0A988
PubMed12832762http://www.ncbi.nlm.nih.gov/pubmed/12832762
PubMed1349852http://www.ncbi.nlm.nih.gov/pubmed/1349852
PubMed14592985http://www.ncbi.nlm.nih.gov/pubmed/14592985
PubMed15150238http://www.ncbi.nlm.nih.gov/pubmed/15150238
PubMed15466025http://www.ncbi.nlm.nih.gov/pubmed/15466025
PubMed1575709http://www.ncbi.nlm.nih.gov/pubmed/1575709
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed18977760http://www.ncbi.nlm.nih.gov/pubmed/18977760
PubMed20005847http://www.ncbi.nlm.nih.gov/pubmed/20005847
PubMed22716942http://www.ncbi.nlm.nih.gov/pubmed/22716942
PubMed23994470http://www.ncbi.nlm.nih.gov/pubmed/23994470
PubMed2841344http://www.ncbi.nlm.nih.gov/pubmed/2841344
PubMed3527871http://www.ncbi.nlm.nih.gov/pubmed/3527871
PubMed6089112http://www.ncbi.nlm.nih.gov/pubmed/6089112
PubMed6234204http://www.ncbi.nlm.nih.gov/pubmed/6234204
PubMed6379647http://www.ncbi.nlm.nih.gov/pubmed/6379647
PubMed7686882http://www.ncbi.nlm.nih.gov/pubmed/7686882
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9298644http://www.ncbi.nlm.nih.gov/pubmed/9298644
RefSeqNP_418156http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418156
RefSeqWP_000673464http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000673464
SMARTSM00480http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00480
SMRP0A988http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A988
STRING511145.b3701http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3701&targetmode=cogs
STRINGCOG0592http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0592&targetmode=cogs
TIGRFAMsTIGR00663http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00663
UniProtKB-ACP0A988http://www.uniprot.org/uniprot/P0A988
UniProtKBDPO3B_ECOLIhttp://www.uniprot.org/uniprot/DPO3B_ECOLI
chargeswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:DPO3B_ECOLI
eggNOGCOG0592http://eggnogapi.embl.de/nog_data/html/tree/COG0592
eggNOGENOG4105CZ8http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CZ8
epestfindswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:DPO3B_ECOLI
garnierswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:DPO3B_ECOLI
helixturnhelixswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:DPO3B_ECOLI
hmomentswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:DPO3B_ECOLI
iepswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:DPO3B_ECOLI
inforesidueswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:DPO3B_ECOLI
octanolswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:DPO3B_ECOLI
pepcoilswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:DPO3B_ECOLI
pepdigestswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:DPO3B_ECOLI
pepinfoswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:DPO3B_ECOLI
pepnetswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:DPO3B_ECOLI
pepstatsswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:DPO3B_ECOLI
pepwheelswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:DPO3B_ECOLI
pepwindowswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:DPO3B_ECOLI
sigcleaveswissprot:DPO3B_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:DPO3B_ECOLI
DataBaseIDURL or Descriptions
# BioGrid4263116175
# CATALYTIC ACTIVITYHOLB_ECOLIDeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
# EcoGeneEG11500holB
# FUNCTIONHOLB_ECOLIDNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
# GO_componentGO:0009360DNA polymerase III complex; IDA:EcoCyc.
# GO_functionGO:0003677DNA binding; IEA:InterPro.
# GO_functionGO:0003887DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
# GO_functionGO:00084083'-5' exonuclease activity; IEA:InterPro.
# GO_processGO:0006261DNA-dependent DNA replication; IDA:EcoCyc.
# GOslim_componentGO:0005575cellular_component
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0004518nuclease activity
# GOslim_functionGO:0016779nucleotidyltransferase activity
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0009058biosynthetic process
# Gene3D3.40.50.300-; 1.
# INTERACTIONHOLB_ECOLIP06710 dnaX; NbExp=17; IntAct=EBI-549161, EBI-549140; P06710-1 dnaX; NbExp=6; IntAct=EBI-549161, EBI-6464728; P28630 holA; NbExp=17; IntAct=EBI-549161, EBI-549153; P28905 holC; NbExp=5; IntAct=EBI-549161, EBI-549169; P23367 mutL; NbExp=2; IntAct=EBI-549161, EBI-554913;
# IntActP2863125
# InterProIPR004622DNA_pol_HolB
# InterProIPR008921DNA_pol3_clamp-load_cplx_C
# InterProIPR015199DNA_pol_III_delta_C
# InterProIPR027417P-loop_NTPase
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko00002 KEGG pathway modules
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03032 M00260 DNA polymerase III complex, bacteria
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Briteko03400 M00260 DNA polymerase III complex, bacteria
# KEGG_Pathwayko00230Purine metabolism
# KEGG_Pathwayko00240Pyrimidine metabolism
# KEGG_Pathwayko03030DNA replication
# KEGG_Pathwayko03430Mismatch repair
# KEGG_Pathwayko03440Homologous recombination
# OrganismHOLB_ECOLIEscherichia coli (strain K12)
# PATRIC32117439VBIEscCol129921_1142
# PDB1A5TX-ray; 2.20 A; A=1-334
# PDB1JR3X-ray; 2.70 A; E=1-334
# PDB1XXHX-ray; 3.45 A; E/J=1-334
# PDB1XXIX-ray; 4.10 A; E/J=1-334
# PDB3GLFX-ray; 3.39 A; E/J=1-334
# PDB3GLGX-ray; 3.25 A; E/J=1-334
# PDB3GLHX-ray; 3.89 A; E/J/O=1-334
# PDB3GLIX-ray; 3.50 A; E/J=1-334
# PIRS35523S35523
# PfamPF09115DNApol3-delta_C
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameHOLB_ECOLIDNA polymerase III subunit delta'
# RefSeqNP_415617NC_000913.3
# RefSeqWP_001267956NZ_LN832404.1
# SUBUNITThe DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4].
# SUPFAMSSF48019SSF48019
# SUPFAMSSF52540SSF52540
# TIGRFAMsTIGR00678holB
# eggNOGCOG0470LUCA
# eggNOGENOG4107QRGBacteria
BLASTswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:HOLB_ECOLI
BioCycECOL316407:JW1085-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW1085-MONOMER
BioCycEcoCyc:EG11500-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG11500-MONOMER
BioCycMetaCyc:EG11500-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG11500-MONOMER
COGCOG0470http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0470
DIPDIP-9932Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9932N
DOI10.1002/bies.950140206http://dx.doi.org/10.1002/bies.950140206
DOI10.1016/S0092-8674(00)80417-1http://dx.doi.org/10.1016/S0092-8674(00)80417-1
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1093/dnares/3.3.137http://dx.doi.org/10.1093/dnares/3.3.137
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:2.7.7.7http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLL01483http://www.ebi.ac.uk/ena/data/view/L01483
EMBLL04577http://www.ebi.ac.uk/ena/data/view/L04577
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
ENZYME2.7.7.7http://enzyme.expasy.org/EC/2.7.7.7
EchoBASEEB1463http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1463
EcoGeneEG11500http://www.ecogene.org/geneInfo.php?eg_id=EG11500
EnsemblBacteriaAAC74183http://www.ensemblgenomes.org/id/AAC74183
EnsemblBacteriaAAC74183http://www.ensemblgenomes.org/id/AAC74183
EnsemblBacteriaBAA35906http://www.ensemblgenomes.org/id/BAA35906
EnsemblBacteriaBAA35906http://www.ensemblgenomes.org/id/BAA35906
EnsemblBacteriaBAA35906http://www.ensemblgenomes.org/id/BAA35906
EnsemblBacteriab1099http://www.ensemblgenomes.org/id/b1099
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0009360http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009360
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887
GO_functionGO:0008408http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008408
GO_processGO:0006261http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261
GOslim_componentGO:0005575http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0004518http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518
GOslim_functionGO:0016779http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
Gene3D3.40.50.300http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneID945661http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945661
HOGENOMHOG000192595http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000192595&db=HOGENOM6
InParanoidP28631http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28631
IntActP28631http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28631*
IntEnz2.7.7.7http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7
InterProIPR004622http://www.ebi.ac.uk/interpro/entry/IPR004622
InterProIPR008921http://www.ebi.ac.uk/interpro/entry/IPR008921
InterProIPR015199http://www.ebi.ac.uk/interpro/entry/IPR015199
InterProIPR027417http://www.ebi.ac.uk/interpro/entry/IPR027417
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko00002http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW1085http://www.genome.jp/dbget-bin/www_bget?ecj:JW1085
KEGG_Geneeco:b1099http://www.genome.jp/dbget-bin/www_bget?eco:b1099
KEGG_OrthologyKO:K02341http://www.genome.jp/dbget-bin/www_bget?KO:K02341
KEGG_Pathwayko00230http://www.genome.jp/kegg-bin/show_pathway?ko00230
KEGG_Pathwayko00240http://www.genome.jp/kegg-bin/show_pathway?ko00240
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
KEGG_Pathwayko03430http://www.genome.jp/kegg-bin/show_pathway?ko03430
KEGG_Pathwayko03440http://www.genome.jp/kegg-bin/show_pathway?ko03440
KEGG_Reactionrn:R00375http://www.genome.jp/dbget-bin/www_bget?rn:R00375
KEGG_Reactionrn:R00376http://www.genome.jp/dbget-bin/www_bget?rn:R00376
KEGG_Reactionrn:R00377http://www.genome.jp/dbget-bin/www_bget?rn:R00377
KEGG_Reactionrn:R00378http://www.genome.jp/dbget-bin/www_bget?rn:R00378
MINTMINT-1239429http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239429
OMACHSCHLMhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CHSCHLM
PDB1A5Thttp://www.ebi.ac.uk/pdbe-srv/view/entry/1A5T
PDB1JR3http://www.ebi.ac.uk/pdbe-srv/view/entry/1JR3
PDB1XXHhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1XXH
PDB1XXIhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1XXI
PDB3GLFhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3GLF
PDB3GLGhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3GLG
PDB3GLHhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3GLH
PDB3GLIhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3GLI
PDBsum1A5Thttp://www.ebi.ac.uk/pdbsum/1A5T
PDBsum1JR3http://www.ebi.ac.uk/pdbsum/1JR3
PDBsum1XXHhttp://www.ebi.ac.uk/pdbsum/1XXH
PDBsum1XXIhttp://www.ebi.ac.uk/pdbsum/1XXI
PDBsum3GLFhttp://www.ebi.ac.uk/pdbsum/3GLF
PDBsum3GLGhttp://www.ebi.ac.uk/pdbsum/3GLG
PDBsum3GLHhttp://www.ebi.ac.uk/pdbsum/3GLH
PDBsum3GLIhttp://www.ebi.ac.uk/pdbsum/3GLI
PSORT-Bswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:HOLB_ECOLI
PSORT2swissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:HOLB_ECOLI
PSORTswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:HOLB_ECOLI
PfamPF09115http://pfam.xfam.org/family/PF09115
Phobiusswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:HOLB_ECOLI
PhylomeDBP28631http://phylomedb.org/?seqid=P28631
ProteinModelPortalP28631http://www.proteinmodelportal.org/query/uniprot/P28631
PubMed1575709http://www.ncbi.nlm.nih.gov/pubmed/1575709
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed8505303http://www.ncbi.nlm.nih.gov/pubmed/8505303
PubMed8505304http://www.ncbi.nlm.nih.gov/pubmed/8505304
PubMed8509334http://www.ncbi.nlm.nih.gov/pubmed/8509334
PubMed8905232http://www.ncbi.nlm.nih.gov/pubmed/8905232
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9363942http://www.ncbi.nlm.nih.gov/pubmed/9363942
RefSeqNP_415617http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415617
RefSeqWP_001267956http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001267956
SMRP28631http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28631
STRING511145.b1099http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1099&targetmode=cogs
STRINGCOG0470http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0470&targetmode=cogs
SUPFAMSSF48019http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48019
SUPFAMSSF52540http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TIGRFAMsTIGR00678http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00678
UniProtKB-ACP28631http://www.uniprot.org/uniprot/P28631
UniProtKBHOLB_ECOLIhttp://www.uniprot.org/uniprot/HOLB_ECOLI
chargeswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:HOLB_ECOLI
eggNOGCOG0470http://eggnogapi.embl.de/nog_data/html/tree/COG0470
eggNOGENOG4107QRGhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QRG
epestfindswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:HOLB_ECOLI
garnierswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:HOLB_ECOLI
helixturnhelixswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:HOLB_ECOLI
hmomentswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:HOLB_ECOLI
iepswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:HOLB_ECOLI
inforesidueswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:HOLB_ECOLI
octanolswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:HOLB_ECOLI
pepcoilswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:HOLB_ECOLI
pepdigestswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:HOLB_ECOLI
pepinfoswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:HOLB_ECOLI
pepnetswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:HOLB_ECOLI
pepstatsswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:HOLB_ECOLI
pepwheelswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:HOLB_ECOLI
pepwindowswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:HOLB_ECOLI
sigcleaveswissprot:HOLB_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:HOLB_ECOLI
DataBaseIDURL or Descriptions
# BRENDA2.7.72026
# BioGrid4262182113
# CATALYTIC ACTIVITYDPO1_ECOLIDeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
# DrugBankDB00548Azelaic Acid
# EcoGeneEG10746polA
# FUNCTIONDPO1_ECOLIIn addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template.
# GO_componentGO:0005737cytoplasm; IDA:EcoCyc.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_functionGO:0003677DNA binding; IDA:EcoCyc.
# GO_functionGO:0003887DNA-directed DNA polymerase activity; IDA:EcoCyc.
# GO_functionGO:00084083'-5' exonuclease activity; IDA:EcoCyc.
# GO_functionGO:00084095'-3' exonuclease activity; IDA:EcoCyc.
# GO_processGO:0006260DNA replication; IDA:EcoCyc.
# GO_processGO:0006261DNA-dependent DNA replication; IDA:EcoCyc.
# GO_processGO:0006281DNA repair; IMP:EcoCyc.
# GO_processGO:0006284base-excision repair; IDA:EcoCyc.
# GOslim_componentGO:0005737cytoplasm
# GOslim_componentGO:0005829cytosol
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0004518nuclease activity
# GOslim_functionGO:0016779nucleotidyltransferase activity
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0006950response to stress
# GOslim_processGO:0009058biosynthetic process
# Gene3D3.30.420.10-; 1.
# Gene3D3.40.50.1010-; 1.
# IntActP0058228
# InterProIPR001098DNA-dir_DNA_pol_A_palm_dom
# InterProIPR002298DNA_polymerase_A
# InterProIPR0024215-3_exonuclease_N
# InterProIPR0025623'-5'_exonuclease_dom
# InterProIPR008918HhH2
# InterProIPR012337RNaseH-like_dom
# InterProIPR018320DNA_polymerase_1
# InterProIPR019760DNA-dir_DNA_pol_A_CS
# InterProIPR0200455-3_exonuclease_C
# InterProIPR0200465-3_exonucl_a-hlix_arch_N
# InterProIPR029060PIN_domain-like
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Pathwayko00230Purine metabolism
# KEGG_Pathwayko00240Pyrimidine metabolism
# KEGG_Pathwayko03030DNA replication
# KEGG_Pathwayko03410Base excision repair
# KEGG_Pathwayko03420Nucleotide excision repair
# KEGG_Pathwayko03440Homologous recombination
# OrganismDPO1_ECOLIEscherichia coli (strain K12)
# PATRIC32123225VBIEscCol129921_3973
# PDB1D8YX-ray; 2.08 A; A=324-928
# PDB1D9DX-ray; 2.18 A; A=324-928
# PDB1D9FX-ray; 3.00 A; A=324-928
# PDB1DPIX-ray; 2.80 A; A=324-928
# PDB1KFDX-ray; 3.90 A; A=324-928
# PDB1KFSX-ray; 2.10 A; A=324-928
# PDB1KLNX-ray; 3.20 A; A=324-928
# PDB1KRPX-ray; 2.20 A; A=324-928
# PDB1KSPX-ray; 2.30 A; A=324-928
# PDB1QSLX-ray; 2.20 A; A=324-928
# PDB2KFNX-ray; 2.03 A; A=324-928
# PDB2KFZX-ray; 2.03 A; A=324-928
# PDB2KZMX-ray; 2.60 A; A=324-928
# PDB2KZZX-ray; 2.25 A; A=324-928
# PIRA92360DJECI
# PRINTSPR00868DNAPOLI
# PROSITEPS00447DNA_POLYMERASE_A
# PfamPF00476DNA_pol_A
# PfamPF013675_3_exonuc
# PfamPF01612DNA_pol_A_exo1
# PfamPF027395_3_exonuc_N
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDPO1_ECOLIDNA polymerase I
# RefSeqNP_418300NC_000913.3
# RefSeqWP_000250006NZ_LN832404.1
# SIMILARITYBelongs to the DNA polymerase type-A family. {ECO0000305}.
# SIMILARITYContains 1 3'-5' exonuclease domain. {ECO0000305}.
# SIMILARITYContains 1 5'-3' exonuclease domain. {ECO0000305}.
# SMARTSM00279HhH2
# SMARTSM0047435EXOc
# SMARTSM0047553EXOc
# SMARTSM00482POLAc
# SUBUNITDPO1_ECOLISingle-chain monomer with multiple functions.
# SUPFAMSSF47807SSF47807
# SUPFAMSSF53098SSF53098
# SUPFAMSSF88723SSF88723
# TIGRFAMsTIGR00593pola
# eggNOGCOG0258LUCA
# eggNOGCOG0749LUCA
# eggNOGENOG4105C2MBacteria
BLASTswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:DPO1_ECOLI
BioCycECOL316407:JW3835-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW3835-MONOMER
BioCycEcoCyc:EG10746-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10746-MONOMER
BioCycMetaCyc:EG10746-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG10746-MONOMER
COGCOG0258http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0258
COGCOG0749http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0749
DIPDIP-10524Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10524N
DOI10.1002/elps.1150180805http://dx.doi.org/10.1002/elps.1150180805
DOI10.1006/abbi.1993.1130http://dx.doi.org/10.1006/abbi.1993.1130
DOI10.1006/jmbi.1997.1586http://dx.doi.org/10.1006/jmbi.1997.1586
DOI10.1016/0022-2836(83)90049-9http://dx.doi.org/10.1016/0022-2836(83)90049-9
DOI10.1021/bi00214a004http://dx.doi.org/10.1021/bi00214a004
DOI10.1021/bi981537ghttp://dx.doi.org/10.1021/bi981537g
DOI10.1038/313762a0http://dx.doi.org/10.1038/313762a0
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1073/pnas.96.25.14240http://dx.doi.org/10.1073/pnas.96.25.14240
DOI10.1093/nar/21.15.3391http://dx.doi.org/10.1093/nar/21.15.3391
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
DOI10.1126/science.8469987http://dx.doi.org/10.1126/science.8469987
DrugBankDB00548http://www.drugbank.ca/drugs/DB00548
EC_numberEC:2.7.7.7http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLJ01663http://www.ebi.ac.uk/ena/data/view/J01663
EMBLJ01664http://www.ebi.ac.uk/ena/data/view/J01664
EMBLL19201http://www.ebi.ac.uk/ena/data/view/L19201
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLV00317http://www.ebi.ac.uk/ena/data/view/V00317
ENZYME2.7.7.7http://enzyme.expasy.org/EC/2.7.7.7
EchoBASEEB0739http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0739
EcoGeneEG10746http://www.ecogene.org/geneInfo.php?eg_id=EG10746
EnsemblBacteriaAAC76861http://www.ensemblgenomes.org/id/AAC76861
EnsemblBacteriaAAC76861http://www.ensemblgenomes.org/id/AAC76861
EnsemblBacteriaBAE77445http://www.ensemblgenomes.org/id/BAE77445
EnsemblBacteriaBAE77445http://www.ensemblgenomes.org/id/BAE77445
EnsemblBacteriaBAE77445http://www.ensemblgenomes.org/id/BAE77445
EnsemblBacteriab3863http://www.ensemblgenomes.org/id/b3863
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887
GO_functionGO:0008408http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008408
GO_functionGO:0008409http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008409
GO_processGO:0006260http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260
GO_processGO:0006261http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261
GO_processGO:0006281http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281
GO_processGO:0006284http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006284
GOslim_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0004518http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518
GOslim_functionGO:0016779http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0006950http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
Gene3D3.30.420.10http://www.cathdb.info/version/latest/superfamily/3.30.420.10
Gene3D3.40.50.1010http://www.cathdb.info/version/latest/superfamily/3.40.50.1010
GeneID948356http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948356
HOGENOMHOG000020998http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020998&db=HOGENOM6
InParanoidP00582http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00582
IntActP00582http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00582*
IntEnz2.7.7.7http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7
InterProIPR001098http://www.ebi.ac.uk/interpro/entry/IPR001098
InterProIPR002298http://www.ebi.ac.uk/interpro/entry/IPR002298
InterProIPR002421http://www.ebi.ac.uk/interpro/entry/IPR002421
InterProIPR002562http://www.ebi.ac.uk/interpro/entry/IPR002562
InterProIPR008918http://www.ebi.ac.uk/interpro/entry/IPR008918
InterProIPR012337http://www.ebi.ac.uk/interpro/entry/IPR012337
InterProIPR018320http://www.ebi.ac.uk/interpro/entry/IPR018320
InterProIPR019760http://www.ebi.ac.uk/interpro/entry/IPR019760
InterProIPR020045http://www.ebi.ac.uk/interpro/entry/IPR020045
InterProIPR020046http://www.ebi.ac.uk/interpro/entry/IPR020046
InterProIPR029060http://www.ebi.ac.uk/interpro/entry/IPR029060
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW3835http://www.genome.jp/dbget-bin/www_bget?ecj:JW3835
KEGG_Geneeco:b3863http://www.genome.jp/dbget-bin/www_bget?eco:b3863
KEGG_OrthologyKO:K02335http://www.genome.jp/dbget-bin/www_bget?KO:K02335
KEGG_Pathwayko00230http://www.genome.jp/kegg-bin/show_pathway?ko00230
KEGG_Pathwayko00240http://www.genome.jp/kegg-bin/show_pathway?ko00240
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
KEGG_Pathwayko03410http://www.genome.jp/kegg-bin/show_pathway?ko03410
KEGG_Pathwayko03420http://www.genome.jp/kegg-bin/show_pathway?ko03420
KEGG_Pathwayko03440http://www.genome.jp/kegg-bin/show_pathway?ko03440
KEGG_Reactionrn:R00375http://www.genome.jp/dbget-bin/www_bget?rn:R00375
KEGG_Reactionrn:R00376http://www.genome.jp/dbget-bin/www_bget?rn:R00376
KEGG_Reactionrn:R00377http://www.genome.jp/dbget-bin/www_bget?rn:R00377
KEGG_Reactionrn:R00378http://www.genome.jp/dbget-bin/www_bget?rn:R00378
MINTMINT-1225247http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225247
OMACFDTETThttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CFDTETT
PDB1D8Yhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1D8Y
PDB1D9Dhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1D9D
PDB1D9Fhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1D9F
PDB1DPIhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1DPI
PDB1KFDhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1KFD
PDB1KFShttp://www.ebi.ac.uk/pdbe-srv/view/entry/1KFS
PDB1KLNhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1KLN
PDB1KRPhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1KRP
PDB1KSPhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1KSP
PDB1QSLhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1QSL
PDB2KFNhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2KFN
PDB2KFZhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2KFZ
PDB2KZMhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2KZM
PDB2KZZhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2KZZ
PDBsum1D8Yhttp://www.ebi.ac.uk/pdbsum/1D8Y
PDBsum1D9Dhttp://www.ebi.ac.uk/pdbsum/1D9D
PDBsum1D9Fhttp://www.ebi.ac.uk/pdbsum/1D9F
PDBsum1DPIhttp://www.ebi.ac.uk/pdbsum/1DPI
PDBsum1KFDhttp://www.ebi.ac.uk/pdbsum/1KFD
PDBsum1KFShttp://www.ebi.ac.uk/pdbsum/1KFS
PDBsum1KLNhttp://www.ebi.ac.uk/pdbsum/1KLN
PDBsum1KRPhttp://www.ebi.ac.uk/pdbsum/1KRP
PDBsum1KSPhttp://www.ebi.ac.uk/pdbsum/1KSP
PDBsum1QSLhttp://www.ebi.ac.uk/pdbsum/1QSL
PDBsum2KFNhttp://www.ebi.ac.uk/pdbsum/2KFN
PDBsum2KFZhttp://www.ebi.ac.uk/pdbsum/2KFZ
PDBsum2KZMhttp://www.ebi.ac.uk/pdbsum/2KZM
PDBsum2KZZhttp://www.ebi.ac.uk/pdbsum/2KZZ
PRINTSPR00868http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00868
PROSITEPS00447http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00447
PSORT-Bswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:DPO1_ECOLI
PSORT2swissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:DPO1_ECOLI
PSORTswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:DPO1_ECOLI
PfamPF00476http://pfam.xfam.org/family/PF00476
PfamPF01367http://pfam.xfam.org/family/PF01367
PfamPF01612http://pfam.xfam.org/family/PF01612
PfamPF02739http://pfam.xfam.org/family/PF02739
Phobiusswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:DPO1_ECOLI
PhylomeDBP00582http://phylomedb.org/?seqid=P00582
ProteinModelPortalP00582http://www.proteinmodelportal.org/query/uniprot/P00582
PubMed10588690http://www.ncbi.nlm.nih.gov/pubmed/10588690
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed1989886http://www.ncbi.nlm.nih.gov/pubmed/1989886
PubMed3883192http://www.ncbi.nlm.nih.gov/pubmed/3883192
PubMed6183253http://www.ncbi.nlm.nih.gov/pubmed/6183253
PubMed6276402http://www.ncbi.nlm.nih.gov/pubmed/6276402
PubMed6302278http://www.ncbi.nlm.nih.gov/pubmed/6302278
PubMed7035456http://www.ncbi.nlm.nih.gov/pubmed/7035456
PubMed8260491http://www.ncbi.nlm.nih.gov/pubmed/8260491
PubMed8346018http://www.ncbi.nlm.nih.gov/pubmed/8346018
PubMed8442659http://www.ncbi.nlm.nih.gov/pubmed/8442659
PubMed8469987http://www.ncbi.nlm.nih.gov/pubmed/8469987
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9298644http://www.ncbi.nlm.nih.gov/pubmed/9298644
PubMed9514742http://www.ncbi.nlm.nih.gov/pubmed/9514742
PubMed9888810http://www.ncbi.nlm.nih.gov/pubmed/9888810
RefSeqNP_418300http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418300
RefSeqWP_000250006http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000250006
SMARTSM00279http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00279
SMARTSM00474http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00474
SMARTSM00475http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00475
SMARTSM00482http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00482
SMRP00582http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00582
STRING511145.b3863http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3863&targetmode=cogs
STRINGCOG0258http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0258&targetmode=cogs
STRINGCOG0749http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0749&targetmode=cogs
SUPFAMSSF47807http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47807
SUPFAMSSF53098http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098
SUPFAMSSF88723http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88723
SWISS-2DPAGEP00582http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00582
TIGRFAMsTIGR00593http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00593
UniProtKB-ACP00582http://www.uniprot.org/uniprot/P00582
UniProtKBDPO1_ECOLIhttp://www.uniprot.org/uniprot/DPO1_ECOLI
chargeswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:DPO1_ECOLI
eggNOGCOG0258http://eggnogapi.embl.de/nog_data/html/tree/COG0258
eggNOGCOG0749http://eggnogapi.embl.de/nog_data/html/tree/COG0749
eggNOGENOG4105C2Mhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2M
epestfindswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:DPO1_ECOLI
garnierswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:DPO1_ECOLI
helixturnhelixswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:DPO1_ECOLI
hmomentswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:DPO1_ECOLI
iepswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:DPO1_ECOLI
inforesidueswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:DPO1_ECOLI
octanolswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:DPO1_ECOLI
pepcoilswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:DPO1_ECOLI
pepdigestswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:DPO1_ECOLI
pepinfoswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:DPO1_ECOLI
pepnetswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:DPO1_ECOLI
pepstatsswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:DPO1_ECOLI
pepwheelswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:DPO1_ECOLI
pepwindowswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:DPO1_ECOLI
sigcleaveswissprot:DPO1_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:DPO1_ECOLI
DataBaseIDURL or Descriptions
# BioGrid4262785113
# CATALYTIC ACTIVITYHOLD_ECOLIDeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
# EcoGeneEG11414holD
# FUNCTIONHOLD_ECOLIDNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown.
# GO_functionGO:0003887DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
# GO_functionGO:00084083'-5' exonuclease activity; IEA:InterPro.
# GO_processGO:0006260DNA replication; IEA:UniProtKB-KW.
# GOslim_functionGO:0004518nuclease activity
# GOslim_functionGO:0016779nucleotidyltransferase activity
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0009058biosynthetic process
# Gene3D3.40.50.10220-; 1.
# INTERACTIONHOLD_ECOLIP06710 dnaX; NbExp=18; IntAct=EBI-549176, EBI-549140; P06710-2 dnaX; NbExp=2; IntAct=EBI-549176, EBI-2604194; P28905 holC; NbExp=22; IntAct=EBI-549176, EBI-549169;
# IntActP2863222
# InterProIPR004615DNA_pol_III_psi
# InterProIPR018382DNA_pol_III_psi_subgr
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko00002 KEGG pathway modules
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03032 M00260 DNA polymerase III complex, bacteria
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Briteko03400 M00260 DNA polymerase III complex, bacteria
# KEGG_Pathwayko00230Purine metabolism
# KEGG_Pathwayko00240Pyrimidine metabolism
# KEGG_Pathwayko03030DNA replication
# KEGG_Pathwayko03430Mismatch repair
# KEGG_Pathwayko03440Homologous recombination
# OrganismHOLD_ECOLIEscherichia coli (strain K12)
# PATRIC32124354VBIEscCol129921_4517
# PDB1EM8X-ray; 2.10 A; B/D=26-137
# PDB3GLIX-ray; 3.50 A; O/P=2-28
# PDB3SXUX-ray; 1.85 A; B=2-137
# PIRA48647A48647
# PIRSFPIRSF029225DNA_pol_III_psi
# PfamPF03603DNA_III_psi
# ProDomPD032475DNA_pol_III_psi
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameHOLD_ECOLIDNA polymerase III subunit psi
# RefSeqNP_418789NC_000913.3
# RefSeqWP_000204012NZ_LN832404.1
# SUBUNITThe DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4].
# SUPFAMSSF102220SSF102220
# TIGRFAMsTIGR00664DNA_III_psi
# eggNOGCOG3050LUCA
# eggNOGENOG4108WPUBacteria
BLASTswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:HOLD_ECOLI
BioCycECOL316407:JW4334-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW4334-MONOMER
BioCycEcoCyc:EG11414-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG11414-MONOMER
BioCycMetaCyc:EG11414-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG11414-MONOMER
COGCOG3050http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3050
DIPDIP-9934Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9934N
DOI10.1002/bies.950140206http://dx.doi.org/10.1002/bies.950140206
DOI10.1007/BF00331153http://dx.doi.org/10.1007/BF00331153
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1046/j.1432-1033.2003.03944.xhttp://dx.doi.org/10.1046/j.1432-1033.2003.03944.x
DOI10.1093/nar/23.12.2105http://dx.doi.org/10.1093/nar/23.12.2105
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:2.7.7.7http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLL04575http://www.ebi.ac.uk/ena/data/view/L04575
EMBLL05387http://www.ebi.ac.uk/ena/data/view/L05387
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU14003http://www.ebi.ac.uk/ena/data/view/U14003
EMBLX06117http://www.ebi.ac.uk/ena/data/view/X06117
ENZYME2.7.7.7http://enzyme.expasy.org/EC/2.7.7.7
EchoBASEEB1386http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1386
EcoGeneEG11414http://www.ecogene.org/geneInfo.php?eg_id=EG11414
EnsemblBacteriaAAC77325http://www.ensemblgenomes.org/id/AAC77325
EnsemblBacteriaAAC77325http://www.ensemblgenomes.org/id/AAC77325
EnsemblBacteriaBAE78360http://www.ensemblgenomes.org/id/BAE78360
EnsemblBacteriaBAE78360http://www.ensemblgenomes.org/id/BAE78360
EnsemblBacteriaBAE78360http://www.ensemblgenomes.org/id/BAE78360
EnsemblBacteriab4372http://www.ensemblgenomes.org/id/b4372
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_functionGO:0003887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887
GO_functionGO:0008408http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008408
GO_processGO:0006260http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260
GOslim_functionGO:0004518http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518
GOslim_functionGO:0016779http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
Gene3D3.40.50.10220http://www.cathdb.info/version/latest/superfamily/3.40.50.10220
GeneID948890http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948890
HOGENOMHOG000218328http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218328&db=HOGENOM6
IntActP28632http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28632*
IntEnz2.7.7.7http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7
InterProIPR004615http://www.ebi.ac.uk/interpro/entry/IPR004615
InterProIPR018382http://www.ebi.ac.uk/interpro/entry/IPR018382
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko00002http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW4334http://www.genome.jp/dbget-bin/www_bget?ecj:JW4334
KEGG_Geneeco:b4372http://www.genome.jp/dbget-bin/www_bget?eco:b4372
KEGG_OrthologyKO:K02344http://www.genome.jp/dbget-bin/www_bget?KO:K02344
KEGG_Pathwayko00230http://www.genome.jp/kegg-bin/show_pathway?ko00230
KEGG_Pathwayko00240http://www.genome.jp/kegg-bin/show_pathway?ko00240
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
KEGG_Pathwayko03430http://www.genome.jp/kegg-bin/show_pathway?ko03430
KEGG_Pathwayko03440http://www.genome.jp/kegg-bin/show_pathway?ko03440
KEGG_Reactionrn:R00375http://www.genome.jp/dbget-bin/www_bget?rn:R00375
KEGG_Reactionrn:R00376http://www.genome.jp/dbget-bin/www_bget?rn:R00376
KEGG_Reactionrn:R00377http://www.genome.jp/dbget-bin/www_bget?rn:R00377
KEGG_Reactionrn:R00378http://www.genome.jp/dbget-bin/www_bget?rn:R00378
MINTMINT-1224283http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224283
OMAQICAHEHhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QICAHEH
PDB1EM8http://www.ebi.ac.uk/pdbe-srv/view/entry/1EM8
PDB3GLIhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3GLI
PDB3SXUhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3SXU
PDBsum1EM8http://www.ebi.ac.uk/pdbsum/1EM8
PDBsum3GLIhttp://www.ebi.ac.uk/pdbsum/3GLI
PDBsum3SXUhttp://www.ebi.ac.uk/pdbsum/3SXU
PSORT-Bswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:HOLD_ECOLI
PSORT2swissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:HOLD_ECOLI
PSORTswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:HOLD_ECOLI
PfamPF03603http://pfam.xfam.org/family/PF03603
Phobiusswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:HOLD_ECOLI
ProteinModelPortalP28632http://www.proteinmodelportal.org/query/uniprot/P28632
PubMed14717711http://www.ncbi.nlm.nih.gov/pubmed/14717711
PubMed1575709http://www.ncbi.nlm.nih.gov/pubmed/1575709
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed2828880http://www.ncbi.nlm.nih.gov/pubmed/2828880
PubMed7610040http://www.ncbi.nlm.nih.gov/pubmed/7610040
PubMed8366044http://www.ncbi.nlm.nih.gov/pubmed/8366044
PubMed8389364http://www.ncbi.nlm.nih.gov/pubmed/8389364
PubMed8505305http://www.ncbi.nlm.nih.gov/pubmed/8505305
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
RefSeqNP_418789http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418789
RefSeqWP_000204012http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000204012
SMRP28632http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28632
STRING511145.b4372http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4372&targetmode=cogs
STRINGCOG3050http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3050&targetmode=cogs
SUPFAMSSF102220http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF102220
TIGRFAMsTIGR00664http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00664
UniProtKB-ACP28632http://www.uniprot.org/uniprot/P28632
UniProtKBHOLD_ECOLIhttp://www.uniprot.org/uniprot/HOLD_ECOLI
chargeswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:HOLD_ECOLI
eggNOGCOG3050http://eggnogapi.embl.de/nog_data/html/tree/COG3050
eggNOGENOG4108WPUhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WPU
epestfindswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:HOLD_ECOLI
garnierswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:HOLD_ECOLI
helixturnhelixswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:HOLD_ECOLI
hmomentswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:HOLD_ECOLI
iepswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:HOLD_ECOLI
inforesidueswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:HOLD_ECOLI
octanolswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:HOLD_ECOLI
pepcoilswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:HOLD_ECOLI
pepdigestswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:HOLD_ECOLI
pepinfoswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:HOLD_ECOLI
pepnetswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:HOLD_ECOLI
pepstatsswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:HOLD_ECOLI
pepwheelswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:HOLD_ECOLI
pepwindowswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:HOLD_ECOLI
sigcleaveswissprot:HOLD_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:HOLD_ECOLI
DataBaseIDURL or Descriptions
# AltNameRNH_ECOLIRibonuclease H
# BRENDA3.1.262026
# BioGrid4263455204
# CATALYTIC ACTIVITYRNH_ECOLIEndonucleolytic cleavage to 5'- phosphomonoester.
# CDDcd09278RNase_HI_prokaryote_like
# COFACTORRNH_ECOLIName=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 9852071}; Note=Binds 1 Mg(2+) ion per subunit in the absence of substrate. Requires millimolar levels of Mg(2+) for maximal activity. Has low activity at micromolar concentrations of Mn(2+) and is inhibited at higher Mn(2+) levels. Can bind a second metal ion at a regulatory site, or after substrate binding. {ECO 0000269|PubMed 9852071};
# EcoGeneEG10860rnhA
# FUNCTIONRNH_ECOLIEndonuclease that specifically degrades the RNA of RNA- DNA hybrids. RNase H participates in DNA replication; it helps to specify the origin of genomic replication by suppressing initiation at origins other than the oriC locus; along with the 5'-3' exonuclease of pol1, it removes RNA primers from the Okazaki fragments of lagging strand synthesis; and it defines the origin of replication for ColE1-type plasmids by specific cleavage of an RNA preprimer.
# GO_componentGO:0005737cytoplasm; IEA:UniProtKB-SubCell.
# GO_functionGO:0000287magnesium ion binding; IEA:UniProtKB-HAMAP.
# GO_functionGO:0003676nucleic acid binding; IDA:EcoliWiki.
# GO_functionGO:0004519endonuclease activity; IDA:EcoliWiki.
# GO_functionGO:0004523RNA-DNA hybrid ribonuclease activity; IDA:EcoCyc.
# GO_processGO:0043137DNA replication, removal of RNA primer; IMP:EcoCyc.
# GOslim_componentGO:0005737cytoplasm
# GOslim_functionGO:0003674molecular_function
# GOslim_functionGO:0004518nuclease activity
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0034655nucleobase-containing compound catabolic process
# Gene3D3.30.420.10-; 1.
# HAMAPMF_00042RNase_H
# IntActP0A7Y421
# InterProIPR002156RNaseH_domain
# InterProIPR012337RNaseH-like_dom
# InterProIPR022892RNaseHI
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Pathwayko03030DNA replication
# OrganismRNH_ECOLIEscherichia coli (strain K12)
# PATRIC32115541VBIEscCol129921_0216
# PDB1F21X-ray; 1.40 A; A=1-155
# PDB1G15X-ray; 1.90 A; A=1-155
# PDB1GOAX-ray; 1.90 A; A=1-155
# PDB1GOBX-ray; 2.00 A; A=1-155
# PDB1GOCX-ray; 2.00 A; A=1-155
# PDB1JL1X-ray; 1.30 A; A=1-155
# PDB1JL2X-ray; 1.76 A; A/B/C/D=1-155
# PDB1JXBX-ray; 1.60 A; A=1-155
# PDB1KVAX-ray; 1.80 A; A=1-155
# PDB1KVBX-ray; 1.90 A; A=1-155
# PDB1KVCX-ray; 1.90 A; A=1-155
# PDB1LAVX-ray; 1.80 A; A=1-155
# PDB1LAWX-ray; 1.80 A; A=1-155
# PDB1RBRX-ray; 1.80 A; A=1-155
# PDB1RBSX-ray; 1.80 A; A=1-155
# PDB1RBTX-ray; 1.80 A; A=1-155
# PDB1RBUX-ray; 1.80 A; A=1-155
# PDB1RBVX-ray; 1.80 A; A=1-155
# PDB1RCHNMR; -; A=1-155
# PDB1RDAX-ray; 2.15 A; A=1-155
# PDB1RDBX-ray; 1.90 A; A=1-155
# PDB1RDCX-ray; 2.30 A; A=1-155
# PDB1RDDX-ray; 2.80 A; A=1-155
# PDB1RNHX-ray; 2.00 A; A=1-155
# PDB1WSEX-ray; 2.30 A; A/B=1-155
# PDB1WSFX-ray; 2.30 A; A/B/C/D=1-155
# PDB1WSGX-ray; 2.20 A; A/B/C/D=1-155
# PDB1WSHX-ray; 1.90 A; A/B/C/D=1-155
# PDB1WSIX-ray; 2.00 A; A/B/C/D=1-155
# PDB1WSJX-ray; 2.00 A; A/B/C/D/E/F/G/H=1-155
# PDB2RN2X-ray; 1.48 A; A=1-155
# PDB2YV0X-ray; 1.40 A; X=1-155
# PDB2Z1GX-ray; 2.10 A; A=1-155
# PDB2Z1HX-ray; 2.60 A; A=1-155
# PDB2Z1IX-ray; 2.00 A; A/B=1-155
# PDB2Z1JX-ray; 2.38 A; A=1-155
# PDB3AA2X-ray; 1.90 A; A=1-155
# PDB3AA3X-ray; 2.20 A; A=1-155
# PDB3AA4X-ray; 1.79 A; A=1-155
# PDB3AA5X-ray; 2.10 A; X=1-155
# PDB3HYFX-ray; 1.70 A; A=79-102
# PDB3QINX-ray; 1.70 A; A=79-102
# PDB3QIOX-ray; 1.40 A; A=79-102
# PDB4Z0UX-ray; 2.00 A; A/B=1-155
# PIRA92401NRECH
# PROSITEPS50879RNASE_H
# PfamPF00075RNase_H
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameRNH_ECOLIRibonuclease HI
# RefSeqNP_414750NC_000913.3
# RefSeqWP_000917883NZ_LN832404.1
# SIMILARITYBelongs to the RNase H family. {ECO0000305}.
# SIMILARITYContains 1 RNase H domain. {ECO0000305}.
# SUBCELLULAR LOCATIONRNH_ECOLICytoplasm {ECO 0000305}.
# SUBUNITRNH_ECOLIMonomer. {ECO 0000269|PubMed 11083878, ECO 0000269|PubMed 1311386, ECO 0000269|PubMed 15644213, ECO 0000269|PubMed 2169648}.
# SUPFAMSSF53098SSF53098
# eggNOGCOG0328LUCA
# eggNOGENOG4108UMWBacteria
BLASTswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:RNH_ECOLI
BioCycECOL316407:JW0204-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW0204-MONOMER
BioCycEcoCyc:EG10860-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10860-MONOMER
BioCycMetaCyc:EG10860-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG10860-MONOMER
COGCOG0328http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0328
DIPDIP-47864Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47864N
DOI10.1016/0022-2836(86)90080-Xhttp://dx.doi.org/10.1016/0022-2836(86)90080-X
DOI10.1016/0022-2836(92)90260-Qhttp://dx.doi.org/10.1016/0022-2836(92)90260-Q
DOI10.1016/j.jmb.2004.11.007http://dx.doi.org/10.1016/j.jmb.2004.11.007
DOI10.1021/bi00051a003http://dx.doi.org/10.1021/bi00051a003
DOI10.1021/bi00238a030http://dx.doi.org/10.1021/bi00238a030
DOI10.1038/347306a0http://dx.doi.org/10.1038/347306a0
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1042/bj2710059http://dx.doi.org/10.1042/bj2710059
DOI10.1073/pnas.80.23.7137http://dx.doi.org/10.1073/pnas.80.23.7137
DOI10.1074/jbc.273.51.34128http://dx.doi.org/10.1074/jbc.273.51.34128
DOI10.1074/jbc.M009626200http://dx.doi.org/10.1074/jbc.M009626200
DOI10.1093/protein/6.1.85http://dx.doi.org/10.1093/protein/6.1.85
DOI10.1093/protein/9.10.857http://dx.doi.org/10.1093/protein/9.10.857
DOI10.1110/ps.9.10.1914http://dx.doi.org/10.1110/ps.9.10.1914
DOI10.1126/science.2169648http://dx.doi.org/10.1126/science.2169648
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:3.1.26.4http://www.genome.jp/dbget-bin/www_bget?EC:3.1.26.4
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLK00985http://www.ebi.ac.uk/ena/data/view/K00985
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU70214http://www.ebi.ac.uk/ena/data/view/U70214
EMBLV00337http://www.ebi.ac.uk/ena/data/view/V00337
EMBLX04027http://www.ebi.ac.uk/ena/data/view/X04027
ENZYME3.1.26.4http://enzyme.expasy.org/EC/3.1.26.4
EchoBASEEB0853http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0853
EcoGeneEG10860http://www.ecogene.org/geneInfo.php?eg_id=EG10860
EnsemblBacteriaAAC73319http://www.ensemblgenomes.org/id/AAC73319
EnsemblBacteriaAAC73319http://www.ensemblgenomes.org/id/AAC73319
EnsemblBacteriaBAA77885http://www.ensemblgenomes.org/id/BAA77885
EnsemblBacteriaBAA77885http://www.ensemblgenomes.org/id/BAA77885
EnsemblBacteriaBAA77885http://www.ensemblgenomes.org/id/BAA77885
EnsemblBacteriab0214http://www.ensemblgenomes.org/id/b0214
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_functionGO:0000287http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287
GO_functionGO:0003676http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676
GO_functionGO:0004519http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519
GO_functionGO:0004523http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004523
GO_processGO:0043137http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043137
GOslim_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_functionGO:0003674http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_functionGO:0004518http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0034655http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655
Gene3D3.30.420.10http://www.cathdb.info/version/latest/superfamily/3.30.420.10
GeneID946955http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946955
HAMAPMF_00042http://hamap.expasy.org/unirule/MF_00042
HOGENOMHOG000040465http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040465&db=HOGENOM6
InParanoidP0A7Y4http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7Y4
IntActP0A7Y4http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7Y4*
IntEnz3.1.26.4http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.26.4
InterProIPR002156http://www.ebi.ac.uk/interpro/entry/IPR002156
InterProIPR012337http://www.ebi.ac.uk/interpro/entry/IPR012337
InterProIPR022892http://www.ebi.ac.uk/interpro/entry/IPR022892
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Geneecj:JW0204http://www.genome.jp/dbget-bin/www_bget?ecj:JW0204
KEGG_Geneeco:b0214http://www.genome.jp/dbget-bin/www_bget?eco:b0214
KEGG_OrthologyKO:K03469http://www.genome.jp/dbget-bin/www_bget?KO:K03469
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
MINTMINT-1224022http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224022
OMALVTDSQYhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LVTDSQY
PDB1F21http://www.ebi.ac.uk/pdbe-srv/view/entry/1F21
PDB1G15http://www.ebi.ac.uk/pdbe-srv/view/entry/1G15
PDB1GOAhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1GOA
PDB1GOBhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1GOB
PDB1GOChttp://www.ebi.ac.uk/pdbe-srv/view/entry/1GOC
PDB1JL1http://www.ebi.ac.uk/pdbe-srv/view/entry/1JL1
PDB1JL2http://www.ebi.ac.uk/pdbe-srv/view/entry/1JL2
PDB1JXBhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1JXB
PDB1KVAhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1KVA
PDB1KVBhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1KVB
PDB1KVChttp://www.ebi.ac.uk/pdbe-srv/view/entry/1KVC
PDB1LAVhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1LAV
PDB1LAWhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1LAW
PDB1RBRhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1RBR
PDB1RBShttp://www.ebi.ac.uk/pdbe-srv/view/entry/1RBS
PDB1RBThttp://www.ebi.ac.uk/pdbe-srv/view/entry/1RBT
PDB1RBUhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1RBU
PDB1RBVhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1RBV
PDB1RCHhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1RCH
PDB1RDAhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1RDA
PDB1RDBhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1RDB
PDB1RDChttp://www.ebi.ac.uk/pdbe-srv/view/entry/1RDC
PDB1RDDhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1RDD
PDB1RNHhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1RNH
PDB1WSEhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1WSE
PDB1WSFhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1WSF
PDB1WSGhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1WSG
PDB1WSHhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1WSH
PDB1WSIhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1WSI
PDB1WSJhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1WSJ
PDB2RN2http://www.ebi.ac.uk/pdbe-srv/view/entry/2RN2
PDB2YV0http://www.ebi.ac.uk/pdbe-srv/view/entry/2YV0
PDB2Z1Ghttp://www.ebi.ac.uk/pdbe-srv/view/entry/2Z1G
PDB2Z1Hhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2Z1H
PDB2Z1Ihttp://www.ebi.ac.uk/pdbe-srv/view/entry/2Z1I
PDB2Z1Jhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2Z1J
PDB3AA2http://www.ebi.ac.uk/pdbe-srv/view/entry/3AA2
PDB3AA3http://www.ebi.ac.uk/pdbe-srv/view/entry/3AA3
PDB3AA4http://www.ebi.ac.uk/pdbe-srv/view/entry/3AA4
PDB3AA5http://www.ebi.ac.uk/pdbe-srv/view/entry/3AA5
PDB3HYFhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3HYF
PDB3QINhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3QIN
PDB3QIOhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3QIO
PDB4Z0Uhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4Z0U
PDBsum1F21http://www.ebi.ac.uk/pdbsum/1F21
PDBsum1G15http://www.ebi.ac.uk/pdbsum/1G15
PDBsum1GOAhttp://www.ebi.ac.uk/pdbsum/1GOA
PDBsum1GOBhttp://www.ebi.ac.uk/pdbsum/1GOB
PDBsum1GOChttp://www.ebi.ac.uk/pdbsum/1GOC
PDBsum1JL1http://www.ebi.ac.uk/pdbsum/1JL1
PDBsum1JL2http://www.ebi.ac.uk/pdbsum/1JL2
PDBsum1JXBhttp://www.ebi.ac.uk/pdbsum/1JXB
PDBsum1KVAhttp://www.ebi.ac.uk/pdbsum/1KVA
PDBsum1KVBhttp://www.ebi.ac.uk/pdbsum/1KVB
PDBsum1KVChttp://www.ebi.ac.uk/pdbsum/1KVC
PDBsum1LAVhttp://www.ebi.ac.uk/pdbsum/1LAV
PDBsum1LAWhttp://www.ebi.ac.uk/pdbsum/1LAW
PDBsum1RBRhttp://www.ebi.ac.uk/pdbsum/1RBR
PDBsum1RBShttp://www.ebi.ac.uk/pdbsum/1RBS
PDBsum1RBThttp://www.ebi.ac.uk/pdbsum/1RBT
PDBsum1RBUhttp://www.ebi.ac.uk/pdbsum/1RBU
PDBsum1RBVhttp://www.ebi.ac.uk/pdbsum/1RBV
PDBsum1RCHhttp://www.ebi.ac.uk/pdbsum/1RCH
PDBsum1RDAhttp://www.ebi.ac.uk/pdbsum/1RDA
PDBsum1RDBhttp://www.ebi.ac.uk/pdbsum/1RDB
PDBsum1RDChttp://www.ebi.ac.uk/pdbsum/1RDC
PDBsum1RDDhttp://www.ebi.ac.uk/pdbsum/1RDD
PDBsum1RNHhttp://www.ebi.ac.uk/pdbsum/1RNH
PDBsum1WSEhttp://www.ebi.ac.uk/pdbsum/1WSE
PDBsum1WSFhttp://www.ebi.ac.uk/pdbsum/1WSF
PDBsum1WSGhttp://www.ebi.ac.uk/pdbsum/1WSG
PDBsum1WSHhttp://www.ebi.ac.uk/pdbsum/1WSH
PDBsum1WSIhttp://www.ebi.ac.uk/pdbsum/1WSI
PDBsum1WSJhttp://www.ebi.ac.uk/pdbsum/1WSJ
PDBsum2RN2http://www.ebi.ac.uk/pdbsum/2RN2
PDBsum2YV0http://www.ebi.ac.uk/pdbsum/2YV0
PDBsum2Z1Ghttp://www.ebi.ac.uk/pdbsum/2Z1G
PDBsum2Z1Hhttp://www.ebi.ac.uk/pdbsum/2Z1H
PDBsum2Z1Ihttp://www.ebi.ac.uk/pdbsum/2Z1I
PDBsum2Z1Jhttp://www.ebi.ac.uk/pdbsum/2Z1J
PDBsum3AA2http://www.ebi.ac.uk/pdbsum/3AA2
PDBsum3AA3http://www.ebi.ac.uk/pdbsum/3AA3
PDBsum3AA4http://www.ebi.ac.uk/pdbsum/3AA4
PDBsum3AA5http://www.ebi.ac.uk/pdbsum/3AA5
PDBsum3HYFhttp://www.ebi.ac.uk/pdbsum/3HYF
PDBsum3QINhttp://www.ebi.ac.uk/pdbsum/3QIN
PDBsum3QIOhttp://www.ebi.ac.uk/pdbsum/3QIO
PDBsum4Z0Uhttp://www.ebi.ac.uk/pdbsum/4Z0U
PROSITEPS50879http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50879
PSORT-Bswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:RNH_ECOLI
PSORT2swissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:RNH_ECOLI
PSORTswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:RNH_ECOLI
PfamPF00075http://pfam.xfam.org/family/PF00075
Phobiusswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:RNH_ECOLI
PhylomeDBP0A7Y4http://phylomedb.org/?seqid=P0A7Y4
ProteinModelPortalP0A7Y4http://www.proteinmodelportal.org/query/uniprot/P0A7Y4
PubMed11083878http://www.ncbi.nlm.nih.gov/pubmed/11083878
PubMed11106164http://www.ncbi.nlm.nih.gov/pubmed/11106164
PubMed1311386http://www.ncbi.nlm.nih.gov/pubmed/1311386
PubMed15644213http://www.ncbi.nlm.nih.gov/pubmed/15644213
PubMed1646006http://www.ncbi.nlm.nih.gov/pubmed/1646006
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed1689729http://www.ncbi.nlm.nih.gov/pubmed/1689729
PubMed1698262http://www.ncbi.nlm.nih.gov/pubmed/1698262
PubMed2169648http://www.ncbi.nlm.nih.gov/pubmed/2169648
PubMed2171503http://www.ncbi.nlm.nih.gov/pubmed/2171503
PubMed3023634http://www.ncbi.nlm.nih.gov/pubmed/3023634
PubMed6296074http://www.ncbi.nlm.nih.gov/pubmed/6296074
PubMed6302075http://www.ncbi.nlm.nih.gov/pubmed/6302075
PubMed6316347http://www.ncbi.nlm.nih.gov/pubmed/6316347
PubMed8381958http://www.ncbi.nlm.nih.gov/pubmed/8381958
PubMed8408067http://www.ncbi.nlm.nih.gov/pubmed/8408067
PubMed8527428http://www.ncbi.nlm.nih.gov/pubmed/8527428
PubMed8931125http://www.ncbi.nlm.nih.gov/pubmed/8931125
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9852071http://www.ncbi.nlm.nih.gov/pubmed/9852071
RefSeqNP_414750http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414750
RefSeqWP_000917883http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000917883
SMRP0A7Y4http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7Y4
STRING511145.b0214http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0214&targetmode=cogs
STRINGCOG0328http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0328&targetmode=cogs
SUPFAMSSF53098http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098
UniProtKB-ACP0A7Y4http://www.uniprot.org/uniprot/P0A7Y4
UniProtKBRNH_ECOLIhttp://www.uniprot.org/uniprot/RNH_ECOLI
chargeswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:RNH_ECOLI
eggNOGCOG0328http://eggnogapi.embl.de/nog_data/html/tree/COG0328
eggNOGENOG4108UMWhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UMW
epestfindswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:RNH_ECOLI
garnierswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:RNH_ECOLI
helixturnhelixswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:RNH_ECOLI
hmomentswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:RNH_ECOLI
iepswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:RNH_ECOLI
inforesidueswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:RNH_ECOLI
octanolswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:RNH_ECOLI
pepcoilswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:RNH_ECOLI
pepdigestswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:RNH_ECOLI
pepinfoswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:RNH_ECOLI
pepnetswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:RNH_ECOLI
pepstatsswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:RNH_ECOLI
pepwheelswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:RNH_ECOLI
pepwindowswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:RNH_ECOLI
sigcleaveswissprot:RNH_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:RNH_ECOLI
DataBaseIDURL or Descriptions
# BioGrid4262228207
# CATALYTIC ACTIVITYDPO3A_ECOLIDeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
# EcoGeneEG10238dnaE
# FUNCTIONDPO3A_ECOLIDNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.
# GO_componentGO:0005737cytoplasm; IDA:EcoliWiki.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_componentGO:0044776DNA polymerase III, core complex; IDA:EcoCyc.
# GO_functionGO:0003677DNA binding; IEA:InterPro.
# GO_functionGO:0003887DNA-directed DNA polymerase activity; IDA:EcoliWiki.
# GO_processGO:0006260DNA replication; IEA:UniProtKB-KW.
# GOslim_componentGO:0005737cytoplasm
# GOslim_componentGO:0005829cytosol
# GOslim_componentGO:0043234protein complex
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0016779nucleotidyltransferase activity
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0009058biosynthetic process
# INTERACTIONDPO3A_ECOLIP0A988 dnaN; NbExp=17; IntAct=EBI-549111, EBI-542385; P03007 dnaQ; NbExp=20; IntAct=EBI-549111, EBI-549131; P06710 dnaX; NbExp=10; IntAct=EBI-549111, EBI-549140; P28630 holA; NbExp=4; IntAct=EBI-549111, EBI-549153;
# IntActP1044369
# InterProIPR003141Pol/His_phosphatase_N
# InterProIPR004013PHP_dom
# InterProIPR004365NA-bd_OB_tRNA
# InterProIPR004805PolC_alpha
# InterProIPR011708DNA_pol3_alpha
# InterProIPR016195Pol/histidinol_Pase-like
# InterProIPR029460DNAPol_HHH
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko00002 KEGG pathway modules
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03032 M00260 DNA polymerase III complex, bacteria
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Briteko03400 M00260 DNA polymerase III complex, bacteria
# KEGG_Pathwayko00230Purine metabolism
# KEGG_Pathwayko00240Pyrimidine metabolism
# KEGG_Pathwayko03030DNA replication
# KEGG_Pathwayko03430Mismatch repair
# KEGG_Pathwayko03440Homologous recombination
# OrganismDPO3A_ECOLIEscherichia coli (strain K12)
# PATRIC32115479VBIEscCol129921_0191
# PDB2HNHX-ray; 2.30 A; A=1-910
# PDB2HQAX-ray; 2.60 A; A=1-917
# PDB4GX8X-ray; 1.70 A; A/B/C/D=1-270
# PDB4GX9X-ray; 2.15 A; A/B/C/D=1-270
# PDB4JOMX-ray; 2.90 A; A=1-917
# PDB5FKUEM; 8.34 A; A=1-1160
# PDB5FKVEM; 8.00 A; A=1-1160
# PDB5FKWEM; 7.30 A; A=1-1160
# PIRC28390DJEC3A
# PfamPF01336tRNA_anti-codon
# PfamPF02811PHP
# PfamPF07733DNA_pol3_alpha
# PfamPF14579HHH_6
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDPO3A_ECOLIDNA polymerase III subunit alpha
# RefSeqNP_414726NC_000913.3
# RefSeqWP_001294757NZ_LN832404.1
# SIMILARITYBelongs to the DNA polymerase type-C family. DnaE subfamily. {ECO0000305}.
# SMARTSM00481POLIIIAc
# SUBCELLULAR LOCATIONDPO3A_ECOLICytoplasm.
# SUBUNITThe DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4].
# SUPFAMSSF89550SSF89550
# TIGRFAMsTIGR00594polc
# eggNOGCOG0587LUCA
# eggNOGENOG4105C0BBacteria
BLASTswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:DPO3A_ECOLI
BioCycECOL316407:JW0179-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW0179-MONOMER
BioCycEcoCyc:EG10238-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10238-MONOMER
BioCycMetaCyc:EG10238-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG10238-MONOMER
COGCOG0587http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0587
DIPDIP-9458Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9458N
DOI10.1002/bies.950140206http://dx.doi.org/10.1002/bies.950140206
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:2.7.7.7http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLD49445http://www.ebi.ac.uk/ena/data/view/D49445
EMBLM19334http://www.ebi.ac.uk/ena/data/view/M19334
EMBLM96394http://www.ebi.ac.uk/ena/data/view/M96394
EMBLS52931http://www.ebi.ac.uk/ena/data/view/S52931
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU70214http://www.ebi.ac.uk/ena/data/view/U70214
ENZYME2.7.7.7http://enzyme.expasy.org/EC/2.7.7.7
EchoBASEEB0234http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0234
EcoGeneEG10238http://www.ecogene.org/geneInfo.php?eg_id=EG10238
EnsemblBacteriaAAC73295http://www.ensemblgenomes.org/id/AAC73295
EnsemblBacteriaAAC73295http://www.ensemblgenomes.org/id/AAC73295
EnsemblBacteriaBAA77859http://www.ensemblgenomes.org/id/BAA77859
EnsemblBacteriaBAA77859http://www.ensemblgenomes.org/id/BAA77859
EnsemblBacteriaBAA77859http://www.ensemblgenomes.org/id/BAA77859
EnsemblBacteriab0184http://www.ensemblgenomes.org/id/b0184
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_componentGO:0044776http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044776
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887
GO_processGO:0006260http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260
GOslim_componentGO:0005737http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_componentGO:0043234http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0016779http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GeneID944877http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944877
HOGENOMHOG000021784http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000021784&db=HOGENOM6
InParanoidP10443http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10443
IntActP10443http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10443*
IntEnz2.7.7.7http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7
InterProIPR003141http://www.ebi.ac.uk/interpro/entry/IPR003141
InterProIPR004013http://www.ebi.ac.uk/interpro/entry/IPR004013
InterProIPR004365http://www.ebi.ac.uk/interpro/entry/IPR004365
InterProIPR004805http://www.ebi.ac.uk/interpro/entry/IPR004805
InterProIPR011708http://www.ebi.ac.uk/interpro/entry/IPR011708
InterProIPR016195http://www.ebi.ac.uk/interpro/entry/IPR016195
InterProIPR029460http://www.ebi.ac.uk/interpro/entry/IPR029460
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko00002http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW0179http://www.genome.jp/dbget-bin/www_bget?ecj:JW0179
KEGG_Geneeco:b0184http://www.genome.jp/dbget-bin/www_bget?eco:b0184
KEGG_OrthologyKO:K02337http://www.genome.jp/dbget-bin/www_bget?KO:K02337
KEGG_Pathwayko00230http://www.genome.jp/kegg-bin/show_pathway?ko00230
KEGG_Pathwayko00240http://www.genome.jp/kegg-bin/show_pathway?ko00240
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
KEGG_Pathwayko03430http://www.genome.jp/kegg-bin/show_pathway?ko03430
KEGG_Pathwayko03440http://www.genome.jp/kegg-bin/show_pathway?ko03440
KEGG_Reactionrn:R00375http://www.genome.jp/dbget-bin/www_bget?rn:R00375
KEGG_Reactionrn:R00376http://www.genome.jp/dbget-bin/www_bget?rn:R00376
KEGG_Reactionrn:R00377http://www.genome.jp/dbget-bin/www_bget?rn:R00377
KEGG_Reactionrn:R00378http://www.genome.jp/dbget-bin/www_bget?rn:R00378
MINTMINT-1224103http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224103
OMAMKFPGYMhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MKFPGYM
PDB2HNHhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2HNH
PDB2HQAhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2HQA
PDB4GX8http://www.ebi.ac.uk/pdbe-srv/view/entry/4GX8
PDB4GX9http://www.ebi.ac.uk/pdbe-srv/view/entry/4GX9
PDB4JOMhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4JOM
PDB5FKUhttp://www.ebi.ac.uk/pdbe-srv/view/entry/5FKU
PDB5FKVhttp://www.ebi.ac.uk/pdbe-srv/view/entry/5FKV
PDB5FKWhttp://www.ebi.ac.uk/pdbe-srv/view/entry/5FKW
PDBsum2HNHhttp://www.ebi.ac.uk/pdbsum/2HNH
PDBsum2HQAhttp://www.ebi.ac.uk/pdbsum/2HQA
PDBsum4GX8http://www.ebi.ac.uk/pdbsum/4GX8
PDBsum4GX9http://www.ebi.ac.uk/pdbsum/4GX9
PDBsum4JOMhttp://www.ebi.ac.uk/pdbsum/4JOM
PDBsum5FKUhttp://www.ebi.ac.uk/pdbsum/5FKU
PDBsum5FKVhttp://www.ebi.ac.uk/pdbsum/5FKV
PDBsum5FKWhttp://www.ebi.ac.uk/pdbsum/5FKW
PSORT-Bswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:DPO3A_ECOLI
PSORT2swissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:DPO3A_ECOLI
PSORTswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:DPO3A_ECOLI
PfamPF01336http://pfam.xfam.org/family/PF01336
PfamPF02811http://pfam.xfam.org/family/PF02811
PfamPF07733http://pfam.xfam.org/family/PF07733
PfamPF14579http://pfam.xfam.org/family/PF14579
Phobiusswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:DPO3A_ECOLI
PhylomeDBP10443http://phylomedb.org/?seqid=P10443
ProteinModelPortalP10443http://www.proteinmodelportal.org/query/uniprot/P10443
PubMed1575709http://www.ncbi.nlm.nih.gov/pubmed/1575709
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed2066347http://www.ncbi.nlm.nih.gov/pubmed/2066347
PubMed3316192http://www.ncbi.nlm.nih.gov/pubmed/3316192
PubMed7678242http://www.ncbi.nlm.nih.gov/pubmed/7678242
PubMed8375647http://www.ncbi.nlm.nih.gov/pubmed/8375647
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
RefSeqNP_414726http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414726
RefSeqWP_001294757http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001294757
SMARTSM00481http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00481
SMRP10443http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10443
STRING511145.b0184http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0184&targetmode=cogs
STRINGCOG0587http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0587&targetmode=cogs
SUPFAMSSF89550http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89550
TIGRFAMsTIGR00594http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00594
UniProtKB-ACP10443http://www.uniprot.org/uniprot/P10443
UniProtKBDPO3A_ECOLIhttp://www.uniprot.org/uniprot/DPO3A_ECOLI
chargeswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:DPO3A_ECOLI
eggNOGCOG0587http://eggnogapi.embl.de/nog_data/html/tree/COG0587
eggNOGENOG4105C0Bhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0B
epestfindswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:DPO3A_ECOLI
garnierswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:DPO3A_ECOLI
helixturnhelixswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:DPO3A_ECOLI
hmomentswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:DPO3A_ECOLI
iepswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:DPO3A_ECOLI
inforesidueswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:DPO3A_ECOLI
octanolswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:DPO3A_ECOLI
pepcoilswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:DPO3A_ECOLI
pepdigestswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:DPO3A_ECOLI
pepinfoswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:DPO3A_ECOLI
pepnetswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:DPO3A_ECOLI
pepstatsswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:DPO3A_ECOLI
pepwheelswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:DPO3A_ECOLI
pepwindowswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:DPO3A_ECOLI
sigcleaveswissprot:DPO3A_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:DPO3A_ECOLI
DataBaseIDURL or Descriptions
# AltNameTopoisomerase IV subunit B {ECO:0000255|HAMAP-RuleMF_00938}
# BioGrid4262393291
# CATALYTIC ACTIVITYPARE_ECOLIATP-dependent breakage, passage and rejoining of double-stranded DNA. {ECO 0000255|HAMAP-Rule MF_00938, ECO 0000269|PubMed 15105144, ECO 0000269|PubMed 21300644}.
# COFACTORPARE_ECOLIName=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00938, ECO 0000269|PubMed 21300644}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_00938, ECO 0000269|PubMed 21300644}; Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000255|HAMAP-Rule MF_00938, ECO 0000269|PubMed 21300644}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO 0000255|HAMAP-Rule MF_00938, ECO 0000269|PubMed 21300644};
# ENZYME REGULATIONPyrrolopyrimidines inhibit both GyrB and its paralog in topoisomerase IV (parE) (PubMed:23294697). {ECO0000269|PubMed:23294697}.
# EcoGeneEG10687parE
# FUNCTIONPARE_ECOLITopoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes (PubMed 9334322). It relaxes supercoiled DNA (PubMed 15105144, PubMed 21300644, PubMed 23294697, PubMed 23352267). MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation (PubMed 20921377). {ECO 0000269|PubMed 15105144, ECO 0000269|PubMed 20921377, ECO 0000269|PubMed 21300644, ECO 0000269|PubMed 23294697, ECO 0000269|PubMed 23352267, ECO 0000269|PubMed 9334322}.
# GO_componentGO:0005694chromosome; IEA:InterPro.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_componentGO:0009295nucleoid; IBA:GO_Central.
# GO_componentGO:0009330DNA topoisomerase complex (ATP-hydrolyzing); IBA:GO_Central.
# GO_functionGO:0000287magnesium ion binding; IEA:UniProtKB-HAMAP.
# GO_functionGO:0003677DNA binding; IEA:UniProtKB-HAMAP.
# GO_functionGO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activity; IBA:GO_Central.
# GO_functionGO:0005524ATP binding; IEA:UniProtKB-HAMAP.
# GO_processGO:0006265DNA topological change; IBA:GO_Central.
# GO_processGO:0006268DNA unwinding involved in DNA replication; IBA:GO_Central.
# GO_processGO:0007062sister chromatid cohesion; IMP:EcoliWiki.
# GO_processGO:0030541plasmid partitioning; IDA:EcoliWiki.
# GO_processGO:0046677response to antibiotic; IEA:UniProtKB-KW.
# GO_processGO:0051276chromosome organization; IMP:EcoliWiki.
# GOslim_componentGO:0005575cellular_component
# GOslim_componentGO:0005694chromosome
# GOslim_componentGO:0005829cytosol
# GOslim_componentGO:0043234protein complex
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0016853isomerase activity
# GOslim_functionGO:0016887ATPase activity
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0051276chromosome organization
# Gene3D3.30.230.10-; 1.
# Gene3D3.30.565.10-; 1.
# Gene3D3.40.50.670-; 1.
# HAMAPMF_00938ParE_type1
# IntActP2008324
# InterProIPR001241Topo_IIA
# InterProIPR002288DNA_gyrase_B_C
# InterProIPR003594HATPase_C
# InterProIPR005737TopoIV_B_Gneg
# InterProIPR006171Toprim_domain
# InterProIPR013506Topo_IIA_bsu_dom2
# InterProIPR013759Topo_IIA_cen_dom
# InterProIPR013760Topo_IIA-like_dom
# InterProIPR014721Ribosomal_S5_D2-typ_fold_subgr
# InterProIPR018522TopoIIA_CS
# InterProIPR020568Ribosomal_S5_D2-typ_fold
# KEGG_Briteko01000Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03036 Chromosome
# OrganismPARE_ECOLIEscherichia coli (strain K12)
# PATRIC32121470VBIEscCol129921_3122
# PDB1S14X-ray; 2.00 A; A/B=1-217
# PDB1S16X-ray; 2.10 A; A/B=1-390
# PDB3FV5X-ray; 1.80 A; A/B=15-215
# PDB4HZ0X-ray; 2.20 A; A/B=12-216
# PIRD65090D65090
# PRINTSPR00418TPI2FAMILY
# PROSITEPS00177TOPOISOMERASE_II
# PROSITEPS50880TOPRIM
# PfamPF00204DNA_gyraseB
# PfamPF00986DNA_gyraseB_C
# PfamPF01751Toprim
# PfamPF02518HATPase_c
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDNA topoisomerase 4 subunit B {ECO:0000255|HAMAP-RuleMF_00938}
# RefSeqNP_417502NC_000913.3
# RefSeqWP_000195296NZ_LN832404.1
# SEQUENCE CAUTIONSequence=AAA24298.1; Type=Frameshift; Positions=597; Evidence={ECO0000305};
# SIMILARITYBelongs to the type II topoisomerase family. ParE type 1 subfamily. {ECO:0000255|HAMAP-RuleMF_00938}.
# SIMILARITYContains 1 Toprim domain. {ECO:0000255|HAMAP- RuleMF_00938}.
# SMARTSM00387HATPase_c
# SMARTSM00433TOP2c
# SUBUNITPARE_ECOLIHeterotetramer composed of ParC and ParE. {ECO 0000255|HAMAP-Rule MF_00938, ECO 0000269|PubMed 15105144, ECO 0000269|PubMed 21300644}.
# SUPFAMSSF54211SSF54211
# SUPFAMSSF55874SSF55874
# SUPFAMSSF56719SSF56719
# TIGRFAMsTIGR01055parE_Gneg
# eggNOGCOG0187LUCA
# eggNOGENOG4105C7DBacteria
BLASTswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:PARE_ECOLI
BioCycECOL316407:JW2998-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW2998-MONOMER
BioCycEcoCyc:EG10687-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10687-MONOMER
COGCOG0187http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0187
DIPDIP-10441Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10441N
DOI10.1016/0092-8674(90)90172-Bhttp://dx.doi.org/10.1016/0092-8674(90)90172-B
DOI10.1016/j.bmcl.2012.11.032http://dx.doi.org/10.1016/j.bmcl.2012.11.032
DOI10.1016/j.bmcl.2012.11.073http://dx.doi.org/10.1016/j.bmcl.2012.11.073
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1073/pnas.1008678107http://dx.doi.org/10.1073/pnas.1008678107
DOI10.1093/nar/21.8.1805http://dx.doi.org/10.1093/nar/21.8.1805
DOI10.1093/nar/gkr018http://dx.doi.org/10.1093/nar/gkr018
DOI10.1101/gad.11.19.2580http://dx.doi.org/10.1101/gad.11.19.2580
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
DOI10.1128/AAC.48.5.1856-1864.2004http://dx.doi.org/10.1128/AAC.48.5.1856-1864.2004
EC_numberEC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00938}http://www.genome.jp/dbget-bin/www_bget?EC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00938}
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLL22026http://www.ebi.ac.uk/ena/data/view/L22026
EMBLM58409http://www.ebi.ac.uk/ena/data/view/M58409
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU28377http://www.ebi.ac.uk/ena/data/view/U28377
ENZYME5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00938}http://enzyme.expasy.org/EC/5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00938}
EchoBASEEB0681http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0681
EcoGeneEG10687http://www.ecogene.org/geneInfo.php?eg_id=EG10687
EnsemblBacteriaAAC76066http://www.ensemblgenomes.org/id/AAC76066
EnsemblBacteriaAAC76066http://www.ensemblgenomes.org/id/AAC76066
EnsemblBacteriaBAE77086http://www.ensemblgenomes.org/id/BAE77086
EnsemblBacteriaBAE77086http://www.ensemblgenomes.org/id/BAE77086
EnsemblBacteriaBAE77086http://www.ensemblgenomes.org/id/BAE77086
EnsemblBacteriab3030http://www.ensemblgenomes.org/id/b3030
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005694http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_componentGO:0009295http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295
GO_componentGO:0009330http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009330
GO_functionGO:0000287http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003918http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003918
GO_functionGO:0005524http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_processGO:0006265http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006265
GO_processGO:0006268http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006268
GO_processGO:0007062http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007062
GO_processGO:0030541http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030541
GO_processGO:0046677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677
GO_processGO:0051276http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276
GOslim_componentGO:0005575http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_componentGO:0005694http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_componentGO:0043234http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0016853http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853
GOslim_functionGO:0016887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0051276http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276
Gene3D3.30.230.10http://www.cathdb.info/version/latest/superfamily/3.30.230.10
Gene3D3.30.565.10http://www.cathdb.info/version/latest/superfamily/3.30.565.10
Gene3D3.40.50.670http://www.cathdb.info/version/latest/superfamily/3.40.50.670
GeneID947501http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947501
HAMAPMF_00938http://hamap.expasy.org/unirule/MF_00938
HOGENOMHOG000075154http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000075154&db=HOGENOM6
InParanoidP20083http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P20083
IntActP20083http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P20083*
IntEnz5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00938}http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00938}
InterProIPR001241http://www.ebi.ac.uk/interpro/entry/IPR001241
InterProIPR002288http://www.ebi.ac.uk/interpro/entry/IPR002288
InterProIPR003594http://www.ebi.ac.uk/interpro/entry/IPR003594
InterProIPR005737http://www.ebi.ac.uk/interpro/entry/IPR005737
InterProIPR006171http://www.ebi.ac.uk/interpro/entry/IPR006171
InterProIPR013506http://www.ebi.ac.uk/interpro/entry/IPR013506
InterProIPR013759http://www.ebi.ac.uk/interpro/entry/IPR013759
InterProIPR013760http://www.ebi.ac.uk/interpro/entry/IPR013760
InterProIPR014721http://www.ebi.ac.uk/interpro/entry/IPR014721
InterProIPR018522http://www.ebi.ac.uk/interpro/entry/IPR018522
InterProIPR020568http://www.ebi.ac.uk/interpro/entry/IPR020568
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03036http://www.genome.jp/dbget-bin/www_bget?ko03036
KEGG_Geneecj:JW2998http://www.genome.jp/dbget-bin/www_bget?ecj:JW2998
KEGG_Geneeco:b3030http://www.genome.jp/dbget-bin/www_bget?eco:b3030
KEGG_OrthologyKO:K02622http://www.genome.jp/dbget-bin/www_bget?KO:K02622
MINTMINT-1223307http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223307
OMADENERDAhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DENERDA
PDB1S14http://www.ebi.ac.uk/pdbe-srv/view/entry/1S14
PDB1S16http://www.ebi.ac.uk/pdbe-srv/view/entry/1S16
PDB3FV5http://www.ebi.ac.uk/pdbe-srv/view/entry/3FV5
PDB4HZ0http://www.ebi.ac.uk/pdbe-srv/view/entry/4HZ0
PDBsum1S14http://www.ebi.ac.uk/pdbsum/1S14
PDBsum1S16http://www.ebi.ac.uk/pdbsum/1S16
PDBsum3FV5http://www.ebi.ac.uk/pdbsum/3FV5
PDBsum4HZ0http://www.ebi.ac.uk/pdbsum/4HZ0
PRINTSPR00418http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00418
PROSITEPS00177http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00177
PROSITEPS50880http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50880
PSORT-Bswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:PARE_ECOLI
PSORT2swissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:PARE_ECOLI
PSORTswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:PARE_ECOLI
PfamPF00204http://pfam.xfam.org/family/PF00204
PfamPF00986http://pfam.xfam.org/family/PF00986
PfamPF01751http://pfam.xfam.org/family/PF01751
PfamPF02518http://pfam.xfam.org/family/PF02518
Phobiusswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:PARE_ECOLI
PhylomeDBP20083http://phylomedb.org/?seqid=P20083
ProteinModelPortalP20083http://www.proteinmodelportal.org/query/uniprot/P20083
PubMed15105144http://www.ncbi.nlm.nih.gov/pubmed/15105144
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed20921377http://www.ncbi.nlm.nih.gov/pubmed/20921377
PubMed21300644http://www.ncbi.nlm.nih.gov/pubmed/21300644
PubMed2170028http://www.ncbi.nlm.nih.gov/pubmed/2170028
PubMed23294697http://www.ncbi.nlm.nih.gov/pubmed/23294697
PubMed23352267http://www.ncbi.nlm.nih.gov/pubmed/23352267
PubMed8227000http://www.ncbi.nlm.nih.gov/pubmed/8227000
PubMed8388096http://www.ncbi.nlm.nih.gov/pubmed/8388096
PubMed8980775http://www.ncbi.nlm.nih.gov/pubmed/8980775
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9334322http://www.ncbi.nlm.nih.gov/pubmed/9334322
RefSeqNP_417502http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417502
RefSeqWP_000195296http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000195296
SMARTSM00387http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387
SMARTSM00433http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00433
SMRP20083http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P20083
STRING511145.b3030http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3030&targetmode=cogs
STRINGCOG0187http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0187&targetmode=cogs
SUPFAMSSF54211http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211
SUPFAMSSF55874http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874
SUPFAMSSF56719http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56719
TIGRFAMsTIGR01055http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01055
UniProtKB-ACP20083http://www.uniprot.org/uniprot/P20083
UniProtKBPARE_ECOLIhttp://www.uniprot.org/uniprot/PARE_ECOLI
chargeswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:PARE_ECOLI
eggNOGCOG0187http://eggnogapi.embl.de/nog_data/html/tree/COG0187
eggNOGENOG4105C7Dhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7D
epestfindswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:PARE_ECOLI
garnierswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:PARE_ECOLI
helixturnhelixswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:PARE_ECOLI
hmomentswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:PARE_ECOLI
iepswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:PARE_ECOLI
inforesidueswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:PARE_ECOLI
octanolswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:PARE_ECOLI
pepcoilswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:PARE_ECOLI
pepdigestswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:PARE_ECOLI
pepinfoswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:PARE_ECOLI
pepnetswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:PARE_ECOLI
pepstatsswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:PARE_ECOLI
pepwheelswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:PARE_ECOLI
pepwindowswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:PARE_ECOLI
sigcleaveswissprot:PARE_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:PARE_ECOLI
DataBaseIDURL or Descriptions
# ALTERNATIVE PRODUCTSDPO3X_ECOLIEvent=Ribosomal frameshifting; Named isoforms=2; Comment=The production of the two protein products from this region is due to programmed ribosomal frameshifting. Frameshifting is about 40% efficient. {ECO 0000269|PubMed 2181440, ECO 0000269|PubMed 2186364, ECO 0000269|PubMed 2187190}; Name=tau; IsoId=P06710-1; Sequence=Displayed; Note=Produced by full-length translation of the dnaX gene.; Name=gamma; IsoId=P06710-2; Sequence=VSP_042848, VSP_042849; Note=Formed by programmed ribosomal frameshifting to a premature stop codon in the -1 frame at codon 430, the last residue is thus Glu and not Ser.;
# AltNameDPO3X_ECOLIDNA polymerase III subunit gamma
# BioGrid4259846114
# CATALYTIC ACTIVITYDPO3X_ECOLIDeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
# EcoGeneEG10245dnaX
# FUNCTIONDPO3X_ECOLIDNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
# FUNCTIONDPO3X_ECOLIIsoform gamma seems to interact with the delta subunit. to transfer the beta subunit on the DNA.
# FUNCTIONDPO3X_ECOLIIsoform tau serves as a scaffold to help in the dimerization of the core complex.
# GO_componentGO:0043846DNA polymerase III, clamp loader complex; IDA:EcoliWiki.
# GO_functionGO:0003677DNA binding; IEA:InterPro.
# GO_functionGO:0003887DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
# GO_functionGO:0005524ATP binding; IEA:UniProtKB-KW.
# GO_functionGO:0016887ATPase activity; IDA:EcoliWiki.
# GO_functionGO:0017111nucleoside-triphosphatase activity; IDA:EcoliWiki.
# GO_functionGO:0030337DNA polymerase processivity factor activity; IDA:EcoliWiki.
# GO_functionGO:0042802identical protein binding; IPI:IntAct.
# GO_processGO:0006260DNA replication; IMP:EcoliWiki.
# GO_processGO:0006261DNA-dependent DNA replication; IBA:GO_Central.
# GOslim_componentGO:0043234protein complex
# GOslim_functionGO:0003674molecular_function
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0016779nucleotidyltransferase activity
# GOslim_functionGO:0016887ATPase activity
# GOslim_functionGO:0030234enzyme regulator activity
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0009058biosynthetic process
# Gene3D3.40.50.300-; 1.
# INTERACTIONDPO3X_ECOLISelf; NbExp=5; IntAct=EBI-549140, EBI-549140; P11989 bglG; NbExp=3; IntAct=EBI-549140, EBI-545674; P0ACB0 dnaB; NbExp=2; IntAct=EBI-549140, EBI-548978; P10443 dnaE; NbExp=10; IntAct=EBI-549140, EBI-549111; P0A988 dnaN; NbExp=4; IntAct=EBI-549140, EBI-542385; P03007 dnaQ; NbExp=4; IntAct=EBI-549140, EBI-549131; P20605 fic; NbExp=2; IntAct=EBI-549140, EBI-1132602; P28630 holA; NbExp=6; IntAct=EBI-2604194, EBI-549153; P28631 holB; NbExp=17; IntAct=EBI-549140, EBI-549161; P28905 holC; NbExp=13; IntAct=EBI-549140, EBI-549169; P28632 holD; NbExp=18; IntAct=EBI-549140, EBI-549176; P23367 mutL; NbExp=2; IntAct=EBI-2604194, EBI-554913; P0AGE0 ssb; NbExp=2; IntAct=EBI-549140, EBI-1118620;
# IntActP0671033
# InterProIPR001270ClpA/B
# InterProIPR003593AAA+_ATPase
# InterProIPR008921DNA_pol3_clamp-load_cplx_C
# InterProIPR012763DNA_pol_III_sug/sutau
# InterProIPR021029DNA_pol_III_tau_dom-5
# InterProIPR022001DNA_pol3_tau_IV
# InterProIPR022754DNA_pol_III_gamma-3
# InterProIPR027417P-loop_NTPase
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko00002 KEGG pathway modules
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03032 M00260 DNA polymerase III complex, bacteria
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Briteko03400 M00260 DNA polymerase III complex, bacteria
# KEGG_Pathwayko00230Purine metabolism
# KEGG_Pathwayko00240Pyrimidine metabolism
# KEGG_Pathwayko03030DNA replication
# KEGG_Pathwayko03430Mismatch repair
# KEGG_Pathwayko03440Homologous recombination
# OrganismDPO3X_ECOLIEscherichia coli (strain K12)
# PATRIC32116097VBIEscCol129921_0490
# PDB1JR3X-ray; 2.70 A; A/B/C=1-373
# PDB1NJFX-ray; 2.30 A; A/B/C/D=1-243
# PDB1NJGX-ray; 2.20 A; A/B=1-243
# PDB1XXHX-ray; 3.45 A; B/C/D/G/H/I=1-373
# PDB1XXIX-ray; 4.10 A; B/C/D/G/H/I=1-368
# PDB2AYANMR; -; A=499-625
# PDB3GLFX-ray; 3.39 A; B/C/D/G/H/I=1-373
# PDB3GLGX-ray; 3.25 A; B/C/D/G/H/I=1-373
# PDB3GLHX-ray; 3.89 A; B/C/D/G/H/I/L/M/N=1-373
# PDB3GLIX-ray; 3.50 A; B/C/D/G/H/I=1-373
# PDB5FKUEM; 8.34 A; E=500-643
# PDB5FKVEM; 8.00 A; E=500-643
# PIRA25549DJEC3G
# PRINTSPR00300CLPPROTEASEA
# PfamPF12168DNA_pol3_tau_4
# PfamPF12169DNA_pol3_gamma3
# PfamPF12170DNA_pol3_tau_5
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDPO3X_ECOLIDNA polymerase III subunit tau
# RefSeqNP_415003NC_000913.3
# RefSeqWP_000122013NZ_LN832404.1
# SEQUENCE CAUTIONSequence=CAA28175.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO0000305};
# SIMILARITYBelongs to the DnaX/STICHEL family. {ECO0000305}.
# SMARTSM00382AAA
# SUBUNITThe DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha, epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, isoform gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(isoform:gamma/tau)[3]-delta,delta', psi,chi-beta[4].
# SUPFAMSSF48019SSF48019
# SUPFAMSSF52540SSF52540
# TIGRFAMsTIGR02397dnaX_nterm
# eggNOGCOG2812LUCA
# eggNOGENOG4107QMPBacteria
BLASTswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:DPO3X_ECOLI
BioCycECOL316407:JW0459-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW0459-MONOMER
BioCycEcoCyc:EG10245-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10245-MONOMER
BioCycEcoCyc:MONOMER0-2383http://biocyc.org/getid?id=EcoCyc:MONOMER0-2383
BioCycMetaCyc:EG10245-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG10245-MONOMER
BioCycMetaCyc:MONOMER0-2383http://biocyc.org/getid?id=MetaCyc:MONOMER0-2383
COGCOG2812http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2812
DIPDIP-9464Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9464N
DOI10.1002/bies.950140206http://dx.doi.org/10.1002/bies.950140206
DOI10.1002/elps.1150180805http://dx.doi.org/10.1002/elps.1150180805
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1073/pnas.87.10.3713http://dx.doi.org/10.1073/pnas.87.10.3713
DOI10.1073/pnas.87.7.2516http://dx.doi.org/10.1073/pnas.87.7.2516
DOI10.1093/nar/14.16.6541http://dx.doi.org/10.1093/nar/14.16.6541
DOI10.1093/nar/14.20.8091http://dx.doi.org/10.1093/nar/14.20.8091
DOI10.1093/nar/18.7.1725http://dx.doi.org/10.1093/nar/18.7.1725
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:2.7.7.7http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLM38777http://www.ebi.ac.uk/ena/data/view/M38777
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU82664http://www.ebi.ac.uk/ena/data/view/U82664
EMBLX04275http://www.ebi.ac.uk/ena/data/view/X04275
EMBLX04487http://www.ebi.ac.uk/ena/data/view/X04487
EMBLX04487http://www.ebi.ac.uk/ena/data/view/X04487
ENZYME2.7.7.7http://enzyme.expasy.org/EC/2.7.7.7
EchoBASEEB0241http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0241
EcoGeneEG10245http://www.ecogene.org/geneInfo.php?eg_id=EG10245
EnsemblBacteriaAAC73572http://www.ensemblgenomes.org/id/AAC73572
EnsemblBacteriaAAC73572http://www.ensemblgenomes.org/id/AAC73572
EnsemblBacteriaBAE76249http://www.ensemblgenomes.org/id/BAE76249
EnsemblBacteriaBAE76249http://www.ensemblgenomes.org/id/BAE76249
EnsemblBacteriaBAE76249http://www.ensemblgenomes.org/id/BAE76249
EnsemblBacteriab0470http://www.ensemblgenomes.org/id/b0470
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0043846http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043846
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887
GO_functionGO:0005524http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524
GO_functionGO:0016887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GO_functionGO:0017111http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017111
GO_functionGO:0030337http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030337
GO_functionGO:0042802http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802
GO_processGO:0006260http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260
GO_processGO:0006261http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261
GOslim_componentGO:0043234http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_functionGO:0003674http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0016779http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779
GOslim_functionGO:0016887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887
GOslim_functionGO:0030234http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
Gene3D3.40.50.300http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneID945105http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945105
HOGENOMHOG000083934http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000083934&db=HOGENOM6
InParanoidP06710http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06710
IntActP06710http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06710*
IntEnz2.7.7.7http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7
InterProIPR001270http://www.ebi.ac.uk/interpro/entry/IPR001270
InterProIPR003593http://www.ebi.ac.uk/interpro/entry/IPR003593
InterProIPR008921http://www.ebi.ac.uk/interpro/entry/IPR008921
InterProIPR012763http://www.ebi.ac.uk/interpro/entry/IPR012763
InterProIPR021029http://www.ebi.ac.uk/interpro/entry/IPR021029
InterProIPR022001http://www.ebi.ac.uk/interpro/entry/IPR022001
InterProIPR022754http://www.ebi.ac.uk/interpro/entry/IPR022754
InterProIPR027417http://www.ebi.ac.uk/interpro/entry/IPR027417
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko00002http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW0459http://www.genome.jp/dbget-bin/www_bget?ecj:JW0459
KEGG_Geneeco:b0470http://www.genome.jp/dbget-bin/www_bget?eco:b0470
KEGG_OrthologyKO:K02343http://www.genome.jp/dbget-bin/www_bget?KO:K02343
KEGG_Pathwayko00230http://www.genome.jp/kegg-bin/show_pathway?ko00230
KEGG_Pathwayko00240http://www.genome.jp/kegg-bin/show_pathway?ko00240
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
KEGG_Pathwayko03430http://www.genome.jp/kegg-bin/show_pathway?ko03430
KEGG_Pathwayko03440http://www.genome.jp/kegg-bin/show_pathway?ko03440
KEGG_Reactionrn:R00375http://www.genome.jp/dbget-bin/www_bget?rn:R00375
KEGG_Reactionrn:R00376http://www.genome.jp/dbget-bin/www_bget?rn:R00376
KEGG_Reactionrn:R00377http://www.genome.jp/dbget-bin/www_bget?rn:R00377
KEGG_Reactionrn:R00378http://www.genome.jp/dbget-bin/www_bget?rn:R00378
MINTMINT-1222776http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222776
OMATALEHEKhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TALEHEK
PDB1JR3http://www.ebi.ac.uk/pdbe-srv/view/entry/1JR3
PDB1NJFhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1NJF
PDB1NJGhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1NJG
PDB1XXHhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1XXH
PDB1XXIhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1XXI
PDB2AYAhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2AYA
PDB3GLFhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3GLF
PDB3GLGhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3GLG
PDB3GLHhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3GLH
PDB3GLIhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3GLI
PDB5FKUhttp://www.ebi.ac.uk/pdbe-srv/view/entry/5FKU
PDB5FKVhttp://www.ebi.ac.uk/pdbe-srv/view/entry/5FKV
PDBsum1JR3http://www.ebi.ac.uk/pdbsum/1JR3
PDBsum1NJFhttp://www.ebi.ac.uk/pdbsum/1NJF
PDBsum1NJGhttp://www.ebi.ac.uk/pdbsum/1NJG
PDBsum1XXHhttp://www.ebi.ac.uk/pdbsum/1XXH
PDBsum1XXIhttp://www.ebi.ac.uk/pdbsum/1XXI
PDBsum2AYAhttp://www.ebi.ac.uk/pdbsum/2AYA
PDBsum3GLFhttp://www.ebi.ac.uk/pdbsum/3GLF
PDBsum3GLGhttp://www.ebi.ac.uk/pdbsum/3GLG
PDBsum3GLHhttp://www.ebi.ac.uk/pdbsum/3GLH
PDBsum3GLIhttp://www.ebi.ac.uk/pdbsum/3GLI
PDBsum5FKUhttp://www.ebi.ac.uk/pdbsum/5FKU
PDBsum5FKVhttp://www.ebi.ac.uk/pdbsum/5FKV
PRINTSPR00300http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00300
PSORT-Bswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:DPO3X_ECOLI
PSORT2swissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:DPO3X_ECOLI
PSORTswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:DPO3X_ECOLI
PfamPF12168http://pfam.xfam.org/family/PF12168
PfamPF12169http://pfam.xfam.org/family/PF12169
PfamPF12170http://pfam.xfam.org/family/PF12170
Phobiusswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:DPO3X_ECOLI
PhylomeDBP06710http://phylomedb.org/?seqid=P06710
ProteinModelPortalP06710http://www.proteinmodelportal.org/query/uniprot/P06710
PubMed1575709http://www.ncbi.nlm.nih.gov/pubmed/1575709
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed2181440http://www.ncbi.nlm.nih.gov/pubmed/2181440
PubMed2186364http://www.ncbi.nlm.nih.gov/pubmed/2186364
PubMed2187190http://www.ncbi.nlm.nih.gov/pubmed/2187190
PubMed3018672http://www.ncbi.nlm.nih.gov/pubmed/3018672
PubMed3283125http://www.ncbi.nlm.nih.gov/pubmed/3283125
PubMed3534795http://www.ncbi.nlm.nih.gov/pubmed/3534795
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9298644http://www.ncbi.nlm.nih.gov/pubmed/9298644
RefSeqNP_415003http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415003
RefSeqWP_000122013http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000122013
SMARTSM00382http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382
SMRP06710http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06710
STRING511145.b0470http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0470&targetmode=cogs
STRINGCOG2812http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2812&targetmode=cogs
SUPFAMSSF48019http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48019
SUPFAMSSF52540http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540
TIGRFAMsTIGR02397http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02397
UniProtKB-ACP06710http://www.uniprot.org/uniprot/P06710
UniProtKBDPO3X_ECOLIhttp://www.uniprot.org/uniprot/DPO3X_ECOLI
chargeswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:DPO3X_ECOLI
eggNOGCOG2812http://eggnogapi.embl.de/nog_data/html/tree/COG2812
eggNOGENOG4107QMPhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QMP
epestfindswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:DPO3X_ECOLI
garnierswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:DPO3X_ECOLI
helixturnhelixswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:DPO3X_ECOLI
hmomentswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:DPO3X_ECOLI
iepswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:DPO3X_ECOLI
inforesidueswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:DPO3X_ECOLI
octanolswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:DPO3X_ECOLI
pepcoilswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:DPO3X_ECOLI
pepdigestswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:DPO3X_ECOLI
pepinfoswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:DPO3X_ECOLI
pepnetswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:DPO3X_ECOLI
pepstatsswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:DPO3X_ECOLI
pepwheelswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:DPO3X_ECOLI
pepwindowswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:DPO3X_ECOLI
sigcleaveswissprot:DPO3X_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:DPO3X_ECOLI
DataBaseIDURL or Descriptions
# BioGrid4262725156
# CATALYTIC ACTIVITYHOLC_ECOLIDeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
# EcoGeneEG11413holC
# FUNCTIONHOLC_ECOLIDNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
# GO_componentGO:0043847DNA polymerase III, clamp loader chi/psi subcomplex; IPI:EcoliWiki.
# GO_functionGO:0003677DNA binding; IEA:InterPro.
# GO_functionGO:0003887DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
# GO_processGO:0006260DNA replication; IEA:UniProtKB-KW.
# GO_processGO:0032298positive regulation of DNA-dependent DNA replication initiation; IDA:EcoliWiki.
# GOslim_componentGO:0043234protein complex
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0016779nucleotidyltransferase activity
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0008150biological_process
# GOslim_processGO:0009058biosynthetic process
# Gene3D3.40.50.10110-; 1.
# INTERACTIONHOLC_ECOLIP06710 dnaX; NbExp=13; IntAct=EBI-549169, EBI-549140; P28631 holB; NbExp=5; IntAct=EBI-549169, EBI-549161; P28632 holD; NbExp=22; IntAct=EBI-549169, EBI-549176; P0AGE0 ssb; NbExp=9; IntAct=EBI-549169, EBI-1118620;
# IntActP2890541
# InterProIPR007459DNA_pol3_chi
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko00002 KEGG pathway modules
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03032 M00260 DNA polymerase III complex, bacteria
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Briteko03400 M00260 DNA polymerase III complex, bacteria
# KEGG_Pathwayko00230Purine metabolism
# KEGG_Pathwayko00240Pyrimidine metabolism
# KEGG_Pathwayko03030DNA replication
# KEGG_Pathwayko03430Mismatch repair
# KEGG_Pathwayko03440Homologous recombination
# OrganismHOLC_ECOLIEscherichia coli (strain K12)
# PATRIC32124089VBIEscCol129921_4389
# PDB1EM8X-ray; 2.10 A; A/C=1-147
# PDB3SXUX-ray; 1.85 A; A=1-147
# PIRA46739A46739
# PfamPF04364DNA_pol3_chi
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameHOLC_ECOLIDNA polymerase III subunit chi
# RefSeqNP_418680NC_000913.3
# RefSeqWP_000786400NZ_LN832404.1
# SUBUNITThe DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4].
# SUPFAMSSF102400SSF102400
# eggNOGCOG2927LUCA
# eggNOGENOG4105MYGBacteria
BLASTswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:HOLC_ECOLI
BioCycECOL316407:JW4216-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW4216-MONOMER
BioCycEcoCyc:EG11413-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG11413-MONOMER
BioCycMetaCyc:EG11413-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG11413-MONOMER
COGCOG2927http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2927
DIPDIP-9933Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9933N
DOI10.1002/bies.950140206http://dx.doi.org/10.1002/bies.950140206
DOI10.1007/BF00284693http://dx.doi.org/10.1007/BF00284693
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1093/nar/23.12.2105http://dx.doi.org/10.1093/nar/23.12.2105
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:2.7.7.7http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLL04574http://www.ebi.ac.uk/ena/data/view/L04574
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU14003http://www.ebi.ac.uk/ena/data/view/U14003
EMBLX15130http://www.ebi.ac.uk/ena/data/view/X15130
EMBLZ14155http://www.ebi.ac.uk/ena/data/view/Z14155
ENZYME2.7.7.7http://enzyme.expasy.org/EC/2.7.7.7
EchoBASEEB1385http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1385
EcoGeneEG11413http://www.ecogene.org/geneInfo.php?eg_id=EG11413
EnsemblBacteriaAAC77216http://www.ensemblgenomes.org/id/AAC77216
EnsemblBacteriaAAC77216http://www.ensemblgenomes.org/id/AAC77216
EnsemblBacteriaBAE78256http://www.ensemblgenomes.org/id/BAE78256
EnsemblBacteriaBAE78256http://www.ensemblgenomes.org/id/BAE78256
EnsemblBacteriaBAE78256http://www.ensemblgenomes.org/id/BAE78256
EnsemblBacteriab4259http://www.ensemblgenomes.org/id/b4259
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0043847http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043847
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887
GO_processGO:0006260http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260
GO_processGO:0032298http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032298
GOslim_componentGO:0043234http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0016779http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0008150http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
Gene3D3.40.50.10110http://www.cathdb.info/version/latest/superfamily/3.40.50.10110
GeneID948787http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948787
HOGENOMHOG000263567http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263567&db=HOGENOM6
InParanoidP28905http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28905
IntActP28905http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28905*
IntEnz2.7.7.7http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7
InterProIPR007459http://www.ebi.ac.uk/interpro/entry/IPR007459
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko00002http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW4216http://www.genome.jp/dbget-bin/www_bget?ecj:JW4216
KEGG_Geneeco:b4259http://www.genome.jp/dbget-bin/www_bget?eco:b4259
KEGG_OrthologyKO:K02339http://www.genome.jp/dbget-bin/www_bget?KO:K02339
KEGG_Pathwayko00230http://www.genome.jp/kegg-bin/show_pathway?ko00230
KEGG_Pathwayko00240http://www.genome.jp/kegg-bin/show_pathway?ko00240
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
KEGG_Pathwayko03430http://www.genome.jp/kegg-bin/show_pathway?ko03430
KEGG_Pathwayko03440http://www.genome.jp/kegg-bin/show_pathway?ko03440
KEGG_Reactionrn:R00375http://www.genome.jp/dbget-bin/www_bget?rn:R00375
KEGG_Reactionrn:R00376http://www.genome.jp/dbget-bin/www_bget?rn:R00376
KEGG_Reactionrn:R00377http://www.genome.jp/dbget-bin/www_bget?rn:R00377
KEGG_Reactionrn:R00378http://www.genome.jp/dbget-bin/www_bget?rn:R00378
MINTMINT-1224072http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224072
OMAWQFEPSAhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQFEPSA
PDB1EM8http://www.ebi.ac.uk/pdbe-srv/view/entry/1EM8
PDB3SXUhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3SXU
PDBsum1EM8http://www.ebi.ac.uk/pdbsum/1EM8
PDBsum3SXUhttp://www.ebi.ac.uk/pdbsum/3SXU
PSORT-Bswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:HOLC_ECOLI
PSORT2swissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:HOLC_ECOLI
PSORTswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:HOLC_ECOLI
PfamPF04364http://pfam.xfam.org/family/PF04364
Phobiusswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:HOLC_ECOLI
ProteinModelPortalP28905http://www.proteinmodelportal.org/query/uniprot/P28905
PubMed1575709http://www.ncbi.nlm.nih.gov/pubmed/1575709
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed2670557http://www.ncbi.nlm.nih.gov/pubmed/2670557
PubMed7610040http://www.ncbi.nlm.nih.gov/pubmed/7610040
PubMed8246893http://www.ncbi.nlm.nih.gov/pubmed/8246893
PubMed8389364http://www.ncbi.nlm.nih.gov/pubmed/8389364
PubMed8505305http://www.ncbi.nlm.nih.gov/pubmed/8505305
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
RefSeqNP_418680http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418680
RefSeqWP_000786400http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000786400
SMRP28905http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28905
STRING511145.b4259http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4259&targetmode=cogs
STRINGCOG2927http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2927&targetmode=cogs
SUPFAMSSF102400http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF102400
UniProtKB-ACP28905http://www.uniprot.org/uniprot/P28905
UniProtKBHOLC_ECOLIhttp://www.uniprot.org/uniprot/HOLC_ECOLI
chargeswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:HOLC_ECOLI
eggNOGCOG2927http://eggnogapi.embl.de/nog_data/html/tree/COG2927
eggNOGENOG4105MYGhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MYG
epestfindswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:HOLC_ECOLI
garnierswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:HOLC_ECOLI
helixturnhelixswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:HOLC_ECOLI
hmomentswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:HOLC_ECOLI
iepswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:HOLC_ECOLI
inforesidueswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:HOLC_ECOLI
octanolswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:HOLC_ECOLI
pepcoilswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:HOLC_ECOLI
pepdigestswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:HOLC_ECOLI
pepinfoswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:HOLC_ECOLI
pepnetswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:HOLC_ECOLI
pepstatsswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:HOLC_ECOLI
pepwheelswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:HOLC_ECOLI
pepwindowswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:HOLC_ECOLI
sigcleaveswissprot:HOLC_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:HOLC_ECOLI
DataBaseIDURL or Descriptions
# AltNameDNA topoisomerase I {ECO:0000255|HAMAP-RuleMF_00952}
# AltNameTOP1_ECOLIOmega-protein
# AltNameTOP1_ECOLIRelaxing enzyme
# AltNameTOP1_ECOLISwivelase
# AltNameTOP1_ECOLIUntwisting enzyme
# BRENDA5.99.12026
# BioGrid4259579139
# CATALYTIC ACTIVITYTOP1_ECOLIATP-independent breakage of single-stranded DNA, followed by passage and rejoining. {ECO 0000255|HAMAP- Rule MF_00952, ECO 0000269|PubMed 10681504, ECO 0000269|PubMed 14604525, ECO 0000269|PubMed 21482796, ECO 0000269|PubMed 9497321}.
# CDDcd00186TOP1Ac
# COFACTORTOP1_ECOLIName=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 10681504, ECO 0000269|PubMed 21482796}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 10681504, ECO 0000269|PubMed 21482796}; Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000269|PubMed 10681504, ECO 0000269|PubMed 21482796}; Note=Binds two Mg(2+) ions per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO 0000269|PubMed 10681504, ECO 0000269|PubMed 21482796};
# EcoGeneEG11013topA
# FUNCTIONTOP1_ECOLIReleases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. {ECO 0000255|HAMAP- Rule MF_00952, ECO 0000269|PubMed 10681504, ECO 0000269|PubMed 21482796, ECO 0000269|PubMed 9497321}.
# GO_componentGO:0005694chromosome; IEA:InterPro.
# GO_componentGO:0005829cytosol; IDA:EcoCyc.
# GO_functionGO:0000287magnesium ion binding; IEA:UniProtKB-HAMAP.
# GO_functionGO:0003677DNA binding; IEA:UniProtKB-KW.
# GO_functionGO:0003916DNA topoisomerase activity; IMP:EcoCyc.
# GO_functionGO:0003917DNA topoisomerase type I activity; IMP:EcoCyc.
# GO_processGO:0006265DNA topological change; IGI:EcoliWiki.
# GOslim_componentGO:0005694chromosome
# GOslim_componentGO:0005829cytosol
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0016853isomerase activity
# GOslim_functionGO:0043167ion binding
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0051276chromosome organization
# Gene3D1.10.460.10-; 3.
# Gene3D2.70.20.10-; 2.
# Gene3D3.40.50.140-; 1.
# HAMAPMF_00952Topoisom_1_prok
# IntActP0661268
# InterProIPR000380Topo_IA
# InterProIPR003601Topo_IA_2
# InterProIPR003602Topo_IA_DNA-bd_dom
# InterProIPR005733TopoI_bac-type
# InterProIPR006171Toprim_domain
# InterProIPR013263TopoI_Znr_bac
# InterProIPR013497Topo_IA_cen
# InterProIPR013498Topo_IA_Znf
# InterProIPR013824Topo_IA_cen_sub1
# InterProIPR013825Topo_IA_cen_sub2
# InterProIPR023405Topo_IA_core_domain
# InterProIPR023406Topo_IA_AS
# InterProIPR028612Topoisom_1_IA
# KEGG_Briteko01000Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03400 DNA repair and recombination proteins
# OrganismTOP1_ECOLIEscherichia coli (strain K12)
# PANTHERPTHR11390PTHR11390; 2
# PATRIC32117806VBIEscCol129921_1323
# PDB1CY0X-ray; 2.45 A; A=1-597
# PDB1CY1X-ray; 2.30 A; A=1-597
# PDB1CY2X-ray; 2.30 A; A=1-597
# PDB1CY4X-ray; 2.55 A; A=1-597
# PDB1CY6X-ray; 2.50 A; A=1-597
# PDB1CY7X-ray; 2.40 A; A=1-597
# PDB1CY8X-ray; 2.45 A; A=1-597
# PDB1CY9X-ray; 1.80 A; A/B=214-477
# PDB1CYYX-ray; 2.15 A; A/B=214-477
# PDB1ECLX-ray; 1.90 A; A=1-597
# PDB1MW8X-ray; 1.90 A; X=1-592
# PDB1MW9X-ray; 1.67 A; X=1-592
# PDB1YUANMR; -; A=745-865
# PDB3PWTX-ray; 1.90 A; A=1-596
# PDB3PX7X-ray; 2.30 A; A=1-595
# PDB4RULX-ray; 2.90 A; A=2-865
# PIRE64875ISECTP
# PRINTSPR00417PRTPISMRASEI
# PROSITEPS00396TOPOISOMERASE_I_PROK
# PROSITEPS50880TOPRIM
# PfamPF01131Topoisom_bac
# PfamPF01396zf-C4_Topoisom; 2
# PfamPF01751Toprim
# PfamPF08272Topo_Zn_Ribbon; 2
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameDNA topoisomerase 1 {ECO:0000255|HAMAP-RuleMF_00952}
# RefSeqNP_415790NC_000913.3
# RefSeqWP_001297122NZ_CP014272.1
# SIMILARITYBelongs to the type IA topoisomerase family. {ECO:0000255|HAMAP-RuleMF_00952}.
# SIMILARITYContains 1 Toprim domain. {ECO:0000255|HAMAP- RuleMF_00952}.
# SMARTSM00436TOP1Bc
# SMARTSM00437TOP1Ac
# SMARTSM00493TOPRIM
# SUBUNITTOP1_ECOLIMonomer. {ECO 0000255|HAMAP-Rule MF_00952, ECO 0000269|PubMed 14604525, ECO 0000269|PubMed 21482796}.
# SUPFAMSSF56712SSF56712
# TIGRFAMsTIGR01051topA_bact
# eggNOGCOG0550LUCA
# eggNOGCOG0551LUCA
# eggNOGENOG4105C73Bacteria
BLASTswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:TOP1_ECOLI
BioCycECOL316407:JW1266-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW1266-MONOMER
BioCycEcoCyc:EG11013-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG11013-MONOMER
BioCycMetaCyc:EG11013-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG11013-MONOMER
COGCOG0550http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0550
COGCOG0551http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0551
COGCOG1754http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1754
DIPDIP-11011Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11011N
DOI10.1002/elps.1150180805http://dx.doi.org/10.1002/elps.1150180805
DOI10.1016/0022-2836(86)90129-4http://dx.doi.org/10.1016/0022-2836(86)90129-4
DOI10.1016/j.str.2003.09.013http://dx.doi.org/10.1016/j.str.2003.09.013
DOI10.1021/bi00023a008http://dx.doi.org/10.1021/bi00023a008
DOI10.1038/13283http://dx.doi.org/10.1038/13283
DOI10.1038/13333http://dx.doi.org/10.1038/13333
DOI10.1038/367138a0http://dx.doi.org/10.1038/367138a0
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1073/pnas.1100300108http://dx.doi.org/10.1073/pnas.1100300108
DOI10.1074/jbc.273.11.6050http://dx.doi.org/10.1074/jbc.273.11.6050
DOI10.1074/jbc.275.8.5318http://dx.doi.org/10.1074/jbc.275.8.5318
DOI10.1093/dnares/3.6.363http://dx.doi.org/10.1093/dnares/3.6.363
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00952}http://www.genome.jp/dbget-bin/www_bget?EC:5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00952}
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLM15041http://www.ebi.ac.uk/ena/data/view/M15041
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLX04475http://www.ebi.ac.uk/ena/data/view/X04475
ENZYME5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00952}http://enzyme.expasy.org/EC/5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00952}
EchoBASEEB1006http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1006
EcoGeneEG11013http://www.ecogene.org/geneInfo.php?eg_id=EG11013
EnsemblBacteriaAAC74356http://www.ensemblgenomes.org/id/AAC74356
EnsemblBacteriaAAC74356http://www.ensemblgenomes.org/id/AAC74356
EnsemblBacteriaBAA14811http://www.ensemblgenomes.org/id/BAA14811
EnsemblBacteriaBAA14811http://www.ensemblgenomes.org/id/BAA14811
EnsemblBacteriaBAA14811http://www.ensemblgenomes.org/id/BAA14811
EnsemblBacteriab1274http://www.ensemblgenomes.org/id/b1274
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005694http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_functionGO:0000287http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003916http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003916
GO_functionGO:0003917http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003917
GO_processGO:0006265http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006265
GOslim_componentGO:0005694http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0016853http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853
GOslim_functionGO:0043167http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0051276http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276
Gene3D1.10.460.10http://www.cathdb.info/version/latest/superfamily/1.10.460.10
Gene3D2.70.20.10http://www.cathdb.info/version/latest/superfamily/2.70.20.10
Gene3D3.40.50.140http://www.cathdb.info/version/latest/superfamily/3.40.50.140
GeneID945862http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945862
HAMAPMF_00952http://hamap.expasy.org/unirule/MF_00952
HOGENOMHOG000004018http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004018&db=HOGENOM6
InParanoidP06612http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06612
IntActP06612http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06612*
IntEnz5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00952}http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00952}
InterProIPR000380http://www.ebi.ac.uk/interpro/entry/IPR000380
InterProIPR003601http://www.ebi.ac.uk/interpro/entry/IPR003601
InterProIPR003602http://www.ebi.ac.uk/interpro/entry/IPR003602
InterProIPR005733http://www.ebi.ac.uk/interpro/entry/IPR005733
InterProIPR006171http://www.ebi.ac.uk/interpro/entry/IPR006171
InterProIPR013263http://www.ebi.ac.uk/interpro/entry/IPR013263
InterProIPR013497http://www.ebi.ac.uk/interpro/entry/IPR013497
InterProIPR013498http://www.ebi.ac.uk/interpro/entry/IPR013498
InterProIPR013824http://www.ebi.ac.uk/interpro/entry/IPR013824
InterProIPR013825http://www.ebi.ac.uk/interpro/entry/IPR013825
InterProIPR023405http://www.ebi.ac.uk/interpro/entry/IPR023405
InterProIPR023406http://www.ebi.ac.uk/interpro/entry/IPR023406
InterProIPR028612http://www.ebi.ac.uk/interpro/entry/IPR028612
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW1266http://www.genome.jp/dbget-bin/www_bget?ecj:JW1266
KEGG_Geneeco:b1274http://www.genome.jp/dbget-bin/www_bget?eco:b1274
KEGG_OrthologyKO:K03168http://www.genome.jp/dbget-bin/www_bget?KO:K03168
MINTMINT-1218330http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218330
OMAVVECDKChttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VVECDKC
PANTHERPTHR11390http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11390
PDB1CY0http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY0
PDB1CY1http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY1
PDB1CY2http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY2
PDB1CY4http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY4
PDB1CY6http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY6
PDB1CY7http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY7
PDB1CY8http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY8
PDB1CY9http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY9
PDB1CYYhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1CYY
PDB1ECLhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1ECL
PDB1MW8http://www.ebi.ac.uk/pdbe-srv/view/entry/1MW8
PDB1MW9http://www.ebi.ac.uk/pdbe-srv/view/entry/1MW9
PDB1YUAhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1YUA
PDB3PWThttp://www.ebi.ac.uk/pdbe-srv/view/entry/3PWT
PDB3PX7http://www.ebi.ac.uk/pdbe-srv/view/entry/3PX7
PDB4RULhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4RUL
PDBsum1CY0http://www.ebi.ac.uk/pdbsum/1CY0
PDBsum1CY1http://www.ebi.ac.uk/pdbsum/1CY1
PDBsum1CY2http://www.ebi.ac.uk/pdbsum/1CY2
PDBsum1CY4http://www.ebi.ac.uk/pdbsum/1CY4
PDBsum1CY6http://www.ebi.ac.uk/pdbsum/1CY6
PDBsum1CY7http://www.ebi.ac.uk/pdbsum/1CY7
PDBsum1CY8http://www.ebi.ac.uk/pdbsum/1CY8
PDBsum1CY9http://www.ebi.ac.uk/pdbsum/1CY9
PDBsum1CYYhttp://www.ebi.ac.uk/pdbsum/1CYY
PDBsum1ECLhttp://www.ebi.ac.uk/pdbsum/1ECL
PDBsum1MW8http://www.ebi.ac.uk/pdbsum/1MW8
PDBsum1MW9http://www.ebi.ac.uk/pdbsum/1MW9
PDBsum1YUAhttp://www.ebi.ac.uk/pdbsum/1YUA
PDBsum3PWThttp://www.ebi.ac.uk/pdbsum/3PWT
PDBsum3PX7http://www.ebi.ac.uk/pdbsum/3PX7
PDBsum4RULhttp://www.ebi.ac.uk/pdbsum/4RUL
PRINTSPR00417http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00417
PROSITEPS00396http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00396
PROSITEPS50880http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50880
PSORT-Bswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:TOP1_ECOLI
PSORT2swissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:TOP1_ECOLI
PSORTswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:TOP1_ECOLI
PfamPF01131http://pfam.xfam.org/family/PF01131
PfamPF01396http://pfam.xfam.org/family/PF01396
PfamPF01751http://pfam.xfam.org/family/PF01751
PfamPF08272http://pfam.xfam.org/family/PF08272
Phobiusswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:TOP1_ECOLI
PhylomeDBP06612http://phylomedb.org/?seqid=P06612
ProteinModelPortalP06612http://www.proteinmodelportal.org/query/uniprot/P06612
PubMed10504724http://www.ncbi.nlm.nih.gov/pubmed/10504724
PubMed10504732http://www.ncbi.nlm.nih.gov/pubmed/10504732
PubMed10681504http://www.ncbi.nlm.nih.gov/pubmed/10681504
PubMed14604525http://www.ncbi.nlm.nih.gov/pubmed/14604525
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed21482796http://www.ncbi.nlm.nih.gov/pubmed/21482796
PubMed3029379http://www.ncbi.nlm.nih.gov/pubmed/3029379
PubMed3032952http://www.ncbi.nlm.nih.gov/pubmed/3032952
PubMed7779808http://www.ncbi.nlm.nih.gov/pubmed/7779808
PubMed8114910http://www.ncbi.nlm.nih.gov/pubmed/8114910
PubMed9097039http://www.ncbi.nlm.nih.gov/pubmed/9097039
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9298644http://www.ncbi.nlm.nih.gov/pubmed/9298644
PubMed9497321http://www.ncbi.nlm.nih.gov/pubmed/9497321
RefSeqNP_415790http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415790
RefSeqWP_001297122http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297122
SMARTSM00436http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00436
SMARTSM00437http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00437
SMARTSM00493http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00493
SMRP06612http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06612
STRING511145.b1274http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1274&targetmode=cogs
STRINGCOG0550http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0550&targetmode=cogs
STRINGCOG0551http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0551&targetmode=cogs
STRINGCOG1754http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1754&targetmode=cogs
SUPFAMSSF56712http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56712
TIGRFAMsTIGR01051http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01051
UniProtKB-ACP06612http://www.uniprot.org/uniprot/P06612
UniProtKBTOP1_ECOLIhttp://www.uniprot.org/uniprot/TOP1_ECOLI
chargeswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:TOP1_ECOLI
eggNOGCOG0550http://eggnogapi.embl.de/nog_data/html/tree/COG0550
eggNOGCOG0551http://eggnogapi.embl.de/nog_data/html/tree/COG0551
eggNOGENOG4105C73http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C73
epestfindswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:TOP1_ECOLI
garnierswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:TOP1_ECOLI
helixturnhelixswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:TOP1_ECOLI
hmomentswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:TOP1_ECOLI
iepswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:TOP1_ECOLI
inforesidueswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:TOP1_ECOLI
octanolswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:TOP1_ECOLI
pepcoilswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:TOP1_ECOLI
pepdigestswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:TOP1_ECOLI
pepinfoswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:TOP1_ECOLI
pepnetswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:TOP1_ECOLI
pepstatsswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:TOP1_ECOLI
pepwheelswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:TOP1_ECOLI
pepwindowswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:TOP1_ECOLI
sigcleaveswissprot:TOP1_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:TOP1_ECOLI
DataBaseIDURL or Descriptions
# AltNameDMA_ECOLIDNA adenine methyltransferase
# AltNameDMA_ECOLIDeoxyadenosyl-methyltransferase
# AltNameDMA_ECOLIM.EcoDam
# BRENDA2.1.1.722026
# BioGrid4261860125
# CATALYTIC ACTIVITYDMA_ECOLIS-adenosyl-L-methionine + adenine in DNA = S- adenosyl-L-homocysteine + N-6-methyladenine in DNA.
# EcoGeneEG10204dam
# FUNCTIONDMA_ECOLIMethylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication.
# GO_functionGO:0009007site-specific DNA-methyltransferase (adenine-specific) activity; IDA:EcoCyc.
# GO_functionGO:0043565sequence-specific DNA binding; IDA:EcoCyc.
# GO_functionGO:1904047S-adenosyl-L-methionine binding; IDA:EcoCyc.
# GO_processGO:0006261DNA-dependent DNA replication; IMP:EcoliWiki.
# GO_processGO:0006298mismatch repair; IDA:EcoliWiki.
# GO_processGO:0032775DNA methylation on adenine; IMP:EcoCyc.
# GO_processGO:1902328bacterial-type DNA replication initiation; IMP:EcoCyc.
# GOslim_functionGO:0003674molecular_function
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0008168methyltransferase activity
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0006950response to stress
# GOslim_processGO:0009058biosynthetic process
# Gene3D1.10.1020.10-; 1.
# Gene3D3.40.50.150-; 2.
# IntActP0AEE824
# InterProIPR002052DNA_methylase_N6_adenine_CS
# InterProIPR012263M_m6A_EcoRV
# InterProIPR012327MeTrfase_D12
# InterProIPR023095Ade_MeTrfase_dom_2
# InterProIPR029063SAM-dependent_MTases
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Pathwayko03430Mismatch repair
# OrganismDMA_ECOLIEscherichia coli (strain K12)
# PATRIC32122206VBIEscCol129921_3480
# PDB2G1PX-ray; 1.89 A; A/B=1-278
# PDB2OREX-ray; 2.99 A; D/E/F=1-278
# PDB4GBEX-ray; 2.66 A; D/E/F=1-278
# PDB4GOLX-ray; 2.57 A; D/E/F=1-278
# PDB4GOMX-ray; 2.45 A; D/E/F=1-278
# PDB4GONX-ray; 2.72 A; D/E/F=1-278
# PDB4GOOX-ray; 2.70 A; D/E/F=1-278
# PDB4RTJX-ray; 1.99 A; A=1-278
# PDB4RTKX-ray; 1.96 A; A=1-278
# PDB4RTLX-ray; 2.19 A; A=1-278
# PDB4RTMX-ray; 2.50 A; A=1-278
# PDB4RTNX-ray; 2.59 A; A=1-278
# PDB4RTOX-ray; 2.69 A; A=1-278
# PDB4RTPX-ray; 2.39 A; A=1-278
# PDB4RTQX-ray; 2.00 A; A=1-278
# PDB4RTRX-ray; 2.39 A; A=1-278
# PDB4RTSX-ray; 2.49 A; A=1-278
# PIRA00555XYECDA
# PIRSFPIRSF000398M_m6A_EcoRV
# PRINTSPR00505D12N6MTFRASE
# PROSITEPS00092N6_MTASE
# PfamPF02086MethyltransfD12
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# REBASE2396M.EcoKDam
# RecNameDMA_ECOLIDNA adenine methylase
# RefSeqNP_417846NC_000913.3
# RefSeqWP_000742143NZ_LN832404.1
# SIMILARITYBelongs to the N(4)/N(6)-methyltransferase family. {ECO0000305}.
# SUPFAMSSF53335SSF53335
# TIGRFAMsTIGR00571dam
# eggNOGCOG0338LUCA
# eggNOGENOG4105DFEBacteria
BLASTswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:DMA_ECOLI
BioCycECOL316407:JW3350-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW3350-MONOMER
BioCycEcoCyc:EG10204-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG10204-MONOMER
BioCycMetaCyc:EG10204-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG10204-MONOMER
COGCOG0338http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0338
DIPDIP-47948Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47948N
DOI10.1007/BF00290345http://dx.doi.org/10.1007/BF00290345
DOI10.1007/BF00330946http://dx.doi.org/10.1007/BF00330946
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1093/nar/11.3.837http://dx.doi.org/10.1093/nar/11.3.837
DOI10.1093/nar/21.14.3183http://dx.doi.org/10.1093/nar/21.14.3183
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:2.1.1.72http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.72
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLJ01600http://www.ebi.ac.uk/ena/data/view/J01600
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU18997http://www.ebi.ac.uk/ena/data/view/U18997
EMBLV00272http://www.ebi.ac.uk/ena/data/view/V00272
EMBLX15162http://www.ebi.ac.uk/ena/data/view/X15162
EMBLZ19601http://www.ebi.ac.uk/ena/data/view/Z19601
ENZYME2.1.1.72http://enzyme.expasy.org/EC/2.1.1.72
EchoBASEEB0200http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0200
EcoGeneEG10204http://www.ecogene.org/geneInfo.php?eg_id=EG10204
EnsemblBacteriaAAC76412http://www.ensemblgenomes.org/id/AAC76412
EnsemblBacteriaAAC76412http://www.ensemblgenomes.org/id/AAC76412
EnsemblBacteriaBAE77904http://www.ensemblgenomes.org/id/BAE77904
EnsemblBacteriaBAE77904http://www.ensemblgenomes.org/id/BAE77904
EnsemblBacteriaBAE77904http://www.ensemblgenomes.org/id/BAE77904
EnsemblBacteriab3387http://www.ensemblgenomes.org/id/b3387
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_functionGO:0009007http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009007
GO_functionGO:0043565http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565
GO_functionGO:1904047http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904047
GO_processGO:0006261http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261
GO_processGO:0006298http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006298
GO_processGO:0032775http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032775
GO_processGO:1902328http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902328
GOslim_functionGO:0003674http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0008168http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0006950http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
Gene3D1.10.1020.10http://www.cathdb.info/version/latest/superfamily/1.10.1020.10
Gene3D3.40.50.150http://www.cathdb.info/version/latest/superfamily/3.40.50.150
GeneID947893http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947893
HOGENOMHOG000281348http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281348&db=HOGENOM6
InParanoidP0AEE8http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEE8
IntActP0AEE8http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEE8*
IntEnz2.1.1.72http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.72
InterProIPR002052http://www.ebi.ac.uk/interpro/entry/IPR002052
InterProIPR012263http://www.ebi.ac.uk/interpro/entry/IPR012263
InterProIPR012327http://www.ebi.ac.uk/interpro/entry/IPR012327
InterProIPR023095http://www.ebi.ac.uk/interpro/entry/IPR023095
InterProIPR029063http://www.ebi.ac.uk/interpro/entry/IPR029063
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW3350http://www.genome.jp/dbget-bin/www_bget?ecj:JW3350
KEGG_Geneeco:b3387http://www.genome.jp/dbget-bin/www_bget?eco:b3387
KEGG_OrthologyKO:K06223http://www.genome.jp/dbget-bin/www_bget?KO:K06223
KEGG_Pathwayko03430http://www.genome.jp/kegg-bin/show_pathway?ko03430
MINTMINT-1230150http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1230150
OMAMNRHGFNhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNRHGFN
PDB2G1Phttp://www.ebi.ac.uk/pdbe-srv/view/entry/2G1P
PDB2OREhttp://www.ebi.ac.uk/pdbe-srv/view/entry/2ORE
PDB4GBEhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4GBE
PDB4GOLhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4GOL
PDB4GOMhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4GOM
PDB4GONhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4GON
PDB4GOOhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4GOO
PDB4RTJhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4RTJ
PDB4RTKhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4RTK
PDB4RTLhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4RTL
PDB4RTMhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4RTM
PDB4RTNhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4RTN
PDB4RTOhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4RTO
PDB4RTPhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4RTP
PDB4RTQhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4RTQ
PDB4RTRhttp://www.ebi.ac.uk/pdbe-srv/view/entry/4RTR
PDB4RTShttp://www.ebi.ac.uk/pdbe-srv/view/entry/4RTS
PDBsum2G1Phttp://www.ebi.ac.uk/pdbsum/2G1P
PDBsum2OREhttp://www.ebi.ac.uk/pdbsum/2ORE
PDBsum4GBEhttp://www.ebi.ac.uk/pdbsum/4GBE
PDBsum4GOLhttp://www.ebi.ac.uk/pdbsum/4GOL
PDBsum4GOMhttp://www.ebi.ac.uk/pdbsum/4GOM
PDBsum4GONhttp://www.ebi.ac.uk/pdbsum/4GON
PDBsum4GOOhttp://www.ebi.ac.uk/pdbsum/4GOO
PDBsum4RTJhttp://www.ebi.ac.uk/pdbsum/4RTJ
PDBsum4RTKhttp://www.ebi.ac.uk/pdbsum/4RTK
PDBsum4RTLhttp://www.ebi.ac.uk/pdbsum/4RTL
PDBsum4RTMhttp://www.ebi.ac.uk/pdbsum/4RTM
PDBsum4RTNhttp://www.ebi.ac.uk/pdbsum/4RTN
PDBsum4RTOhttp://www.ebi.ac.uk/pdbsum/4RTO
PDBsum4RTPhttp://www.ebi.ac.uk/pdbsum/4RTP
PDBsum4RTQhttp://www.ebi.ac.uk/pdbsum/4RTQ
PDBsum4RTRhttp://www.ebi.ac.uk/pdbsum/4RTR
PDBsum4RTShttp://www.ebi.ac.uk/pdbsum/4RTS
PRINTSPR00505http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00505
PROSITEPS00092http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00092
PSORT-Bswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:DMA_ECOLI
PSORT2swissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:DMA_ECOLI
PSORTswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:DMA_ECOLI
PfamPF02086http://pfam.xfam.org/family/PF02086
Phobiusswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:DMA_ECOLI
PhylomeDBP0AEE8http://phylomedb.org/?seqid=P0AEE8
ProteinModelPortalP0AEE8http://www.proteinmodelportal.org/query/uniprot/P0AEE8
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed2549371http://www.ncbi.nlm.nih.gov/pubmed/2549371
PubMed6300769http://www.ncbi.nlm.nih.gov/pubmed/6300769
PubMed7603433http://www.ncbi.nlm.nih.gov/pubmed/7603433
PubMed8341592http://www.ncbi.nlm.nih.gov/pubmed/8341592
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
REBASE2396http://rebase.neb.com/rebase/enz/2396.html
RefSeqNP_417846http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417846
RefSeqWP_000742143http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000742143
SMRP0AEE8http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEE8
STRING511145.b3387http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3387&targetmode=cogs
STRINGCOG0338http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0338&targetmode=cogs
SUPFAMSSF53335http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335
TIGRFAMsTIGR00571http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00571
UniProtKB-ACP0AEE8http://www.uniprot.org/uniprot/P0AEE8
UniProtKBDMA_ECOLIhttp://www.uniprot.org/uniprot/DMA_ECOLI
chargeswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:DMA_ECOLI
eggNOGCOG0338http://eggnogapi.embl.de/nog_data/html/tree/COG0338
eggNOGENOG4105DFEhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DFE
epestfindswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:DMA_ECOLI
garnierswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:DMA_ECOLI
helixturnhelixswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:DMA_ECOLI
hmomentswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:DMA_ECOLI
iepswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:DMA_ECOLI
inforesidueswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:DMA_ECOLI
octanolswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:DMA_ECOLI
pepcoilswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:DMA_ECOLI
pepdigestswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:DMA_ECOLI
pepinfoswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:DMA_ECOLI
pepnetswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:DMA_ECOLI
pepstatsswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:DMA_ECOLI
pepwheelswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:DMA_ECOLI
pepwindowswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:DMA_ECOLI
sigcleaveswissprot:DMA_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:DMA_ECOLI
DataBaseIDURL or Descriptions
# AltNameLIGB_ECOLIPolydeoxyribonucleotide synthase [NAD(+)] B
# BioGrid4262567167
# CATALYTIC ACTIVITYLIGB_ECOLINAD(+) + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + beta-nicotinamide D- ribonucleotide + (deoxyribonucleotide)(n+m).
# COFACTORLIGB_ECOLIName=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 11812821}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 11812821};
# EcoGeneEG11334ligB
# FUNCTIONLIGB_ECOLICatalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. {ECO 0000269|PubMed 11812821}.
# GO_componentGO:0005829cytosol; IBA:GO_Central.
# GO_functionGO:0003911DNA ligase (NAD+) activity; IDA:EcoCyc.
# GO_processGO:0006260DNA replication; IEA:UniProtKB-KW.
# GO_processGO:0006266DNA ligation; IDA:EcoCyc.
# GO_processGO:0006288base-excision repair, DNA ligation; IBA:GO_Central.
# GOslim_componentGO:0005829cytosol
# GOslim_functionGO:0016874ligase activity
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0009058biosynthetic process
# HAMAPMF_01587DNA_ligase_B
# IntActP257723
# InterProIPR004150NAD_DNA_ligase_OB
# InterProIPR010994RuvA_2-like
# InterProIPR012340NA-bd_OB-fold
# InterProIPR013839DNAligase_adenylation
# InterProIPR013840DNAligase_N
# InterProIPR018239DNA_ligase_AS
# InterProIPR020923DNA_ligase_B
# InterProIPR033136DNA_ligase_CS
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Pathwayko03030DNA replication
# KEGG_Pathwayko03410Base excision repair
# KEGG_Pathwayko03420Nucleotide excision repair
# KEGG_Pathwayko03430Mismatch repair
# MISCELLANEOUSLIGB_ECOLIConsiderably less active in nick joining than LigA.
# OrganismLIGB_ECOLIEscherichia coli (strain K12)
# PATRIC32122781VBIEscCol129921_3767
# PIRA65166A65166
# PROSITEPS01055DNA_LIGASE_N1
# PROSITEPS01056DNA_LIGASE_N2
# PfamPF01653DNA_ligase_aden
# PfamPF03120DNA_ligase_OB
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameLIGB_ECOLIDNA ligase B
# RefSeqNP_418104NC_000913.3
# RefSeqWP_000870036NZ_LN832404.1
# SEQUENCE CAUTIONSequence=AAA62000.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAB88710.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO0000305};
# SIMILARITYBelongs to the NAD-dependent DNA ligase family. LigB subfamily. {ECO0000305}.
# SMARTSM00532LIGANc
# SUPFAMSSF47781SSF47781
# SUPFAMSSF50249SSF50249
# eggNOGCOG0272LUCA
# eggNOGENOG410649JBacteria
BLASTswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:LIGB_ECOLI
BioCycECOL316407:JW3622-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW3622-MONOMER
BioCycEcoCyc:EG11334-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG11334-MONOMER
BioCycMetaCyc:EG11334-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG11334-MONOMER
COGCOG0272http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0272
DOI10.1006/geno.1993.1230http://dx.doi.org/10.1006/geno.1993.1230
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1093/nar/29.24.4930http://dx.doi.org/10.1093/nar/29.24.4930
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:6.5.1.2http://www.genome.jp/dbget-bin/www_bget?EC:6.5.1.2
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLL10328http://www.ebi.ac.uk/ena/data/view/L10328
EMBLM84400http://www.ebi.ac.uk/ena/data/view/M84400
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
ENZYME6.5.1.2http://enzyme.expasy.org/EC/6.5.1.2
EchoBASEEB1310http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1310
EcoGeneEG11334http://www.ecogene.org/geneInfo.php?eg_id=EG11334
EnsemblBacteriaAAC76671http://www.ensemblgenomes.org/id/AAC76671
EnsemblBacteriaAAC76671http://www.ensemblgenomes.org/id/AAC76671
EnsemblBacteriaBAE77646http://www.ensemblgenomes.org/id/BAE77646
EnsemblBacteriaBAE77646http://www.ensemblgenomes.org/id/BAE77646
EnsemblBacteriaBAE77646http://www.ensemblgenomes.org/id/BAE77646
EnsemblBacteriab3647http://www.ensemblgenomes.org/id/b3647
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GO_functionGO:0003911http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003911
GO_processGO:0006260http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260
GO_processGO:0006266http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006266
GO_processGO:0006288http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006288
GOslim_componentGO:0005829http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829
GOslim_functionGO:0016874http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
GeneID948164http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948164
HAMAPMF_01587http://hamap.expasy.org/unirule/MF_01587
HOGENOMHOG000267776http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267776&db=HOGENOM6
IntActP25772http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25772*
IntEnz6.5.1.2http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.5.1.2
InterProIPR004150http://www.ebi.ac.uk/interpro/entry/IPR004150
InterProIPR010994http://www.ebi.ac.uk/interpro/entry/IPR010994
InterProIPR012340http://www.ebi.ac.uk/interpro/entry/IPR012340
InterProIPR013839http://www.ebi.ac.uk/interpro/entry/IPR013839
InterProIPR013840http://www.ebi.ac.uk/interpro/entry/IPR013840
InterProIPR018239http://www.ebi.ac.uk/interpro/entry/IPR018239
InterProIPR020923http://www.ebi.ac.uk/interpro/entry/IPR020923
InterProIPR033136http://www.ebi.ac.uk/interpro/entry/IPR033136
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW3622http://www.genome.jp/dbget-bin/www_bget?ecj:JW3622
KEGG_Geneeco:b3647http://www.genome.jp/dbget-bin/www_bget?eco:b3647
KEGG_OrthologyKO:K01972http://www.genome.jp/dbget-bin/www_bget?KO:K01972
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
KEGG_Pathwayko03410http://www.genome.jp/kegg-bin/show_pathway?ko03410
KEGG_Pathwayko03420http://www.genome.jp/kegg-bin/show_pathway?ko03420
KEGG_Pathwayko03430http://www.genome.jp/kegg-bin/show_pathway?ko03430
OMALFVWDWPhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LFVWDWP
PROSITEPS01055http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01055
PROSITEPS01056http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01056
PSORT-Bswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:LIGB_ECOLI
PSORT2swissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:LIGB_ECOLI
PSORTswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:LIGB_ECOLI
PfamPF01653http://pfam.xfam.org/family/PF01653
PfamPF03120http://pfam.xfam.org/family/PF03120
Phobiusswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:LIGB_ECOLI
PhylomeDBP25772http://phylomedb.org/?seqid=P25772
ProteinModelPortalP25772http://www.proteinmodelportal.org/query/uniprot/P25772
PubMed11812821http://www.ncbi.nlm.nih.gov/pubmed/11812821
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed7686882http://www.ncbi.nlm.nih.gov/pubmed/7686882
PubMed8390989http://www.ncbi.nlm.nih.gov/pubmed/8390989
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
RefSeqNP_418104http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418104
RefSeqWP_000870036http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000870036
SMARTSM00532http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00532
SMRP25772http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25772
STRING511145.b3647http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3647&targetmode=cogs
STRINGCOG0272http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0272&targetmode=cogs
SUPFAMSSF47781http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47781
SUPFAMSSF50249http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249
UniProtKB-ACP25772http://www.uniprot.org/uniprot/P25772
UniProtKBLIGB_ECOLIhttp://www.uniprot.org/uniprot/LIGB_ECOLI
chargeswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/charge/swissprot:LIGB_ECOLI
eggNOGCOG0272http://eggnogapi.embl.de/nog_data/html/tree/COG0272
eggNOGENOG410649Jhttp://eggnogapi.embl.de/nog_data/html/tree/ENOG410649J
epestfindswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/epestfind/swissprot:LIGB_ECOLI
garnierswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/garnier/swissprot:LIGB_ECOLI
helixturnhelixswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/helixturnhelix/swissprot:LIGB_ECOLI
hmomentswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/hmoment/swissprot:LIGB_ECOLI
iepswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/iep/swissprot:LIGB_ECOLI
inforesidueswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/inforesidue/swissprot:LIGB_ECOLI
octanolswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/octanol/swissprot:LIGB_ECOLI
pepcoilswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/pepcoil/swissprot:LIGB_ECOLI
pepdigestswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/pepdigest/swissprot:LIGB_ECOLI
pepinfoswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/pepinfo/swissprot:LIGB_ECOLI
pepnetswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/pepnet/swissprot:LIGB_ECOLI
pepstatsswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/pepstats/swissprot:LIGB_ECOLI
pepwheelswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/pepwheel/swissprot:LIGB_ECOLI
pepwindowswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/pepwindow/swissprot:LIGB_ECOLI
sigcleaveswissprot:LIGB_ECOLIhttp://rest.g-language.org/emboss/sigcleave/swissprot:LIGB_ECOLI
DataBaseIDURL or Descriptions
# BioGrid4259908201
# CATALYTIC ACTIVITYHOLA_ECOLIDeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
# EcoGeneEG11412holA
# FUNCTIONHOLA_ECOLIDNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.
# GO_componentGO:0009360DNA polymerase III complex; IDA:EcoCyc.
# GO_functionGO:0003677DNA binding; IEA:InterPro.
# GO_functionGO:0003887DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
# GO_processGO:0006261DNA-dependent DNA replication; IDA:EcoCyc.
# GOslim_componentGO:0005575cellular_component
# GOslim_functionGO:0003677DNA binding
# GOslim_functionGO:0016779nucleotidyltransferase activity
# GOslim_processGO:0006259DNA metabolic process
# GOslim_processGO:0009058biosynthetic process
# Gene3D3.40.50.300-; 1.
# INTERACTIONHOLA_ECOLIP10443 dnaE; NbExp=4; IntAct=EBI-549153, EBI-549111; P0A988 dnaN; NbExp=10; IntAct=EBI-549153, EBI-542385; P06710-1 dnaX; NbExp=5; IntAct=EBI-549153, EBI-6464728; P06710-2 dnaX; NbExp=6; IntAct=EBI-549153, EBI-2604194; P28631 holB; NbExp=17; IntAct=EBI-549153, EBI-549161; P23367 mutL; NbExp=2; IntAct=EBI-549153, EBI-554913; P17117 nfsA; NbExp=3; IntAct=EBI-549153, EBI-1120624; P64526 yeeW; NbExp=2; IntAct=EBI-549153, EBI-9146863;
# IntActP2863049
# InterProIPR005790DNA_polIII_delta
# InterProIPR008921DNA_pol3_clamp-load_cplx_C
# InterProIPR010372DNA_pol3_delta_N
# InterProIPR027417P-loop_NTPase
# InterProIPR032780DNA_pol3_delt_C
# KEGG_Briteko00001KEGG Orthology (KO)
# KEGG_Briteko00002 KEGG pathway modules
# KEGG_Briteko01000 Enzymes
# KEGG_Briteko03032 DNA replication proteins
# KEGG_Briteko03032 M00260 DNA polymerase III complex, bacteria
# KEGG_Briteko03400 DNA repair and recombination proteins
# KEGG_Briteko03400 M00260 DNA polymerase III complex, bacteria
# KEGG_Pathwayko00230Purine metabolism
# KEGG_Pathwayko00240Pyrimidine metabolism
# KEGG_Pathwayko03030DNA replication
# KEGG_Pathwayko03430Mismatch repair
# KEGG_Pathwayko03440Homologous recombination
# OrganismHOLA_ECOLIEscherichia coli (strain K12)
# PATRIC32116463VBIEscCol129921_0671
# PDB1JQJX-ray; 2.90 A; C/D=1-343
# PDB1JQLX-ray; 2.50 A; B=1-140
# PDB1JR3X-ray; 2.70 A; D=1-343
# PDB1XXHX-ray; 3.45 A; A/F=1-343
# PDB1XXIX-ray; 4.10 A; A/F=1-343
# PDB3GLFX-ray; 3.39 A; A/F=1-343
# PDB3GLGX-ray; 3.25 A; A/F=1-343
# PDB3GLHX-ray; 3.89 A; A/F/K=1-343
# PDB3GLIX-ray; 3.50 A; A/F=1-343
# PIRA45251A45251
# PfamPF06144DNA_pol3_delta
# PfamPF14840DNA_pol3_delt_C
# ProteomesUP000000318Chromosome
# ProteomesUP000000625Chromosome
# RecNameHOLA_ECOLIDNA polymerase III subunit delta
# RefSeqNP_415173NC_000913.3
# RefSeqWP_000620535NZ_LN832404.1
# SUBUNITThe DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4].
# SUPFAMSSF48019SSF48019
# SUPFAMSSF52540SSF52540
# TIGRFAMsTIGR01128holA
# eggNOGCOG1466LUCA
# eggNOGENOG4105DJFBacteria
BLASTswissprot:HOLA_ECOLIhttp://rest.g-language.org/emboss/kblast/swissprot:HOLA_ECOLI
BioCycECOL316407:JW0635-MONOMERhttp://biocyc.org/getid?id=ECOL316407:JW0635-MONOMER
BioCycEcoCyc:EG11412-MONOMERhttp://biocyc.org/getid?id=EcoCyc:EG11412-MONOMER
BioCycMetaCyc:EG11412-MONOMERhttp://biocyc.org/getid?id=MetaCyc:EG11412-MONOMER
COGCOG1466http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1466
DIPDIP-9931Nhttp://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9931N
DOI10.1002/bies.950140206http://dx.doi.org/10.1002/bies.950140206
DOI10.1002/elps.1150180805http://dx.doi.org/10.1002/elps.1150180805
DOI10.1038/msb4100049http://dx.doi.org/10.1038/msb4100049
DOI10.1093/dnares/3.3.137http://dx.doi.org/10.1093/dnares/3.3.137
DOI10.1126/science.277.5331.1453http://dx.doi.org/10.1126/science.277.5331.1453
EC_numberEC:2.7.7.7http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7
EMBLAP009048http://www.ebi.ac.uk/ena/data/view/AP009048
EMBLL04576http://www.ebi.ac.uk/ena/data/view/L04576
EMBLM18277http://www.ebi.ac.uk/ena/data/view/M18277
EMBLM94267http://www.ebi.ac.uk/ena/data/view/M94267
EMBLU00096http://www.ebi.ac.uk/ena/data/view/U00096
EMBLU82598http://www.ebi.ac.uk/ena/data/view/U82598
ENZYME2.7.7.7http://enzyme.expasy.org/EC/2.7.7.7
EchoBASEEB1384http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1384
EcoGeneEG11412http://www.ecogene.org/geneInfo.php?eg_id=EG11412
EnsemblBacteriaAAC73741http://www.ensemblgenomes.org/id/AAC73741
EnsemblBacteriaAAC73741http://www.ensemblgenomes.org/id/AAC73741
EnsemblBacteriaBAA35287http://www.ensemblgenomes.org/id/BAA35287
EnsemblBacteriaBAA35287http://www.ensemblgenomes.org/id/BAA35287
EnsemblBacteriaBAA35287http://www.ensemblgenomes.org/id/BAA35287
EnsemblBacteriab0640http://www.ensemblgenomes.org/id/b0640
G-LinksNC_000913http://link.g-language.org/NC_000913/format=tsv
GO_componentGO:0009360http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009360
GO_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GO_functionGO:0003887http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887
GO_processGO:0006261http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261
GOslim_componentGO:0005575http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575
GOslim_functionGO:0003677http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677
GOslim_functionGO:0016779http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779
GOslim_processGO:0006259http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259
GOslim_processGO:0009058http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058
Gene3D3.40.50.300http://www.cathdb.info/version/latest/superfamily/3.40.50.300
GeneID947573http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947573
HOGENOMHOG000256204http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256204&db=HOGENOM6
InParanoidP28630http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28630
IntActP28630http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28630*
IntEnz2.7.7.7http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7
InterProIPR005790http://www.ebi.ac.uk/interpro/entry/IPR005790
InterProIPR008921http://www.ebi.ac.uk/interpro/entry/IPR008921
InterProIPR010372http://www.ebi.ac.uk/interpro/entry/IPR010372
InterProIPR027417http://www.ebi.ac.uk/interpro/entry/IPR027417
InterProIPR032780http://www.ebi.ac.uk/interpro/entry/IPR032780
KEGG_Briteko00001http://www.genome.jp/dbget-bin/www_bget?ko00001
KEGG_Briteko00002http://www.genome.jp/dbget-bin/www_bget?ko00002
KEGG_Briteko01000http://www.genome.jp/dbget-bin/www_bget?ko01000
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03032http://www.genome.jp/dbget-bin/www_bget?ko03032
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Briteko03400http://www.genome.jp/dbget-bin/www_bget?ko03400
KEGG_Geneecj:JW0635http://www.genome.jp/dbget-bin/www_bget?ecj:JW0635
KEGG_Geneeco:b0640http://www.genome.jp/dbget-bin/www_bget?eco:b0640
KEGG_OrthologyKO:K02340http://www.genome.jp/dbget-bin/www_bget?KO:K02340
KEGG_Pathwayko00230http://www.genome.jp/kegg-bin/show_pathway?ko00230
KEGG_Pathwayko00240http://www.genome.jp/kegg-bin/show_pathway?ko00240
KEGG_Pathwayko03030http://www.genome.jp/kegg-bin/show_pathway?ko03030
KEGG_Pathwayko03430http://www.genome.jp/kegg-bin/show_pathway?ko03430
KEGG_Pathwayko03440http://www.genome.jp/kegg-bin/show_pathway?ko03440
KEGG_Reactionrn:R00375http://www.genome.jp/dbget-bin/www_bget?rn:R00375
KEGG_Reactionrn:R00376http://www.genome.jp/dbget-bin/www_bget?rn:R00376
KEGG_Reactionrn:R00377http://www.genome.jp/dbget-bin/www_bget?rn:R00377
KEGG_Reactionrn:R00378http://www.genome.jp/dbget-bin/www_bget?rn:R00378
MINTMINT-1235044http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1235044
OMARQQGFDEhttp://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RQQGFDE
PDB1JQJhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1JQJ
PDB1JQLhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1JQL
PDB1JR3http://www.ebi.ac.uk/pdbe-srv/view/entry/1JR3
PDB1XXHhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1XXH
PDB1XXIhttp://www.ebi.ac.uk/pdbe-srv/view/entry/1XXI
PDB3GLFhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3GLF
PDB3GLGhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3GLG
PDB3GLHhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3GLH
PDB3GLIhttp://www.ebi.ac.uk/pdbe-srv/view/entry/3GLI
PDBsum1JQJhttp://www.ebi.ac.uk/pdbsum/1JQJ
PDBsum1JQLhttp://www.ebi.ac.uk/pdbsum/1JQL
PDBsum1JR3http://www.ebi.ac.uk/pdbsum/1JR3
PDBsum1XXHhttp://www.ebi.ac.uk/pdbsum/1XXH
PDBsum1XXIhttp://www.ebi.ac.uk/pdbsum/1XXI
PDBsum3GLFhttp://www.ebi.ac.uk/pdbsum/3GLF
PDBsum3GLGhttp://www.ebi.ac.uk/pdbsum/3GLG
PDBsum3GLHhttp://www.ebi.ac.uk/pdbsum/3GLH
PDBsum3GLIhttp://www.ebi.ac.uk/pdbsum/3GLI
PSORT-Bswissprot:HOLA_ECOLIhttp://rest.g-language.org/emboss/kpsortb/swissprot:HOLA_ECOLI
PSORT2swissprot:HOLA_ECOLIhttp://rest.g-language.org/emboss/kpsort2/swissprot:HOLA_ECOLI
PSORTswissprot:HOLA_ECOLIhttp://rest.g-language.org/emboss/kpsort/swissprot:HOLA_ECOLI
PfamPF06144http://pfam.xfam.org/family/PF06144
PfamPF14840http://pfam.xfam.org/family/PF14840
Phobiusswissprot:HOLA_ECOLIhttp://rest.g-language.org/emboss/kphobius/swissprot:HOLA_ECOLI
PhylomeDBP28630http://phylomedb.org/?seqid=P28630
ProteinModelPortalP28630http://www.proteinmodelportal.org/query/uniprot/P28630
PubMed1400251http://www.ncbi.nlm.nih.gov/pubmed/1400251
PubMed1575709http://www.ncbi.nlm.nih.gov/pubmed/1575709
PubMed16738553http://www.ncbi.nlm.nih.gov/pubmed/16738553
PubMed3316191http://www.ncbi.nlm.nih.gov/pubmed/3316191
PubMed8505303http://www.ncbi.nlm.nih.gov/pubmed/8505303
PubMed8505304http://www.ncbi.nlm.nih.gov/pubmed/8505304
PubMed8905232http://www.ncbi.nlm.nih.gov/pubmed/8905232
PubMed9278503http://www.ncbi.nlm.nih.gov/pubmed/9278503
PubMed9298644http://www.ncbi.nlm.nih.gov/pubmed/9298644
RefSeqNP_415173http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415173
RefSeqWP_000620535http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000620535
SMRP28630http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28630